Article
Cell Biology
Wenhui Dong, Yuwen Zhu, Yangxi Zhang, Zhiwen Fan, Ziyu Zhang, Xiangshan Fan, Yong Xu
Summary: This study demonstrates the significant role of the BRG1-TLR4-SREBP1a axis in mediating LPS-induced liver injury in mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jian-Quan Luo, Huan Ren, Man-Yun Chen, Qing Zhao, Nian Yang, Qian Liu, Yong-Chao Gao, Hong-Hao Zhou, Wei-Hua Huang, Wei Zhang
Summary: Hydrochlorothiazide (HCTZ) impairs glucose tolerance and may induce new onset of diabetes through its interaction with the gut microbiome. HCTZ consumption disrupts the intestinal microbiota, leading to elevated levels of Gram-negative bacteria and lipopolysaccharide (LPS), which results in intestinal barrier dysfunction. Activation of TLR4 signaling by HCTZ further induces macrophage polarization, inflammation, and metabolic disorders in the liver. Blocking TLR4 signaling can alleviate HCTZ-induced macrophage polarization and metabolic disorders.
Article
Cell Biology
Jie Huang, Jing Liu, Guangjun Chang, Yan Wang, Nana Ma, Animesh Chadra Roy, Xiangzhen Shen
Summary: GLN supplementation alleviates LPS-induced acute lung injury in mice, potentially mediated by the TLR4/MAPK signaling pathway.
Review
Immunology
Ioannis Kienes, Ella L. Johnston, Natalie J. Bitto, Maria Kaparakis-Liaskos, Thomas A. Kufer
Summary: This article summarizes the subversion strategies used by bacterial pathogens to evade host immune detection, focusing on the well-studied NLRs NOD1/2, NLRP3, and NLRC4. The authors discuss how bacterial pathogens activate these NLRs to promote inflammation and disease, as well as mechanisms used by bacteria to attenuate NLR activation and interfere with host immunity. They also highlight the role of NLRs in facilitating immunotolerance and persistence of bacteria in the host, and the therapeutic potential of harnessing bacterial immune subversion strategies for chronic inflammatory conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Qing Zhao, Meng-Fei Sheng, Yao-Yun Wang, Xing-Yu Wang, Wei-Yi Liu, Yuan-Yuan Zhang, Tiao-Ying Ke, Shu Chen, Gao-Zong Pang, Liang Yong, Zhan Ding, Yu-Jun Shen, Yu-Xian Shen, Wei Shao
Summary: Our study revealed that silencing of LPS-induced lncRNA Gm26917 protects against LPS-induced liver injury by regulating the TLR4/NF-kappa B signaling pathway in macrophages.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yelin Tang, Wenxin Zhang, Liqin Wu, Bin Bai, Bin Zheng, Mengying Li, Yue Tang, Xiaona Zhu, Yali Zhang, Yi Wang, Bing Zhang
Summary: In this study, it was found that piperlongumine (PL) can alleviate LPS-induced acute lung injury (ALI) by inhibiting inflammatory response and directly influencing cytokine expression through the inhibition of the TAK1 and TBK1 pathways. PL may be a potential candidate for treating LPS-triggered ALI.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Mingan Li, Ce Zhang, Lin Zhou, Xiaohui Sun, Tian Wang, Fenghua Fu
Summary: RoMS, a sustained-release formulation of rotigotine, attenuates LPS-induced liver injury in mice by activating dopamine receptors and negatively regulating the beta-arrestin2-dependent Akt/NF-kappa B signaling pathway, thereby inhibiting inflammation and the release of pro-inflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Xiao-qin Qu, Qiong-feng Chen, Qiao-qing Shi, Qian-qian Luo, Shuang-yan Zheng, Yan-hong Li, Liang-yu Bai, Shuai Gan, Xiao-yan Zhou
Summary: PEBP4 plays an important role in LPS/D-GalN-induced acute liver injury, with its knockout exacerbating liver damage, inflammation, and apoptosis, mediated through the TLR4/NF-κB signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiong Zhang, Chenlin Su, Shuxin Zhao, Ji Li, Feng Yu
Summary: Our study reports an effective two-drug combination therapy using urine-derived Ulinastatin and Thrombomodulin to treat liver and kidney injury induced by endotoxin. The combination therapy significantly improved pathological structures and functional injuries, and increased survival rates in endotoxic rats.
