Article
Biochemistry & Molecular Biology
Xiang Xu, Ruimin Liang, Yubin Zheng, Ye Qiu, Nan Zheng
Summary: In this work, a library of highly sulfated glycomimetic polypeptides was developed, which can control the helicity, molecular weight, rigidity, and side-chain structure. The potential of these polypeptides as inhibitors of SARS-CoV-2 and common enteroviruses was investigated, and the structure-activity relationship was explored. The results showed that the alpha-helical conformation and sulfated sugars played crucial roles in inhibiting SARS-CoV-2, and other structural properties also contributed to blocking viral entry. Among these polypeptides, L-60-SG-POB exhibited the highest inhibition efficiency. Furthermore, they also showed inhibitory activity against enteroviruses.
Article
Fisheries
Jyotsna, Parameswaran Vijayakumar, Tharmathass Stalin Dhas, Ravi Mani, Vasantharaja Raguraman
Summary: The study revealed that polysaccharides extracted from brown seaweed exhibit high antiviral potential against Betanodavirus infection in fishes, both in vitro and in vivo, by reducing cytopathic effect formation and effectively blocking viral attachment and entry.
AQUACULTURE INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Maria Laura Alfieri, Lucia Panzella, Barbara Duarte, Salome Goncalves-Monteiro, Franklim Marques, Manuela Morato, Marta Correia-da-Silva, Luisella Verotta, Alessandra Napolitano
Summary: Sulfated phenolic polymers have been studied as anticoagulants due to their higher bioavailability and resistance to degradation. Different approaches were used to prepare sulfated derivatives of tyrosol, a phenolic constituent of olive oil, which showed varied structural features and anticoagulant activities. This study highlights the importance of structural characteristics in dictating the anticoagulant activity of phenol polymers and suggests a rationale for designing alternative anticoagulant agents.
Article
Agriculture, Multidisciplinary
Chenghai Wang, Xiansheng Ye, Chengchao Ding, Mengqi Zhou, Weiling Li, Yuansong Wang, Qiang You, Shan Zong, Qian Peng, Deqiang Duanmu, Haifeng Chen, Binlian Sun, Jialu Qiao
Summary: In this study, it was found that miyabenol C and trans-epsilon-viniferin, two resveratrol oligomers, specifically inhibit the entry of SARS-CoV-2 by targeting host protease cathepsin L. Molecular docking analysis showed that these oligomers can occupy the active cavity of cathepsin L. Surface plasmon resonance assay demonstrated their excellent binding ability for cathepsin L. This study demonstrates the potential application of resveratrol oligomers as lead compounds in controlling SARS-CoV-2 infection.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Polymer Science
Rebekah Duke, Vinayak Bhat, Andrew Smith, Stephen Goodlett, Sergei Tretiak, Chad Risko
Summary: The conformational variability of π-conjugated molecules or polymers, which is determined by the rotation capacity among the connected ring moieties, plays a crucial role in the properties of organic semiconductors. This study systematically examines the effects of ring chemistries, ortho-positioned substituents, and oligomer length on inter-ring rotation in order to guide the design of new molecular and polymer classes with desired properties.
Review
Biochemistry & Molecular Biology
Jonathan Ardhianto Panggabean, Sya'ban Putra Adiguna, Siti Irma Rahmawati, Peni Ahmadi, Elmi Nurhaidah Zainuddin, Asep Bayu, Masteria Yunovilsa Putra
Summary: An antiviral agent is urgently needed for future viral diseases. Searching for effective and non-toxic options, algal-based sulfated polysaccharides are considered as a potential source for the development of antiviral agents.
Article
Polymer Science
Matthieu Soete, Chiel Mertens, Resat Aksakal, Nezha Badi, Filip Du Prez
Summary: Sequence-encoded oligo(thioether urethane)s with two different coding monomers per backbone unit were synthesized via a solid phase, two-step iterative protocol. This strategy increases data storage capacity and the exact monomer order can be revealed using tandem mass spectrometry techniques.
