期刊
BIOSCIENCE
卷 65, 期 7, 页码 651-666出版社
OXFORD UNIV PRESS
DOI: 10.1093/biosci/biv047
关键词
human-reservoir interactions; Sin Nombre virus; hantavirus pulmonary syndrome; Peromyscus maniculatus; emerging infectious disease
类别
资金
- National Center for Research Resources [5P20RR016455-11]
- National Institute of General Medical Sciences from National Institutes of Health [8 P20 GM103474-11]
- US Centers for Disease Control and Prevention, in Atlanta, Georgia
- Research and Policy for Infectious Disease Dynamics (RAPIDD) program of the Science and Technology Directorate (US Department of Homeland Security)
- Fogarty International Center (National Institutes of Health)
- Sevilleta LTER Program (NSF) [DEB 9411976, DEB 0080529]
- National Institutes of Health (DHHSPHS/NIAID) [PO1 A1 39780-02]
- Federal Centers for Disease Control and Prevention (CDC) [U50/CCU613416]
- Direct For Biological Sciences
- Division Of Environmental Biology [1440478] Funding Source: National Science Foundation
Understanding the environmental drivers of zoonotic reservoir and human interactions is crucial to understanding disease risk, but these drivers are poorly predicted. We propose a mechanistic understanding of human-reservoir interactions, using hantavirus pulmonary syndrome as a case study. Crucial processes underpinning the disease's incidence remain poorly studied, including the connectivity among natural and peridomestic deer mouse host activity, virus transmission, and human exposure. We found that disease cases were greatest in arid states and declined exponentially with increasing precipitation. Within arid environments, relatively rare climatic conditions (e.g., El Nino) are associated with increased rainfall and reservoir abundance, producing more frequent virus transmission and host dispersal. We suggest that deer mice increase their occupancy of peridomestic structures during spring-summer, amplifying intraspecific transmission and human infection risk. Disease incidence in arid states may increase with predicted climatic changes. Mechanistic approaches incorporating reservoir behavior, reservoir-human interactions, and pathogen spillover could enhance our understanding of global hantavirus ecology, with applications to other directly transmitted zoonoses.
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