Review
Virology
Charles W. Stratton, Yi-Wei Tang, Hongzhou Lu
Summary: COVID-19 is considered a global public health emergency and therapy should be based on the pathogenic mechanisms, including testing and treatment, correcting hypoxia, reducing viral load, addressing hyperinflammation, and hypercoagulability, among six major therapeutic goals identified.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jie Zhan, Haijun Li, Honghui Yu, Xiaochen Liu, Xianjun Zeng, Dechang Peng, Wei Zhang
Summary: In this study, CT scans of 110 patients with COVID-19 pneumonia were analyzed to determine the manifestations and evolution patterns. The most common initial CT findings were bilateral multifocal subpleural ground-glass opacities, and the predominant evolution pattern observed was type 2, characterized by disease progression followed by improvement on follow-up CT scans.
EUROPEAN RADIOLOGY
(2021)
Review
Endocrinology & Metabolism
Hidefumi Inaba, Toru Aizawa
Summary: COVID-19 infection can lead to thyroid diseases and related issues, with ties to similar problems seen during the SARS-CoV outbreak in 2002. This highlights a potential link between Coronavirus infection and thyroid dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Xinchun Ye, Yuping Yuan, Risheng Huang, Aiqiong Cheng, Zhijie Yu, Ziyang Huang, Rongrong Chen, Xiangao Jiang, Yuanliang Zheng, Jichan Shi
Summary: During the COVID-19 pandemic, 12 patients were re-admitted to the hospital for a second COVID-19 infection. The prognoses of the re-admitted patients were good, and most did not need to be re-admitted.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Honglv Xu, Yi Zhang, Min Yuan, Liya Ma, Meng Liu, Hong Gan, Wenwen Liu, Gillian Gianna Anne Lum, Fangbiao Tao
Summary: The study analyzed the latent class of basic reproduction number trends of COVID-19 in major endemic areas of China. Results showed that the overall R-0 trend decreased with the strengthening of comprehensive prevention and control measures in China for COVID-19, with regional differences.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Cardiac & Cardiovascular Systems
Bo Wu, Man Huang, Guohui Jiao, Chunxiao Hu, Yi Yang, Chen Jingyu
Summary: This study retrospectively analyzed lung transplantation data during the COVID-19 crisis and demonstrated that lung transplantation can be safely performed with proper management strategies.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Immunology
Xiaowei Deng, Juan Yang, Wei Wang, Xiling Wang, Jiaxin Zhou, Zhiyuan Chen, Jing Li, Yinzi Chen, Han Yan, Juanjuan Zhang, Yongli Zhang, Yan Wang, Qi Qiu, Hui Gong, Xianglin Wei, Lili Wang, Kaiyuan Sun, Peng Wu, Marco Ajelli, Benjamin J. Cowling, Cecile Viboud, Hongjie Yu
Summary: Our study on the case fatality risk of COVID-19 in mainland China found that the national CFR was 5.65%, with the highest in Wuhan (7.71%) and lowest in provinces outside Hubei (0.86%). Critical patients had a 3.6 times higher fatality risk compared to all patients, and the risk was between 0.8 to 10.3 times higher than that of mild-to-severe patients. Older age and being male were identified as risk factors for mortality. Additionally, time intervals from symptom onset to first healthcare consultation, to laboratory confirmation, and to hospitalization were longer for deceased patients than for those who recovered.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Immunology
Lei Zhou, Zunyou Wu, Zhongjie Li, Yanping Zhang, Jennifer M. McGoogan, Qun Li, Xiaoping Dong, Ruiqi Ren, Luzhao Feng, Xiaopeng Qi, Jingjing Xi, Ying Cui, Wenjie Tan, Guoqing Shi, Guizhen Wu, Wenbo Xu, Xiaoqi Wang, Jiaqi Ma, Xuemei Su, Zijian Feng, George F. Gao
Summary: The article discusses the emergence of the novel coronavirus pandemic in China, detailing the country's response with two phases of containment strategy, key areas of focus, and future considerations. It also describes specific strategies used by China for risk assessment, resource prioritization, and public health interventions at different risk levels, as well as challenges faced in terms of societal involvement, logistics, and supply chains. Finally, the methods China is taking to cautiously restart social life and economic activity are outlined.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Justin S. Lee, Jason M. Goldstein, Jonathan L. Moon, Owen Herzegh, Dennis A. Bagarozzi, Oberste M. Steven, Heather Hughes, Kanwar Bedi, Dorothie Gerard, Brenique Cameron, Christopher Benton, Asiya Chida, Ausaf Ahmad, David J. Petway, Xiaoling Tang, Nicky Sulaiman, Dawit Teklu, Dhwani Batra, Dakota Howard, Mili Sheth, Wendi Kuhnert, Stephanie R. Bialek, Christina L. Hutson, Jan Pohl, Darin S. Carroll
Summary: At the beginning of the COVID-19 pandemic, CDC developed a Real-Time RT-PCR Diagnostic Panel for SARS-CoV-2 detection, but encountered issues with false-positive reactions in N1 and N3 components. An internal investigation revealed that contamination with a synthetic template caused false reactivity in N1, while base pairing between probe and primer led to false reactivity in N3. These findings prompted improvements in quality control, assurance, and validation practices at CDC.
