Article
Biochemistry & Molecular Biology
Tingyi Du, Qin Fang, Zhihao Zhang, Chuanmeng Zhu, Renfan Xu, Guangzhi Chen, Yan Wang
Summary: This study shows that Lentinan (LNT) can ameliorate hepatic steatosis, decrease oxidative stress and apoptosis by activating the PPAR alpha pathway, providing a potential drug target for NAFLD.
Article
Biochemistry & Molecular Biology
Emilio Sosa-Diaz, Estefani Yaquelin Hernandez-Cruz, Jose Pedraza-Chaverri
Summary: Vitamin D is considered essential for human health and plays a crucial role in delaying cellular senescence and attenuating oxidative stress, making it a promising candidate for preventing age-related diseases. However, further research is needed to fully understand the mechanisms behind its effects.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Pediatrics
Doaa El Amrousy, Dina Abdelhai, Dina Shawky
Summary: This study found that vitamin D supplementation can be beneficial in the treatment of NAFLD in children, improving hepatic fat content and disease progression.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Medicine, Research & Experimental
Cong Li, Shuang Jiang, Hengfei Wang, Yuhong Wang, Yanxing Han, Jiandong Jiang
Summary: Berberine has anti-aging effects on the heart by upregulating Klotho expression, reducing reactive oxygen species levels, inhibiting apoptosis, and alleviating mitochondrial dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Manli Hu, Dingran Zhang, Hongyang Xu, Yan Zhang, Hongjie Shi, Xiaoli Huang, Xinhui Wang, Yan Wu, Zhili Qi
Summary: The study found that SAL can protect against metabolic-stress-induced NASH progression by activating the AMPK signaling pathway, indicating that SAL could be a potential drug component for NASH therapy.
Review
Oncology
Vinesh Dhokia, John A. Y. Moss, Salvador Macip, Joanna L. Fox
Summary: Cellular senescence and apoptosis were historically considered as distinct cell fate pathways, but they share common proteins. p53 plays a key role in determining cell fate, but its decision-making process is not fully understood. Cell fate is dynamic and can be shifted by the right combination of activators and inhibitors. This review focuses on the regulation and induction of apoptosis and senescence, as well as their alterations in chronic diseases.
Review
Cardiac & Cardiovascular Systems
Federico Carbone, Luca Liberale, Peter Libby, Fabrizio Montecucco
Summary: Experimental and clinical findings linking vitamin D to cardiovascular risk have prompted consideration of its supplementation for overall health improvement. However, several meta-analyses do not support its clinical effectiveness, and recent research has revealed complex non-classical effects of vitamin D in cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Aunchalee Jaroenlapnopparat, Pichatorn Suppakitjanusant, Ben Ponvilawan, Nipith Charoenngam
Summary: This study aimed to investigate the association of vitamin D-related genetic variations with nonalcoholic fatty liver disease (NAFLD). The results revealed multiple genetic variations associated with NAFLD, highlighting the importance of vitamin D in the pathogenesis of this disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Tongshuai Chen, Chang Ma, Guanqi Fan, Hui Liu, Xie Lin, Jingyuan Li, Na Li, Shujian Wang, Mei Zeng, Yun Zhang, Peili Bu
Summary: Hyperglycemia accelerates endothelial cell dysfunction and vascular complications by inducing ECs senescence, with molecular mechanisms involving SIRT3-p53 pathway.
Article
Biochemistry & Molecular Biology
Haoyang Zhou, Dafeng Yang, Henry S. Cheng, Michael G. McCoy, Daniel Perez-Cremades, Stefan Haemmig, Danny Wong, Lei Chen, Mark W. Feinberg
Summary: The study uncovers an important role of miR-181b in regulating vascular endothelial aging through the MAP3K3-MAPK signaling pathway, revealing potential therapeutic targets for anti-aging therapy in cardiovascular disease.
Review
Nutrition & Dietetics
Abdulhadi Bima, Basmah Eldakhakhny, Dina Nuwaylati, Abrar Alnami, Mohammed Ajabnoor, Ayman Elsamanoudy
Summary: This scoping review explores the interplay between obesity, vitamin D deficiency, cellular senescence, and their related metabolic consequences, such as subclinical atherosclerosis and NAFLD. Markers of cellular senescence have been found to accumulate in obese individuals, contributing to chronic low-grade inflammation associated with conditions like subclinical atherosclerosis. Studies have highlighted the significant roles of obesity, vitamin D deficiency, and cellular senescence in the development of NAFLD as the hepatic manifestation of metabolic syndrome.
Article
Nutrition & Dietetics
Meng-Chun Lu, I-Te Lee, Ling-Zong Hong, Eyal Ben-Arie, Yu-Hsuan Lin, Wei-Ting Lin, Pei-Yu Kao, Mei-Due Yang, Yin-Ching Chan
Summary: The study found that coffeeberry can protect the liver through multiple pathways, including reducing oxidative stress, regulating the CaMKII/CREB/BDNF pathway, and improving autophagic and apoptotic expressions.
Article
Agriculture, Multidisciplinary
Wei Xu, Xi Xiang, Ling Lin, Zhi-Hua Gong, Wen-Jun Xiao
Summary: The study indicates that l-Theanine (LTA) can attenuate intestinal epithelial cell senescence by regulating the cell cycle and inhibiting apoptosis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Basile Keshavjee, Valentine Lambelet, Hanna Coppola, David Viertl, John O. Prior, Laurent Kappeler, Jean-Baptiste Armengaud, Jean-Pierre Chouraqui, Hassib Chehade, Paul-Emmanuel Vanderriele, Manon Allouche, Anne Balsiger, Alexandre Sarre, Anne-Christine Peyter, Umberto Simeoni, Catherine Yzydorczyk
Summary: Metabolic syndrome is a cardiometabolic risk factor that can lead to metabolic and hepatic disorders. This study found that oxidative stress and cellular senescence are associated with the development of metabolic syndrome in individuals born after intrauterine growth restriction (IUGR), particularly in males. The livers of IUGR males displayed stress-induced premature senescence and impaired liver structure and function related to oxidative stress.
Review
Biochemistry & Molecular Biology
Wentao Ma, Xiaoqian Tan, Zhongcheng Xie, Jiang Yu, Pin Li, Xiaoyan Lin, Siyu Ouyang, Zhiyang Liu, Qin Hou, Nan Xie, Tianhong Peng, Liang Li, Zhu Dai, Xi Chen, Wei Xie
Summary: Osteoarthritis is a chronic degenerative disease characterized by damage to the articular cartilage, and it is closely related to the pathological processes of chondrocyte senescence, apoptosis, autophagy, proliferation, and differentiation. Current clinical strategies for osteoarthritis only provide symptomatic relief, sometimes with side effects. Therefore, it is important to identify new ideas and targets for clinical treatment.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.