Article
Nutrition & Dietetics
Jong-Wook Yoo, Yoon-Jung Shin, Xiaoyang Ma, Young-Hoo Son, Hyo-Min Jang, Chang Kyun Lee, Dong-Hyun Kim
Summary: Gut microbiota dysbiosis is closely related to psychiatric disorders and inflammatory bowel disease. The transplantation of Enterobacteriaceae-rich gut microbiota can cause depression and colitis in mice. However, treatment with anti-inflammatory probiotics can alleviate these symptoms.
Article
Food Science & Technology
Shumao Cui, Danfeng Zhu, Bingyong Mao, Fangli Ma, Jianxin Zhao, Hao Zhang, Wei Chen
Summary: This study aimed to improve the industrial production of Bifidobacterium adolescentis strain Z25 by optimizing substrate materials and culture conditions. Glucose, yeast extract, fish peptone were identified as the optimal substrates for efficient proliferation of the strain, while Mg2+ concentration was positively correlated with maximum biomass within a certain range. The use of automatic feedback feeding method was found to be more conducive for high-density bifidobacterial culture.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Cell Biology
Shujie Chen, Luyi Chen, Yadong Qi, Jilei Xu, Qiwei Ge, Yuedan Fan, Du Chen, Yawen Zhang, Lan Wang, Tongyao Hou, Xiaohang Yang, Yongmei Xi, Jianmin Si, Lijun Kang, Liangjing Wang
Summary: The study identified lower abundance of Bifidobacterium adolescentis in older individuals and showed that dietary supplementation of this bacteria improved osteoporosis and neurodegeneration. Additionally, it was found that B. adolescentis increased catalase enzyme activity and suppressed cellular senescence, ultimately leading to improved healthspan and lifespan.
Article
Biotechnology & Applied Microbiology
Noa Mandelbaum, Lihan Zhang, Shaqed Carasso, Tamar Ziv, Sapir Lifshiz-Simon, Irina Davidovich, Ishai Luz, Elliot Berinstein, Tal Gefen, Tomer Cooks, Yeshayahu Talmon, Emily P. Balskus, Naama Geva-Zatorsky
Summary: This study examined the extracellular vesicles (EVs) secreted by a newly sequenced Gram-positive human gut symbiont strain, Bifidobacterium longum AO44. The EVs were found to have anti-inflammatory effects, inducing the secretion of IL-10 from splenocytes and dendritic cells (DC)-CD4+ T cells co-cultures. The protein content of the EVs was enriched in ABC transporters, quorum sensing proteins, and extracellular solute-binding proteins, which are known to play a significant role in the anti-inflammatory effects of other strains of B. longum. This study highlights the importance of bacterial vesicles in modulating the host immune system and suggests their potential as future therapeutics.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Review
Pharmacology & Pharmacy
Carolina Otero, Carolina Klagges, Bernardo Morales, Paula Sotomayor, Jorge Escobar, Juan A. Fuentes, Adrian A. Moreno, Felipe M. Llancalahuen, Ramiro Arratia-Perez, Felipe Gordillo-Fuenzalida, Michelle Herrera, Jose L. Martinez, Maite Rodriguez-Diaz
Summary: Medicinal plants have a long history of being used to treat diseases, and their anti-inflammatory properties make them a novel approach to treating conditions such as rheumatic diseases, cancer, obesity, and diabetes. This review focuses on various native Chilean plants, such as Fragaria chiloensis and Berberis microphylla, whose anti-inflammatory effects have been studied in experimental research. By combining scientific and ancestral knowledge, this review aims to provide a multidimensional therapeutic approach to inflammation with plant extracts.
Article
Biochemistry & Molecular Biology
Matteo Brindisi, Luca Frattaruolo, Vincenzo Sicari, Monica Rosa Loizzo, Gianni Bedini, Vittoria Rago, Rosa Tundis, Anna Rita Cappello
Summary: This study comprehensively investigated the multi-target biological potential of Italian Santolina pinnata, a traditional medicinal plant, and its chemical composition, revealing its valuable phytochemicals with anticancer and anti-inflammatory features.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Franco Corvace, Timo Jendrik Faustmann, Pedro M. Faustmann, Fatme Seval Ismail
Summary: This study investigated the effects of the antiepileptic drug lacosamide (LCM) on glial cells and found that LCM did not affect glial cell viability but inhibited microglial activation and increased astroglial Cx43 expression under inflammatory conditions.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Erick Bahena Culhuac, Aristide Maggiolino, Mona M. M. Y. Elghandour, Pasquale De Palo, Abdelfattah Z. M. Salem
Summary: The Yucca genus, native to North America, has been used in traditional medicine for its antioxidant and anti-inflammatory properties. However, research on this genus is limited. This study aimed to analyze the phytochemical composition and the mechanisms of action behind these properties. The results showed that the antioxidant and anti-inflammatory effects are mainly due to free radical scavenging activity, inhibition of arachidonic acid metabolism, and modulation of various cytokines and enzymes. More studies are needed to fully understand the potential of Yucca genus in managing chronic inflammation.
