Article
Biochemistry & Molecular Biology
Yeela Talmor-Barkan, Noam Bar, Aviv A. Shaul, Nir Shahaf, Anastasia Godneva, Yuval Bussi, Maya Lotan-Pompan, Adina Weinberger, Alon Shechter, Chava Chezar-Azerrad, Ziad Arow, Yoav Hammer, Kanta Chechi, Sofia K. Forslund, Sebastien Fromentin, Marc-Emmanuel Dumas, S. Dusko Ehrlich, Oluf Pedersen, Ran Kornowski, Eran Segal
Summary: Multi-omic profiling of patients with coronary artery disease reveals links between alterations in the serum metabolome with genetics, diet, and the microbiome. The study found that these metabolomic alterations are associated with metabolic impairment preceding clinically overt coronary artery disease. The results highlight the importance of understanding risk-factor heterogeneity in coronary artery disease through the serum metabolome.
Article
Sport Sciences
Charles A. German, Jason Fanning, Matthew J. Singleton, Michael D. Shapiro, Peter H. Brubaker, Alain G. Bertoni, Joseph Yeboah
Summary: This study found that high levels of physical activity are negatively correlated with cardiovascular disease and all-cause mortality, indicating that high PA can reduce the risk of CVD and overall death. The research also suggests that even among individuals at high risk of CVD, high levels of PA do not pose additional risks.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Nutrition & Dietetics
Yusuke Akiyama, Shunsuke Katsuki, Tetsuya Matoba, Yasuhiro Nakano, Susumu Takase, Soichi Nakashiro, Mitsutaka Yamamoto, Yasushi Mukai, Shujiro Inoue, Keiji Oi, Taiki Higo, Masao Takemoto, Nobuhiro Suematsu, Kenichi Eshima, Kenji Miyata, Makoto Usui, Kenji Sadamatsu, Toshiaki Kadokami, Kiyoshi Hironaga, Ikuyo Ichi, Koji Todaka, Junji Kishimoto, Hiroyuki Tsutsui
Summary: Oxysterols are believed to contribute to the development of cardiovascular diseases, and their serum levels are positively associated with cholesterol absorption and synthesis. However, the regulation of different oxysterols in the body is largely unknown. This study aimed to investigate the relationship between clinical factors and cholesterol metabolism markers, as well as identify oxysterols associated with cholesterol absorption and synthesis in patients with coronary artery disease.
Article
Cardiac & Cardiovascular Systems
So Mi Jemma Cho, Satoshi Koyama, Michael C. Honigberg, Ida Surakka, Sara Haidermota, Shriienidhie Ganesh, Aniruddh P. Patel, Romit Bhattacharya, Hokyou Lee, Hyeon Chang Kim, Pradeep Natarajan
Summary: This study examined the associations and clinical utilities of various factors on coronary artery disease (CAD) recurrence, including genetic, sociodemographic, lifestyle, and clinical risk factors. The findings showed that current smoking and age at first CAD diagnosis were the most significant predictors of CAD recurrence. Other factors such as age at enrolment, CAD polygenic risk score, laboratory test results, and HDL cholesterol concentration were also significantly associated with recurrence risk.
EUROPEAN HEART JOURNAL
(2023)
Article
Physiology
Sandra Gegunde, Amparo Alfonso, Rebeca Alvarino, Nadia Perez-Fuentes, Jeremias Bayon-Lorenzo, Eva Alonso, Raymundo Ocaranza-Sanchez, Rosa Alba Abellas-Sequeiros, Melisa Santas-Alvarez, Mercedes R. Vieytes, Carlos Juanatey-Gonzalez, Luis M. Botana
Summary: This study revealed that serum levels of cyclophilin A and C are elevated in patients with coronary artery disease regardless of the presence of cardiovascular risk factors. On the other hand, cyclophilin B levels are increased in male patients with hypertension, type 2 diabetes, or high glucose levels. All three cyclophilins were significantly correlated with cardiovascular risk factors, with cyclophilin B specifically associated with type 2 diabetes. Multivariate analysis further demonstrated the predictive value of cyclophilin A and C in the presence of coronary artery disease, along with other cardiovascular risk factors. Additionally, high levels of cyclophilin B, combined with hypertension or dyslipidemia, increased the risk of coronary artery disease in male patients.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Clinical Neurology
Michelle C. Johansen, Rebecca F. Gottesman, Brian G. Kral, Dhananjay Vaidya, Lisa R. Yanek, Lewis C. Becker, Diane M. Becker, Paul Nyquist
Summary: In healthy high-risk individuals, the presence and volume of coronary artery plaque are associated with larger WMH volumes, appearing the strongest for periventricular WMH. These findings in high-risk families suggest a disease relationship in 2 different vascular beds, possibly due to genetic predisposition.
