Article
Biochemistry & Molecular Biology
Wei Gao, Ying Zhang
Summary: Inflammation is crucial in the pathogenesis of acute lung injury, and lncRNA MINCR may exacerbate ALI/ARDS progression by inducing alveolar epithelial cell injury and inflammation through the miR-146b-5p and TRAF6/NF-κB pathways, serving as a potential therapeutic target.
MOLECULAR MEDICINE
(2021)
Article
Oncology
Paula Gonzalez-Lopez, Marta Alvarez-Villarreal, Ruben Ruiz-Simon, Andrea R. Lopez-Pastor, Melina Vega de Ceniga, Leticia Esparza, Jose L. Martin-Ventura, Oscar Escribano, Almudena Gomez-Hernandez
Summary: MicroRNAs miR-15a-5p and miR-199a-3p are significantly decreased in aortic and carotid samples from atherosclerosis patients and mice. Overexpression of these miRNAs can reduce inflammation and progression of atherosclerosis. MiR-15a-5p may serve as a novel diagnostic biomarker for advanced atherosclerosis.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Talha Umar, Xiaofei Ma, Baoyi Yin, Saqib Umer, Arshad Zahoor, Muhammad Akhtar, Zaima Umar, Aftab Shaukat, Ganzhen Deng
Summary: Research has shown that miR-424-5p inhibits the inflammatory response in endometritis by suppressing IRAK2 expression, indicating its potential as a unique medical treatment for endometritis and other inflammation-related diseases.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sho Inoue, Yuki Inahashi, Makoto Itakura, Gen Inoue, Kyoko Muneshige, Tomoyasu Hirose, Masato Iwatsuki, Masashi Takaso, Masayuki Miyagi, Kentaro Uchida
Summary: This study found that Medermycin (MED) can reduce inflammatory reactions in synovial cells and inhibit the expression of proinflammatory cytokines. Further experiments demonstrated that MED can also inhibit the activation of NF?B and Akt, thereby modulating the inflammatory response. These results highlight the potential therapeutic value of MED in managing inflammatory conditions in osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yangbing Jin, Qu Cai, Lingquan Wang, Jun Ji, Ying Sun, Jinling Jiang, Chao Wang, Junwei Wu, Benyan Zhang, Liqin Zhao, Feng Qi, Beiqin Yu, Jun Zhang
Summary: Our study revealed that INHBB is significantly upregulated in gastric cancer (GC) and its increased expression is associated with poor survival. INHBB promotes the proliferation, migration, and invasion of GC cells in vitro. Additionally, activin B reprograms fibroblasts into cancer-associated fibroblasts (CAFs) and promotes GC development. The high expression of INHBB in GC cells activates the NF-kappa B pathway in normal gastric fibroblasts via the secretion of activin B, leading to fibroblast proliferation, migration, and invasion. Activin B induces NF-kappa B pathway activation in fibroblasts through controlling TRAF6 autoubiquitination and TAK1 phosphorylation. Activated fibroblasts release pro-inflammatory factors IL-1 beta, which induce p65 phosphorylation in GC cells. p65 directly binds to the INHBB promoter, increasing INHBB transcription in GC cells and establishing a positive regulatory feedback loop that promotes GC progression.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Qian Zhang, Kun Yu, Yazhen Cao, Yanli Luo, Yan Liu, Caiyan Zhao
Summary: The study revealed that miR-125b expression is up-regulated in NAFLD patients, along with increased levels of inflammatory-related genes in the liver. MiR-125b promotes NF-kappa B-mediated inflammatory responses by directly targeting TNFAIP3, suggesting it as a potential target for treating NAFLD.
