Review
Medicine, Research & Experimental
Simone Negrini, Giacomo Emmi, Monica Greco, Matteo Borro, Federica Sardanelli, Giuseppe Murdaca, Francesco Indiveri, Francesco Puppo
Summary: Sjogren's syndrome is a chronic autoimmune disease characterized by dryness in the eyes and mouth, with systemic manifestations and unclear pathogenesis. Diagnosis is based on clinical symptoms and specific tests, while treatment ranges from local to systemic medications. New classification criteria and disease activity scores have been developed for research and clinical practice.
CLINICAL AND EXPERIMENTAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Marijana Jankovic Danolic, Dijana Perkovic, Marin Petric, Igor Barisic, Katarina Gugo, Josko Bozic
Summary: The study revealed that pSS patients have higher levels of adropin compared to healthy controls, with positive correlations with HDL and specific antibodies, and negative correlation with disease damage index. Multivariant linear regression showed adropin levels are independently associated with HDL and disease damage index.
Article
Clinical Neurology
Ali M. Afzali, Philipp Moog, Sudhakar Reddy Kalluri, Benedikt Hofauer, Andreas Knopf, Jan Stefan Kirschke, Bernhard Hemmer, Achim Berthele
Summary: The study aimed to assess the prevalence, clinical characteristics, and therapeutic outcomes of CNS demyelinating disease in patients with primary Sjogren's syndrome (pSS). Among 194 pSS patients, 22 had CNS manifestations, including 19 with demyelination. The CNS manifestations in pSS can mimic multiple sclerosis (MS), and treatment with B-cell-depleting agents may be more effective.
FRONTIERS IN NEUROLOGY
(2023)
Review
Immunology
Francisco Vilchez-Oya, Hector Balastegui Martin, E. Garcia-Martinez, Hector Corominas
Summary: This paper critically reviews the classic and novel autoantibodies in Sjogren's syndrome, including the methods of detection, their pathogenic role, and the wide range of clinical phenotypes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
L. G. Chatzis, V Pezoulas, P. V. Voulgari, C. Baldini, T. P. Exarchos, D. Fotiadis, C. P. Mavragani, F. N. Skopouli, H. M. Moutsopoulos, A. G. Tzioufas, A. Goules
Summary: This study described the clinical spectrum of Sjogren's syndrome patients with combined seronegativity, revealing that such patients have a milder disease phenotype. Triple seronegative patients showed lower frequency of peripheral nervous involvement compared to controls, while quadruple seronegative patients presented less frequently with persistent lymphadenopathy and lymphoma.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Medicine, General & Internal
Geoffrey Urbanski, Aline Gury, Pascale Jeannin, Alain Chevailler, Pierre Lozac'h, Pascal Reynier, Christian Lavigne, Carole Lacout, Emeline Vinatier
Summary: This study compares the effects of different methods for detecting anti-SSA antibodies on the phenotypes and occurrence of extraglandular manifestations in primary Sjogren's syndrome. The presence of anti-SSA antibodies solely in counterimmunoelectrophoresis (CIE) was significantly associated with the occurrence of extraglandular manifestations, while methods using non-native antigens were unable to predict systemic expression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Rheumatology
Jose M. Pego-Reigosa, Juliana Restrepo Velez, Chiara Baldini, Inigo Rua-Figueroa Fernandez de Larrinoa
Summary: Information about comorbidities in primary Sjogren's syndrome (pSS) is limited, but cardiovascular disease, infections, musculoskeletal conditions, and malignancy are likely the most relevant comorbid conditions in pSS. Infections such as oral candidal infections and fibromyalgia are common in daily practice, while incidences of cardiovascular events and cancer in pSS are relatively low compared to the general population. Early atherosclerosis has been found in pSS patients through different techniques, with a slightly increased risk of coronary events and malignancy in these patients.
