Review
Gastroenterology & Hepatology
Eugeni Domenech, Joan-Ramon Grifols, Ayesha Akbar, Axel U. Dignass
Summary: Half of patients with ulcerative colitis require systemic corticosteroids, and 75% may need immunosuppressive drugs to avoid colectomy. Granulocyte/monocyteapheresis (GMA) is a safe and effective non-pharmacological treatment targeting neutrophils in ulcerative colitis, but its use in Europe is limited to a few centers and countries.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Makoto Naganuma, Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Toshiyuki Matsui, Yasuo Suzuki, Lyann Ursos, Shigeru Sakamoto, Mitsuhiro Shikamura, Tetsuharu Hori, Jovelle Fernandez, Mamoru Watanabe, Toshifumi Hibi, Takanori Kanai
Summary: This study aimed to evaluate the efficacy and safety of vedolizumab treatment with or without concurrent immunomodulator use in Japanese patients with moderate-to-severe ulcerative colitis. The results suggested that concurrent immunomodulator use may benefit in maintaining the clinical efficacy of vedolizumab without significantly increasing the incidence of infections.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Medicine, General & Internal
Szabolcs Kiss, David Nemeth, Peter Hegyi, Maria Foldi, Zsolt Szakacs, Balint Eross, Benedek Tinusz, Peter Jeno Hegyi, Patricia Sarlos, Hussain Alizadeh
Summary: GMA as an adjunctive treatment appears to be more effective in inducing and maintaining remission in patients with UC than conventional therapy alone, with no significant difference in adverse events.
Article
Gastroenterology & Hepatology
Carlos Taxonera, Maria Jesus Fernandez-Acenero, David Olivares, Marta Calvo, Begona Casis, Fernando Bermejo, Pilar Lopez Serrano, Marisa Iborra, Francisco Mesonero, Maia Bosca Watts, Cristina Diaz del Arco, Isabel Vera, Sonsoles Olivares, Alicia Algaba, Cristina Alba
Summary: This study investigated the association between golimumab trough concentrations during maintenance and outcomes such as endoscopic healing, histologic remission, and long-term persistence in UC patients. The results showed that golimumab concentrations were associated with favorable treatment outcomes.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Cristian Hernandez-Rocha, Shadi Nayeri, Williams Turpin, Mike Steel, Krzysztof Borowski, Joanne M. Stempak, James Conner, Mark S. Silverberg
Summary: This study aimed to establish the prognosis, transcriptional and microbial features of histo-endoscopic remission and activity in ulcerative colitis (UC) patients. The results showed that UC patients with histo-endoscopic remission had a lower risk of relapse and their rectosigmoid mucosa transcriptional profile resembled that of healthy controls. Host genes with antimicrobial properties were significantly associated with mucosal microbiota.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Immunology
Yiyoung Kwon, Yoon Zi Kim, Yon Ho Choe, Mi Jin Kim
Summary: This study found that patients with high monocyte counts at the time of discontinuation were more likely to experience relapse after stopping biologics. The monocyte percentage can be used to predict the risk of relapse within 6 months after discontinuation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Mauro Mastronardi, Elisabetta Cavalcanti, Nunzia Labarile, Raffaele Armentano, Francesco Gabriele, Margherita Curlo
Summary: Extraintestinal manifestations are common in patients with ulcerative colitis and Crohn's disease. This study highlights the potential of adsorptive granulocyte/monocyte apheresis (GMA) as a new therapeutic option for patients with severe and refractory pyoderma gangrenosum (PG) complicated with ulcerative colitis. The study showed favorable outcomes and a good safety profile for GMA treatment.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2023)
Article
Gastroenterology & Hepatology
Jun Miyoshi, Ryo Ozaki, Hiromi Yonezawa, Hideaki Mori, Naohiro Kawamura, Minoru Matsuura, Tadakazu Hisamatsu
Summary: The development of a new parameter (SMI) for estimating endoscopic remission of ulcerative colitis was investigated. The SMI is a practical, quantitative parameter based on the bowel wall structure. It has the potential to be widely used in daily practice.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Hematology
Yoh Ishiguro, Toshihide Ohmori, Ken Umemura, Masahiro Iizuka
Summary: This study found that ulcerative colitis patients who were corticosteroid-naive had better outcomes with granulocyte and monocyte adsorptive apheresis (GMA) therapy, and those who did not receive immunomodulators had higher sustained remission rates. The use of immunomodulators was associated with a higher risk of relapse, suggesting that GMA may be more effective in patients who have not been previously treated with corticosteroids and are not receiving immunomodulators.