Article
Genetics & Heredity
Li-Qiong Lou, Wen-Qiang Zhou, Xin Song, Zhi Chen
Summary: In this study, it was found that the AP1 transcription factor recruits p300 histone acetyltransferase and CtBP1 to form the CtBP1-p300-AP1 complex, which transactivates hsa-miR-7-5p expression in ARDS biopsies. Hsa-miR-7-5p targets ATXN1 to trigger an NF-kappa B-dependent inflammatory response. Interfering with the CtBP1-p300-AP1 signaling pathway may be a potential strategy for treating ARDS.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Cell Biology
Ruiqin Hu, Yanna Xu, Bingshe Han, Yi Chen, Wenhao Li, Guijun Guan, Peng Hu, Yan Zhou, Qianghua Xu, Liangbiao Chen
Summary: Developmental growth is a complex process that involves the coordinated regulation of gene expression. This study identifies miR-202-3p as a key factor in determining embryonic fate during the mid-blastula transition (MBT) in zebrafish. miR-202-3p regulates the expression of a trio of genes involved in cell proliferation and survival, and is crucial for embryonic viability and development during MBT.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Peng Jiao, Jinpeng Wang, Jian Yang, Xingping Wang, Zhuoma Luoreng
Summary: Bta-miR-223 attenuated LPS-induced inflammatory response in bMecs by targeting RHOB and deactivating NF-kappa B gene activity. Silencing RHOB inhibited LPS-induced inflammatory response in bMECs, suggesting bta-miR-223 acts as a negative feedback regulator to provide a novel avenue for mastitis treatment.
Article
Plant Sciences
Hong-Ying Yang, Weidong Yao, Pei-Zhi Huang, Hui Xu, Qian Ma, Xiaoming Chen, Jian-Jun Chen, Kun Gao
Summary: This study isolated three unreported ent-abietane-type norditerpene lactones, named euphohelides A-C (1-3), from the whole plants of Euphorbia helioscopia L. The structures of euphohelides A-C were established using spectroscopic methods, computational ECD, and X-ray crystallographic analyses. Euphohelide A (1) is a novel 2-nor-ent-abietane lactone with a unique 5/6/6/5 tetracyclic system.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Immunology
Wei Tan, Fangfang Dai, Dongyong Yang, Zhimin Deng, Ran Gu, Xiaomiao Zhao, Yanxiang Cheng
Summary: This study found that miR-93-5p is upregulated in the granulosa cells of PCOS patients and promotes apoptosis and ferroptosis in these cells by negatively regulating the NF-kappa B signaling pathway. Silencing miR-93-5p can protect granulosa cell function, which is of great significance for improving the function of granulosa cells in PCOS patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Lihui Xuan, Jinming Guo, Dexin Xia, Lu Li, Daining Wang, Ying Chang
Summary: This study found that profenofos (PFF) as an environmental pollutant can harm human health through the food chain. Albicanol, a sesquiterpene compound, has been shown to antagonize the toxicity caused by PFF exposure. However, the mechanism of PFF toxicity and the role of Albicanol in regulating immune function, apoptosis, and necroptosis have not been reported. The study revealed that PFF exposure led to mitochondrial damage, increased expression of innate immunity-related factors, and activated TNF/NF-kappa B pathway, while Albicanol countered these effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Cell Biology
Yiming Zhang, Qiaohan Liu, Hao Wu, Yongzhen Du, Xixi Wang, Shiwen Xu
