Article
Integrative & Complementary Medicine
Cui Shuang, Pan Xiao-Jie, Ge Chao-Liang, Guo Yi-Tong, Zhang Peng-Fei, Yan Ting-Ting, Zhou Ji-Yu, He Qing-Xian, Cheng Long-Hao, Wang Guang-Ji, Hao Hai-Ping, Wang Hong
Summary: Silymarin protects against NAFLD by activating PPARα to reduce lipid accumulation in mice, and it is not recommended to take silymarin and classical PPARα agonists simultaneously for NAFLD therapy.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Review
Biochemistry & Molecular Biology
Miao Miao, Xue Wang, Tian Liu, Yan-Jie Li, Wen-Qian Yu, Tong-Mei Yang, Shou-Dong Guo
Summary: Atherosclerosis, a major factor of cardiovascular disease, is influenced by inflammation, dyslipidemia, and oxidative stress. Peroxisome proliferator-activated receptors (PPARs), as nuclear receptors, have tissue- and cell-specific expression and regulate genes involved in lipid metabolism, inflammation, and redox homeostasis. Despite controversies, accumulating evidence supports the role of PPAR activation in attenuating atherosclerosis. Recent advances provide valuable insights into the mechanisms of PPAR activation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Claudia Theys, Dorien Lauwers, Claudina Perez-Novo, Wim Vanden Berghe
Summary: Nonalcoholic fatty liver disease (NAFLD) is a growing epidemic and the most common cause of chronic liver disease worldwide. This review focuses on the epigenetic regulation of NAFLD, particularly the role of the nuclear receptor PPAR alpha in lipid metabolism. The interaction between PPAR alpha and epigenetic enzymes has become a potential therapeutic target for NAFLD.
Article
Genetics & Heredity
Jia Luo, Zheng Yan, Manyun Dai, Liping Xu, Haoyue Zhang, Yang Xi, Julin Yang, Aiming Liu
Summary: This study aimed to investigate the role of PPAR alpha in modifying the circadian clock and its relevance to NAFLD. The authors used a mouse model and hepatocyte experiments to verify the effects of PPAR alpha on CLOCK regulation and lipid accumulation. They found that high-fat diet led to the down-regulation of CLOCK in the liver, and this down-regulation was dependent on PPAR alpha activity. Furthermore, they observed that down-regulation of hepatic CLOCK by basal PPAR alpha contributed to the inhibition of NAFLD development, while inhibition of CLOCK by activated PPAR alpha was involved in the inhibition of NAFLD by PPAR alpha agonists.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Pharmacology & Pharmacy
Tong Zhou, Ke Yan, Yuhan Zhang, Linfangzi Zhu, Yi Liao, Xiaoxiang Zheng, Yongxiong Chen, Xiaoxin Li, Zuguo Liu, Zhaoqiang Zhang
Summary: This study explored the potential mechanism of fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR alpha) agonist, against corneal neovascularization by investigating changes in lipid metabolism. The findings suggest that lipid metabolism disorder may contribute to suture-induced corneal neovascularization, and fenofibrate exerts anti-neovascularization and anti-inflammatory effects by regulating key enzymes in lipid metabolism and reducing lipid peroxidation damage through the PPAR alpha signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biology
Laila Naif Al-Harbi, Ghedeir M. Alshammari, Alhanouf Mohammed Al-Dossari, Pandurangan Subash-Babu, Manal Abdulaziz Binobead, Maha H. Alhussain, Sahar Abdulaziz AlSedairy, Doha M. Al-Nouri, Ghalia Shamlan
Summary: Beetroot extract showed significant improvements in liver structure and reduced hepatic lipid accumulation in T2DM rats, while also reducing serum levels of glucose, insulin, cholesterol, triglycerides, and inflammatory markers. The extract upregulated antioxidants and PPAR a in both control and T2DM rats, indicating its potential for preventing hepatic steatosis and liver damage in T2DM.