THERAPEUTIC APHERESIS AND DIALYSIS
(2021)
Article
Medicine, General & Internal
Keijiro Numa, Kazuki Kakimoto, Yasuyoshi Tanaka, Noboru Mizuta, Naohiko Kinoshita, Kei Nakazawa, Ryoji Koshiba, Yuki Hirata, Kazuhiro Ota, Takako Miyazaki, Shiro Nakamura, Kazuhide Higuchi, Hiroki Nishikawa
Summary: This study evaluated the efficacy of adalimumab (ADA) for maintaining remission in patients with refractory ulcerative colitis (UC). The results showed that switching to ADA after tacrolimus (TAC) therapy can effectively prevent relapse in these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Floris de Voogd, Elsa A. van Wassenaer, Aart Mookhoek, Steven Bots, Sara van Gennep, Mark Lowenberg, Geert R. D'Haens, Krisztina B. Gecse
Summary: This study evaluated the use of intestinal ultrasound (IUS) in the treatment response of ulcerative colitis (UC). The results showed that bowel wall thickness (BWT) is the most accurate parameter for determining endoscopic improvement and treatment response.
Review
Gastroenterology & Hepatology
Rocio Sedano, Malcolm Hogan, Tran M. Nguyen, Joshua Chang, G. Y. Zou, John K. Macdonald, Niels Vande Casteele, Jurij Hanzel, Eileen Crowley, Robert Battat, Parambir S. Dulai, Siddharth Singh, Geert D'Haens, William Sandborn, Brian G. Feagan, Christopher Ma, Vipul Jairath
Summary: This study provides a summary of placebo rates in induction and maintenance clinical trials of ulcerative colitis, as well as identifying the factors influencing these rates. The results show that placebo rates vary depending on the endpoint assessed, trial purpose, and drug class.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Gastroenterology & Hepatology
Jun Ohara, Tetsuo Nemoto, Yasuharu Maeda, Noriyuki Ogata, Shin-Ei Kudo, Toshiko Yamochi
Summary: This study demonstrates that an automated quantitative method using a deep learning-based model is useful in predicting the prognosis of patients with ulcerative colitis by evaluating mucin depletion.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Keiichi Haga, Tomoyoshi Shibuya, Taro Osada, Shunsuke Sato, Yuka Fukuo, Osamu Kobayashi, Toshio Yamada, Daisuke Asaoka, Kentaro Ito, Kei Nomura, Mayuko Haraikawa, Osamu Nomura, Hirofumi Fukushima, Takashi Murakami, Dai Ishikawa, Mariko Hojo, Akihito Nagahara
Summary: This study found that VDZ is effective in the majority of UC patients, with a high rate of mucosal healing even in those who have previously failed biological therapy. Early clinical remission can predict long-term remission, and week 6 can be a useful evaluation point when using VDZ for UC treatment.