Summary: This study established a Cd-exposure pig model and found that Cd exposure can cause artery damage. The downregulated expression of miR-210 and its targeting relationship with NF-κB were screened. The effect of miR-210/NF-κB on Cd-induced artery damage was investigated, revealing that Cd can induce artery necroptosis and Th1/Th2 imbalance through the regulation of the miR-210/NF-κB axis, leading to artery inflammatory damage.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Leifeng Liang, Liangwen Chen, Gongwei Liu, Liujun Jiang, Lilin Que, Jie Chen, Rensheng Wang, Haisheng Zhu
Summary: Oral mucositis, the most common complication in cancer patients undergoing radiotherapy or chemotherapy, can significantly reduce the patients' quality of life. Thalidomide has been shown to effectively alleviate radiotherapy-induced oral mucositis based on increasing clinical studies. In this study, a mouse model of radiation-induced human oral epithelial cells (HOECs) was established to investigate the mechanism underlying the protective effect of thalidomide against oral mucositis. Through RNA sequencing, the gene NFATC2 was identified as a potential target. Thalidomide downregulated NFATC2 expression, reduced HOECs apoptosis, and promoted the secretion of pro-inflammatory factors. Further experiments demonstrated that NFATC2 overexpression promoted apoptosis and pro-inflammatory cytokine production in HOECs, while NFATC2 inhibition had the opposite effect. The miRNA miR-9-3p was predicted as a regulator of NFATC2 and its targeting relationship with NFATC2 was confirmed. miR-9-3p mimic reversed the increased apoptosis and pro-inflammatory cytokine levels induced by radiation or NFATC2 overexpression. Moreover, NFATC2 upregulated the phosphorylation of p65, activating the NF-kappa B pathway in radiation-induced oral mucositis, while miR-9-3p reduced this effect. In conclusion, thalidomide attenuates oral epithelial cell apoptosis and pro-inflammatory cytokine secretion induced by radiotherapy through the miR-9-3p/NFATC2/NF-kappa B axis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Immunology
Xiaoying Ma, Jinfang Xu, Qingsheng Lu, Xiang Feng, Jiajun Liu, Chaoyi Cui, Chao Song
Summary: This study investigates the role of circRNA in abdominal aortic aneurysms (AAA) and macrophages. The researchers found that hsa_circ_0087352, a circRNA, is up-regulated in human AAA specimens and is related to the inflammatory response in THP-1 macrophages. Further experiments revealed that hsa_circ_0087352 promotes IL-6 transcription and the secretion of inflammatory cytokines by sponging endogenous hsa-miR-149-5p in macrophages, potentially through the ERK/NF-kappa B pathway. Additionally, hsa_circ_0087352 overexpression induces apoptosis in human vascular smooth muscle cells. These findings suggest the potential of hsa_circ_0087352 as a biomarker and therapeutic target for AAA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Neurosciences
Bingbing Li, Yiran Xu, Xiaoli Zhang, Lingling Zhang, Yanan Wu, Xiaoyang Wang, Changlian Zhu
Summary: This meta-analysis suggests that vitamin D supplementation has limited efficacy in improving symptoms of Autism Spectrum Disorder (ASD) in children, with only a small but significant improvement observed in hyperactivity.
NUTRITIONAL NEUROSCIENCE
(2022)
Correction
Clinical Neurology