Review
Pharmacology & Pharmacy
Hao Chen, Huabing Tan, Juan Wan, Yong Zeng, Jincheng Wang, Haichuan Wang, Xiaojie Lu
Summary: Non-alcoholic fatty liver disease (NAFLD), the leading cause of chronic liver disease worldwide, requires more efficient therapeutics. Peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, plays a crucial role in hepatic lipid metabolism and inflammation. Its involvement in NAFLD pathogenesis through adipogenesis, insulin resistance, inflammation, oxidative stress, endoplasmic reticulum stress, and fibrosis is increasingly recognized. This article summarizes the evidence for PPAR-gamma-targeted therapy for NAFLD, highlighting its potential as a promising therapeutic target.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Food Science & Technology
Haoran Chen, Xiaofen Qi, Kaifang Guan, Yuxiang Gu, Rongchun Wang, Qiming Li, Ying Ma
Summary: The study showed that peptides from alpha-lactalbumin hydrolysate could improve lipid metabolism in HepG2 cells, with P2 and P8 being more effective in enhancing intracellular TG and PPAR alpha levels. These peptides acted as PPAR alpha ligands to regulate lipid metabolism-related gene expression, showing promise in ameliorating obesity.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Tzu-Chieh Liao, Jiung-Pang Huang, Yu-Ting Tsai, Wei-Ching Shih, Chi-Chang Juan, Po-Shiuan Hsieh, Li-Man Hung, Chao-Lan Yu
Summary: CCR5 plays a role in mediating the interaction between hepatocytes and g-MDSCs in the pathogenesis of NAFLD, and targeting g-MDSCs' CCR5 signaling might be a potential therapeutic strategy for the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Liangge Li, Yiming Qin, Xijian Xin, Shendong Wang, Zhaojun Liu, Xiujing Feng
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common liver disease with a high morbidity and mortality rate. The pathogenesis of NAFLD involves excess lipid accumulation and inflammation. Currently, there are no specific drugs for NAFLD, but phytochemicals such as flavonoids have shown potential in preventing and treating excess lipid accumulation. Understanding the classification, properties, and functions of flavonoids will contribute to the development of effective therapies for NAFLD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Si Tan, Zunli Ke, Chongbing Zhou, Yuping Luo, Xiaobo Ding, Gangjun Luo, Wenfeng Li, Shengyou Shi
Summary: The study aimed to analyze the phenolic composition of longan byproduct polyphenol extracts (LPPE), evaluate their antioxidant activity in vitro, and investigate their regulating effect on lipid metabolism in vivo. The results showed that LPPE had high antioxidant activity and could prevent body weight gain and decrease serum and liver lipids in high-fat diet-induced-obese mice. This study supports the use of LPPE as a dietary supplement in regulating lipid metabolism.
Article
Plant Sciences
Jozaa Z. ALTamimi, Ghedeir M. Alshammari, Nora A. AlFaris, Reham Alagal, Dalal H. Aljabryn, Norah A. Albekairi, Mahmoud Ahmad Alkhateeb, Mohammed Abdo Yahya
Summary: Ellagic acid (EA) has anti-steatotic effects in streptozotocin-induced type 1 diabetes mellitus in rats, potentially mediated through the AMPK signaling pathway. It reduces blood glucose levels, increases insulin levels, prevents hepatic lipid accumulation, and decreases levels of triglycerides, cholesterol, and free fatty acids. It also reduces oxidative stress and inflammation in the liver.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tomomi Yamazaki, Megumi Ihato
Summary: PPAR-alpha prevents fatty liver caused by excessive sucrose intake through regulating SREBP-1c target gene expression and liver TG accumulation. Gender differences may be related to the expression level of PPAR-gamma.
Article
Multidisciplinary Sciences
Divina C. Cominguez, Yea-Jin Park, Yun-Mi Kang, Agung Nugroho, Suhyun Kim, Hyo-Jin An
Summary: Clitorin can significantly alleviate WD-induced hepatic steatosis in mice and oleic acid-stimulated HepG2 cells. The mechanism may involve the downregulation of fatty acid synthase and cholesterol-related genes, as well as the upregulation of fatty acid metabolism-related genes. Clitorin has the potential to be an effective candidate for the management of NAFLD.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Wang Zhang, Jing-Ya Li, Xiao-Chen Wei, Qian Wang, Ji-Yang Yang, Huan Hou, Zi-Wei Du, Xin-An Wu
Summary: The study revealed that DBP can induce fatty liver disease by activating the PPAR alpha signaling pathway and inhibiting AMPK phosphorylation. The results indicated that DBP affects protein expression, leading to hyperlipidemia and abnormal liver function, which can be alleviated through the PPAR alpha/SREBP-1c/FAS/GPAT/AMPK signaling pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Applied
Rui Xu, Dongdong Zhang, Fangfang Shu, Zehai Long, Yiming Li, Zhengtao Wang, Li Yang, Rui Wang
Summary: Three new phenolic derivatives, picraquanines A-C, along with 6 known ones were isolated from Picrasma quassioides. The structures were determined through extensive spectroscopic analysis, and the absolute configuration of one compound was determined by comparing experimental and calculated ECD spectra. All compounds showed no significant inhibitory effects against nitric oxide.
