期刊
JOURNAL OF NEUROCHEMISTRY
卷 154, 期 1, 页码 11-24出版社
WILEY
DOI: 10.1111/jnc.14968
关键词
alpha-synuclein; Gaucher disease; GBA1; Parkinson disease
The discovery of genes involved in familial as well as sporadic forms of Parkinson disease (PD) constitutes an important milestone in understanding this disorder's pathophysiology and potential treatment. Among these genes, GBA1 is one of the most common and well-studied, but it is still unclear how mutations in GBA1 translate into an increased risk for developing PD. In this review, we provide an overview of the biochemical and structural relationship between GBA1 and PD to help understand the recent advances in the development of PD therapies intended to target this pathway.
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