Article
Nanoscience & Nanotechnology
Junjin Zhu, Yahong Li, Wenjia Xie, Linxin Yang, Ruyi Li, Yuting Wang, Qianbing Wan, Xibo Pei, Junyu Chen, Jian Wang
Summary: This study developed a low-swelling adhesive hydrogel with rapid hemostasis and potent anti-inflammatory capability for treating full-thickness oral mucosal defects. The hydrogel exhibited excellent physical and chemical properties, and demonstrated significant hemostatic, antibacterial, and anti-inflammatory effects, promoting the repair of defective mucosa. Results showed that the hydrogel performed better than a commercial oral tissue repair membrane in the moist and dynamic oral environment.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Kun Lei, Kaiqi Wang, Yunlong Sun, Zhen Zheng, Xinling Wang
Summary: The study introduces injectable and recoverable dual-network hydrogels with excellent physicochemical properties and biocompatibility, making them a promising candidate for potential wound dressings. The hydrogels, based on PLL-g-HPA and Aga, exhibit fast gelation time, connective pore structure, good formability, and superior stability in extreme conditions. Additionally, the hydrogels have a helical structure and antibacterial ability, making them suitable for tissue attachment and preventing bacterial infection.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Roel C. Op't Veld, Lieke Joosten, Peter Laverman, Ewald M. Bronkhorst, John A. Jansen, X. Frank Walboomers, Frank A. D. T. G. Wagener
Summary: Polyisocyanopeptide (PIC) hydrogels are proposed as promising wound dressings due to their thermo-sensitivity and easy removal. Evaluation on murine wounds showed that regular application and removal of PIC dressings resulted in smaller and less encapsulated wounds compared to the control treatment. The gel could be easily washed out of wounds with cold irrigation solution but personal technique influenced the outcome. No morphological damage related to the removal procedure was observed, indicating that PIC gels are atraumatic and perform similarly to currently used wound dressings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Hong Pan, Junjie Tang
Summary: Hydrogels are widely used as wound dressings. In this study, a double-layered porous breathable water-retaining hydrogel was constructed, which showed excellent swelling ratio, water retention capacity, water vapor transmission rate, mechanical property, and bacterial-barrier property. The double-layer hydrogel can absorb exudate and maintain appropriate humidity, while preventing bacterial infection, and has great potential as a dressing.
CHEMICAL PHYSICS LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Wenchao Li, Zhengnan Su, Yanru Hu, Lihui Meng, Fang Zhu, Bin Xie, Jiangling Wan, Qingzhi Wu
Summary: This work developed a novel strategy to prepare Methacrylated Gelatin-Dopamine (GelMA-DA)/Quaternized Chitosan (QCS)/Glycerol (Gly) composite sponges, which exhibited good biocompatibility, tissue self-adhesion, antibacterial activity, and hemostatic ability. The sponges showed high water absorption capacity and excellent lap shear strength against skin, liver, muscle, and fat. They also demonstrated better antibacterial activity and hemostasis efficiency compared to commercial Gelatin and CS hemostatic sponges in animal experiments. These results suggest the potential of GelMA-DA/QCS/Gly sponges as effective wound dressings for clinical surgery and emergency treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Yuqin Feng, Si Qin, Huarun Li, Yemei Yang, Yushi Zheng, Hongsheng Liu, Wei Yin Yap, Xianyi Zhou, Ju Wen
Summary: This study proposes a composite hydrogel dressing with multiple crosslinking mechanisms, which exhibits excellent mechanical properties, adhesive capability, biocompatibility, and wound healing capacity in vivo.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Multidisciplinary Sciences
Lianglong Chen, Chaoyang Huang, Yu Zhong, Yujia Chen, Huihui Zhang, Zijun Zheng, Ziwei Jiang, Xuerong Wei, Yujie Peng, Lei Huang, Libin Niu, Yanbin Gao, Jun Ma, Lei Yang
Summary: In this study, a compound network with physical-chemical double cross-linking was constructed using chemical cross-linking and the intertwining of ADM and chito-san chains under freezing conditions. The heparin-modified composite scaffold with good biocompatibility and cell/tissue affinity significantly promoted cell adhesion and proliferation to achieve adequate fixation and slow down the release of CGF. Polydopamine nanoparticles with excellent photothermal conversion ability promoted the survival of rat autologous skin grafts. In conclusion, this multifunctional composite scaffold shows great potential in delivering CGF to promote healing of full-thickness skin defects.
