Review
Oncology
Chiara Romei, Salvatore Claudio Fanni, Federica Volpi, Alessio Milazzo, Caterina Aida D'Amore, Leonardo Colligiani, Emanuele Neri, Annalisa De Liperi, Giulia Maria Stella, Chandra Bortolotto
Summary: Computed tomography (CT) plays a crucial role in the diagnosis, staging, and assessment of therapy response in malignant pleural mesothelioma, but has limitations such as poor soft tissue contrast and lack of consideration for the tumor's complex growth pattern. Computer-based methods show potential in overcoming these limitations, while MRI may replace CT in various clinical settings due to its high soft tissue contrast.
Review
Radiology, Nuclear Medicine & Medical Imaging
Yun Zhang, Hong Wei, Bin Song
Summary: Hepatocellular carcinoma (HCC) is the majority of primary liver cancer and a major global health challenge. Thermal ablation, including radiofrequency ablation (RFA) and microwave ablation (MWA), is recommended for early-stage HCC. Magnetic resonance imaging (MRI) plays a central role in evaluating treatment response and patient prognosis.
INSIGHTS INTO IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Niels W. Schurink, Simon R. van Kranen, Joost J. M. van Griethuysen, Sander Roberti, Petur Snaebjornsson, Frans C. H. Bakers, Shira H. de Bie, Gerlof P. T. Bosma, Vincent C. Cappendijk, Remy W. F. Geenen, Peter A. Neijenhuis, Gerald M. Peterson, Cornelis J. Veeken, Roy F. A. Vliegen, Femke P. Peters, Nino Bogveradze, Najim el Khababi, Max J. Lahaye, Monique Maas, Geerard L. Beets, Regina G. H. Beets-Tan, Doenja M. J. Lambregts
Summary: This study aims to develop and validate a multiparametric model to predict neoadjuvant treatment response in rectal cancer using a heterogeneous multicenter MRI dataset.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Anna Pellat, Anthony Dohan, Philippe Soyer, Julie Veziant, Romain Coriat, Maximilien Barret
Summary: Esophageal cancer is the eighth most frequent cancer worldwide, with a poor prognosis. Current imaging modalities like CT and PET/CT are used for staging and follow-up. MRI, a non-irradiating and non-invasive technique, has shown potential in the staging and treatment assessment of EC, with improving diagnostic performance after technical refinements.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao-Quan Xu, Yue Chu, Guang-Chen Shen, Gao Ma, Shan-Shan Lu, Sheng Liu, Hai-Bin Shi, Fei-Yun Wu
Summary: This study assessed the prognostic value of post-treatment DWI ASPECTS in predicting the clinical outcome of AIS patients after EVT, and found that both DWI ASPECTS and infarction volume were independent predictors of good clinical outcome, with high accuracy.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kari S. Wagner-Larsen, Njal Lura, Oyvind Salvesen, Mari Kylleso Halle, David Forsse, Jone Trovik, Noeska Smit, Camilla Krakstad, Ingfrid S. Haldorsen
Summary: The study evaluated the interobserver agreement and prognostic value of MRI-based 2018 FIGO staging parameters in cervical cancer patients. The results showed substantial agreement among radiologists for these parameters, and MRI improved the identification of patients with aggressive clinicopathological features and poor survival.
EUROPEAN RADIOLOGY
(2022)
Article
Urology & Nephrology
Andreas G. Wibmer, Joshua Chaim, Yulia Lakhman, Robert A. Lefkowitz, Josip Nincevic, Ines Nikolovski, Evis Sala, Mithat Gonen, Sigrid V. Carlsson, Samson W. Fine, Michael J. Zelefsky, Peter Scardino, Hedvig Hricak, Hebert Alberto Vargask
Summary: T2-weighted magnetic resonance imaging findings in localized prostate cancer patients are associated with long-term oncologic outcomes. Combining MRI results with clinical risk markers improves prognostication accuracy for metastases and prostate cancer death.