Review
Gastroenterology & Hepatology
Giorgos Bamias, Evanthia Zampeli, Eugeni Domenech
Summary: Inflammatory bowel disease (IBD) is a chronic immune-mediated disease that includes Crohn's disease (CD) and ulcerative colitis (UC). This article provides an overview of the immunological aspects, pharmacological management, and biomarkers of IBD. Adsorptive granulocyte and monocyte apheresis (GMA) with Adacolumn can effectively treat UC and has secondary immune effects. Fecal calprotectin concentrations, neutrophil counts in histological samples, and the neutrophil/lymphocyte ratio in peripheral blood may serve as useful biomarkers for predicting GMA effectiveness in the future.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Makoto Naganuma, Shinya Sugimoto, Hideo Suzuki, Yuichi Matsuno, Toshimitsu Araki, Hirotaka Shimizu, Ryohei Hayashi, Tomohiro Fukuda, Nobuhiro Nakamoto, Hideki Iijima, Shiro Nakamura, Masaharu Kataoka, Yuichi Tamura, Koichiro Tatsumi, Toshifumi Hibi, Yasuo Suzuki, Takanori Kanai, Yusuke Yoshimatsu, Po-sung Chu, Motoi Uchino, Kenji Watanabe, Atsushi Hirano, Motohiro Esaki, Yoshitaka Ueno, Takayuki Yamamoto, Koji Sawada, Kosaku Kawashima, Shunji Ishihara, Toshimitsu Araki, Shinichi Hashimoto, Junji Yokoyama, Shinya Ashizuka, Tatsuya Toyokawa, Hirotake Sakuraba, Kazuhiro Matsueda, Naoki Yoshimura, Naoki Ohmiya, Yoshiyuki Kayashima, Shunichi Yanai, Takayuki Matsumoto, Hiroyuki Kobayashi, Sachiko Nakajima, Tsutomu Nishida, Yoshiaki Takeuchi, Kenji Ina, Takuji Kawamura
JOURNAL OF GASTROENTEROLOGY
(2019)
Letter
Gastroenterology & Hepatology
Makoto Naganuma, Takanori Kanai
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Makoto Naganuma, Taku Kobayashi, Masanao Nasuno, Satoshi Motoya, Shingo Kato, Katsuyoshi Matsuoka, Ryota Hokari, Chikako Watanabe, Hirotsugu Sakamoto, Hironori Yamamoto, Makoto Sasaki, Kenji Watanabe, Hideki Iijima, Yutaka Endo, Hitoshi Ichikawa, Keiji Ozeki, Satoshi Tanida, Nobuhiro Ueno, Mikihiro Fujiya, Minako Sako, Ken Takeuchi, Shinya Sugimoto, Takayuki Abe, Toshifumi Hibi, Yasuo Suzuki, Takanori Kanai
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Makoto Naganuma, Shinya Sugimoto, Tomohiro Fukuda, Keiichi Mitsuyama, Taku Kobayashi, Naoki Yoshimura, Hidehisa Ohi, Shinji Tanaka, Akira Andoh, Naoki Ohmiya, Keiichiro Saigusa, Takayuki Yamamoto, Yuichi Morohoshi, Hitoshi Ichikawa, Katsuyoshi Matsuoka, Tadakazu Hisamatsu, Kenji Watanabe, Shinta Mizuno, Takayuki Abe, Yasuo Suzuki, Takanori Kanai, Makoto Naganuma, Shinya Sugimoto, Shinta Mizuno, Yoshihiro Nakazato, Tomohiro Fukuda, Toshiaki Teratani, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai, Hiroshi Yamasaki, Keiichi Mitsuyama, Taku Kobayashi, Takahiko Toyonaga, Masaru Nakano, Toshifumi Hibi, Naoki Yoshimura, Yoichi Sameshima, Hidehisa Ohi, Ryohei Hayashi, Yoshitaka Ueno, Shinji Tanaka, Shigeki Bamba, Akira Andoh, Mamoru Watanabe, Keiichiro Saigusa, Atsushi Nakazawa, Yuichi Morohoshi, Yuji Koike, Jin Imai, Hitoshi Ichikawa, Takahiro Shimoyama, Takayuki Yamamoto, Katsuyoshi Matsuoka, Ken Takeuchi, Yasuo Suzuki, Mitsuo Nagasaka, Naoki Ohmiya, Atsuo Kitano, Shinya Ashizuka, Haruhiko Inatsu, Kei Onodera, Hiroshi Nakase, Kazuya Kitamura, Kentaro Ikeya, Hiroyuki Hanai, Chikako Watanabe, Ryota Hokari, Fumihito Hirai, Yuji Naito, Namiko Hoshi, Fukunori Kinjo, Yo Ishiguro, Makoto Sasaki, Takayuki Matsumoto, Kenji Watanabe, Tadakazu Hisamatsu, Fumiya Sano, Rachel Roberts, Takayuki Abe, Wataru Suda, Masahira Hattori, Shinji Fukuda, Akiyoshi Hirayama