Review
Multidisciplinary Sciences
Rajesh K. Thimmulappa, Kiran Kumar Mudnakudu-Nagaraju, Chandan Shivamallu, K. J. Thirumalai Subramaniam, Arun Radhakrishnan, Suresh Bhojraj, Gowthamarajan Kuppusamy
Summary: COVID-19, caused by SARS-CoV-2, has led to a significant number of cases and deaths. Curcumin, a bioactive compound in turmeric, is considered a potential prophylactic therapeutic for COVID-19.
Article
Polymer Science
Matthieu Soete, Jens Van Hoorde, Filip Du Prez
Summary: A straightforward solution-phase approach for the synthesis of N-substituted oligourethanes was reported. The obtained oligourethanes were characterized by structure elucidation and intramolecular reaction studies, and successfully applied as molecular tags in a polyurethane material.
Review
Pharmacology & Pharmacy
Mehwish Jabeen, Melody Dutot, Roxane Fagon, Bernard Verrier, Claire Monge
Summary: Natural marine sulfated polysaccharides with promising antiviral activity could be a safe alternative to synthetic broad-spectrum antiviral drugs.
Article
Virology
Daniela Jimenez-Arriagada, Alejandro A. Hidalgo, Victor Neira, Andronico Neira-Carrillo, Sergio A. Bucarey
Summary: The study suggests that sulfated chitosan can serve as an effective antiviral polymer to reduce the impact of PCV2 infection on pigs, showing specific antiviral effects under different molecular weights, sulfate functionalization, and concentrations. Low molecular weight sulfated chitosan exerts antiviral activity by impeding viral attachment and penetration into cells.
Article
Pharmacology & Pharmacy
Eun-Bin Kwon, You-Chang Oh, Youn-Hwan Hwang, Wei Li, Seok-Man Park, Ryong Kong, Young Soo Kim, Jang-Gi Choi
Summary: OCD20015-V009 modulates murine innate immune response by regulating macrophages to inhibit influenza A virus replication, reducing mortality in infected mice. Chlorogenic acid and ginsenoside Rd are identified as antiviral components in this herbal mix, enhancing mice's resistance to viral infections. Further studies are needed to clarify the protective effects of active components in OCD20015-V009 against influenza A viruses.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Virology
Stephanie Moeller, Janine Theiss, Thaira I. L. Deinert, Karoline Golat, Julian Heinze, Daniela Niemeyer, Ralf Wyrwa, Matthias Schnabelrauch, Elke Bogner
Summary: The study characterized the antiviral effects of two high-sulfated glycosaminoglycan derivatives against SARS-CoV-2 and BCoV, showing strong inhibitory effects on both coronaviruses at different stages of infection. Additionally, the compounds demonstrated low cytotoxicity and have the potential to be promising candidates for anti-coronavirus therapy.
Article
Chemistry, Multidisciplinary
Zhanpeng Zhang, Shuai Lu, Xiujun Yu, Lei Hua, Weiguo Wang, Menglin Xue, Jianfeng Cai, Heng Wang, Xiaopeng Li
Summary: Metallo-helicoids are constructed by intermolecular coordination interactions and exhibit high antimicrobial activities.
CHEMICAL COMMUNICATIONS
(2023)
Article
Polymer Science
Xue Han, Cece Xue, Zhuo Zhao, Min Peng, Qing Wang, Haiming Liu, Na Yu, Chaodan Pu, Yi Ren
Summary: Doping boron into organic π-conjugated polymers endows them with interesting optoelectronic properties. In this study, a new series of thienylborane-pyridine Lewis pairs were synthesized via reactions between thienylborane and various pyridine derivatives. The Lewis pairs were then cross-linked with distannylated thiophene to form BN-cross-linked polythiophenes. The resulting polymers showed highly uniform chemical structures and good stability, and the presence of topological BN structures enhanced their intramolecular charge separation. As a proof-of-concept, a representative BN-cross-linked polythiophene was tested as a catalyst for photocatalytic hydrogen evolution.