JOURNAL OF UROLOGY
(2021)
Article
Medicine, General & Internal
Alfonso Reginelli, Alfredo Clemente, Angelo Sangiovanni, Valerio Nardone, Francesco Selvaggi, Guido Sciaudone, Fortunato Ciardiello, Erika Martinelli, Roberto Grassi, Salvatore Cappabianca
Summary: Accurate preoperative staging is crucial for the management and surgical approach in rectal cancer patients. MRI is considered the best imaging modality, and the combination of DWI and ERUS can enhance diagnostic performance to determine the optimal treatment strategy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Yongjian Zhu, Zhichao Jiang, Bingzhi Wang, Ying Li, Jun Jiang, Yuxin Zhong, Sicong Wang, Liming Jiang
Summary: This study explored the predictive value of quantitative dynamic contrast-enhanced MRI (DCE-MRI) and intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) parameters for the response to neoadjuvant chemotherapy (NCT) and the prognosis of locally advanced gastric cancer (LAGC) patients. The results showed that the combined model based on DCE-MRI and IVIM-DWI could help stratify the recurrence-free survival (RFS) of LAGC patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Zhi-da Chen, Peng-Fei Zhang, Hong-Qing Xi, Bo Wei, Lin Chen, Yun Tang
Summary: Gastric cancer is a common cause of cancer deaths worldwide, with surgical resection being the only radical treatment option. Lack of early diagnosis leads to treatment failure, hence advanced gastric cancer is usually treated with surgery combined with neoadjuvant chemotherapy.
FRONTIERS IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mickael Tordjman, Charles Honore, Amandine Crombe, Amine Bouhamama, Antoine Feydy, Laurent Dercle, Leila Haddag, Pierre-Alban Bouche, Carine Ngo, Axel Le Cesne, Jean-Yves Blay, Olivier Mir, Mehdi Brahmi, Charlotte Martin, Marie Karanian, Samy Ammari, Michele Kind, Virginie Audard, Francois Le Loarer, Behnam Rabiee, Antoine Italiano, Pascaline Boudou-Rouquette, David Biau, Corinne Balleyguier, Frederique Larousserie, Jean-Luc Drape, Fadila Mihoubi
Summary: This study demonstrated that imaging biomarkers can be used to predict long-term outcome in patients with synovial sarcomas. Strikingly, the presence of calcifications on CT scan is associated with favorable outcome and provides an incremental value over existing prognostic factors such as age, grade, and size.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaohong Xing, Xiaochun Kuang, Xiaobing Li, Yingsheng Cheng, Fengjun Liu
Summary: This study investigated the clinical value of high resolution axial T2-weighted MRI as a noninvasive method for esophageal carcinoma tumor staging. The results showed that HR-T2WI had high diagnostic accuracy in evaluating tumor invasion and in MRI-T staging for esophageal carcinoma, and it could be used as a supplemental noninvasive method for the local T staging of esophageal carcinoma.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiang Zeng, Yanling Hong, Jia Cheng, Wangyu Cai, Huiqin Zhuo, JingJing Hou, Lin Wang, Yizhuo Lu, Jianchun Cai
Summary: The study aimed to evaluate the utility of intravoxel incoherent motion (IVIM) diffusion-weighted imaging in quantitatively analyzing preoperative tumor (T) and node (N) stages of gastric cancer. Significant correlations were found between IVIM parameters and different T and N stages of gastric cancer, with D value serving as the diagnostic threshold for serosal invasion and lymphatic metastasis.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaohong Xing, Xiaochun Kuang, Xiaobing Li, Yingsheng Cheng, Fengjun Liu
Summary: High resolution T2-weighted MRI (HR-T2WI) showed higher accuracy than CT in the classification and staging of esophageal carcinoma by assessing the discrepancies between the esophageal wall layers and tumor tissue using a visual MRI signal intensity scale.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hayato Tomita, Tatsuaki Kobayashi, Eichi Takaya, Sono Mishiro, Daisuke Hirahara, Atsuko Fujikawa, Yoshiko Kurihara, Hidefumi Mimura, Yasuyuki Kobayashi
Summary: This preliminary study aimed to develop a deep learning model using diffusion-weighted imaging and apparent diffusion coefficient maps to predict local recurrence and 2-year progression-free survival in laryngeal and hypopharyngeal cancer patients. The results showed that using intra-treatment diffusion-weighted imaging for prediction had high accuracy and area under the receiver operating characteristics curve. Intra-treatment diffusion-weighted imaging was found to be an independent prognostic factor for progression-free survival.
EUROPEAN RADIOLOGY
(2022)
Article
Surgery
Michele Manigrasso, Marco Milone, Mario Musella, Pietro Venetucci, Francesco Maione, Ugo Elmore, Gaetano Gallo, Roberto Perinotti, Giovanni Domenico De Palma
Summary: This study compared the accuracy of CT and colonoscopy in localizing colonic lesions and found no significant difference between the two methods for visible lesions. However, colonoscopy significantly failed to correctly locate lesions in the descending colon. Further research is needed to determine the best approach for localizing colonic tumors.