Article
Biochemistry & Molecular Biology
Geyan Duan, Pan Huang, Changbing Zheng, Jie Zheng, Jiayi Yu, Peiwen Zhang, Mengliao Wan, Fengna Li, Qiuping Guo, Yulong Yin, Yehui Duan
Summary: This study investigated the effects of incremental injection of lipopolysaccharide (LPS) on liver histopathology, inflammation, oxidative status, and mitochondrial function in piglets. Results showed that LPS injection caused liver injury, inflammation, oxidative stress, and mitochondrial dysfunction in the early phase, but these parameters improved in the later phase.
Article
Immunology
Yale Yang, Wuling Zhong, Yali Zhang, Yalan Cheng, Hejin Lai, Huimin Yu, Ning Feng, Yumo Han, Rui Huang, Qiwei Zhai
Summary: In this study, researchers found that sustained inflammation leads to fat loss in mice in a tolerable manner. Additionally, they demonstrate that inflammation induced by LPS through Tlr4 affects lipid metabolism and anorexia.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Chemistry, Medicinal
Yujin Jin, Hyesu Jeon, Thuy Le Lam Nguyen, Lila Kim, Kyung-Sun Heo
Summary: 3'-SL and 6'-SL protect against LPS-induced ALI by inhibiting inflammation and phosphorylation of NF-kappa B and STAT1.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Immunology
Le Chang, Aiqing Zhang, Wenjuan Liu, Ping Cao, Lixian Dong, Xiaoxue Gao
Summary: This study investigated the role and molecular mechanisms of calycosin in acute liver failure. The results showed that calycosin can alleviate inflammatory damage by inhibiting the TLR4/NF-κB pathway, suggesting it as a potential therapeutic agent for acute liver failure.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Medicine, General & Internal
Yu-Chih Wu, Sung-Po Hsu, Meng-Chun Hu, Yu-Ting Lan, Edward T. H. Yeh, Feng-Ming Yang
Summary: In this study, a cell permeable PEP-sNASP peptide was generated to ameliorate acute lung injury by reducing inflammation through binding to TRAF6. The PEP-sNASP peptide showed potential as a protein therapy for pulmonary diseases.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Jia Tang, Lingqi Xu, Yiwen Zeng, Fang Gong
Summary: The study explores the regulatory mechanism of gut flora in the host defense against LPS-induced ALI through the TLR4/NF-kB pathway. It is found that gut microbiota imbalance may regulate the TLR4/NF-kB signaling pathway in the lung immune system, activating oxidative stress in the lung and mediating lung injury through the regulation of the gut barrier. Additionally, fecal microbiota transplantation impairs the activity of the TLR4/NF-kB signaling pathway in the lung and decreases oxidative stress in animals with ALI by restoring the gut microecology.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Rebecca Fox, Kate Stenning, Adrian Slee, Jane Macnaughtan, Nathan Davies
Summary: Sarcopenia, characterized by muscle loss, is associated with increased mortality and poor clinical outcomes in patients with liver cirrhosis. The development of sarcopenia in liver cirrhosis involves various mechanisms, many of which are related to liver dysfunction and treatment interventions. Sarcopenia severity may be influenced by patient gender and the primary cause of liver cirrhosis, and a combination of assessment tools is required for clinical detection. Malnutrition is also a relevant factor, and screening tools can aid in diagnosis. Myostatin and titin-N represent potential diagnostic biomarkers. Physical activity and nutrition are important elements in treatment, and further research into these areas is needed for the management of sarcopenia in liver cirrhosis patients.
