Article
Immunology
Perrine Parize, Jeremie Somme, Laura Schaeffer, Florence Ribadeau-Dumas, Sheherazade Benabdelkader, Agnes Durand, Arnaud Tarantola, Johann Cailhol, Julia Goesch, Lauriane Kergoat, Anne-Sophie Le Guern, Marie-Laurence Mousel, Laurent Dacheux, Paul-Henri Consigny, Arnaud Fontanet, Beata Francuz, Herve Bourhy
Summary: Pre-exposure rabies prophylaxis (PrEP) is recommended for individuals at risk of professional exposure to lyssavirus. A study on 498 vaccinated individuals found that a single booster dose of vaccine after PrEP conferred a high and long-term immune response in almost all individuals. This systematic rabies booster after primary vaccination may alleviate the post-PrEP antibody titer monitoring strategy among exposed professionals.
Editorial Material
Public, Environmental & Occupational Health
Patrick Soentjens, Mieke Croughs
Summary: By simplifying the two-visit rabies pre-exposure prophylaxis into a one-time procedure, compliance among last-minute travellers will increase dramatically and post-exposure procedures in endemic countries will be made easier. Various arguments are being presented to condense this vaccination scheme even further into a single-day process.
JOURNAL OF TRAVEL MEDICINE
(2021)
Review
Psychology, Developmental
Bianca A. Allison, Laura Widman, J. L. Stewart, Reina Evans, Martha Perry
Summary: This meta-analysis examined adherence to pre-exposure prophylaxis (PrEP) among adolescents and young adults, finding that adherence was lower in young cisgender women compared to other young participants.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Review
Public, Environmental & Occupational Health
Benjamin Damanet, Diana Isabela Costescu Strachinaru, Alain Leveque
Summary: A literature review found that single visit rabies pre-exposure prophylaxis (PrEP) might be sufficient to prime the immunity. Results from 11 studies showed that 99.51% of subjects achieved sufficient protection one week after vaccination, regardless of the vaccination schedule. Therefore, single visit PrEP seems to provide adequate protection in most healthy individuals, potentially increasing the accessibility and usability of vaccines.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Review
Medicine, General & Internal
Luh Putu Lila Wulandari, Shi Yi He, Christopher K. Fairley, Benjamin R. Bavinton, Heather-Marie Schmidt, Virginia Wiseman, Rebecca Guy, Weiming Tang, Lei Zhang, Jason J. Ong
Summary: This article systematically reviewed the literature on patient preferences for HIV pre-exposure prophylaxis (PrEP) using discrete choice experiments (DCEs), an attribute-based stated preference method. The study found that dosing frequency, cost, the effectiveness of PrEP, dispensing venue, and side effects were the most commonly examined attributes in DCEs. Despite significant heterogeneity in preferences across subpopulations, overall, the most important attributes were cost, followed by effectiveness, and then dosing frequency.
Review
Immunology
Chang Xu, Colleen L. Lau, Justin Clark, Anna C. Rafferty, Deborah J. Mills, Lani Ramsey, Brian Gilbert, Suhail A. R. Doi, Luis Furuya-Kanamori
Summary: There are various vaccination schedules for rabies prevention and post-exposure prophylaxis, with older individuals showing lower antibody responses and 1-week vaccination schedules being as effective as 3-12 week schedules.
Review
Public, Environmental & Occupational Health
Norfazilah Ahmad, Azmawati Mohammed Nawi, Mohd Nazrin Jamhari, Siti Rohani Nurumal, Juliana Mansor, Mohd Ammar Ihsan Ahmad Zamzuri, Teh Li Yin, Mohd Rohaizat Hassan
Summary: This systematic review aimed to compare the effectiveness of different PEP vaccines, regimens, and routes of administration among Asian populations, and it provided valuable conclusions.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2022)
Article
Infectious Diseases
Napaporn Chantasrisawad, Watsamon Jantarabenjakul, Suvaporn Anugulruengkitt, Suda Punrin, Kornvika Limsuwun, Panadda Sawangsinth, Chayapa Phasomsap, Jiratchaya Sophonphan, Chitsanu Pancharoen, Thanyawee Puthanakit
Summary: The study showed that the 2-dose rabies pre-exposure prophylaxis regimen produced adequate immune response whether administered on days 0 and 7, or days 0 and 28. 100 children aged 3 to 9 years participated in the study from November 2019 to January 2020.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Hidetoshi Nomoto, Kei Yamamoto, Satoshi Kutsuna, Yusuke Asai, Yu Kasamatsu, Michinori Shirano, Toshinori Sahara, Fukumi Nakamura, Yukiko Katsuragi, Masaya Yamato, Koh Shinohara, Naoya Sakamoto, Ryota Hase, Taku Ogawa, Atsushi Nagasaka, Nobuyuki Miyata, Norio Ohmagari
Summary: This study investigated animal exposure among Japanese travelers abroad and found that even on short trips, there is a possibility of contact with animals that can transmit the rabies virus. Therefore, promoting pre-travel consultation and increasing awareness of the potential for rabies exposure are crucial for preventing rabies among Japanese international travelers.