UPDATES IN SURGERY
(2022)
Article
Gastroenterology & Hepatology
Swathikan Chidambaram, Nikhil M. Patel, Viknesh Sounderajah, Rita Alfieri, Luigi Bonavina, Edward Cheong, Andy Cockbain, Xavier Benoit D'Journo, Lorenzo Ferri, Ewen A. Griffiths, Peter Grimminger, Caroline Gronnier, Christian Gutschow, Jakob Hedberg, Joonas H. Kauppila, Sjoerd Lagarde, Donald Low, Philippe Nafteux, Grard Nieuwenhuijzen, Magnus Nilsson, Riccardo Rosati, Wolfgang Schroeder, B. Mark Smithers, Mark I. van Berge Henegouwen, Richard van Hillegesberg, David Watson, Ravinder Vohra, Nick Maynard, Sheraz R. Markar
Summary: Currently, there is a lack of evidence-based guidelines for surveillance of recurrence after esophageal and gastric (OG) cancer surgical resection. This study used a modified Delphi consensus process to identify eight symptoms that should prompt further investigations for suspected recurrent malignancy.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Surgery
Gian Luca Baiocchi, Simone Giacopuzzi, Giovanni Vittimberga, Stefano De Pascale, Elisabetta Pastorelli, Roberta Gelmini, Jacopo Vigano, Luigina Graziosi, Alessio Vagliasindi, Fausto Rosa, Francesca Steccanella, Paolo Demartini, Rossella Reddavid, Mattia Berselli, Ugo Elmore, Uberto Fumagalli Romario, Maurizio Degiuli, Paolo Morgagni, Daniele Marrelli, Domenico D'Ugo, Riccardo Rosati, Giovanni De Manzoni
Summary: Gastrectomy for gastric cancer in Western countries still has high rates of morbidity and mortality. In 2015, the EGCA launched a project to establish a list and definitions of post-operative complications specific for gastrectomy. This study investigated 386 cases of post-operative complications in Italy, with non-surgical infections and anastomotic leaks being the most frequent complications.
UPDATES IN SURGERY
(2023)
Article
Surgery
Ugo Elmore, Marco Milone, Paolo Parise, Nunzio Velotti, Andrea Cossu, Francesco Puccetti, Lavinia Barbieri, Sara Vertaldi, Francesco Milone, Giovanni Domenico De Palma, Riccardo Rosati
Summary: This study describes the experience in managing complications following laparoscopic gastrectomy for gastric cancer. The results show that among the patients who underwent reintervention, 34.3% required conversion to open surgery. The findings also indicate that recovery outcomes were significantly better for patients who completed the reoperation through laparoscopy.
UPDATES IN SURGERY
(2023)
Review
Oncology
Tiuri E. Kroese, Peter S. N. van Rossum, Magnus Nilsson, Florian Lordick, Elizabeth C. Smyth, Riccardo Rosati, Philippe Nafteux, Domenico D'Ugo, M. Asif Chaudry, Wojciech Polkowkski, Franco Roviello, Ines Gockel, Piotr Kolodziejczyk, Karin Haustermans, Matthias Guckenberger, Marianne Nordsmark, Maria A. Hawkins, Andres Cervantes, Tania Fleitas, Eric van Cutsem, Markus Moehler, Anna D. Wagner, Hanneke W. M. van Laarhoven, Richard van Hillegersberg
Summary: Currently, there is a lack of uniform definition and treatment for oligometastatic esophagogastric cancer. The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to develop a multidisciplinary European consensus statement to improve outcomes for these patients.