Article
Chemistry, Multidisciplinary
Selina Beatrice van Der Meer, Theresa Seiler, Christin Buchmann, Georgia Partalidou, Sophia Boden, Kateryna Loza, Marc Heggen, Jurgen Linders, Oleg Prymak, Cristiano L. P. Oliveira, Laura Hartmann, Matthias Epple
Summary: The study demonstrates that precision macromolecules carrying cysteine can effectively surface functionalize ultrasmall gold nanoparticles, with each nanoparticle carrying between 40 and 100 ligands and each ligand having a footprint of about 0.074 nm². Additionally, the presence of a PEG chain in the ligands significantly increases the hydrodynamic diameter of both dissolved macromolecules and macromolecule-conjugated gold nanoparticles.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Virology
Anandi Rajan, Elin Palm, Fredrik Trulsson, Sarah Mundigl, Miriam Becker, B. David Persson, Lars Frangsmyr, Annasara Lenman
Summary: This study identified heparan sulfate as an interaction partner for the short fiber of enteric HAdVs, which remains unaffected by acidic pH and enhances attachment to host cells. The research also revealed a switch in receptor usage of enteric HAdVs after exposure to acidic pH.
Article
Chemistry, Multidisciplinary
Marvin Mantel, Markus Giesler, Marian Guder, Elisabeth Ruethlein, Laura Hartmann, Joerg Pietruszka
Summary: Efficient synthesis of enantiopure key building blocks for natural product syntheses can be achieved by utilizing multiple catalytic steps within the same reaction vessel using two catalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Peter Pasch, Matthias Killa, Hauke Lukas Junghans, Melanie Schmidt, Stephan Schmidt, Jens Voskuhl, Laura Hartmann
Summary: The use of AIE luminophore for conjugation onto supramolecular ligands enables the detection of ligand binding. The positioning of the luminophore within the ligand scaffold strongly affects the AIE properties. Studies demonstrate that the position within the ligand structure significantly influences the performance of AIE.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Polymer Science
Stephen Andrew Hill, Robert Steinfort, Sandra Muecke, Josefine Reifenberger, Tobias Sengpiel, Laura Hartmann
Summary: This study outlines the preparation of sequence-defined macromolecules using cyclic sulfamidates on solid-phase. Challenges in ring-opened side product formation are described, with a focus on iterative ring-opening strategy. Successful ring-opening on primary and secondary amines for linear and branched chain growth is reported.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Urology & Nephrology
Karin Welen, Ebba Rosendal, Magnus Gisslen, Annasara Lenman, Eva Freyhult, Osvaldo Fonseca-Rodriguez, Daniel Bremell, Johan Stranne, Ase Ostholm Balkhed, Katarina Niward, Johanna Repo, David Robinsson, Anna J. Henningsson, Johan Styrke, Martin Angelin, Elisabeth Lindquist, Annika Allard, Miriam Becker, Stina Rudolfsson, Robert Buckland, Camilla Thellenberg Carlsson, Anders Bjartell, Anna C. Nilsson, Clas Ahlm, Anne-Marie Fors Connolly, Anna K. Overby, Andreas Josefsson
Summary: The study suggests that antiandrogens may not have therapeutic or preventive effects in COVID-19 patients, and androgen inhibition may lead to longer hospitalizations and higher risk of death.
Article
Multidisciplinary Sciences
Francisco J. Zapatero-Belinchon, Rebecca Moeller, Lisa Lasswitz, Marco van Ham, Miriam Becker, Graham Brogden, Ebba Rosendal, Wenjie Bi, Belen Carriqui-Madronal, Koushikul Islam, Annasara Lenman, Antonia P. Gunesch, Jared Kirui, Thomas Pietschmann, Anna K. Overby, Lothar Jansch, Gisa Gerold
Summary: Clinical data suggests that statin therapy, particularly fluvastatin, may have a moderate beneficial effect on SARS-CoV-2 infection in human lung cells by downregulating proteins related to protein translation and viral replication, without affecting innate antiviral immune responses.
