Article
Oncology
Raja Shaikh, Brent R. Weil, Christopher B. Weldon, Nan Chen, Wendy B. London, Morgan Krush, Megan Anderson, Mark Gebhardt, Alanna J. Church, Steven G. DuBois, Yana Pikman, Jennifer Spidle, Catherine B. Wall, Angela Feraco, Nicole J. Ullrich, Jennifer W. Mack, Elizabeth Mullen, Junne Kamihara, Suzanne Forrest, Suzanne Shusterman, Katherine A. Janeway, Ahmad Alomari, Horacio Padua, Carlos Rodriguez-Galindo, Allison F. O'Neill
Summary: This study collected data from pediatric patients with benign and malignant tumors who underwent interventional radiology procedures, and evaluated radiologic response using mRECIST. Approximately 40% of patients with malignant tumors and 60% of patients with benign tumors achieved complete or partial response. The study suggests that interventional radiology-guided interventions can be an alternative or complementary approach for the treatment of pediatric tumors.
Review
Oncology
Antonella Cammarota, Valentina Zanuso, Tiziana Pressiani, Nicola Personeni, Lorenza Rimassa
Summary: Management of advanced hepatocellular carcinoma (HCC) has become increasingly complex with the introduction of novel therapies. The assessment and monitoring of systemic treatment response are essential for clinical trials and practice. Parameters such as progression-free survival and objective response rate provide early information on treatment efficacy. However, none of them can replace overall survival as a surrogate endpoint. Tumor assessment relies on the Response Evaluation Criteria for Solid Tumors (RECIST), but modified criteria more accurately capture HCC response. Prognosticators and novel imaging techniques are being explored for better treatment response evaluation.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)
Article
Hematology
Karin Senk, Juliane Wilcke, Michael Haimerl, Niklas Verloh, Carolina Rio Bartulos, Wolf Baeumler, Christian Stroszczynski, Philipp Wiggermann
Summary: The LiMAx test showed better correlation with the outcome of TACE treatment compared to the MELD score in predicting patient responses. Patients with higher pre-interventional LiMAx values tended to have better treatment outcomes with TACE.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Article
Oncology
Genhao Zhang, Kai Zhang, Yanteng Zhao, Qiankun Yang, Xianping Lv
Summary: This study constructed and validated a prognostic signature related to stemness and hypoxia in hepatocellular carcinoma, and identified C7, CLEC1B, and CXCL6 as genes associated with stemness and hypoxia. These findings provide new insights for individualized immunotherapy.
Article
Immunology
Kai Zhang, Enwu Yuan
Summary: This study created a unique prognostic profile based on NK cell marker genes that can accurately predict the efficacy of immunotherapy for HCC patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nieun Seo, Dong Jin Joo, Mi-Suk Park, Seung-seob Kim, Hye Jung Shin, Yong Eun Chung, Jin-Young Choi, Myoung Soo Kim, Myeong-Jin Kim
Summary: The study aimed to investigate the optimal radiologic method for determining Milan criteria (MC) in predicting post-liver transplantation (LT) recurrence in hepatocellular carcinoma (HCC) patients. The findings showed that MRI with mRECIST was the optimal method in predicting recurrence, with higher accuracy and sensitivity compared to CT with LI-RADS TRA or MRI with mRECIST.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Yu Jiang, Shulin Chen, Yaxian Wu, Yuanye Qu, Lina Jia, Qingxia Xu, Shuqin Dai, Ning Xue
Summary: This study aimed to establish a prognostic model to evaluate the overall survival (OS) of patients with non-virus-related hepatocellular carcinoma (NV-HCC). The prognostic model was developed using LASSO-Cox regression analysis and its predictive ability was evaluated using the concordance index (C-index) and time-dependent receiver operating characteristic curve (TD-ROC). The results showed that the prognostic model had better predictive ability than TNM stage and treatment, and could assist clinicians in designing individualized therapeutic strategies for NV-HCC patients.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Jianye Wang, Ying Wang, Marcella Steffani, Christian Stoess, Donna Ankerst, Helmut Friess, Norbert Hueser, Daniel Hartmann
Summary: Pyroptosis plays an important role in cancer development and immune response, but the specific roles of pyroptosis-related genes in tumor progression, immune response, prognosis, and immunotherapy have not been fully elucidated. Through clustering analysis, three distinct molecular subtypes related to pyroptosis were identified in hepatocellular carcinoma, and these subtypes had differential prognostic effects on patient survival. Immune characteristics analysis revealed diverse immune cell infiltration among the subtypes.