ANALYTICAL BIOCHEMISTRY
(2022)
Meeting Abstract
Oncology
Hiroaki Kanzaki, Sadahisa Ogasawara, Takafumi Sakuma, Naoto Fujita, Ryuta Kojima, Keisuke Koroki, Kazufumi Kobayashi, Masato Nakamura, Naoya Kanogawa, Soichiro Kiyono, Takayuki Kondo, Tomoko Saito, Ryo Nakagawa, Shingo Nakamoto, Ryosuke Muroyama, Tetsuhiro Chiba, Junichiro Ikeda, Masayuki Ohtsuka, Naoya Kato
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Sadahisa Ogasawara, Keisuke Koroki, Hirokazu Makishima, Masaru Wakatsuki, Takafumi Sakuma, Naoto Fujita, Hiroaki Kanzaki, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Tomoko Saito, Takayuki Kondo, Ryo Nakagawa, Shingo Nakamoto, Ryosuke Muroyama, Tetsuhiro Chiba, Hideki Hanaoka, Hiroshi Tsuji, Naoya Kato
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Kazufumi Kobayashi, Sadahisa Ogasawara, Takamasa Ishino, Hidemi Unozawa, Miyuki Nakagawa, Kisako Fujiwara, Takafumi Sakuma, Naoto Fujita, Hiroaki Kanzaki, Keisuke Koroki, Masato Nakamura, Soichiro Kiyono, Naoya Kanogawa, Takayuki Kondo, Tomoko Saito, Ryo Nakagawa, Shingo Nakamoto, Ryosuke Muroyama, Tetsuhiro Chiba, Naoya Kato
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Gastroenterology & Hepatology
Sadahisa Ogasawara, Keisuke Koroki, Hiroaki Kanzaki, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Tomoko Saito, Takayuki Kondo, Ryo Nakagawa, Shingo Nakamoto, Ryosuke Muroyama, Tetsuhiro Chiba, Naoya Kato
Summary: The incidence rate of hepatocellular carcinoma (HCC) is expected to increase, with a significant rise in cases caused by metabolic-related liver disease in recent years in some parts of Asia. Advances in treatment strategies, especially the emergence of combination immunotherapy, have shown improved outcomes for HCC patients.
LIVER INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Takayuki Kondo, Keisuke Koroki, Hiroaki Kanzaki, Kazufumi Kobayashi, Soichiro Kiyono, Masato Nakamura, Naoya Kanogawa, Tomoko Saito, Sadahisa Ogasawara, Yoshihiko Ooka, Shingo Nakamoto, Tetsuhiro Chiba, Makoto Arai, Jun Kato, Satoshi Kuboki, Masayuki Ohtsuka, Naoya Kato
Summary: Organ failure in patients with acute decompensation is a defining characteristic of acute-on-chronic liver failure. The occurrence of acute decompensation is closely related to prognosis, regardless of cirrhosis and HCC stage, with early-onset having a negative impact. Surgical resection may have a positive impact on AD incidence in intermediate-advanced-stage HCC patients, while renal impairment is predictive of AD development after systemic therapy for HCC.
Article
Cell Biology
Takayuki Kondo, Stewart Macdonald, Cornelius Engelmann, Abeba Habtesion, Jane Macnaughtan, Gautam Mehta, Rajeshwar P. Mookerjee, Nathan Davies, Marco Pavesi, Richard Moreau, Paolo Angeli, Vicente Arroyo, Fausto Andreola, Rajiv Jalan
Summary: This study investigates the role of RIPK1 mediated cell death in acute-on-chronic liver failure (ACLF) and the involvement of necroptosis in ACLF. The results suggest that plasma RIPK3 levels can predict the risk of mortality and disease progression in ACLF patients. In animal models, inhibiting RIPK1 can reduce the severity of ACLF and protect the liver, kidney, and brain from injury.
CELL DEATH & DISEASE
(2022)
Article
Gastroenterology & Hepatology
Cornelius Engelmann, Abeba Habtesion, Mohsin Hassan, Annarein J. C. Kerbert, Linda Hammerich, Simone Novelli, Marco Fidaleo, Alexandra Philips, Nathan Davies, Sofia Ferreira-Gonzalez, Stuart J. Forbes, Thomas Berg, Fausto Andreola, Rajiv Jalan
Summary: The combination treatment of TAK-242 and G-CSF can reduce inflammation, promote liver regeneration, and prevent mortality in models of acute-on-chronic liver failure.
