Article
Clinical Neurology
Jacques Lara-Reyna, Lea Alali, Raymond Wedderburn, Konstantinos Margetis
Summary: This study aimed to evaluate the compliance of venous thromboembolism (VTE) prophylaxis after non-operative traumatic brain injury (TBI), and the reasons for deviation. The study found that the overall compliance rate was 52.2%, with compliance rates of 51.4% in the low-risk subgroup and 55.1% in the moderate-risk subgroup. The most common reasons for non-compliance were a stay of less than 48 hours in the low-risk subgroup, and starting prophylaxis before the recommended time frame in the moderate-risk subgroup.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Surgery
Dina M. Filiberto, Saskya Byerly, Emily K. Lenart, Peter E. Fischer, Andrew J. Kerwin
Summary: This study aimed to evaluate the association between body mass index (BMI) and type of pharmacological venous thromboembolism (VTE) prophylaxis with the occurrence of VTE in patients with severe traumatic brain injury (TBI). The results showed that patients with higher BMI and those with delayed initiation of VTE prophylaxis were more likely to develop VTE. Patients treated with unfractionated heparin had a higher risk of VTE and increased mortality compared to those treated with low molecular weight heparin, regardless of BMI and timing of prophylaxis initiation.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Emergency Medicine
Freeman Condon, Areg Grigorian, Dylan Russell, Demetrios Demetriades
Summary: The study aimed to investigate whether low-molecular-weight-heparin (LMWH) is associated with a decreased risk of venous thromboembolism (VTE) and mortality in elderly patients with isolated traumatic brain injury (TBI). The results showed that LMWH reduced the risk of mortality compared to unfractionated heparin (UH), but had no significant effect on VTE risk.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Surgery
Manuel Castillo-Angeles, Anupamaa J. Seshadri, Leo A. Benedict, Nikita Patel, Ramsis Ramsis, Reza Askari, Ali Salim, Deepika Nehra
Summary: This study aimed to evaluate differential care and outcomes for patients with isolated mild-to-moderate traumatic brain injury based on admission service. The research found that patients admitted to different services received varying levels of care, with patients admitted to Neurosurgery undergoing more repeat head CTs and those admitted to Neurology/Medicine being less likely to receive venous thromboembolism chemoprophylaxis.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Emergency Medicine
Lincoln M. Tracy, Peter A. Cameron, Yvonne Singer, Arul Earnest, Fiona Wood, Heather Cleland, Belinda J. Gabbe
Summary: The study found variations in the prevalence of VTE prophylaxis use among burn units in Australia and New Zealand, with prophylaxis use associated with a decrease in the odds of in-hospital mortality. These findings highlight the importance of further research and the development of future best practice guidelines.
Article
Hematology
Alexander Cohen, Virginia Noxon, Amol Dhamane, Robert Bruette, Shrushti Shah, Dionne M. Hines, Tamuno Alfred, Xuemei Luo
Summary: This study compared the risks of recurrent venous thromboembolism (VTE), major bleeding (MB), and clinically relevant non-major bleeding (CRNMB) among cancer patients with brain cancer and other types of cancer who initiated apixaban, low molecular weight heparin (LMWH), or warfarin. The results showed that apixaban was associated with a lower risk of these adverse events compared to LMWH and warfarin, and there were no significant differences in the anticoagulant treatment effects between patients with brain cancer and those with other cancer.
THROMBOSIS RESEARCH
(2023)
Review
Surgery
Alexandre Tran, Shannon M. Fernando, Marc Carrier, Deborah M. Siegal, Kenji Inaba, Kelly Vogt, Paul T. Engels, Shane W. English, Salmaan Kanji, Kwadwo Kyeremanteng, Jacinthe Lampron, Dennis Kim, Bram Rochwerg
Summary: This study summarizes the efficacy and safety of low molecular weight heparin (LMWH) versus unfractionated heparin (UFH) for the prevention of venous thromboembolism (VTE) in trauma patients. The results showed that LMWH is more effective than UFH in reducing the risk of deep vein thrombosis and VTE, and may also reduce the risk of pulmonary embolism and mortality. However, the impact on adverse events and heparin induced thrombocytopenia is uncertain.