Article
Materials Science, Multidisciplinary
Philipp Reuther, Philipp Duennwald, Monir Tabatabai, Christian Schuh, Laura Hartmann, Helmut Ritter
Summary: In this study, imidazole-containing polymeric accelerators were synthesized and applied in the curing process of resins. The results showed that the incorporation of accelerators into polymers increased the pot life of curing and improved the storage stability by adjusting the compatibility with resins. Additionally, the accelerators were found to dissolve in resin above a certain temperature, enabling a high reactivity. The best performing accelerator was then applied in an adhesive film formulation, demonstrating superior long-term stability and efficient acceleration.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Microbiology
Ebba Rosendal, Ionut Sebastian Mihai, Miriam Becker, Debojyoti Das, Lars Frangsmyr, B. David Persson, Gregory D. Rankin, Remigius Groning, Johan Trygg, Mattias Forsell, Johan Ankarklev, Anders Blomberg, Johan Henriksson, Anna K. Overby, Annasara Lenman
Summary: Identification of host factors affecting individual susceptibility to SARS-CoV-2 can help understand disease severity and identify potential targets for antiviral drug development. In this study, the researchers found that cellular protease inhibitors, serpins, restrict SARS-CoV-2 infection by inhibiting the serine protease TMPRSS2. The findings suggest that genetic variations and deficiencies of cellular serpins may increase the risk for severe COVID-19.
Article
Biochemistry & Molecular Biology
Miriam Hoffmann, Nicole L. Snyder, Laura Hartmann
Summary: Sulfated glycosaminoglycans (sGAGs) are important in various biological processes and have potential as antiviral compounds. The structure and sulfation patterns of sGAGs play a key role in their biological function. However, synthesizing sGAG mimetics is still challenging. In this study, three groups of sulfated glycomacromolecules were successfully synthesized, demonstrating the wide applicability of this method. The synthesized structures had high purity and sulfation degree, and showed anticoagulant properties similar to natural HS.
Article
Biochemistry & Molecular Biology
Alexander Hoeing, Abbna Kirupakaran, Christine Beuck, Marius Poerschke, Felix C. Niemeyer, Theresa Seiler, Laura Hartmann, Peter Bayer, Thomas Schrader, Shirley K. Knauer
Summary: Many natural proteins utilize flexible loops to interact with their binding partners and undergo structural rearrangements for perfect binding. The molecular recognition of such flexible structures is challenging due to their conformational dynamics. Protein-protein interactions, on the other hand, involve the display of multiple complementary binding partners to enhance affinity and specificity. In this study, advanced multivalent supramolecular tweezers were rationally designed to target specific lysine and arginine clusters on a flexible protein surface loop.
Article
Biochemistry & Molecular Biology
Patrick B. Konietzny, Hannelore Peters, Marc L. Hofer, Ulla I. M. Gerling-Driessen, Robert P. de Vries, Thomas Peters, Laura Hartmann
Summary: Sialoglycans play a key role in biological recognition processes and their multivalent presentation is crucial for high-affinity binding. This study combines solid phase polymer synthesis and enzymatic sialylation to successfully synthesize sequence-defined sialylated macromolecules. Surprisingly, an unexpected side reaction involving Tris-sialoside formation was observed.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Polymer Science
Miriam Hoffmann, Nicole L. Snyder, Laura Hartmann
Summary: This article provides an overview of the roles of HP/HS in viral engagement and examines historical and recent approaches toward oligo-/polysaccharide, glycopolymer, and anionic polymer HP/HS mimetics. An overview of current applications and future prospects of these molecules is provided, demonstrating their potential in addressing current and future epidemics and pandemics.
Article
Polymer Science
Alexander Banger, Peter Pasch, Luca-Cesare Blawitzki, Simon Weber, Marius Otten, Cornelia Monzel, Stephan Schmidt, Jens Voskuhl, Laura Hartmann
Summary: This study explores the cell's glycocalyx model by synthesizing amphiphilic glycan-functionalized oligomers and introducing an aggregation-induced luminophore for detection and localization of clustering events in self-assembled structures.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Review
Polymer Science
Stephen A. Hill, Robert Steinfort, Laura Hartmann
Summary: The synthesis and application of sequence-defined materials allows for the creation of tailored materials with specific functions based on heterocyclic building blocks. Despite being mainly used in biomimicry, data storage, and sensing, there are challenges and potential future research directions for further exploration.
