Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium

An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 mu M without cytotoxicity against human cancer cell lines at 10 mu M.