Functional Variation of IL-1R–Associated Kinases in the Conserved MyD88–TRAF6 Pathway during Evolution

Comparative transcriptomic analysis provides insights into antibacterial mechanisms of Branchiostoma belcheri under Vibrio parahaemolyticus infection

(2018) Qi-Lin Zhang et al.   FISH & SHELLFISH IMMUNOLOGY

Cloning and functional characterization of IRAK4 in large yellow croaker ( Larimichthys crocea ) that associates with MyD88 but impairs NF-κB activation

(2017) Peng Fei Zou et al.   FISH & SHELLFISH IMMUNOLOGY

The conserved ancient role of chordate PIAS as a multilevel repressor of the NF-κB pathway

(2017) Ruihua Wang et al.   Scientific Reports

Characterization, expression, and functional study of IRAK-1 from grouper, Epinephelus coioides

(2016) Yan-Wei Li et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and characterization of a TAB1 gene involved in innate immunity of amphioxus (Branchiostoma belcheri)

(2016) Denghua Yin et al.   GENE

Amphioxus as a model for investigating evolution of the vertebrate immune system

(2015) Shaochun Yuan et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Identification, characterization, and functional studies of a Pelle gene in the Chinese mitten crab, Eriocheir sinensis

(2015) Ying Huang et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and expression analysis of IRAK-4 cDNA and its gene from the ayu Plecoglossus altivelis altivelis

(2015) Kyuma Suzuki et al.   FISHERIES SCIENCE

Novel Toll/IL-1 Receptor Homologous Region Adaptors Act as Negative Regulators in Amphioxus TLR Signaling

(2015) Jian Peng et al.   JOURNAL OF IMMUNOLOGY

Identification of IRAK-4 in grouper (Epinephelus coioides) that impairs MyD88-dependent NF-κB activation

(2014) Yan-Wei Li et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Molecular cloning and expression of IRAK-4, IL-17 and I-κB genes in Haliotis rufescens challenged with Vibrio anguillarum

(2014) Valentina Valenzuela-Muñoz et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and characterization of Tube in the Chinese mitten crab Eriocheir sinensis

(2014) Ai-Qing Yu et al.   GENE

Zebrafish TRIF, a Golgi-Localized Protein, Participates in IFN Induction and NF- B Activation

(2014) S. Fan et al.   JOURNAL OF IMMUNOLOGY

Emergence of the A20/ABIN-mediated inhibition of NF- B signaling via modifying the ubiquitinated proteins in a basal chordate

(2014) S. Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes

(2014) Shengfeng Huang et al.   Nature Communications

IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production

(2013) Hao Zhou et al.   EMBO JOURNAL

Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: The functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells

(2013) Andreas Brietzke et al.   FISH & SHELLFISH IMMUNOLOGY

The Archaic Roles of the Amphioxus NF- B/I B Complex in Innate Immune Responses

(2013) S. Yuan et al.   JOURNAL OF IMMUNOLOGY

The IRAK Homolog Pelle Is the Functional Counterpart of IκB Kinase in the Drosophila Toll Pathway

(2013) Jessica Daigneault et al.   PLoS One

Identification, Characterization, and Functional Analysis of Tube and Pelle Homologs in the Mud Crab Scylla paramamosain

(2013) Xin-Cang Li et al.   PLoS One

How much does the amphioxus genome represent the ancestor of chordates?

(2012) A. Louis et al.   Briefings in Functional Genomics

Identification, characterization and the interaction of Tollip and IRAK-1 in grass carp (Ctenopharyngodon idellus)

(2012) Rong Huang et al.   FISH & SHELLFISH IMMUNOLOGY

Identification and characterization of IL-1 receptor-associated kinase-4 (IRAK-4) in half-smooth tongue sole Cynoglossus semilaevis

(2012) Yan Yu et al.   FISH & SHELLFISH IMMUNOLOGY

Involvement of AmphiREL, a Rel-like gene identified in Brachiastoma belcheri, in LPS-induced response: Implication for evolution of Rel subfamily genes

(2012) Xiaojun Song et al.   GENOMICS

Molecular Evolution and Structural Features of IRAK Family Members

(2012) Vijayakumar Gosu et al.   PLoS One

A mammalian like interleukin-1 receptor-associated kinase 4 (IRAK-4), a TIR signaling mediator in intestinal innate immunity of black tiger shrimp (Penaeus monodon)

(2011) Apiruck Watthanasurorot et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates

(2011) Manyi Yang et al.   CELL RESEARCH

Molecular cloning and expression of interleukin-1 receptor-associated kinase 4, an important mediator of Toll-like receptor signal pathway, from small abalone Haliotis diversicolor

(2011) Hui Ge et al.   FISH & SHELLFISH IMMUNOLOGY

The Drosophila Toll Signaling Pathway

(2011) S. Valanne et al.   JOURNAL OF IMMUNOLOGY

The Evolution and Regulation of the Mucosal Immune Complexity in the Basal Chordate Amphioxus

(2011) S. Huang et al.   JOURNAL OF IMMUNOLOGY

The interleukin-1 receptor-associated kinases: Critical regulators of innate immune signalling

(2010) Sinead Flannery et al.   BIOCHEMICAL PHARMACOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll-like and interleukin 1 receptor pathways

(2010) Marie E. A. Gauthier et al.   EVOLUTION & DEVELOPMENT

Amphioxus SARM Involved in Neural Development May Function as a Suppressor of TLR Signaling

(2010) S. Yuan et al.   JOURNAL OF IMMUNOLOGY

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Characterization of the Extrinsic Apoptotic Pathway in the Basal Chordate Amphioxus

(2010) S. Yuan et al.   Science Signaling

An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4

(2009) Precious G. Motshwene et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic and Functional Uniqueness of the TNF Receptor-Associated Factor Gene Family in Amphioxus, the Basal Chordate

(2009) S. Yuan et al.   JOURNAL OF IMMUNOLOGY

Tube Is an IRAK-4 Homolog in a Toll Pathway Adapted for Development and Immunity

(2009) Par Towb et al.   Journal of Innate Immunity

An amphioxus TLR with dynamic embryonic expression pattern responses to pathogens and activates NF-κB pathway via MyD88

(2009) Shaochun Yuan et al.   MOLECULAR IMMUNOLOGY

The amphioxus genome illuminates vertebrate origins and cephalochordate biology

(2008) L. Z. Holland et al.   GENOME RESEARCH

Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity

(2008) S. Huang et al.   GENOME RESEARCH

The amphioxus genome and the evolution of the chordate karyotype

(2008) Nicholas H. Putnam et al.   NATURE

IRAK2 takes its place in TLR signaling

(2008) Etienne Meylan et al.   NATURE IMMUNOLOGY

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

(2008) Tatsukata Kawagoe et al.   NATURE IMMUNOLOGY

Primer: Toll-like receptor signaling pathways—what do rheumatologists need to know?

(2008) Luke AJ O'Neill   Nature clinical practice. Rheumatology

IRAK1: A critical signaling mediator of innate immunity

(2007) Sridevi Gottipati et al.   CELLULAR SIGNALLING