Manuela Wiessner, Reza Maroofian, Meng-Yuan Ni, Andrea Pedroni, Juliane S. Muller, Rolf Stucka, Christian Beetz, Stephanie Efthymiou, Filippo M. Santorelli, Ahmed A. Alfares, Changlian Zhu, Anna Uhrova Meszarosova, Elham Alehabib, Somayeh Bakhtiari, Andreas R. Janecke, Maria Gabriela Otero, Jin Yun Helen Chen, James T. Peterson, Tim M. Strom, Peter De Jonghe, Tine Deconinck, Willem De Ridder, Jonathan De Winter, Rossella Pasquariello, Ivana Ricca, Majid Alfadhel, Bart P. van de Warrenburg, Ruben Portier, Carsten Bergmann, Saghar Ghasemi Firouzabadi, Sheng Chih Jin, Kaya Bilguvar, Sherifa Hamed, Mohammed Abdelhameed, Nourelhoda A. Haridy, Shazia Maqbool, Fatima Rahman, Najwa Anwar, Jenny Carmichael, Alistair T. Pagnamenta, Nick W. Wood, Frederic Tran Mau-Them, Tobias Haack, Maja Di Rocco, Isabella Ceccherini, Michele Iacomino, Federico Zara, Vincenzo Salpietro, Marcello Scala, Marta Rusmini, Yiran Xu, Yinghong Wang, Yasuhiro Suzuki, Kishin Koh, Haitian Nan, Hiroyuki Ishiura, Shoji Tsuji, Laetitia Lambert, Emmanuelle Schmitt, Elodie Lacaze, Hanna Kuepper, David Dredge, Cara Skraban, Amy Goldstein, Mary J. H. Willis, Katheryn Grand, John M. Graham, Richard A. Lewis, Francisca Millan, Ozguer Duman, Nihal Olgac Dundar, Goekhan Uyanik, Ludger Schoels, Peter Nuernberg, Gudrun Nuernberg, Andrea Catala-Bordes, Pavel Seeman, Martin Kuchar, Hossein Darvish, Adriana Rebelo, Filipa Boucanova, Jean-Jacques Medard, Roman Chrast, Michaela Auer-Grumbach, Fowzan S. Alkuraya, Hanan Shamseldin, Saeed Al Tala, Jamileh Rezazadeh Varaghchi, Maryam Najafi, Selina Deschner, Dieter Glaeser, Wolfgang Huettel, Michael C. Kruer, Erik-Jan Kamsteeg, Yoshihisa Takiyama, Stephan Zuechner, Jonathan Baets, Matthis Synofzik, Rebecca Schuele, Rita Horvath, Henry Houlden, Luca Bartesaghi, Hwei-Jen Lee, Konstantinos Ampatzis, Tyler Mark Pierson, Jan Senderek
Letter
Clinical Neurology
Juan Song, Yong Wang, Xiaoyang Wang, Changlian Zhu
Article
Nursing
Xiaoli Zhang, Xi Chen, Bingbing Li, Lei Xia, Shan Zhang, Wenjun Ding, Liang Gao, Aiqing Liu, Falin Xu, Ruili Zhang, Shihong Cui, Xiaoyang Wang, Changlian Zhu
Summary: The preterm birth rate has significantly increased over the past 32 years in a provincial hospital in Henan, China, becoming the leading cause of neonatal death. Birth asphyxia is the major risk factor for term infants' death.
BIRTH-ISSUES IN PERINATAL CARE
(2022)
Article
Immunology
Kai Zhou, Jinming Han, Harald Lund, Nageswara Rao Boggavarapu, Volker M. Lauschke, Shinobu Goto, Huaitao Cheng, Yuyu Wang, Asuka Tachi, Cuicui Xie, Keying Zhu, Ying Sun, Ahmed M. Osman, Dong Liang, Wei Han, Kristina Gemzell-Danielsson, Christer Betsholtz, Xing-Mei Zhang, Changlian Zhu, Martin Enge, Bertrand Joseph, Robert A. Harris, Klas Blomgren
Summary: A subpopulation of microglia lacking genetic modification and showing high CX3CR1 expression was identified in Cx3cr1(CreER-Eyfp/wt) mouse strain. This subpopulation escaped depletion and proliferated extensively after microglial depletion, eventually occupying a large proportion of microglial pool. Additionally, it was demonstrated that CX3CL1-CX3CR1 signaling regulates microglial repopulation.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Yafeng Wang, Yiran Xu, Kai Zhou, Shan Zhang, Yong Wang, Tao Li, Cuicui Xie, Xiaoli Zhang, Juan Song, Xiaoyang Wang, Changlian Zhu
Summary: The study showed that genetic inhibition of autophagy in mice can partially prevent myelin disruption and oligodendrocyte progenitor cell loss in the subcortical white matter after irradiation, mainly by increasing mitochondrial fusion and inhibiting mitochondrial fission.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Medical Laboratory Technology
Ling Liu, Jing Wang, Haiyu Li, Yan Dong, Ying Li, Lei Xia, Bo Yang, Handuo Wang, Yiran Xu, Guomei Cheng, Kaixian Du, Xiaoli Zhang, Changlian Zhu, Shihong Cui, Chenchen Ren
Summary: Two patients with intractable epilepsy were diagnosed with a milder form of ASNSD, characterized by compound heterozygous mutations in the ASNS gene. The study suggests that plasma asparagine levels may not be the sole basis for diagnosing ASNSD.