Article
Public, Environmental & Occupational Health
Yihan Guo, Deborah J. J. Mills, Colleen L. L. Lau, Christine Mills, Luis Furuya-Kanamori
Summary: Periodic vaccination against rabies is crucial for those with ongoing risk of exposure. This study examined the long-term immunity after a 3-dose intramuscular (3IM) pre-exposure prophylaxis and single IM booster dose in Australian bat carers. The findings suggest that a serology test should be conducted 1 year after 3IM PrEP, followed by a booster if necessary. The antibodies against rabies can persist for many years after receiving the booster doses.
ZOONOSES AND PUBLIC HEALTH
(2023)
Review
Medicine, General & Internal
Daniel Bradshaw, Graham Philip Taylor
Summary: This article discusses the epidemiological context of HIV-PrEP and HTLV-1 transmission, presents current knowledge of antiretrovirals in preventing HTLV-1 transmission, and identifies knowledge gaps that urgently require data to inform global public health measures to protect HIV-PrEP users from HTLV-1 acquisition.
FRONTIERS IN MEDICINE
(2022)
Review
Psychiatry
Danielle Guy, Jason Doran, Trenton M. White, Lena van Selm, Teymur Noori, Jeffrey V. Lazarus
Summary: This study aimed to synthesize existing knowledge on the full PrEP continuum of care among women who inject drugs (WWID). The findings showed low awareness, knowledge, and usage of PrEP among WWID, although acceptability was high. Homelessness, sexual violence, unpredictability of drug use, and limited access to healthcare were identified as challenges to PrEP usage and adherence. WWID were willing to share PrEP information with other WWID, especially those at high risk of HIV. To improve PrEP usage and engagement in care among WWID, the integration of PrEP services within gender-responsive harm reduction and drug treatment services, as well as peer-based interventions, are recommended.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
Yuanqi Mi, Yuhong Zeng, Peicheng Wang, Mengge Zhou, Feng Cheng
Summary: This review assessed the cost-effectiveness of pre-exposure prophylaxis implementation among men who have sex with men in China. The findings suggest that pre-exposure prophylaxis is only cost-effective when the market price is reduced by at least 5.5%. The study calls for more standardized and transparent modeling studies that consider the latest drug types and market prices.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Infectious Diseases
Cham-mill Kim, Victor Zhao, Maeve Brito De Mello, Rachel Baggaley, Cheryl C. Johnson, Erica Spielman, Christopher K. Fairley, Lei Zhang, Henry de Vries, Jeffrey Klausner, Rui Zhao, Jason J. Ong
Summary: There is no evidence for optimal frequency of STI screening for people using pre-exposure prophylaxis for HIV, although more frequent screening could reduce delayed diagnoses and incidence.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Veterinary Sciences
Woottichai Khamduang, Sayamon Hongjaisee, Tippayathida Pothita, Natedao Kongyai, Sirithorn Surajinda, Wilaiwan Petsophonsakul, Sakorn Pornprasert
Summary: This study conducted in Mae Kha sub district, Thailand, aimed to evaluate the antibody levels and adverse effects of rabies immunization for village health volunteers. The results showed a high seroconversion rate of 92% with no serious adverse reactions after vaccination. The regimen of a two-dose, seven-day vaccination series using intradermal administration proved to be effective and safe for pre-exposure vaccination in high-risk health volunteers.