Article
Emergency Medicine
Angela Allen, Areg Grigorian, Ashton Christian, Sebastian D. Schubl, Cristobal Barrios, Michael Lekawa, Borris Borazjani, Victor Joe, Jeffry Nahmias
Summary: ICPM use in severe TBI patients is associated with a delay in initiation of VTE chemoprophylaxis and an increased risk of VTE. There is a nearly two-fold higher risk of VTE in patients with ICPMs even when controlling for known risk factors. Improved adherence to initiation of VTE chemoprophylaxis may help decrease the associated risk of VTE with ICPMs.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Sophie Samuel, Carlton Menchaca, Aaron M. Gusdon
Summary: Currently, there is no consensus guideline for initiating anticoagulation in patients with a traumatic or vascular brain injury. This study compared the clinical outcomes of early versus late initiation of therapeutic anticoagulation in patients with VTE. The results showed that early initiation of anticoagulation did not worsen clinical outcomes.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Orthopedics
Stefano R. Muscatelli, Huiyong Zheng, Richard E. Hughes, Mark E. Cowen, Brian R. Hallstrom
Summary: The study found that using aspirin alone as prophylaxis for venous thromboembolism after total hip arthroplasty is not inferior to other anticoagulants, not only in preventing venous thromboembolism, but also in terms of bleeding events.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Clinical Neurology
Blake M. Hauser, Samantha E. Hoffman, Saksham Gupta, Mark M. Zaki, Edward Xu, Melissa Chua, Joshua D. Bernstock, Ayaz Khawaja, Timothy R. Smith, Mark R. Proctor, Hasan A. Zaidi
Summary: This study conducted a retrospective cohort analysis of pediatric patients with traumatic spinal injuries (TSIs) to investigate the epidemiology and clinical predictors of venous thromboembolism (VTE). The results showed that VTE occurs in a low percentage of hospitalized pediatric patients with TSI. Injury severity, concomitant injuries, and obesity were identified as specific risk factors for VTE. Patients with VTE also required longer hospital stays and more rehabilitative care.
JOURNAL OF NEUROSURGERY-SPINE
(2022)
Article
Medicine, General & Internal
Jesus Abelardo Barea-Mendoza, Mario Chico-Fernandez, Manuel Quintana-Diaz, Lluis Servia-Goixart, Ana Fernandez-Cuervo, Maria Bringas-Bollada, Maria Angeles Ballesteros-Sanz, Iker Garcia-Saez, Jon Perez-Barcena, Juan Antonio Llompart-Pou
Summary: The aim of this study was to analyze the impact of acute kidney injury (AKI) on mortality in patients with isolated traumatic brain injury (TBI) and identify associated risk factors. The results showed that 10.6% of patients developed AKI, which was significantly associated with increased mortality. Age, hemodynamic instability, rhabdomyolysis, trauma-associated coagulopathy, and transfusion of packed red-blood-cell concentrates were identified as the main risk factors for AKI in isolated TBI patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Surgery
Mbaga Walusimbi, Avafia Y. Dossa, Kiran Faryar, Ronald J. Markert, Mary C. McCarthy
Summary: This study aimed to identify the risk factors, mortality, and morbidity associated with upper extremity deep venous thrombosis (UEDVT) in trauma patients and the impact of pharmacological prophylaxis. The results showed that UEDVT is associated with higher mortality and the presence of upper extremity fractures, peripherally inserted central catheter (PICC) lines, and traumatic brain injury (TBI) were identified as independent risk factors for UEDVT. Additionally, pharmacological prophylaxis reduced the risk of UEDVT.
WORLD JOURNAL OF SURGERY
(2022)
Review
Medicine, General & Internal
Emanuele Valeriani, Nicola Potere, Matteo Candeloro, Silvia Spoto, Ettore Porreca, Anne W. S. Rutjes, Marcello Di Nisio
Summary: Extended venous thromboprophylaxis in patients hospitalized for acute ischemic stroke may have a greater net clinical benefit compared to standard thromboprophylaxis, with a lower risk of VTE and a minimal increase in major bleeding.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Lennart Riemann, Obada T. Alhalabi, Andreas W. W. Unterberg, Alexander Younsi
Summary: Spine injuries are common in patients with traumatic brain injury (TBI). In this study, they analyzed data from a European multi-center study to assess the prevalence and outcomes of patients with TBI and concurrent spinal injuries. They found that after 6 months, mortality, unfavorable outcomes, and full recovery rates were comparable between TBI patients with and without concomitant spinal injuries. However, in patients with mild TBI, concomitant spinal injuries were associated with a negative predictor for full recovery.
FRONTIERS IN NEUROLOGY
(2022)