Article
Biotechnology & Applied Microbiology
Paulina Czechowicz, Maciej Jaskiewicz, Damian Neubauer, Grazyna Gosciniak, Wojciech Kamysz
Summary: Vulvovaginal candidiasis is a common vaginal infection caused by Candida albicans, with the pathomechanism not fully understood. Antimicrobial peptides are considered crucial in combating biofilm formation, and modified Omiganan has shown activity against biofilm and Candida strains in studies.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Pharmacology & Pharmacy
Valerie Amann, Ann-Kathrin Kissmann, Markus Kramer, Imke Krebs, Julio A. Perez-Erviti, Anselmo J. Otero-Gonzalez, Fidel Morales-Vicente, Armando Rodriguez, Ludger Standker, Tanja Weil, Frank Rosenau
Summary: Antimicrobial peptides (AMPs) are a potential therapeutic option for infectious diseases due to their broad range of activity against diverse pathogens. However, their unspecific pore formation in biomembranes can cause significant side effects in human cells. AMPs isolated from sea and freshwater molluscs show promising antimicrobial activities, as these organisms primarily rely on innate defense mechanisms to fight pathogens. Pomacea poeyana, a Cuban freshwater snail, is a promising candidate for AMPs isolation, with Pom-1 and Pom-2 peptides showing significant antimicrobial activities.
Article
Biochemistry & Molecular Biology
Mojtaba Memariani, Hamed Memariani, Hamideh Moravvej, Hossein Goudarzi, Reza Mahmoud Robati
Summary: This article examines the anticandidal activity and mechanism of action of four designed cationic chimeric antimicrobial peptides (AMPs): PV, BVP, PVP, and PV3. The results show that these peptides have a high tendency to adopt an alpha-helical conformation and exhibit strong antimicrobial activity against Candida albicans. Among the tested peptides, PV3 demonstrates the highest cell selectivity index.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS
(2023)
Article
Infectious Diseases
Katherine Aguirre-Guataqui, Mateo Marquez-Torres, Hector Manuel Pineda-Castaneda, Yerly Vargas-Casanova, Andres Ceballos-Garzon, Zuly Jenny Rivera-Monroy, Javier Eduardo Garcia-Castaneda, Claudia Marcela Parra-Giraldo
Summary: Antimicrobial peptides are valuable resources for the discovery or design of potential antifungal candidates. Bovine lactoferricin and Buforin II are AMPs with great antimicrobial potential. Chimeras containing the minimal active motifs of these peptides were synthesized and evaluated for their antifungal activity against various strains of Candida. Some chimeras exhibited strong antifungal activity against specific strains.
Article
Multidisciplinary Sciences
Ibtisam Mohammed Ababutain, Azzah Ibrahim Alghamdi
Summary: The leaf extracts of Vitex agnus-castus showed significant anticandidal activity against Candida species, with the most effective inhibition seen against Candida tropicalis. Different solvents and Candida species contributed to variations in inhibition activity. Phytochemical analysis revealed various bioactive compounds with potential anticandidal activity. Further toxicology screening is recommended before clinical use.
Article
Pharmacology & Pharmacy
Rapee Jarungsirawat, Wanassnant Kajthunyakarn, Chaipat Siriwachirachai, Thaned Pongjanyakul
Summary: The study formulates and evaluates fluconazole tablets for preparing a disinfectant mixture with anticandidal activity, providing a solution for preventing denture stomatitis caused by Candida species.
Article
Immunology
Alessandra Fusco, Vittoria Savio, Maria Donniacuo, Brunella Perfetto, Giovanna Donnarumma
Summary: The intestinal mucosa is made up of a single layer of epithelial cells that are highly polarized and connected by tight junctions. Disruption of the mucus layer and tight junctions can increase intestinal permeability, leading to microbial translocation and systemic disorders. Studying the interaction between antimicrobial peptides and microbiota can help us understand how they play a role in host defense against intestinal pathogens.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mostafa A. Elbahnasawy, Amr M. Shehabeldine, Abdelrahman M. Khattab, Basma H. Amin, Amr H. Hashem
Summary: This study utilized Rothia endophytica to biosynthesize silver nanoparticles and found it exhibited significant antifungal activity against Candida albicans, disrupting cell walls and reducing cell viability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Microbiology
Jonggwan Park, Hyeongsun Kim, Hee-Kyoung Kang, Moon-Chang Choi, Yoonkyung Park
Summary: Lycosin-II, an antimicrobial peptide, exhibits antifungal activity against Candida albicans by damaging the fungal membrane and inducing oxidative stress. It also inhibits dual-species biofilm formation of Candida albicans and Staphylococcus aureus.