PREVENTIVE VETERINARY MEDICINE
(2022)
Article
Immunology
Nelly R. Mugo, Randy M. Stalter, Renee Heffron, Helen Rees, Caitlin W. Scoville, Charles Morrison, Athena P. Kourtis, Elizabeth Bukusi, Mags Beksinka, Neena M. Philip, Ivana Beesham, Jen Deese, Vinodh Edward, Deborah Donnell, Jared M. Baeten
Summary: This study found no association between HSV-2 acquisition and the use of three contraceptive methods through a randomized trial. Previous observational studies have suggested a possible association between the use of intramuscular depot medroxyprogesterone acetate (DMPA-IM) and HSV-2 acquisition.
CLINICAL INFECTIOUS DISEASES
(2022)
Editorial Material
Immunology
Sonali Kochhar, Draurio Barreira, Pauline Beattie, Marco Cavaleri, Alejandro Cravioto, Mike W. Frick, Ann M. Ginsberg, Ian Hudson, David C. Kaslow, Sherry Kurtz, Christian Lienhardt, Shabir A. Madhi, Christopher Morgan, Yalda Momeni, Deepali Patel, Helen Rees, Taryn Rogalski-Salter, Alexander Schmidt, Boitumelo Semete-Makokotlela, Gerald Voss, Richard G. White, Matteo Zignol, Birgitte Giersing
Summary: Currently, there is a lack of formal mechanisms or systematic approaches to provide vaccine developers with anticipated evidence to support global policy recommendations. To address this issue, the World Health Organization (WHO) is evaluating a new strategic alignment tool called Evidence Considerations for Vaccine Policy (ECVP). The aim of ECVPs is to bridge the gap in evidence needs and reduce the risk of delays between vaccine recommendation and use.
Review
Infectious Diseases
Erin A. Beasley, Ryan M. Wallace, Andre Coetzer, Louis H. Nel, Emily G. Pieracci
Summary: Traditionally, traditional medicine has been widely used globally to treat various injuries and illnesses, including dog bites and exposures to rabies. However, the efficacy of traditional remedies used for the prevention and treatment of rabies has not been proven through controlled trials or community-based surveys.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Immunology
Melinda S. Suchard, Neil Martinson, Susan Malfeld, Debbie de Assis Rosa, Romel D. Mackelprang, Jairam Lingappa, Xuanlin Hou, Helen Rees, Sinead Delany-Moretlwe, Hadassa Goldfein, Heena Ranchod, David Coetzee, Kennedy Otwombe, Lynn Morris, Caroline T. Tiemessen, Dana M. Savulescu
Summary: This study found that the presence of HLA antibodies in highly exposed persistently seronegative individuals was associated with reduced odds of HIV acquisition. These findings may have important implications for the development of HIV vaccines and treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Obstetrics & Gynecology
Matthew F. Chersich, Fiona Scorgie, Veronique Filippi, Stanley Luchters
Summary: Anatomical, physiologic, and socio-cultural changes during pregnancy and childbirth increase vulnerability to high ambient temperatures in women and newborns. This can lead to various clinical consequences. To adapt to this situation, behavioral changes, health system interventions, building modifications, and climate financing are proposed.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Review
Immunology
Kurayi Mahachi, Joss Kessels, Kofi Boateng, Anne Eudes Jean Baptiste, Pamela Mitula, Ebru Ekeman, Laura Nic Lochlainn, Alexander Rosewell, Samir V. Sodha, Bernadette Abela-Ridder, Albis Francesco Gabrielli
Summary: "Zero-dose" and "missed-dose" children in Nigeria are vulnerable to vaccine-preventable diseases due to factors such as poverty, conflict, and limited access to healthcare services. Maternal factors, community heterogeneity, access to vaccination facilities, and awareness about immunization are key factors influencing childhood vaccine uptake. There is a need for further research on effective and sustainable routine childhood immunization, as there are significant gaps in evidence and implementation of interventions.
Article
Public, Environmental & Occupational Health
Emma Taylor, Elsa Gladys Aguilar-Ancori, Ashley C. Banyard, Isis Abel, Clara Mantini-Briggs, Charles L. Briggs, Carolina Carrillo, Cesar M. Gavidia, Ricardo Castillo-Neyra, Alejandro D. Parola, Fredy E. Villena, Joaquin M. Prada, Brett W. Petersen, Nestor Falcon Perez, Cesar Cabezas Sanchez, Moises Sihuincha, Daniel G. Streicker, Ciro Maguina Vargas, Ana Maria Navarro Vela, Marco A. N. Vigilato, Hui Wen Fan, Rodney Willoughby, Daniel L. Horton, Sergio E. Recuenco
Summary: The Amazonian Tropical Bites Research Initiative (ATBRI) has been established to unify the control methods for neglected zoonotic diseases related to animal bites across Latin America, and provide evidence for policy-making.