CLINICA CHIMICA ACTA
(2022)
Article
Endocrinology & Metabolism
Juan Song, Gisela Nilsson, Yiran Xu, Aura Zelco, Eridan Rocha-Ferreira, Yafeng Wang, Xiaoli Zhang, Shan Zhang, Joakim Ek, Henrik Hagberg, Changlian Zhu, Xiaoyang Wang
Summary: Germinal matrix hemorrhage (GMH) is a common complication in preterm infants, leading to adverse neurodevelopmental outcomes. A rat model of GMH was used to investigate the molecular mechanisms underlying brain injury. The study identified changes in mitochondrial activity, cell protection pathways, cell cycle progression, inflammation, and ferroptosis following GMH. Dysregulation of processes involved in development, mitochondrial function, cholesterol biosynthesis, and inflammation contribute to neurodevelopmental deterioration. This study provides valuable insights for therapeutic interventions.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Multidisciplinary Sciences
Lingling Zhang, Yiran Xu, Hongwei Li, Bingbing Li, Guiqin Duan, Changlian Zhu
Summary: This study aims to evaluate the efficacy of probiotics on the symptoms of children with ASD. Children will be divided into probiotics and placebo groups for a 3-month oral supplementation, with evaluation on immune and inflammation, metabolism, and metagenome impact.
Article
Clinical Neurology
Yong Wang, Juan Song, Xiaoli Zhang, Wenqing Kang, Wenhua Li, Yuyang Yue, Shan Zhang, Falin Xu, Xiaoyang Wang, Changlian Zhu
Summary: The study evaluated the impact of different degrees of intraventricular hemorrhage (IVH) on mortality and neurodevelopmental outcomes in very preterm infants. The results showed that severe IVH increased the risk of death and neurodevelopmental disabilities.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Kai Zhou, Jinming Han, Yafeng Wang, Yiran Xu, Yaodong Zhang, Changlian Zhu
Summary: Circulating monocytes can transform into bone marrow-derived macrophages (BMDMs) and play important roles in the central nervous system (CNS). Modulating BMDMs may be a way to treat neurological diseases, and BMDMs can serve as gene delivery vehicles after bone marrow transplantation. Understanding the roles of BMDMs in CNS diseases and their potential as gene delivery vehicles provides new opportunities for therapeutic interventions.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Oncology
Yafeng Wang, Yiran Xu, Changlian Zhu
Summary: Autophagy is a physiological process that plays a complex role in cancer. Understanding autophagy mechanisms is important for the treatment of pediatric central nervous system tumors.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Correction
Cell Biology
Wei Han, Eva-Maria Meissner, Stefanie Neunteibl, Madeline Guenther, Joerg Kahnt, Amalia Dolga, Cuicui Xie, Nikolaus Plesnila, Changlian Zhu, Klas Blomgren, Carsten Culmsee
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Wei Han, Eva-Maria Meissner, Stefanie Neunteibl, Madeline Gunther, Joerg Kahnt, Amalia Dolga, Cuicui Xie, Nikolaus Plesnila, Changlian Zhu, Klas Blomgren, Carsten Culmsee
Summary: Neural stem and progenitor cell (NSPC) transplants provide neuroprotection by releasing a protective secretome, containing heat-stable proteins, that promote neuronal survival in acute brain injury models.
CELL DEATH & DISEASE
(2023)
Article
Clinical Neurology
Juan Song, Yuyang Yue, Huiqing Sun, Ping Cheng, Falin Xu, Bingbing Li, Kenan Li, Changlian Zhu
Summary: This study analyzed the clinical manifestations, imaging features, and long-term neurodevelopmental outcomes in preterm infants and term infants with leukomalacia. It was found that periventricular leukomalacia mainly occurred in preterm infants, while subcortical cystic leukomalacia was commonly seen in term infants. Although both groups had poor long-term neurodevelopmental outcomes, preterm infants were more prone to cerebral palsy, while term infants were more prone to intellectual disability, epilepsy, and the combination of cerebral palsy with intellectual disability and epilepsy.
JOURNAL OF NEURODEVELOPMENTAL DISORDERS
(2023)
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.