Article
Gastroenterology & Hepatology
Zhewen Ren, Pomme I. H. G. Simons, Anke Wesselius, Coen D. A. Stehouwer, Martijn C. G. J. Brouwers
Summary: The study found a significant association between genetically predicted non-alcoholic fatty liver disease (NAFLD) and risk of coronary artery disease (CAD). However, there was no significant association for other NAFLD-related traits.
Article
Multidisciplinary Sciences
Sukma Azureen Nazli, Yung-An Chua, Noor Alicezah Mohd Kasim, Zaliha Ismail, Ahmad Bakhtiar Md Radzi, Khairul Shafiq Ibrahim, Sazzli Shahlan Kasim, Azhari Rosman, Hapizah Nawawi
Summary: This study aimed to determine the prevalence of clinically diagnosed familial hypercholesterolemia (FH) among angiogram-proven premature coronary artery disease (PCAD) patients in the Asian population. The study found that potential FH is common among PCAD patients and contributes greatly to PCAD. The presence of FH, diabetes, hypertension, obesity, and family history of PCAD are independent predictors of PCAD.
Article
Multidisciplinary Sciences
Sukma Azureen Nazli, Yung-An Chua, Noor Alicezah Mohd Kasim, Zaliha Ismail, Ahmad Bakhtiar Md Radzi, Khairul Shafiq Ibrahim, Sazzli Shahlan Kasim, Azhari Rosman, Hapizah Nawawi
Summary: This study investigated the prevalence of FH and CRFs among AP-PCAD patients in the Asian population. The results showed that potential FH is common among AP-PCAD patients and contributes greatly to the development of AP-PCAD. FH-PCAD patients have higher proportions of various risk factors compared to other groups.
Article
Cardiac & Cardiovascular Systems
Shinjeong Song, Su-Yeon Choi, Hyo Eun Park, Hae-Won Han, Sung Hak Park, Jidong Sung, Hae Ok Jung, Ji Min Sung, Hyuk-Jae Chang
Summary: This study investigated the role of the TyG index as a predictor of coronary artery calcification (CAC) progression in a low-risk population. The results showed that the TyG index is an independent predictor of CAC progression, adding incremental risk stratification over established factors.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Multidisciplinary Sciences
Ya-Wen Lu, Chuan-Tsai Tsai, Ruey-Hsin Chou, Yi-Lin Tsai, Chin-Sung Kuo, Po-Hsun Huang, Shing-Jong Lin
Summary: Insulin resistance is associated with cardiovascular disease in non-diabetic patients. The triglyceride-glucose index is a surrogate marker for insulin resistance. A higher TyG index is associated with an increased risk of obstructive coronary artery disease, especially in non-diabetic women. Further studies are needed to validate these findings.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Simone Marschner, Edwina Wing-Lun, Clara Chow, Louise Maple-Brown, Sian Graham, Stephen J. Nicholls, Alex Brown, Anna Wood, Abdul Ihdayhid, Amy Von Huben, Sarah Zaman
Summary: Cardiovascular disease is the leading cause of death in women worldwide, with higher risk and earlier onset in Aboriginal and Torres Strait Islander women in Australia. Traditional risk prediction tools underestimate the risk in women and Indigenous people, and do not consider female-specific risk-enhancers. CT coronary artery calcium score is an effective predictor for future cardiac events and may help improve medical therapy in women with risk-enhancing factors.