Article
Medicine, General & Internal
James C. Glasbey, Tom E. F. Abbott, Adesoji Ademuyiwa, Adewale Adisa, Ehab AlAmeer, Sattar Alshryda, Alexis P. Arnaud, Brittany Bankhead-Kendall, M. K. Abou Chaar, Daoud Chaudhry, Ainhoa Costas-Chavarri, Miguel F. Cunha, Justine I. Davies, Anant Desai, Muhammed Elhadi, Marco Fiore, J. Edward Fitzgerald, Maria Fourtounas, Alex James Fowler, Kay Futaba, Gaetano Gallo, Dhruva Ghosh, Rohan R. Gujjuri, Rebecca Hamilton, Parvez Haque, Ewen M. Harrison, Peter Hutchinson, Gabriella Hyman, Arda Isik, Umesh Jayarajah, Haytham M. A. Kaafarani, Bryar Kadir, Ismail Lawani, Hans Lederhuber, Elizabeth Li, Markus W. Loffler, Maria Aguilera Lorena, Harvinder Mann, Janet Martin, Dennis Mazingi, Craig D. McClain, Kenneth A. McLean, John G. Meara, Antonio Ramos-De La Medina, Mengistu Mengesha, Ana Minaya, Maria Marta Modolo, Rachel Moore, Dion Morton, Dmitri Nepogodiev, Faustin Ntirenganya, Francesco Pata, Rupert Pearse, Maria Picciochi, Thomas Pinkney, Peter Pockney, Gabrielle H. van Ramshorst, Toby Richards, April Camilla Roslani, Sohei Satoi, Raza Sayyed, Richard Shaw, Joana Filipa Ferreira Simoes, Neil Smart, Richard Sulliva, Malin Sund, Sudha Sundar, Stephen Tabiri, Elliott H. Taylor, Mary L. Venn, Dakshitha Wickramasinghe, Naomi Wright, Sebastian Bernardo Shu Yip, Aneel Bhangu
Summary: This study developed and validated a novel index (SPI) to support the strengthening of local elective surgical systems and address growing backlogs. The findings showed that hospitals with a higher SPI were associated with an increased planned surgical volume ratio, independent of income status, COVID-19 burden, and hospital type. Annual self-assessment of surgical preparedness is recommended to identify areas for improvement and enhance the resilience of local surgical systems.
Article
Surgery
Maurizio Degiuli, Monica Ortenzi, Mariano Tomatis, Lucia Puca, Desiree Cianflocca, Daniela Rega, Annalisa Maroli, Ugo Elmore, Francesca Pecchini, Marco Milone, Roberta La Mendola, Erica Soligo, Simona Deidda, Domenico Spoletini, Diletta Cassini, Alessandra Aprile, Michela Mineccia, Herald Nikaj, Francesco Marchegiani, Fabio Maiello, Cristina Bombardini, Michele Zuolo, Michele Carlucci, Luca Ferraro, Armando Falato, Alberto Biondi, Roberto Persiani, Patrizia Marsanich, Daniele Fusario, Leonardo Solaini, Sara Pollesel, Gianluca Rizzo, Claudio Coco, Alberto Di Leo, Davide Cavaliere, Franco Roviello, Andrea Muratore, Domenico D'Ugo, Francesco Bianco, Paolo Pietro Bianchi, Paola De Nardi, Marco Rigamonti, Gabriele Anania, Claudio Belluco, Roberto Polastri, Salvatore Pucciarelli, Sergio Gentilli, Alessandro Ferrero, Stefano Scabini, Gianandrea Baldazzi, Massimo Carlini, Angelo Restivo, Silvio Testa, Dario Parini, Giovanni Domenico De Palma, Micaela Piccoli, Riccardo Rosati, Antonino Spinelli, Paolo Delrio, Felice Borghi, Marco Guerrieri, Rossella Reddavid
Summary: This study investigated the efficacy and short-term outcomes of minimally invasive (MI) and open treatment for splenic flexure cancer (SFC). The results showed that MI was noninferior to open procedure in terms of postoperative complications and pathological outcomes in SFC patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Uberto Fumagalli Romario, Filippo Ascari, Stefano De Pascale
Summary: Although ERAS programs have been widely adopted for colorectal surgery, their implementation for upper gastrointestinal surgery is challenging in Italy. A survey showed that Italian centers dedicated to gastric cancer do not fully follow evidence-based practices and guidelines of ERAS for gastric surgery. This may be due to surgeons' hesitation to introduce radical changes to traditional postoperative management after gastrectomy.
UPDATES IN SURGERY
(2023)
Article
Surgery
Eider Talavera-Urquijo, Paolo Parise, Agnese Carresi, Andrea Cossu, Lavinia Barbieri, Francesco Puccetti, Ugo Elmore, Riccardo Rosati
Summary: This study describes TBEF cases after esophagectomy and compares them with other cases. Surgical treatment as the first approach achieved good results, but treatment guidelines need to be developed.
