期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 1, 页码 623-632出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b12297
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资金
- University of Geneva
- Swiss National Science Foundation [200021_159199]
- Kundig (University of Geneva)
- Swiss National Science Foundation (SNF) [200021_159199] Funding Source: Swiss National Science Foundation (SNF)
A Cu-catalyzed borylative carboxamidation reaction has been developed using vinylarenes and isocyanates. Alkynes, branched 1,3-dienes, and bicyclic alkenes were also found to be competent coupling partners. Using a chiral phosphanamine ligand, an enantioselective variant of this transformation was developed, affording a set of alpha-chiral amides with unprecedented levels of enantioselectivity. The synthetic utility of the method was demonstrated through a series of representative stereoretentive postcatalytic derivatizations.
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