Article
Medicine, General & Internal
Katelyn A. Bruno, Andrea Carolina Morales-Lara, Edsel B. Bittencourt, Habeeba Siddiqui, Gabriella Bommarito, Jenil Patel, John M. Sousou, Gary R. Salomon, Rinald Paloka, Shelby T. Watford, David O. Hodge, Scott M. Lieberman, Todd D. Rozen, Paldeep S. Atwal, Peter T. Dorsher, Lynsey A. Seim, DeLisa Fairweather
Summary: The most common comorbidities in Sjogren's disease patients are fibromyalgia, depression, and pain. Women with Sjogren's disease have a higher risk of developing conditions like hypermobile syndromes and migraines, while men with Sjogren's disease are more likely to develop cardiovascular diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Jingran Ma, Zhenghong Li, Hongmei Song, Lejia Zhang
Summary: This study analyzed the clinical characteristics and risk factors of high-risk groups of neonatal lupus erythematosus (NLE) in term infants. It found that there is still a high risk of dermal, hepatic, or hematological system involvement for high-risk groups of NLE, even after standardized prenatal health care. Specific indicators for predicting whether babies will develop NLE are currently lacking, highlighting the need for close follow-up within one year after birth.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Medicine, General & Internal
Ji Yeon Song, Su Eun Park, Joung-Hee Byun, Narae Lee, Young Mi Han, Shin Yun Byun, Seong Heon Kim
Summary: Neonatal lupus erythematosus (NLE) is a rare multi-organ system disease characterized by symptoms such as rash and fever. The most common maternal disease associated with NLE is systemic lupus erythematosus (SLE), and some mothers may remain undiagnosed with any autoimmune disease until their babies are diagnosed.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Huang-Hsi Chen, Kevin Sheng-Kai Ma, Chen Dong, Wen-Jung Chang, Kuan-Rong Gao, Wuu-Tsun Perng, Jing-Yang Huang, James Cheng-Chung Wei
Summary: This study found that patients with HPV infections have a significantly higher risk of primary Sjogren's syndrome (pSS), regardless of age and sex.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Chun-Yan Li, Yi-Man Li, Mei Tian
Summary: This case report highlights an unusual presentation of primary Sjogren's syndrome in a 43-year-old female with minimal lesion nephropathy, who tested negative for serum anti-SSA and anti-SSB antibodies and showed no signs of exocrine gland involvement. The diagnosis of Sjogren's syndrome was confirmed through a minor salivary gland biopsy and a filter paper test, and the patient responded positively to treatment.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Medicine, General & Internal
Charalampos Skarlis, Nikolaos Marketos, Adrianos Nezos, Asimina Papanikolaou, Michael Voulgarelis, Michael Koutsilieris, Haralampos M. Moutsopoulos, Clio P. Mavragani
Summary: The study reveals that genetic variations of the IGF1R are associated with the pathogenesis of Sjogren's syndrome (SS), particularly with a significantly higher prevalence of the A/A genotype of the rs2229765 IGF1R polymorphism in the anti-Ro/SSA positive SS population. Reduced expression of IGF1R in salivary gland tissues of SS patients is linked to apoptosis-related genes and inflammasome pathways.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Immunology
Fabiola Atzeni, Francesco Gozza, Giacomo Cafaro, Carlo Perricone, Elena Bartoloni
Summary: Sjogren Syndrome (SS) is associated with an increased risk of cardiovascular and cerebrovascular events, which represent a major burden for SS patients. The risk of CV events is influenced by multiple factors, including traditional risk factors and disease-related mechanisms. The impact of drugs used for treating SS on CV events is still lacking sufficient data.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Chien-Hsueh Tung, Yen-Chun Chen, Yi-Chun Chen
Summary: This study found that anti-HCV intervention therapy was not associated with lower SS risk in HCV-infected patients, but was associated with lower death risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Sabrina Meisgen, Malin Hedlund, Aurelie Ambrosi, Lasse Folkersen, Vijole Ottosson, David Forsberg, Gudny Ella Thorlacius, Luca Biavati, Linn Strandberg, Johannes Mofors, Daniel Ramskold, Sabrina Ruhrmann, Lauro Meneghel, William Nyberg, Alexander Espinosa, Robert Murray Hamilton, Anders Franco-Cereceda, Anders Hamsten, Tomas Olsson, Lois Greene, Per Eriksson, Kristina Gemzell-Danielsson, Stina Salomonsson, Vijay K. Kuchroo, Eric Herlenius, Ingrid Kockum, Sven-Erik Sonesson, Marie Wahren-Herlenius
