期刊
JOURNAL OF STATISTICAL PHYSICS
卷 180, 期 1-6, 页码 459-473出版社
SPRINGER
DOI: 10.1007/s10955-019-02461-7
关键词
Tissue growth; Phase separation; Precipitation; Surface tension; Wetting
The growth of living tissue is known to be modulated by mechanical as well as biochemical signals. We study a simple numerical model where the tissue growth rate depends on a chemical potential describing biochemical and mechanical driving forces in the material. In addition, the growing tissue is able to adhere to a three-dimensional surface and is subjected to surface tension where not adhering. We first show that this model belongs to a wider class of models describing particle growth during phase separation. We then analyse the predicted tissue shapes growing on a solid support corresponding to a cut hollow cylinder, which could be imagined as an idealized description of a broken long bone. We demonstrate the appearance of complex shapes described by Delauney surfaces and reminiscent of the shapes of callus appearing during bone healing. This complexity of shapes arises despite the extreme simplicity of the growth model, as a consequence of the three-dimensional boundary conditions imposed by the solid support.
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