Article
Medicine, General & Internal
Sadiya S. Khan, Wendy S. Post, Xiuqing Guo, Jingyi Tan, Fang Zhu, Daniel Bos, Bahar Sedaghati-Khayat, Jeroen van Rooij, Aaron Aday, Norrina B. Allen, Maxime M. Bos, Andre G. Uitterlinden, Matthew J. Budoff, Donald M. Lloyd-Jones, Jonathan D. Mosley, Jerome I. Rotter, Philip Greenland, Maryam Kavousi
Summary: Coronary artery calcium score and polygenic risk score were evaluated for their ability to predict risk of coronary heart disease (CHD) in two population-based studies. The results showed that coronary artery calcium score had better discrimination and improved risk prediction when added to traditional risk factors compared to the polygenic risk score.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Clinical Neurology
Suzanne M. Bertisch, Michelle Reid, Pamela L. Lutsey, Joel D. Kaufman, Robyn McClelland, Sanjay R. Patel, Susan Redline
Summary: The study found that insomnia symptoms were associated with an 18% higher prevalence of CAC in women, but not in men. Additionally, there was no evidence that the association between insomnia symptoms and CAC score >0 differed based on objective short sleep duration status in males or females.
Article
Radiology, Nuclear Medicine & Medical Imaging
Amit Gupta, Kaustav Bera, Elias Kikano, Jonathan D. Pierce, Jonathan Gan, Maharshi Rajdev, Leslie M. Ciancibello, Aekta Gupta, Sanjay Rajagopalan, Robert C. Gilkeson
Summary: Coronary artery calcium (CAC) scores obtained from CT scans have been proven to predict the risk of cardiovascular diseases and disease-specific mortality. However, there are challenges associated with the acquisition, calculation, and interpretation of this score. Current research focuses on improving scoring methods and image acquisition strategies.
Article
Peripheral Vascular Disease
Kiminori Kato, Tomoaki Ishigami, Takashi Kobayashi, Minoru Tahiro, Shigemi Tashiro, Takaho Yamada, Midori Iwanaga, Satoru Kodama, Kazuya Fujihara, Koji Sato, Hirohito Sone
Summary: Salt excretion using spot urine (e-NaCl) is a convenient method to determine salt intake. In this study, e-NaCl was measured during health checkups and compared with seasonal changes in blood pressure. The results showed that e-NaCl decreased in summer, possibly due to reduced burden on the kidneys for salt excretion caused by sweating, which may be related to decreases in blood pressure.
HYPERTENSION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Ayako Kobayashi, Kazuya Fujihara, Mayuko Harada Yamada, Takaaki Sato, Yuta Yaguchi, Masaru Kitazawa, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone
Summary: This study investigated the combined effects of blood pressure and glycemic status on the risk of heart failure using a Japanese claims database. The results showed that the relationship between blood pressure and heart failure risk weakened with worsening of glucose metabolism. In patients with diabetes, comprehensive management of risk factors other than blood pressure may be essential to prevent heart failure.
JOURNAL OF HYPERTENSION
(2023)
Review
Medicine, General & Internal
Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Yasuhiro Matsubayashi, Masaru Kitazawa, Midori Iwanaga, Takaho Yamada, Kiminori Kato, Yoshimi Nakagawa, Shiro Tanaka, Hitoshi Shimano, Hirohito Sone
Summary: This network meta-analysis aimed to find optimal glucose-lowering drug treatment regimens in terms of glycemic control and hypoglycemia risk for patients with type 2 diabetes. The use of insulin and non-insulin glucose-lowering agents showed better glycemic control and lower risk of hypoglycemia. Certain combinations of insulin and non-insulin agents were identified as high-efficacy and relatively high-efficacy options for glycemic control. Clinicians should consider appropriate combinations of non-insulin agents to reduce hypoglycemia risk before switching to insulin therapies and be willing to add non-insulin agents to insulin for further improvement in glycemic control.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Maki Kawasaki, Naoko Arata, Takashi Sugiyama, Tatsumi Moriya, Atsuo Itakuda, Ichiro Yasuhi, Yasuko Uchigata, Eiji Kawasaki, Hirohito Sone, Yuji Hiramatsu
Summary: This study aimed to establish a prospective registry system for gestational diabetes mellitus (GDM) in Japan and to clarify the actual status of GDM according to the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. The results showed that the risk of low birth weight (LBW) and small-for-gestational age in the GDM group was significantly higher than in the normal glucose tolerance (NGT) group.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Sport Sciences
Takaaki Sato, Kazuya Fujihara, Mayuko Harada Yamada, Kaori Chou, Yuta Yaguchi, Masaru Kitazawa, Hajime Ishiguro, Taeko Osawa, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hirohito Sone
Summary: A new Physical Score (PS) was developed and its association with metabolic diseases among Japanese individuals was elucidated. The PS was calculated based on physical fitness indicators and showed a significant association with an increased risk of metabolic diseases, especially metabolic syndrome. The PS was found to be a useful and simple non-invasive tool for screening Japanese people for metabolic diseases.
