Article
Medicine, General & Internal
Yumei Cao, Su'an Tang, Xiaoyu Nie, Zuoqing Zhou, Guangfeng Ruan, Weiyu Han, Zhaohua Zhu, Changhai Ding
Summary: The study identified miR-214-3p as a key regulator in osteoarthritis, impacting ECM metabolism and cell apoptosis in cartilage by modulating the NF-kappa B signaling pathway. Targeting IKKP, decreased miR-214-3p exacerbates OA development, suggesting it as a potential novel therapeutic target for OA.
Article
Medicine, Research & Experimental
Liang Liu, Li-Na Yan, Zheng Sui
Summary: The study revealed that miR-150 regulates sepsis-induced endothelial injury by modulating ER stress and inflammation through MALAT1-mediated NF-kappa B pathway.
Article
Cell Biology
Qianqian Huang, Sheng Chen, Xiaowei Xiong, Tingting Yin, Yanan Zhang, Guohua Zeng, Qiren Huang
Summary: Vascular endothelium dysfunction caused by endothelium inflammation is a trigger of numerous cardiovascular diseases. This study investigated the effect of Asprosin (ASP) on endothelium inflammation induced by hyperlipidemia. The results showed that ASP may play a pro-inflammation role in obesity-associated endothelium dysfunction, and could be a potential target for the prevention and treatment of obesity-related cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Xin Geng, Shipeng Li, Jinghui Li, Renli Qi, Lianmei Zhong, Hualin Yu
Summary: This study found that MDMA promoted the expression of MALAT1 and inhibited the targeted downregulation of MEKK3 by miR-124, resulting in upregulation of MEKK3 expression and jointly promoting the progression of PD.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Zhifeng Shi, Zhixiong Zheng, Xiaodan Lin, Hengzhang Ma
Summary: The study found that in atherosclerosis, MALAT1 promotes inflammation by regulating miR-330-5p and the NF-κB signal pathway, driving the progression of the disease, and providing a new biomarker for its diagnosis.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Yang Nan, Liyun Guo, Yingwei Zhen, Le Wang, Bingcheng Ren, Xingjie Chen, Yalin Lu, Kai Yu, Yue Zhong, Qiang Huang
Summary: The study found that miRNA-451 regulates the NF-kappa B signaling pathway by targeting IKK beta, inhibiting the growth and invasion ability of glioma cells. Overexpression of miRNA-451 decreased the expression of IKK beta and other proteins, leading to reduced cell proliferation and invasion.
Article
Immunology
Yilin Li, Tao Jin, Naixin Liu, Junsong Wang, Zihan Qin, Saige Yin, Yingxuan Zhang, Zhe Fu, Yutong Wu, Yinglei Wang, Yixiang Liu, Meifeng Yang, Ailan Pang, Jun Sun, Ying Wang, Xinwang Yang
Summary: In this study, a new non-toxic peptide NP1 was discovered, which exerted neuroprotective effects on cerebral ischemia-reperfusion injury by reducing inflammation via the miR-6328/IKK beta/NF-kappa B axis. The results not only provide candidate drugs for exogenous peptides and endogenous small nucleic acids, but also a new drug target for the treatment of IS.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Chemistry, Multidisciplinary
Zhu-Qi Huang, Wu Luo, Wei-Xin Li, Pan Chen, Zhe Wang, Rui-Jie Chen, Yi Wang, Wei-Jian Huang, Guang Liang
Summary: Costunolide (CTD) has anti-atherosclerotic effects by reducing inflammatory responses and oxLDL uptake, and its mechanism involves the inhibition of NF-kappa B signaling pathway through covalent binding to IKKβ.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Pediatrics
Zhen-Bo Wu, Sen-Lin Shi, Feng-Jun Pan, Li Li, Hong-Yu Chen
Summary: Propranolol affects the malignant biological behavior of IHA cells by regulating the miR-424/VEGFA axis, inhibiting XPTS-1 cell growth and invasion, and increasing apoptosis level.
TRANSLATIONAL PEDIATRICS
(2021)
Article
Surgery
Haihong Zhang, Ting Wei, Adam Johnson, Ravi Sun, Gresham Richter, Graham M. Strub
Summary: The study characterized the role of NOTCH signaling cascade activation in the angiogenic drive of infantile hemangioma tissue. The results showed that perturbations in NOTCH signaling follow the natural course and treatment outcome of infantile hemangiomas, suggesting a critical role in their pathogenesis.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2021)
Letter
Biochemistry & Molecular Biology
Adnan Erol
Summary: Oxidative stress plays a significant role in the development of obesity-related nephropathy (ORN). A causal relationship between IKK and ORN via CYLD-mediated inhibition of NRF2 has been identified. However, contradictory explanations regarding the mechanisms involved need clarification.
MOLECULAR MEDICINE
(2022)
Article
Environmental Sciences
Yanghuan Yu, Ruiyan Niu, Fangye Zhao, Yangfei Zhao, Jinglu Wang, Jixiang Wang, Qiqi Cao, Rong Fu, Mohammad Hassan Nateghahmadi, Zilong Sun
Summary: With the increase of environmental pollution, the level of fluoride is rising in human and animal habitats. Long-term exposure to fluoride can cause liver and kidney damage. However, the mechanism of exercise on fluoride-induced liver and kidney injury is not yet clear. In this study, a mouse model of fluoride exposure and/or exercise was established to explore the influence of exercise on fluoride-induced liver and kidney inflammation. The results showed that long-term moderate treadmill exercise relieved fluoride-induced liver and kidney inflammatory responses through the IKK beta/NF kappa B pathway, suggesting that exercise can be used to prevent fluoride-induced liver and kidney damage.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Immunology
Talha Umar, Xiaofei Ma, Baoyi Yin, Saqib Umer, Arshad Zahoor, Muhammad Akhtar, Zaima Umar, Aftab Shaukat, Ganzhen Deng
Summary: Research has shown that miR-424-5p inhibits the inflammatory response in endometritis by suppressing IRAK2 expression, indicating its potential as a unique medical treatment for endometritis and other inflammation-related diseases.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Cell Biology
Minliang Wu, Yong Chen, Ling Feng, Haiying Dai, Shuo Fang, Jianguo Xu
Summary: MiR-206 was found to suppress the malignant development of HemECs by regulating ECM-related genes, with DNMT3A being highly expressed in IH tissues and negatively correlated with miR-206. Overexpressed DNMT3A could counteract the inhibitory effect of miR-206 mimic on HemECs. The study discussed the effects of miR-206 on the growth, migration, and invasion of HemECs, as well as its relationship with DNMT3A.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.