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Multidisciplinary Sciences
Makoto Naganuma, Fumihito Hirai, Kiyonori Kobayashi, Kenji Watanabe, Ken Takeuchi, Nobuo Aoyama, Hiroshi Nozawa, Satoshi Motoye, Toshihide Ohmori, Akio Harada, Yushi Nagai, Takayuki Abe, Yoji Yamada, Katsutoshi Inagaki, Naoki Shimizu, Takanori Kanai, Mamoru Watanabe, Shinji Tanaka, Takehiro Arai, Masahiro Kishi, Chiyuki Watanabe, Yasuhisa Sakata, Toshifumi Ashida, Atsuo Maemoto, Souken Sai, Atsuo Kitano, Yukinori Sameshima, Kaoru Yokoyama, Taku Kobayashi, Takehisa Suekane, Koichiro Matsuda, Hirozumi Obata, Mikihiro Fujiya, Takayuki Shirai, Keiichi Tominaga, Hidetoshi Takedatsu, Ryouichi Suzuki
Article
Gastroenterology & Hepatology
Tomohiro Fukuda, Makoto Naganuma, Kaoru Takabayashi, Yuya Hagihara, Shun Tanemoto, Ena Nomura, Yusuke Yoshimatsu, Shinya Sugimoto, Kosaku Nanki, Shinta Mizuno, Yohei Mikami, Kayoko Fukuhara, Tomohisa Sujino, Makoto Mutaguchi, Nagamu Inoue, Haruhiko Ogata, Yasushi Iwao, Takayuki Abe, Takanori Kanai
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Review
Gastroenterology & Hepatology
Makoto Naganuma
JOURNAL OF GASTROENTEROLOGY
(2020)
Article
Gastroenterology & Hepatology
Makoto Naganuma, Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Toshiyuki Matsui, Yasuo Suzuki, Lyann Ursos, Shigeru Sakamoto, Mitsuhiro Shikamura, Tetsuharu Hori, Jovelle Fernandez, Mamoru Watanabe, Toshifumi Hibi, Takanori Kanai
Summary: This study aimed to evaluate the efficacy and safety of vedolizumab treatment with or without concurrent immunomodulator use in Japanese patients with moderate-to-severe ulcerative colitis. The results suggested that concurrent immunomodulator use may benefit in maintaining the clinical efficacy of vedolizumab without significantly increasing the incidence of infections.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Makoto Naganuma, Taku Kobayashi, Reiko Kunisaki, Katsuyoshi Matsuoka, Shojiro Yamamoto, Ami Kawamoto, Daisuke Saito, Kosaku Nanki, Kazuyuki Narimatsu, Hisashi Shiga, Motohiro Esaki, Shinichiro Yoshioka, Shingo Kato, Masayuki Saruta, Shinji Tanaka, Eriko Yasutomi, Kaoru Yokoyama, Kei Moriya, Yoshikazu Tsuzuki, Makoto Ooi, Mikihiro Fujiya, Atsushi Nakazawa, Takayuki Abe, Tadakazu Hisamatsu, Japanese UC Study Grp
Summary: Most first-use advanced therapies were effective for patients with acute severe ulcerative colitis, while second-use advanced therapies might have had limited benefits in inducing clinical remission. These findings may provide insights for the management of hospitalized patients.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Shinta Mizuno, Keiko Ono, Yohei Mikami, Makoto Naganuma, Tomohiro Fukuda, Kazuhiro Minami, Tatsuhiro Masaoka, Soichiro Terada, Takeshi Yoshida, Keiichiro Saigusa, Norimichi Hirahara, Hiroaki Miyata, Wataru Suda, Masahira Hattori, Takanori Kanai
INTESTINAL RESEARCH
(2020)
Article
Gastroenterology & Hepatology
Toshifumi Hibi, Makoto Naganuma, Eisei Oda, Yoji Yamada, Yoshitomo Chujoh, Ryoichi Yoshihara, Mamoru Watanabe
INTESTINAL RESEARCH
(2020)