JOURNAL OF HEPATOLOGY
(2022)
Article
Oncology
Hans Binder, Maria Schmidt, Lydia Hopp, Suren Davitavyan, Arsen Arakelyan, Henry Loeffler-Wirth
Summary: In large-scale tumor studies, multiple omics data are generated to enhance our understanding of cancer molecular mechanisms. This study presents an integrated mapping scheme combining the transcriptome, methylome, and genome data, allowing the deciphering of functional links within and between these omics domains. The application of this mapping scheme to lower grade gliomas reveals distinct networks governed by methylation and copy number variations, affecting the transcriptomic modes of cell activity. The integrated maps provide a comprehensive view of tumour heterogeneity and can distinguish different glioma types. Multi-omics high-throughput technologies produce data sets consisting of multiple omics modalities, and the integrative analysis of this data is essential to obtain a holistic view of tumor characteristics. The proposed method enables the combined analysis of multi-omics data and allows for the visualization and comparison of different omics layers on a personalized basis.
Article
Gastroenterology & Hepatology
Konstantin Kazankov, Simone Novelli, Devnandan A. Chatterjee, Alexandra Phillips, Anu Balaji, Maruthi Raja, Graham Foster, Dhiraj Tripathi, Ravan Boddu, Ravi Kumar, Rajiv Jalan, Rajeshwar P. Mookerjee
Summary: This study aimed to assess the feasibility and potential clinical benefits of remote management using CirrhoCare (R) for individuals with acutely decompensated cirrhosis. The results showed that individuals managed with CirrhoCare (R) had lower risk of re-decompensation, fewer readmissions, and shorter hospital stays. This approach warrants further investigation in larger controlled clinical trials.
JOURNAL OF HEPATOLOGY
(2023)
Article
Engineering, Chemical
Yunjie Liao, Nathan A. Davies, I. David L. Bogle
Summary: This study investigates the impact of fructose on the liver system and validates the findings through in vivo experiments. The results suggest that targeting three intervention points simultaneously can effectively reduce lipid production under insulin resistance conditions. This demonstrates the potential of system models in understanding the liver system's response to fructose variation and identifying potential drug targets.
CHEMICAL ENGINEERING SCIENCE
(2022)
Article
Biology
Claudia Lehmann, Henry Loeffler-Wirth, Vera Balz, Juergen Enczmann, Ramona Landgraf, Nicole Lakowa, Thomas Gruenewald, Johannes C. C. Fischer, Ilias Doxiadis
Summary: Since the beginning of the SARS-CoV-2 pandemic, immunogenetics has been found to play a crucial role in the susceptibility and severity of infection. This study investigated the association between various HLA alleles, blood group systems, and the molecular detection of COVID-19. The results showed that certain HLA alleles and blood group antigens were enriched in either the positive or negative group, suggesting their potential influence on COVID-19 infection.
Article
Biology
Karla Rottmayer, Henry Loeffler-Wirth, Thomas Gruenewald, Ilias Doxiadis, Claudia Lehmann
Summary: During the study, the immune response towards SARS-CoV-2 and seasonal coronaviruses was analyzed in a cohort of 512 individuals. Differential reactivity was observed, and specific HLA proteins were found to be associated with the antibody response towards SARS-CoV-2. These findings provide insights into individual immune response and may contribute to personalized protective measures.
Meeting Abstract
Gastroenterology & Hepatology
Alexandra Phillips, Qianwen Zhao, Abeba Habtesion, Fausto Andreola, Nathan Davies, Lindsey A. Edwards, Jane Macnaughtan, Rajiv Jalan
JOURNAL OF HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Anna Hadjihambi, Cristina Cudalbu, Katarzyna Pierzchala, Dunja Simicic, Chris Donnelly, Christos Konstantinou, Nathan Davies, Abeba Habtesion, Alexander V. Gourine, Rajiv Jalan, Patrick S. Hosford
Summary: This study found that hyperammonemia significantly reduces cortical oxygenation, potentially compromising brain energy metabolism. These findings have potential clinical implications for the treatment of patients with minimal hepatic encephalopathy.