NATURAL PRODUCT RESEARCH
(2021)
Review
Plant Sciences
Yuangui Yang, Zhengcai Ju, Yingbo Yang, Yanhai Zhang, Li Yang, Zhengtao Wang
Summary: This review investigates the identification and evaluation methods of chemical constituents in Panax species, as well as discusses different extraction methods. A total of 219 articles published between 1980 and 2018 are surveyed, focusing on the chemical components of different Panax species in raw and processed forms, as well as potential biomarkers.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Chemistry, Applied
Yilin Chen, Linnan Li, Fen Xiong, Yanqiao Xie, Aizhen Xiong, Zhengtao Wang, Li Yang
Summary: A novel analytical strategy utilizing DART-MS for fast analysis of PAs was developed in this research, and the results were in good agreement with HPLC-MS results but consumed less time without chromatographic separation, showing promising applications in various fields.
Article
Medicine, Research & Experimental
Zhiying Wang, Xiaohui Liang, Aizhen Xiong, Lili Ding, Wei Li, Li Yang, Xiaojun Wu, Hailian Shi, Yue Zhou, Zhengtao Wang
Summary: Helichrysetin inhibits NF-kappa B activation by blocking the phosphorylation of key proteins induced by TNF-alpha, and in combination with TNF-alpha, it synergistically promotes apoptosis in HeLa and T98G cells. This potentially represents a promising therapeutic strategy for cancer.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Chemistry, Analytical
Zhengcai Ju, Xiaowen Tang, Qi Liao, Huida Guan, Li Yang, Zhengtao Wang
Summary: The study investigated the metabolic profiles and pharmacokinetics of lusianthridin in rats, identifying major metabolic pathways and absorption characteristics. A validated method for determining lusianthridin in rat plasma was established, showing quick absorption and plasma concentration reaching a max at 22.00 min after oral administration in rats.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Lili Ding, Eryun Zhang, Qiaoling Yang, Lihua Jin, Kyle M. Sousa, Bingning Dong, Yangmeng Wang, Jui Tu, Xiaoxiao Ma, Jingyan Tian, Hongli Zhang, Zhipeng Fang, Ana Guan, Yixin Zhang, Zhengtao Wang, David D. Moore, Li Yang, Wendong Huang
Summary: The study suggests that vertical sleeve gastrectomy (VSG) achieves its metabolic benefits by reducing intestinal bile acids and fat absorption levels.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Pharmacology & Pharmacy
Xunjiang Wang, Wei Zhang, Yongfeng Yang, Yiran Chen, Yuzheng Zhuge, Aizhen Xiong, Li Yang, Zhengtao Wang
Summary: This study identified three miRNAs (miR-148a-3p, miR-362-5p, and miR-194-5p) that were overexpressed in PA-induced HSOS and showed potential as biomarkers, with good diagnostic accuracy for patients with HSOS.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Yuangui Yang, Yanhai Zhang, Xiaoqun Zhang, Li Yang, Zhengtao Wang
Summary: Based on the research findings, red ginseng and white ginseng have different chemical constituents and exhibit different effects; a rapid and comprehensive method was developed to determine the ginsenoside contents in red and white ginseng using two-dimensional liquid chromatography techniques, revealing higher contents of certain components in red ginseng than in white ginseng.
JOURNAL OF CHROMATOGRAPHIC SCIENCE
(2022)
Article
Oncology
Leixin Song, Fan Yang, Zhengtao Wang, Li Yang, Yue Zhou
Summary: The study demonstrated that ginsenoside Rg5 inhibits cancer cell migration by suppressing the phosphorylation of NF-κB and EphA2, providing a scientific basis for the development of ginsenoside Rg5 as a potential antimetastatic drug.