Article
Food Science & Technology
Priyanka Rose Mary, Mukesh Kapoor
Summary: This study investigates the cross-feeding and resource sharing between a generalist degrader and probiotic utilizers for utilizing dietary galactomannans. The results show that the breakdown products of galactomannans produced by Bacteroides ovatus DSMZ 1896 can support the growth of Lactiplantibacillus plantarum WCFS1 and Bifidobacterium adolescentis DSMZ 20083, and alter the production patterns of short-chain fatty acids and organic acids in co-cultures.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Biophysics
Kumar Sagar Jaiswal, Orit Malka, Nitzan Shauloff, Marina Bersudsky, Elena Voronov, Bhawna Gupta, Raz Jelinek
Summary: Genistein-C-dots, synthesized from genistein, exhibit antioxidant and anti-inflammatory properties. They inhibit pro-inflammatory cytokine levels and enhance anti-inflammatory cytokine expression. These C-dots also feature biocompatibility and low cytotoxicity, making them a potential therapeutic vehicle against inflammatory conditions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Jameel M. Al-Khayri, Gandasi Ravikumar Sahana, Praveen Nagella, Biljo V. Joseph, Fatima M. Alessa, Muneera Q. Al-Mssallem
Summary: Hydroxylated polyphenols, or flavonoids, are plant-based compounds with various medicinal properties, including anti-inflammatory effects. They activate antioxidant pathways, regulate cytokine expression, and inhibit pro-inflammatory enzyme activity, providing potential treatment options for inflammatory diseases. Understanding the anti-inflammatory action of flavonoids is important for improving human health.
Review
Plant Sciences
Gopalsamy Rajiv Gandhi, Gnanasekaran Jothi, Thiruchenduran Mohana, Alan Bruno Silva Vasconcelos, Monalisa Martins Montalvao, Govindasamy Hariharan, Gurunagarajan Sridharan, Perumal Madan Kumar, Ricardo Querioz Gurgel, Hua-Bin Li, Jinming Zhang, Ren-You Gan
Summary: This review focuses on the bioactive compounds from medicinal plants that have shown potential in modulating the immune response in the treatment of rheumatoid arthritis. These compounds have the ability to regulate interleukins and may offer promising alternatives to traditional RA treatments with fewer side effects.
Article
Biochemistry & Molecular Biology
Sobia Tabassum, Saeed Ahmad, Kashif Ur Rehman Khan, Fouzia Tabassum, Anjum Khursheed, Qamar Uz Zaman, Najat A. Bukhari, Alanoud Alfagham, Ashraf A. Hatamleh, Yinglong Chen
Summary: The study aimed to investigate the phytochemical composition of Portulacaria afra and evaluate its potential in antioxidant, anticoagulant, anti-inflammatory, and enzyme-inhibitory activities. The results demonstrated that P. afra extracts exhibited high antioxidant activity and could inhibit clotting and inflammation.
Article
Microbiology
Akira Sen, Tatsuki Nishimura, Shin Yoshimoto, Keisuke Yoshida, Aina Gotoh, Toshihiko Katoh, Yasuko Yoneda, Toyoyuki Hashimoto, Jin-Zhong Xiao, Takane Katayama, Toshitaka Odamaki
Summary: Examining the influence of host cells on the metabolism of probiotics is crucial for understanding the mechanisms underlying the efficacy of probiotics in vivo. However, there is limited research on the interaction between probiotics and host cells, such as intestinal epithelial cells. In this study, a comprehensive metabolome analysis was conducted on a co-culture of Bifidobacterium breve MCC1274 and induced pluripotent stem cells (iPS)-derived small intestinal-like cells, revealing increased levels of amino acid metabolites and gene expression related to ILA synthesis in B. breve MCC1274 cells. The presence of purines produced by intestinal epithelial cells enhanced ILA production, suggesting a synergistic interaction between probiotics and IECs as the molecular basis of host-probiotic interaction in vivo.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Food Science & Technology
Ruyuf Alfurayhi, Lei Huang, Kirsten Brandt
Summary: Polyacetylene phytochemicals found in apiaceous vegetables have been suggested to contribute to the chemoprotective effects against cancer. These chemicals, known as PAs, can influence various signaling pathways related to inflammation, apoptosis, and cell cycle regulation. Studies have shown that a higher intake of PA-rich vegetables is associated with a reduced risk of inflammation and cancer. PA supplementation has been found to affect cell growth, gene expression, and immune responses, and can reduce tumor development in animal models. Cancer chemoprevention by dietary PAs involves multiple mechanisms, including effects on inflammatory cytokines, cell signaling pathways, and apoptosis. This review summarizes the current research on falcarinol-type PA compounds and their mechanisms of cancer chemoprevention, as well as identifies gaps in our understanding of their health benefits.