JOURNAL OF SPORTS SCIENCE AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hirohito Sone
JOURNAL OF DIABETES INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Kazuya Fujihara, Hirohito Sone
Summary: Globally, the number of people with diabetes mellitus has increased by four times in the past 30 years, and approximately one in 11 adults worldwide have diabetes mellitus. Managing blood glucose levels is crucial for diabetes care due to its impact on the quality of life and mortality rates of the patients. Various classes of antihyperglycemic drugs are available, but the application of clinical trial results to actual clinical practice is challenging. Machine learning approaches in drug treatment strategies for diabetes care have been slow to be adopted.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Kazuya Fujihara, Mayuko Yamada Harada, Chika Horikawa, Midori Iwanaga, Hirofumi Tanaka, Hitoshi Nomura, Yasuharu Sui, Kyouhei Tanabe, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hirohito Sone
Summary: This study developed a machine learning model to predict weight change over three years. It found that lifestyle had a significant impact on weight in individuals with high BMI and in young people. The model showed comparable accuracy to multiple regression, suggesting its potential for personalized weight management.
FRONTIERS IN PUBLIC HEALTH
(2023)
Correction
Nutrition & Dietetics
Kanako Sumi, Yuiko Hatanaka, Reina Takahashi, Naoko Wada, Chihiro Ono, Yuri Sakamoto, Hirohito Sone, Kaoruko Iida
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Kazuya Fujihara, Laymon Khin, Koshiro Murai, Yurie Yamazaki, Kahori Tsuruoka, Noriko Yagyuda, Katsuya Yamazaki, Hiroshi Maegawa, Shiro Tanaka, Satoru Kodama, Hirohito Sone, DDM Study Grp
Summary: This study found an association between the magnitude of weight loss and the incidence of remission in patients with diabetes. Significant weight loss is required, with at least 10% reduction, to achieve a 10% remission rate in clinical settings.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Hiroki Yokoyama, Shin-ichi Araki, Koichi Kawai, Katsuya Yamazaki, Osamu Tomonaga, Hajime Maeda, Masafumi Ohtaki, Hiromi Obata, Hirohito Sone, Daijiro Kabata, Ayumi Shintani, Hiroshi Maegawa, JDDM Study Group
Summary: This study aimed to investigate the reduction in all-cause mortality and cardiovascular disease morbidity in type 2 diabetes patients over the past decade in real-world practice. The results showed a significant reduction in cardiovascular disease in the recent cohort, implying the impact of treatment advances.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Masaru Kitazawa, Yasunaga Takeda, Mariko Hatta, Chika Horikawa, Takaaki Sato, Taeko Osawa, Masahiro Ishizawa, Hiroshi Suzuki, Yasuhiro Matsubayashi, Kazuya Fujihara, Takaho Yamada, Hirohito Sone
Summary: Intervention with a smartphone app and intermittently scanned continuous glucose monitoring can improve glycemic control and lead to decreased carbohydrate intake and weight loss.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Meeting Abstract
Peripheral Vascular Disease
Kiminori Kato, Tomoaki Ishigami, Hirohito Sone
JOURNAL OF HYPERTENSION
(2023)
Article
Primary Health Care
Haruka Shiozaki, Kazuya Fujihara, Mayuko Yamada-Harada, Masahiko Yamamoto, Yurie Mitsuma, Masaru Kitazawa, Yuta Yaguchi, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone
Summary: This study aimed to investigate the independent associations of fast walking and habitual physical activity with the incidence of functional disability. The results showed that the absence of habitual physical activity and inability to walk fast were both significant risk factors for functional disability. Furthermore, the impact of these factors on disability risk varied according to age.