Article
Pharmacology & Pharmacy
Tongxi Zhuang, Xinhua Liu, Wen Wang, Jing Song, Le Zhao, Lili Ding, Li Yang, Mingmei Zhou
Summary: The study indicates that herbal polyphenols and flavonoids have multiple beneficial effects on obesity caused by chronic metabolic disorders, and the combination of CQR has significant therapeutic effects in combating obesity. Through urinary metabolomic analysis, it was found that CQR has a significant impact on the metabolites of HFD-induced obese rats.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lili Ding, Qiaoling Yang, Eryun Zhang, Yangmeng Wang, Siming Sun, Yingbo Yang, Tong Tian, Zhengcai Ju, Linshan Jiang, Xunjiang Wang, Zhengtao Wang, Wendong Huang, Li Yang
Summary: The study has shown that notoginsenoside Ft1 from Panax notoginseng can improve symptoms of obesity and insulin resistance by promoting adipose lipolysis and browning of fat, thus highlighting its potential as a therapeutic agent for metabolic disorders.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Plant Sciences
Jingyi Cai, Jiasheng Wu, Su Fang, Shaoyong Liu, Tianming Wang, Yuanyuan Li, Juan Zou, Rong Shi, Zhengtao Wang, Li Yang, Yueming Ma
Summary: CBBP treatment alleviates ANIT-induced cholestasis and liver injury by reducing hepatocyte inflammation and apoptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yanqiao Xie, Leixin Song, Chunge Li, Yingbo Yang, Siyu Zhang, Hong Xu, Zhengtao Wang, Zhuzhen Han, Li Yang
Summary: Eleven previously unreported sesquiterpenes were isolated from agarwood, including nine eudesmane-type and two agarospirane-type sesquiterpenes, along with eight known sesquiterpenes. The structures were elucidated through extensive spectroscopic analyses, and the bioactivity of the compounds against LPS-induced NO production in cells was evaluated, with compounds 1 and 2 showing significant anti-inflammatory activities.
Article
Plant Sciences
Wenjing Fan, Beibei Zhang, Caiqin Wu, Hui Wu, Jing Wu, Shijia Wu, Jinxian Zhang, Xinhua Yang, Li Yang, Zhibi Hu, Xiaojun Wu
Summary: PASE attenuated ISO-induced cardiac hypertrophy in mice by inhibiting excessive autophagy and apoptosis in cardiomyocytes, leading to improved cardiac function and decreased expression of hypertrophic markers. The findings suggest the potential clinical usage of PASE for preventing heart diseases related to cardiac hypertrophy.
Article
Multidisciplinary Sciences
Qi Liao, Ziyu Chen, Yanlin Tao, Beibei Zhang, Xiaojun Wu, Li Yang, Qingzhong Wang, Zhengtao Wang
Summary: An improved integrated approach successfully identified potential anti-SARS-CoV-2 candidates from effective Chinese herbal formulas and confirmed their effectiveness against COVID-19 through molecular dynamics simulation. These molecules were found to tightly bind to 3CLpro, showcasing their potential as antiviral drugs.
SCIENTIFIC REPORTS
(2021)
Correction
Plant Sciences
Lingmiao Wen, Tinglan Zhang, Fangfang Chen, Lin Hu, Chongyang Dou, Xian Ding, Alvin Altamirano, Guihua Wei, Zhiyong Yan
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Qing Tang, Mengfei Xu, Shunqin Long, Yaya Yu, Changju Ma, Rui Wang, Jing Li, Xi Wang, Fang Fang, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study demonstrates that Fuzheng Kang-Ai (FZKA) decoction can inhibit the cell growth, proliferation, and invasion of lung adenocarcinoma (LUAD) and reverse the acquired resistance of gefitinib. FZKA exerts its effects by regulating the p-ERK1/2-EZH2-Snail/EGFR signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Xiang Zhao, Xianrun Hu, Qi Xie, Shenglan Qi, Zedong Xiang, Xin Sun, Zhejun Xie, Rui Dang, Limei Zhou, Wei Liu, Xuemei Cheng, Changhong Wang
Summary: This study investigated the effects of Fufangmuniziqi formula (FFMN) on Alzheimer's disease (AD) and the role of alkaloids, flavonoids, and saponins in the process. The results showed that FFMN improved cognitive and memory impairment in the AD mouse model. Alkaloids enhanced the cholinergic system, while flavonoids and saponins attenuated neuroinflammation and oxidative stress. These findings suggest that the combination of alkaloid, flavonoid, and saponin fractions derived from FFMN is a promising anti-AD agent.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Bangjian Dong, Ying Peng, Mengyue Wang, Chongsheng Peng, Xiaobo Li