Article
Cell Biology
Le Chang, Lei Zhao, Yan Xiao, Tingting Xu, Lan Chen, Yan Cai, Xiaojing Dong, Conghui Wang, Xia Xiao, Lili Ren, Lunan Wang
Summary: By studying blood donors in Wuhan from September to December 2019, it was found that there were no SARS-CoV-2 specific antibodies existing before 2020, indicating no evidence of COVID-19 transmission in Wuhan before December 2019.
Article
Virology
Lutfiye Karcioglu Batur, Nezih Hekim
Summary: This study identified a significant correlation between polymorphisms in the IL-10 gene at rs1800896, IL-17A gene at rs2275913, and IL-17F gene at rs763780, and the prevalence and mortality rates of COVID-19 among populations of 23 countries.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Shuai Qin, Dongyue Lv, Ran Duan, Xiaojin Zheng, Asaiti Bukai, Xinmin Lu, Qun Duan, Mingrun Yu, Huaiqi Jing, Xin Wang
Summary: Brucellosis is a significant zoonotic disease with non-specific symptoms that are often overlooked and misdiagnosed in clinical practice. This case report highlights a misdiagnosis of brucellosis as COVID-19/influenza during strict COVID-19 control measures, leading to delayed treatment. Neglecting other diseases due to the COVID-19 pandemic and empirical diagnosis and treatment by medical staff contribute to misdiagnosis. Additionally, normal ESR, increased WBC, and increased NEUT also played a role in misdiagnosis, emphasizing the importance of considering brucellosis in patients with fever of unknown origin and related symptoms, especially those from endemic areas. Screening for brucellosis should be prioritized, and healthcare professionals should follow standardized diagnostic criteria based on epidemiological history, clinical manifestations, and laboratory tests.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Jing Nan, Tong Zhang, Yali Tian, Ke Song, Qun Li, Qiang Fu, Yan Ma, Zening Jin
Summary: The study found that the COVID-19 pandemic had an impact on medical services in the cardiovascular department, with a decrease in both outpatient and emergency department visits and an increase in the proportion of patients hospitalized for acute myocardial infarction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Luke Carson, Christopher Kui, Gemma Smith, Anand K. Dixit
Summary: During the COVID-19 pandemic, there was a significant reduction in stroke admissions and transient ischemic attack referrals. Questionnaire findings revealed that some patients experienced reduced physical activity, increased isolation, and delayed seeking medical help due to the pandemic.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Jing Han, Xi Zhang, Shengchao Zhang, Yuting Li, Dongmei Zhang, Qingsong Chen
Summary: According to this study, the outbreak of the COVID-19 pandemic has had a significant impact on the mental health of parents. However, no detailed study on the mental health status of parents has been conducted to date. The study found that factors such as female family roles, higher levels of education, unemployed or jobless status, children not being an only child, and children having negative attitudes toward online courses are more likely to cause anxiety symptoms in parents.
FRONTIERS IN PUBLIC HEALTH
(2023)
