Review
Chemistry, Applied
Sara Demartis, Antonella Obinu, Elisabetta Gavini, Paolo Giunchedi, Giovanna Rassu
Summary: Rose Bengal, an anionic xanthene dye derived from fluorescein, originally used as a textile dye, is now primarily known in ophthalmology and biomedical field. It exhibits intrinsic cytotoxicity against tumor and microbial cells, making it suitable for sono-photodynamic therapy. However, due to its disadvantageous bio-pharmaceutical profile, it is currently approved only for ocular diagnostics.
Article
Biophysics
K. Sztandera, M. Gorzkiewicz, X. Wang, S. Boye, D. Appelhans, B. Klajnert-Maculewicz
Summary: Photodynamic therapy is a noninvasive alternative to traditional cancer treatments, utilizing light-activated drugs to produce reactive oxygen species and induce cell death. Current research focuses on nanosystems to improve the properties of photosensitizers. This study presents a pH-stable nanosystem, polymersomes, as a potential nanocarrier for photodynamic therapy, enhancing the effects of rose bengal.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Krzysztof Sztandera, Michal Gorzkiewicz, Mateusz Batal, Valeria Arkhipova, Nadezhda Knauer, Javier Sanchez-Nieves, Fco Javier de la Mata, Rafael Gomez, Evgeny Apartsin, Barbara Klajnert-Maculewicz
Summary: This study reports the incorporation of rose bengal into vesicle-like constructs of amphiphilic triazine-carbosilane dendrons and the characterization of this nanosystem. The results show that encapsulation of rose bengal enhances cellular uptake, intracellular ROS production, and phototoxicity. Thus, triazine-carbosilane dendrimersomes demonstrate high potential as drug carriers for anticancer photodynamic therapy.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Physical
Yao Huang, Tingting Peng, Yangyan Chen, Fapeng Zhang, Wanshan Hu, XinYi Gao, Hongyu Chen, Ping Tang, Chuanbin Wu, Xin Pan
Summary: This study developed an oxygen reservoir-irrigated photodynamic therapy (PDT) that integrates oxygen supply, oxygen economizing, and oxygen infiltration. By modulating tumor oxygenation and permeability, it achieves complete eradication of primary melanoma and stimulates immunogenic cell death.
Article
Chemistry, Physical
Yao Huang, Tingting Peng, Yangyan Chen, Fapeng Zhang, Wanshan Hu, XinYi Gao, Hongyu Chen, Ping Tang, Chuanbin Wu, Xin Pan
Summary: An oxygen reservoir-irrigated photodynamic therapy has been developed to improve the efficacy of tumor treatment by considering oxygen supply, economizing, and infiltration. This therapy effectively reduces tumor hypoxia, promotes immunogenic cell death, and enhances the antitumor effects when combined with checkpoint-blockade inhibitors.
Article
Chemistry, Physical
Katieli da Silva Souza Campanholi, Isabella Cazelatto da Silva, Rafaela Said dos Santos, Camila Felix Vecchi, Jessica Bassi da Silva, Marcos Luciano Bruschi, Magali Soares dos Santos Pozza, Lidiane Vizioli de Castro-Hoshino, Mauro Luciano Baesso, Wilker Caetano, Vagner Roberto Batistela
Summary: To meet the need of reducing the load of resistant microorganisms and accelerating healing, a phototherapeutic emulgel containing Carbopol, Pluronic F127 and F68 polymers, Rose Bengal, and Copaifera reticulata Ducke oil-resin was developed. The emulgel demonstrated gelation temperature of 11.2 +/- 0.0 degrees C and exhibited thixotropic and viscoelasticity performance at body temperature, as well as drug skin permeation ability. The multidrug topical emulgel has advantageous properties and microbicidal and healing potential for future in vitro and in vivo studies.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Paloma Kalegari, Daniela Morais Leme, Geonildo Rodrigo Disner, Marta Margarete Cestari, Daniel de Lima Bellan, Willian Vanderlei Meira, Ester Mazepa, Glaucia Regina Martinez
Summary: The presence of higher amounts of melanin in melanoma cells may affect the levels of DNA damage when subjected to RBAc-PDT treatment.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Juan Ferrera-Gonzalez, Maria Gonzalez-Bejar, Julia Perez-Prieto
Summary: This study utilized a nanohybrid consisting of rose bengal dye and upconversion nanoparticles to investigate the fundamental mechanisms underlying the interaction between the two and its impact on the dye's photophysical behavior.
