期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 142, 期 5, 页码 2168-2174出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b12053
关键词
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资金
- Alfried Krupp von Bohlen and Halbach Foundation
- Deutsche Forschungsgemeinschaft (Leibniz Award) [GRK 2515]
Herein, we report the synthesis of protected 1,2-amino alcohols starting from carbonyl compounds and alpha-silyl amines. The reaction is enabled by a Cr/photoredox dual catalytic system that allows the in situ generation of alpha-amino carbanion equivalents which act as nucleophiles. The unique nature of this reaction was demonstrated through the aminoalkylation of ketones and an acyl silane, classes of electrophiles that were previously unreactive toward addition of alkyl-Cr reagents. Overall, this reaction broadens the scope of Cr-mediated carbonyl alkylations and discloses an underexplored retrosynthetic strategy for the synthesis of 1,2-amino alcohols.
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