Summary: This study identifies DNAJC6 as a novel genetic susceptibility factor in NLE, modulating cardiac function and providing new insights into the development of screening and therapeutic strategies for CHB.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Christian Lundtoft, Pascal Pucholt, Myriam Martin, Matteo Bianchi, Emeli Lundstrom, Maija-Leena Eloranta, Johanna K. Sandling, Christopher Sjowall, Andreas Jonsen, Iva Gunnarsson, Solbritt Rantapaa-Dahlqvist, Anders A. Bengtsson, Dag Leonard, Eva Baecklund, Roland Jonsson, Daniel Hammenfors, Helena Forsblad-d'Elia, Per Eriksson, Thomas Mandl, Sara Magnusson Bucher, Katrine B. Norheim, Svein Joar Auglaend Johnsen, Roald Omdal, Marika Kvarnstrom, Marie Wahren-Herlenius, Antonella Notarnicola, Helena Andersson, Oyvind Molberg, Louise Pyndt Diederichsen, Jonas Almlof, Ann-Christine Syvanen, Sergey Kozyrev, Kerstin Lindblad-Toh, Bo Nilsson, Anna M. Blom, Ingrid E. Lundberg, Gunnel Nordmark, Lina Marcela Diaz-Gallo, Elisabet Svenungsson, Lars Ronnblom
Summary: Copy number variation of C4A is associated with the autoimmune repertoire in systemic autoimmune diseases, with a low C4A copy number strongly linked to the presence of autoantibodies. These findings have implications for understanding the mechanisms of autoimmune diseases and patient stratification based on genetic profiles.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Immunology
Charlotta Preger, Antonella Notarnicola, Cecilia Hellstrom, Edvard Wigren, Catia Fernandes-Cerqueira, Marika Kvarnstrom, Marie Wahren-Herlenius, Helena Idborg, Ingrid E. Lundberg, Helena Persson, Susanne Graslund, Per-Johan Jakobsson
Summary: This study identified new potential autoantigens among human cytoplasmic aminoacyl tRNA synthetases in IIM patients, even those previously classified as seronegative. These new autoantibodies have high clinical relevance and may provide insights into the pathogenesis of idiopathic inflammatory myopathies.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Rheumatology
Javier Rodriguez-Carrio, Agata Burska, Philip G. Conaghan, Willem A. Dik, Robert Biesen, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, Marjan A. Versnel, Edward M. Vital
Summary: This study developed evidence-based points to consider for the measurement and reporting of IFN-I assays in clinical research. The study provides recommendations on terminology, assay characteristics, and reporting practices, as well as explores the clinical applications of IFN-I assays in diagnosis and outcome assessments.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Immunology
Laura Andreoli, Cecilia B. Chighizola, Luca Iaccarino, Angela Botta, Maria Gerosa, Veronique Ramoni, Chiara Tani, Bonnie Bermas, Antonio Brucato, Jill Buyon, Irene Cetin, Christina D. Chambers, Megan E. B. Clowse, Nathalie Costedoat-Chalumeau, Maurizio Cutolo, Sara De Carolis, Radboud Dolhain, Elisa M. Fazzi, Frauke Foerger, Ian Giles, Isabell Haase, Munther Khamashta, Roger A. Levy, Pier Luigi Meroni, Marta Mosca, Catherine Nelson-Piercy, Luigi Raio, Jane Salmon, Peter Villiger, Marie Wahren-Herlenius, Marianne Wallenius, Cristina Zanardini, Yehuda Shoenfeld, Angela Tincani
Summary: Autoimmune rheumatic diseases (ARD) pose challenges to reproductive health. Preconception counseling should consider factors such as fertility, disease impact on pregnancy outcomes, disease activity during pregnancy, medication compatibility, and biomarkers predictive of adverse pregnancy outcomes (APO). Diseases like preeclampsia and pregnancy-induced hypertension are more likely to occur in women with ARD. Placental insufficiency can result in restricted fetal growth. Treatment with compatible drugs is essential for maternal and fetal wellbeing. While limited data is available on medication usage during pregnancy, TNF inhibitors are recommended. Non-medical issues like sexual dysfunction and long-term outcomes of children also require attention in this review. Collaborative research and pregnancy registries will contribute to future insights.
AUTOIMMUNITY REVIEWS
(2023)
Review
Rheumatology
Gudny Ella Thorlacius, Albin Bjork, Marie Wahren-Herlenius
Summary: In primary Sjogren syndrome (pSS), chronic inflammation of exocrine glands leads to tissue destruction and sicca symptoms, mainly affecting the mouth and eyes. Fatigue, arthralgia, and myalgia are common, and some patients also experience extraglandular manifestations involving the respiratory, nervous, and vascular systems. The disease primarily affects women, with a female to male ratio of 14 to 1. The genetic and epigenetic studies have provided insights into the dysregulated molecular mechanisms of pSS and could potentially lead to new therapeutic options.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Review
Rheumatology
Agata Burska, Javier Rodriguez-Carrio, Robert Biesen, Willem A. Dik, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, P. G. Conaghan, Marjan Versnel, Ed Vital
Summary: This study systematically reviewed the literature on assay methods for evaluating type I interferon (IFN-I) pathway activation and aimed to harmonize related terminology. Data from 276 papers on 412 methods were extracted and summarized. Consensus terminology was developed to define different aspects of IFN-I research and practice.