Article
Biochemical Research Methods
Jessica Houang, Catriona Halliday, Sharon Chen, Chun-Hoong Ho, Alina Bekmukhametova, Antonio Lauto
Summary: The study demonstrated that photodynamic therapy using Rose Bengal can act against a broader spectrum of fungal pathogens, potentially expanding its clinical antifungal applications.
JOURNAL OF BIOPHOTONICS
(2021)
Article
Biology
Mykhailo Nahorniak, Ognen Pop-Georgievski, Nadiia Velychkivska, Marcela Filipova, Eliska Rydvalova, Kristyna Gunar, Petr Matous, Uliana Kostiv, Daniel Horak
Summary: High-quality upconverting NaYF4:Yb3+,Er3+ nanoparticles were synthesized and modified with bisphosphonate-terminated poly(ethylene glycol) and Rose Bengal photosensitizer. The particles were thoroughly characterized and found to have the potential for photodynamic therapy of cancer due to the generation of reactive oxygen species under 980 nm excitation.
Article
Chemistry, Multidisciplinary
Anne Nsubuga, Gabrielle A. Mandl, John A. Capobianco
Summary: It is crucial to use multiple assays to determine the mechanism of X-ray mediated photodynamic therapy using radioluminescent nanomaterials. Different assays showed that some nanoparticles exclusively produced superoxide and hydroxyl radicals under X-ray excitation, highlighting the importance of understanding the correct PDT mechanism for effective disease treatment using PDT nanosystems.
NANOSCALE ADVANCES
(2021)
Review
Chemistry, Medicinal
Batoul Dhaini, Laurene Wagner, Morgane Moinard, Joel Daouk, Philippe Arnoux, Herve Schohn, Perrine Schneller, Samir Acherar, Tayssir Hamieh, Celine Frochot
Summary: This review summarizes the history of using Rose Bengal as a photosensitizer coupled with nanoparticles, and highlights its remarkable cytotoxicity in photodynamic therapy and its potential in nanomedical applications.
Editorial Material
Oncology
Batoul Dhaini, Joel Daouk, Herve Schohn, Valerie Jouan-hureaux, Samir Acherar, Philippe Arnoux, Paul Rocchi, Francois Lux, Olivier Tillement, Tayssir Hamieh, Celine Frochot
Summary: This study explores the use of photosensitizer Rose Bengal coupled with nanoparticles in photodynamic therapy, enabling singlet oxygen production through X-ray excitation and overcoming the limited tissue penetration ability of photodynamic therapy. Furthermore, targeting efficiency is enhanced by grafting peptides onto the nanoparticles.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Chemistry, Multidisciplinary
Leilei Shi, Xiaoxiao Liu, Yuzhen Li, Sha Li, Wenbo Wu, Xihui Gao, Bin Liu
Summary: Metabolic engineering labeled anaerobic oncolytic bacteria can effectively ablate melanoma by modifying the bacterial metabolic substrate and photosensitizer, enabling engineered bacteria to proliferate in the tumor and stimulate immune environment, eliminate the hypoxic region, and then exert a photodynamic effect in the oxygen-rich region to completely remove melanoma.