Article
Endocrinology & Metabolism
Emilie Steinbach, Davide Masi, Agnes Ribeiro, Patricia Serradas, Tiphaine Le Roy, Karine Clement
Summary: The study of the gut microbiome is crucial for understanding and treating metabolic diseases. While research on the fecal microbiome has provided valuable insights, relying solely on this may not be enough to draw comprehensive conclusions. The microbiome in the proximal part of the small intestine may play a significant role in metabolic regulation, but further exploration is needed due to limited accessibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Evangelia Chavdoula, Vollter Anastas, Alessandro La Ferlita, Julian Aldana, Giuseppe Carota, Mariarita Spampinato, Burak Soysal, Ilaria Cosentini, Sameer Parashar, Anuvrat Sircar, Giovanni Nigita, Lalit Sehgal, Michael A. Freitas, Philip N. Tsichlis
Summary: This study reveals the important role of KDM2B in triple-negative breast cancer (TNBC). KDM2B affects cellular resistance to oxidative stress by regulating a network of genes and metabolic enzymes, in collaboration with ATF4 and MYC. Additionally, high expression of KDM2B is associated with poor prognosis in patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Joongmin Kim, Hyeongsoo Kim, Sang Hyun Park, Yura Kang, Kyungdo Han, Sang-Hak Lee
Summary: This study aimed to investigate the optimal LDL-C level after statin therapy in individuals with intermediate cardiovascular risk. The results showed that achieving LDL-C levels <120 mg/dL after statin therapy could lower the event risk.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Ze Chen, Li -Ping Xia, Lang Shen, Dan Xu, Yu Guo, Hui Wang
Summary: Accumulating evidence suggests that NAFLD has an intrauterine origin, with adverse prenatal environments and glucocorticoid exposure playing a crucial role in the developmental programming of fetal hepatic lipid metabolism. The offspring's glucocorticoid-insulin-like growth factor 1 (GC-IGF1) axis is programmed in utero, leading to postnatal catch-up growth and disrupted glucose and lipid metabolism, increasing susceptibility to NAFLD. Mismatch between intrauterine and postnatal environments can further disturb the programmed endocrine axes and accelerate the onset of NAFLD.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Article
Endocrinology & Metabolism
Fuwen Zuo, Youzhao Wang, Xinlei Xu, Ruihao Ding, Wei Tang, Yu Sun, Xiaojie Wang, Yan Zhang, Jichao Wu, Yusheng Xie, Min Liu, Ziying Wang, Fan Yi
Summary: This study investigates the role of CCDC92 in the pathogenesis of diabetic kidney disease (DKD). The expression of CCDC92 was found to increase in kidney biopsies from patients with DKD and was correlated with glomerular lipid accumulation. Animal studies further confirmed the induction of CCDC92 in the kidney, particularly in podocytes, and the podocyte-specific deletion of Ccdc92 ameliorated podocyte injury and lipid deposition. CCDC92 was shown to promote podocyte lipotoxicity through ABCA1 signaling-mediated lipid homeostasis. Therefore, CCDC92 may serve as a potential biomarker of podocyte injury in DKD and targeting CCDC92 could be an innovative therapeutic strategy for DKD patients.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)
Review
Endocrinology & Metabolism
Khanyisani Ziqubu, Phiwayinkosi Dludla, Sihle E. Mabhida, Babalwa U. Jack, Susanne Keipert, Martin Jastroch, Sithandiwe E. Mazibuko-Mbeje
Summary: The discovery and revival of brown adipose tissue (BAT) in adult humans have opened up new possibilities for treating obesity and metabolic diseases. BAT not only plays a role in generating heat, but also secretes signaling molecules known as batokines, which regulate overall metabolism. This review highlights the importance of BAT-derived metabolites in controlling thermogenesis, substrate metabolism, and other biological processes, as well as their potential to alleviate obesity and related metabolic complications.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2024)