Article
Biotechnology & Applied Microbiology
Xiaohua Li, Qun Hu, Qiong Lin, Jianxiong Luo, Junping Xu, Lifang Chen, Liyu Xu, Xin Lin
Summary: This study confirms the inhibitory effect of Chromogranin A-N12 (CGA-N12) on Candida albicans (C. albicans) and demonstrates significant improvement in histological damage through the microRNA-155/SOCS1 pathway. It provides a novel therapeutic strategy for the treatment and prevention of C. albicans.
Article
Biotechnology & Applied Microbiology
Rong Cheng, Qiang Xu, Fangfang Hu, Hongling Li, Bin Yang, Zonggang Duan, Kai Zhang, Jianwei Wu, Wei Li, Zhenhua Luo
Summary: In the current study, MAF-1A was found to exert antifungal action by disrupting the cell membrane of C. albicans and affecting nucleic acid binding, with the potential to be effective against drug-resistant strains of the pathogen.
INTERNATIONAL MICROBIOLOGY
(2021)
Article
Infectious Diseases
Diletta Punginelli, Valentina Catania, Mirella Vazzana, Manuela Mauro, Angelo Spinello, Giampaolo Barone, Giuseppe Barberi, Calogero Fiorica, Maria Vitale, Vincenzo Cunsolo, Rosaria Saletti, Antonella Di Francesco, Vincenzo Arizza, Domenico Schillaci
Summary: The defense system of freshwater crayfish Procambarus clarkii is a diversified source of bioactive molecules with antimicrobial properties, with interesting peptide fractions showing activity against a range of pathogens.
Article
Chemistry, Applied
Barbara Gatti Cardoso, William Gustavo de Lima, Simone Odilia Antunes Fernandes, Maria Elena de Lima, Valbert Nascimento Cardoso
Summary: Due to limited therapeutic options and increasing resistance of pathogenic fungi, the incidence of fungal infections is increasing, emphasizing the need for research on new antifungal agents. This study evaluated the antifungal activity of the shortened analogue of the natural peptide LyeTx I, called LyeTx I mn Delta K, derived from spider venom, against Candida species. The results showed that LyeTx I mn Delta K exhibited potent activity against Candida spp., inhibiting their growth and biofilm formation.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Felicia Diodata D'Auria, Bruno Casciaro, Marta De Angelis, Maria Elena Marcocci, Anna Teresa Palamara, Lucia Nencioni, Maria Luisa Mangoni
Summary: The study investigates the activity of frog skin antimicrobial peptide Temporin G (TG) against various fungal strains. TG shows activity against Candida species, Cryptococcus neoformans, dermatophytes, and Aspergillus strains. It also inhibits Candida albicans virulence factors and reduces yeast-mycelial switching, biofilm formation, and biofilm biomass.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Ifeoluwa D. Gbala, Rosaline W. Macharia, Joel L. Bargul, Gabriel Magoma
Summary: AMPs are considered essential alternatives to conventional antimicrobials due to their broad-spectrum efficacy and low potential for resistance by target cells. In this study, we established that the recombinant AMPs defensin-d2 and actifensin exert proteomic changes in P. aeruginosa and C. albicans within 1 h after treatment. The differentially expressed proteins (DEPs) in treated P. aeruginosa are related to ion transport and homeostasis, nucleic and amino acid metabolism, and structural biogenesis and activity, while the DEPs in treated C. albicans are mainly involved in membrane synthesis and mitochondrial metabolism. Our results also highlight ATP synthase as a potential drug target for multidrug-resistant P. aeruginosa and C. albicans.
MICROBIOLOGY SPECTRUM
(2022)