Article
Medicine, General & Internal
Iwona Niedzielska, Lukasz Obszynski, Michal Bak, Damian Niedzielski
Summary: This study evaluated the benefits of full-thickness skin grafts in the reconstruction of midface defects after maxillectomy. The results showed that full-thickness skin grafts contributed to patient's convalescence and reduced postoperative pain, making them a good alternative for patients who are not eligible for microsurgical treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Ke Yang, Xueyao Zhou, Zhaoli Li, Zefeng Wang, Le Deng, Dinggeng He
Summary: A well-designed hybrid hydrogel dressing is developed, which possesses satisfactory mechanical properties, fast self-healing ability, desirable tissue-adhesive performance, antibacterial activity, antioxidant activity, anti-inflammatory property, and cell proliferation to promote tissue regeneration. In vivo animal assays demonstrate the effectiveness of the hybrid hydrogel in eliminating biofilm bacteria and accelerating the healing process of infected wounds.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Biomaterials
Xiaomin Luo, Fen Ao, Qianqian Huo, Ying Liu, Xuechuan Wang, Huijie Zhang, Min Yang, Yun Ma, Xinhua Liu
Summary: This study developed a skin-inspired gelatin/HA-based injectable remoistenable adhesive hydrogel with excellent physical properties and biological effects to improve wound healing, which has significant implications.
BIOMATERIALS ADVANCES
(2022)
Article
Engineering, Biomedical
Xueyan Li, Shibin Sun, Xiaofan Feng, Yuxin Chen, Shaojuan Chen, Jianwei Ma, Fang Zhou
Summary: Tannic acid encapsulated CMC hydrogels exhibited enhanced hemostatic and antibacterial properties, with the 5% tannic acid-cosslinked CMC hydrogel showing the best performance. Additionally, the hydrogel promoted blood clotting and achieved effective bleeding control.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Materials Science, Biomaterials
O. Goncharuk, O. Korotych, Yu Samchenko, L. Kernosenko, A. Kravchenko, L. Shtanova, O. Tsymbalyuk, T. Poltoratska, N. Pasmurtseva, I Mamyshev, E. Pakhlov, O. Siryk
Summary: The study evaluated the hemostatic properties of porous sponges based on PVF polymer, finding that they exhibit high hemostatic activity and can significantly reduce bleeding time compared to a well-known commercial product.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Chemistry, Multidisciplinary
John Jackson, Helen Burt, Dirk Lange, In Whang, Robin Evans, David Plackett
Summary: The study successfully developed a silver nitrate-loaded/poly(vinyl alcohol) film that forms a water-compatible hydrogel with sustained release of antibacterial silver nanoparticles. An optimal formulation was achieved with 5% silver nitrate in PVA membrane films heated at 140 degrees C for 90 minutes.
Article
Chemistry, Analytical
Praveen Gupta, Afsana Sheikh, Mohammed A. S. Abourehab, Prashant Kesharwani
Summary: This study developed a dendrimer-based hydrogel bandage for the treatment of full-thickness wounds. Incorporating hesperidin, a bioflavonoid, into the dendrimer core improved its water solubility and bioavailability. The experimental results showed that the prepared formulation had better wound healing activity compared to the control group.
Article
Chemistry, Applied
Lin Huang, Wenqiang Li, Mingtao Guo, Zhiguan Huang, Yuhui Chen, Xueping Dong, Yuhe Li, Lin Zhu
Summary: A double network (DN) hydrogel dressing based on PEGDA and C-HA-AMSN was proposed for promoting the regeneration of bacterial-infected full-thickness skin wounds. The hydrogel dressing exhibited improved physicochemical properties and could release silver in the acidic environment of bacterial-infected wounds, providing durable antibacterial activity.
CARBOHYDRATE POLYMERS
(2023)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