Review
Rheumatology
Javier Rodriguez-Carrio, Agata Burska, P. G. Conaghan, Willem A. Dik, Robert Biesen, Maija-Leena Eloranta, Giulio Cavalli, Marianne Visser, Dimitrios T. Boumpas, George Bertsias, Marie Wahren-Herlenius, Jan Rehwinkel, Marie-Louise Fremond, Mary K. Crow, Lars Ronnblom, Ed Vital, Marjan Versnel
Summary: This article provides a systematic review of assays measuring IFN-I pathway activation and summarizes the potential clinical utility in various rheumatic and musculoskeletal diseases. The results show that IFN-I pathway activation is associated with disease diagnosis, disease activity assessment, prognosis, response to treatment, and assay responsiveness. However, the heterogeneity in techniques and technical conditions are major limitations.
Meeting Abstract
Rheumatology
Angeles S. Galindo-Feria, Karin Lodin, Begum Horuluoglu, Sepehr Sarrafzadeh-Zargar, Edvard Wigren, Susanne Graslund, Olof Danielsson, Aladdin J. Mohammad, Dag Leonard, Christopher Sjowall, Thomas Husmark, Malin Hemberg, Silva Puksic, Theodoros Lappas, Balsam Hanna, Marie Wahren-Herlenius, Maryam Dastmalchi, Ingrid E. Lundberg
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2023)
Meeting Abstract
Rheumatology
M. Wiley, B. Khatri, K. Tessneer, M. Joachims, A. Stolarczyk, A. Nagel, A. Rasmussen, S. J. Bowman, L. Radfar, R. Omdal, M. Wahren-Herlenius, B. Warner, T. Witte, R. Jonsson, M. Rischmueller, P. Gaffney, J. A. James, L. Ronnblom, R. H. Scofield, X. Mariette, W. F. Ng, K. Sivils, G. Nordmark, B. Tsao, C. J. Lessard
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Anna Nagel, Bhuwan Khatri, Marcin Radziszewski, Mandi Wiley, Anna Stolarczyk, Michelle Joachims, Kandice Tessneer, Astrid Rasmussen, Simon Bowman, Lida Radfar, Roald Omdal, Marie Wahren-Herlenius, Blake Warner, Torsten Witte, Roland Jonsson, Maureen Rischmueller, Patrick Gaffney, Judith James, Lars Ronnblom, Hal Scofield, Xavier Mariette, Marta Alarcon-Riquelme, Fai Ng, Gunnel Nordmark, Qing Sun, Kwangwoo Kim, Sang-Cheol Bae, Betty Tsao, A. Darise Farris, Christopher Lessard
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Stephanie Benjamin, Lisa Vi, Diptendu Chatterjee, Edgar Jaeggi, Marie Wahren-Herlenius, Amelia Ruffatti, Linda Hiraki, Michelle Lohbihler, Lusia Sepiashvili, Carl Laskin, Meena Fatah, Daniela Dominguez, Lawrence Ng, Anthony Gramolini, Vincent Christoffels, Stephanie Protze, Robert Hamilton
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Marcin Radziszewski, Mandi Wiley, Bhuwan Khatri, Kandice Tessneer, Astrid Rasmussen, Simon Bowman, Lida Radfar, Roald Omdal, Marie Wahren-Herlenius, Blake Warner, Torsten Witte, Roland Jonsson, Maureen Rischmueller, Patrick Gaffney, Judith James, Lars Ronnblom, R. Hal Scofield, Xavier Mariette, Marta Alarcon-Riquelme, Fai Ng, Gunnel Nordmark, Umesh Deshmukh, A. Darise Farris, Christopher Lessard
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Rheumatology
Mandi Wiley, Bhuwan Khatri, Kandice Tessneer, Michelle Joachims, Anna Stolarczyk, Anna Nagel, Astrid Rasmussen, Simon Bowman, Lida Radfar, Roald Omdal, Marie Wahren-Herlenius, Blake Warner, Torsten Witte, Roland Jonsson, Maureen Rischmueller, Patrick Gaffney, Judith James, Lars Ronnblom, Hal Scofield, Xavier Mariette, Fai Ng, Gunnel Nordmark, Betty Tsao, Christopher Lessard
ARTHRITIS & RHEUMATOLOGY
(2022)
Meeting Abstract
Dermatology
Andrea Scheffschick, Julia Nenonen, Anna Winther, Marcus Ehrstrom, Marie Wahren-Herlenius, Liv Eidsmo, Hanna Brauner
ACTA DERMATO-VENEREOLOGICA
(2022)