UPDATES IN SURGERY
(2023)
Review
Surgery
Francesco Puccetti, Ugo Elmore, Riccardo Rosati
Summary: Management and treatment of esophagogastric diseases are constantly evolving, focusing on multimodal approach and quality of care. The introduction of standardized perioperative protocols has offered a chance to enhance patients' recovery after surgery worldwide. This review provides a comprehensive overview of the scientific basis, current evidence, and potential limitations of these protocols.
UPDATES IN SURGERY
(2023)
Article
Gastroenterology & Hepatology
Andrea Balla, Federica Saraceno, Marika Rullo, Salvador Morales-Conde, Eduardo M. Targarona Soler, Salomone Di Saverio, Mario Guerrieri, Pasquale Lepiane, Nicola Di Lorenzo, Michel Adamina, Isaias Alarcon, Alberto Arezzo, Jesus Bollo Rodriguez, Luigi Boni, Sebastiano Biondo, Francesco Maria Carrano, Manish Chand, John T. Jenkins, Justin Davies, Salvadora Delgado Rivilla, Paolo Delrio, Ugo Elmore, Eloy Espin-Basany, Alessandro Fichera, Blas Flor Lorente, Nader Francis, Marcos Gomez Ruiz, Dieter Hahnloser, Eugenio Licardie, Carmen Martinez, Monica Ortenzi, Yves Panis, Carlos Pastor Idoate, Alessandro M. Paganini, Miguel Pera, Roberto Perinotti, Daniel A. Popowich, Timothy Rockall, Riccardo Rosati, Alberto Sartori, Daniele Scoglio, Mostafa Shalaby, Vicente Simo Fernandez, Neil J. Smart, Antonino Spinelli, Patricia Sylla, Pieter J. Tanis, Javier Valdes-Hernandez, Steven D. Wexner, Pierpaolo Sileri
Summary: This qualitative study investigated the decision-making process of surgeons regarding protective ileostomy creation after rectal cancer surgery. The results showed that 76% of surgeons supported the creation of ileostomy. When making the decision, 88% of surgeons considered risk factors. Emotions influenced the decision-making process in 22% of cases, and personal experiences influenced it in 49% of cases. The most frequently considered risk factors were the distance between the anus and the tumor (96%), neoadjuvant chemoradiotherapy (88%), positive intraoperative leak test (65%), blood loss (37%), and immunosuppression therapy (35%).
COLORECTAL DISEASE
(2023)
Letter
Gastroenterology & Hepatology
Francesco V. Mandarino, Alberto Barchi, Lorella Fanti, Francesco Azzolini, Riccardo Rosati, Silvio Danese
Editorial Material
Surgery
Giovanni de Manzoni, Riccardo Rosati
UPDATES IN SURGERY
(2023)
Review
Biology
Francesco Vito Mandarino, Alberto Barchi, Ferdinando D'Amico, Lorella Fanti, Francesco Azzolini, Edi Viale, Dario Esposito, Riccardo Rosati, Gionata Fiorino, Willem Adrianus Bemelman, Ugo Elmore, Lavinia Barbieri, Francesco Puccetti, Sabrina Gloria Giulia Testoni, Silvio Danese
Summary: This study compared the outcomes of Self-Expandable Metal Stents (SEMS) and Endoscopic Vacuum Therapy (EVT) in the treatment of anastomotic leaks after esophagectomy/gastrectomy, with a focus on oncologic surgery. The results showed that EVT was more effective and had fewer complications compared to SEMS. However, in the oncologic surgery subgroup, there was no significant difference in the success rate between the two treatments.
Article
Oncology
Arianna Orsini, Luca Mastracci, Isotta Bozzarelli, Anna Ferrari, Federica Isidori, Roberto Fiocca, Marialuisa Lugaresi, Antonietta D'Errico, Deborah Malvi, Erica Cataldi-Stagetti, Paola Spaggiari, Anna Tomezzoli, Luca Albarello, Ari Ristimaki, Luca Bottiglieri, Kausilia K. Krishnadath, Riccardo Rosati, Uberto Fumagalli Romario, Giovanni De Manzoni, Jari Rasanen, Giovanni Martinelli, Sandro Mattioli, Elena Bonora
Summary: Esophageal adenocarcinoma (EAC) is a severe malignancy with increasing incidence, poorly understood pathogenesis, and low survival rates. TP53 gene alterations, especially missense mutations, negatively affect cancer-specific survival in EAC. HNF1alpha gene disruption is associated with other gene alterations and is identified as a new EAC-mutated gene.