INTERNATIONAL HEALTH
(2023)
Article
Oncology
Aimee R. Kreimer, Tania Cernuschi, Helen Rees, Julia M. L. Brotherton, Carolina Porras, John Schiller
Summary: Many countries burdened by cervical cancer have not provided HPV vaccines to most eligible girls, resulting in limited access to screening and treatment. However, the increased vaccine supply and single-dose recommendation provide an opportunity to expand vaccination and prevent millions of projected cervical cancer cases.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Immunology
Kirthana Sharma, Dorothy A. Machalek, Zheng Q. Toh, Demisew Amenu, Mazvita Muchengeti, Andrew K. Ndlovu, Alex Mremi, Bariki Mchome, Andrew J. Vallely, Lynette Denny, Helen Rees, Suzanne M. Garland
Summary: Cervical cancer is a major concern for women globally, particularly in low-income and middle-income countries and among women with HIV. Eliminating cervical cancer among women with HIV requires addressing both biological and social factors. There is a lack of research and evidence on cervical cancer elimination in this population, particularly in terms of HPV vaccination and its long-term effectiveness. Social and structural factors such as poverty, stigma, and gender discrimination pose challenges to the elimination strategy for cervical cancer.
Article
Public, Environmental & Occupational Health
Olimpia Chuquista-Alcarraz, Nestor Falcon, Marco A. N. Vigilato, Felipe Rocha, Gisely Toledo-Barone, Juliana Amorim-Conselheiro, Sergio E. Recuenco, Ricardo Castillo-Neyra
Summary: Lima, Peru has not had any cases of canine rabies since 1999, but there is still a risk of reintroduction due to the movement of dogs from nearby rabies-endemic areas. Our study evaluated the immunity level of the dog population in Lima before a mass vaccination campaign and found that vaccination coverage was below the recommended level of 80%.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2023)
Editorial Material
Veterinary Sciences
Anna S. Fahrion, Conrad M. Freuling, Monique Lechenne, Thomas Mueller, Sergio Recuenco, Marco A. N. Vigilato, Frank Busch, Kathrin Heitz-Tokpa, Stephanie Mauti, Mathew Muturi, Salome Duerr
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Infectious Diseases
Khadija N. Omar, Andre Coetzer, Maulid Hamdu, Ayla J. Malan, Ali Z. Moh'd, Talib S. Suleiman, Louis H. Nel
Summary: Providing dog collars can enhance owner participation in dog rabies vaccination campaigns and improve the community's perception of vaccinated dogs and vaccination campaigns. This study demonstrates the positive impact of dog collars on participation and community perception.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Public, Environmental & Occupational Health
Benido Impouma, Franck Mboussou, Bridget Farham, Lindiwe Makubalo, Kasonde Mwinga, Adelheid Onyango, Lisa Sthreshley, Kalu Akpaka, Thierno Balde, Phionah Atuhebwe, Abdou Salam Gueye, Felicitas Zawaira, Helen Rees, Joseph Cabore, Matshidiso Moeti
Summary: By the end of June 2022, two countries in the WHO African region have achieved the vaccination targets set by WHO, and seven countries are on track. Additionally, some countries have made significant progress in increasing their vaccination rates in a short period of time. However, the African region still has the lowest vaccination rate globally and efforts need to continue to improve the vaccination coverage.
EPIDEMIOLOGY AND INFECTION
(2022)
Article
Medicine, General & Internal
Summary: This study presents the final results of the Solidarity trial and meta-analyses of mortality in relevant trials. The findings suggest that remdesivir does not have a significant effect on COVID-19 patients who are already on ventilators. However, it does have a small effect against death or progression to ventilation in other hospitalized patients.
Letter
Medicine, General & Internal
Philip R. Krause, Helen Rees, J. Peter Figueroa, Soumya Swaminathan, Ana Maria Henao Restrepo