Article
Cell Biology
Wen Zhang, Zhongjian Liu, Shilin Xia, Lei Yao, Lan Li, Ziying Gan, Hui Tang, Qiang Guo, Xinmin Yan, Zhiwei Sun
Summary: The elevated expression of GDI2 in HCC patients is associated with more aggressive tumor status, including severe primary tumor extent, advanced pathological stage, and mutated TP53 status. High GDI2 expression is strongly correlated with a poor survival rate. Enrichment and immune infiltration analyses suggest that GDI2-associated signaling involves lipid metabolism and ECM constructing pathways related to the tumor microenvironment.
Article
Biotechnology & Applied Microbiology
Christos Dimitrakopoulos, Sravanth Kumar Hindupur, Marco Colombi, Dritan Liko, Charlotte K. Y. Ng, Salvatore Piscuoglio, Jonas Behr, Ariane L. Moore, Jochen Singer, Hans-Joachim Ruscheweyh, Matthias S. Matter, Dirk Mossmann, Luigi M. Terracciano, Michael N. Hall, Niko Beerenwinkel
Summary: This study explores the functional consequences of genetic aberrations in hepatocellular carcinoma through analyzing the transcriptome, proteome, and phosphoproteome. It identifies potential therapeutic targets such as YAP1 and GRB2 signaling pathways, as well as pathways regulating histone acetylation in HCC with hyperactive mTOR signaling.
Article
Immunology
Tong Wu, Zhangyi Song, Haiqiu Huang, Tanja Jakos, Hua Jiang, Yueqing Xie, Jianwei Zhu
Summary: A novel immunotoxin GT5 targeting GPC3 was found to effectively inhibit hepatocellular tumor growth, showing promising therapeutic potential.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Editorial Material
Cell Biology
Ji Feng, Jing Zhou, Yong Wu, Han-Ming Shen, Tao Peng, Guo-Dong Lu
Summary: Ischemia is a common pathological process that restricts nutrient availability and induces autophagy. Although autophagy helps sustain nutrient/energy and restrict damages in short-term scenarios, it leads to cell death in long-term scenarios. Ischemia has been used as a clinical application for cancer treatment, but its efficacy is limited. Our recent research shows that combining sorafenib with glucose starvation can enhance cell death in hepatocellular carcinoma (HCC) by impairing mitophagy. We also identified SIAH1 as an important E3 ubiquitin ligase for mitophagic induction in HCC cells.
Article
Oncology
Juan Lu, Yanfei Chen, Xiaoqian Zhang, Jing Guo, Kaijin Xu, Lanjuan Li
Summary: This study used single-cell RNA sequencing data and gene expression data to construct a gene coexpression network and developed a three-gene risk model using Cox and LASSO analysis. The risk model can predict the survival outcome and immunotherapy response in hepatocellular carcinoma patients.
CANCER CELL INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Zheng Zhou, Yusong Zhou, Dongbo Liu, Qingping Yang, Mengjie Tang, Wei Liu
Summary: This study constructed a prognostic model of cuproptosis-related genes (CRGs) in hepatocellular carcinoma (HCC) and investigated the prognostic and immune relevance of CRGs in HCC. The results suggested that CRGs, especially CDKN2A, may serve as potential prognostic predictors in HCC patients and provide novel insights into cancer therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Lu Zhang, Haisu Tao, Jiang Li, Erlei Zhang, Huifang Liang, Bixiang Zhang
Summary: By analyzing RNA sequencing data, a prognostic network containing differentially expressed mRNAs, lncRNAs, and circRNAs was constructed, with validation of its accuracy in predicting HCC prognosis. Experimental results indicate that DTYMK plays a crucial role in liver cancer cell proliferation and invasion.