Article
Chemistry, Multidisciplinary
Minling Jiang, Jinjin Zhang, Yaojun Li, Tingyu Shi, Tiantian Ma, Yiqi Sun, Huayu Qiu, Yang Li, Shouchun Yin
Summary: This study proposes a strategy of introducing hydrophilic chains and halogen atoms in boron dipyrromethene (BODIPY) to form J-aggregate nano-micelles, enabling both imaging and multiple therapeutics. The study shows that the steric effects of the 3,5-position group of BODIPY can affect the degree of nanoparticle aggregation. It provides an emerging strategy for cancer therapy and a novel idea for the future development of new efficient photosensitizers.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Review
Dermatology
A. Durack, S. Gran, M. D. Gardiner, A. Jain, E. Craythorne, C. M. Proby, J. Marsden, C. A. Harwood, R. N. Matin
Summary: A retrospective comparative review of surgical management of DFSP in the UK National Health Service showed that wide local excision was the most common surgical modality used and had a low local recurrence rate. Although there were reported deaths during the follow-up analysis period, the study highlights the importance of considering patient preference, clinical expertise, and cost in making treatment decisions when there is no clearly superior surgical modality.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Meeting Abstract
Rheumatology
A. Vivekanantham, M. Kesavan, J. Evans, R. N. Matin, I. Elliott, R. Luqmani
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Editorial Material
Dermatology
C. Morton, R. N. Matin
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
A. Ji-Xu, J. Dinnes, R. N. Matin
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Joshua Philip Totty, Rubeta N. Matin, Aaron Wernham, Ruby Ray, Emma Thomas-Jones, Rachel Angharad Abbott
Summary: Skin cancer is the most common malignancy in the UK, and a significant number of lesions are ulcerated at the time of excision. Ulceration has been linked to increased risk of surgical site infection, and studies have shown varying rates of infection. However, there are no specific guidelines for antibiotic prophylaxis in these cases. A survey of clinicians who regularly perform skin lesion excisions revealed significant variability in their practice, indicating a need for a well-designed clinical trial to guide future treatment approaches.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Letter
Dermatology
W. Ye, M. Kim, B. P. Fairfax, N. Coupe, M. J. Payne, R. N. Matin
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
R. A. Abbott, A. Cordaro, B. Lloyd, R. Cannings-John, M. Wootton, N. Kirby, T. Pickles, A. McQueen, M. Westmoreland, S. Ziaj, A. Martin-Clavijo, A. Wernham, R. Matin, E. Thomas-Jones
Summary: This study investigated the proportion of surgical site infection (SSI) after excision of ulcerated skin cancer and found a high rate of SSI. The results showed that the Wound Healing Questionnaire was acceptable to patients, but further evaluation is needed to ensure validity.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Health Care Sciences & Services
Chidiebere Nwolise, Pippa Corrie, Ray Fitzpatrick, Avinash Gupta, Crispin Jenkinson, Mark Middleton, Rubeta Matin
Summary: This study highlights the substantial burden faced by patients with advanced melanoma in a clinical trial and the factors that may lessen or worsen this burden. Considering these burdens can reduce the burden experienced by research participants during trial design and execution.
Review
Medical Informatics
David Wen, Saad M. Khan, Antonio Ji Xu, Hussein Ibrahim, Luke Smith, Jose Caballero, Luis Zepeda, Carlos de Blas Perez, Alastair K. Denniston, Xiaoxuan Liu, Rubeta N. Matin
Summary: This systematic review evaluated publicly available skin image datasets for skin cancer diagnosis and found that the majority originated from Europe, North America, and Oceania. Most datasets contained dermoscopic images or macroscopic photographs only. Clinical information such as age, sex, and body site were reported for a high percentage of images, but there was limited representation of darker skin types in the datasets.
LANCET DIGITAL HEALTH
(2022)
Meeting Abstract
Oncology
Kevin Molloy, Constanze Jonak, Stefanie Porkert, Robert Knobler, Emmanuella Guenova, Chrstina Fassnacht, F. J. Sherida H. Woei-A-Ji, Anne-Marie Busschots, An Bervoets, Esther Hauben, Richard Cowan, Evangelina Papadavid, Marie Beylot-Barry, Emilio Berti, Silvia Alberti Violetti, Teresa Estrach, Rubeta Matin, Oleg Akilov, Liisa Vakeva, Miles Prince, Andrew Bates, Mike Bayne, Rachel Wachsmuch, Ulrike Wehkamp, Marta Marschalko, Octavio Servitje, Deborah Turner, Sophie Weatherhead, Marion Wobser, Jose Antonio Sanches, Julia Scarisbrick
EUROPEAN JOURNAL OF CANCER
(2021)
Meeting Abstract
Dermatology
A. Ji-Xu, J. Dinnes, R. Matin
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Correction
Dermatology
Quaglino, K. Molloy, R. N. Matin
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Meeting Abstract
Dermatology
R. Abbott, R. Matin, A. Martin-Clavijo, A. Wernham, S. Ziaj, M. Wootton, N. Kirby, B. Lloyd, E. Thomas-Jones, R. Cannings-John
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Meeting Abstract
Dermatology
R. Bali, S. Khan, C. Nwolise, A. J. Xu, R. Doohan, C. M. Proby, C. Jenkinson, F. M. Walter, R. N. Matin
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Meeting Abstract
Dermatology
L. Bovijn, S. Arianayagam, C. Stonard, N. Coupe, R. Matin
BRITISH JOURNAL OF DERMATOLOGY
(2021)