Summary: This study elucidated the tissue distribution and excretion characteristics of the non-polysaccharide components of Sijunzi decoction in rats with spleen deficiency syndrome. It proposed new insights into the rationality of the compatibility of Sijunzi decoction.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jung-Seop Kim, Man-Gi Kim, Ji Eun Ryu, Ye-Been Lee, Quan Feng Liu, Kwang Ki Kim, Seung-Hun Cho, Sung Joon Shin, Byung-Soo Koo, Hyung-Kyoon Choi
Summary: Co-treatment with WCW and donepezil shows promise in improving cognitive function and serum metabolic profiles in a scopolamine-induced AD model. This combination therapy may reduce tyrosine and methionine levels, enhancing cognitive function by mitigating known risk factors for AD. The study provides a foundation for developing other bioactive compounds in AD treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Kuang-Hsing Chiang, Tain-Junn Cheng, Wei-Chih Kan, Hsien-Yi Wang, Jui-Chen Li, Yan-Ling Cai, Chia-Hui Cheng, Yi-Chien Liu, Chia-Yu Chang, Jiunn-Jye Chuu
Summary: The ethanolic extract of Orthosiphon aristatus (OA) demonstrated an improving effect on memory and could serve as a potential therapeutic target for the treatment of neurodegenerative diseases like Alzheimer's disease (AD).
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Meryem Tourabi, Asmae EL Ghouizi, Ghizlane Nouioura, Khaoula Faiz, Hind Elfatemi, Karima El-yagoubi, Badiaa Lyoussi, Elhoussine Derwich
Summary: Mentha longifolia is a native plant in Morocco, traditionally used to treat various diseases. This study analyzed the phytochemical profile of the aqueous extract of M. longifolia and evaluated its acute and subacute toxicity in mice. The results showed that M. longifolia extract is rich in phenolic compounds and has no observed toxicity up to a certain dosage limit.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yue Zhang, Liang Li, Tao Chai, Han Xu, Hong-yan Du, Yan Jiang
Summary: Mulberry leaf multi-components (MMC) have hypoglycemic effects and can improve insulin resistance by activating the PI-3K/Akt signaling pathway. These findings highlight the multi-component, multi-target, and combined effects of MMC, and suggest it may be further developed as a hypoglycemic drug.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Correction
Plant Sciences
Shan Luo, Yuanchun Chen, Ruoxi Zhao, Donglai Ma, Yanmeng Zhao, Ying Zhang, Jianming Jiang, Wentao Yu
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Nittaya Chansiw, Pattranuch Chusri, Siwaporn Praman, Thaneeya Hawiset, Wannisa Sukhorum, Sorraya Champakam, Rawiwan Charoensup
Summary: This study evaluates the anti-inflammatory activity of Prabchompoothaweep (PCT) extract in an animal model. The results show that PCT significantly reduces inflammation and pro-inflammatory cytokines in acute and sub-acute inflammation. These findings suggest that PCT could be a new option for the treatment of inflammatory diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Yanting Wang, Guoqiang Liang, Wei Mu, Shu Sun, Xuanyi Chen, Xiaofeng Xu
Summary: Bushen Tianjing Recipe (BTR) is a tonic-kidney formula of Traditional Chinese Medicine (TCM) with good therapeutic effects in clinical settings. The aim of this study was to investigate the effect of BTR on women's reproductive system by incubating miR-23a-induced KGN cells.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Jiayi Zhi, Li Yin, Zhoudong Zhang, Yaozhong Lv, Fan Wu, Yang Yang, Enming Zhang, Huanqiu Li, Ning Lu, Mengze Zhou, Qinghua Hu
Summary: This study verified the pharmacodynamics of JSW in the treatment of AD and explored its potential mechanism using network pharmacology, molecular docking, and experimental validation.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Review
Plant Sciences
Elizabeth Syowai Mutinda, Dong-Juan Zhang, Felix Wambua Muema, Elijah Mbandi Mkala, Emmanuel Nyongesa Waswa, Wyclif Ochieng Odago, Clintone Onyango Ochieng, Moses Kirega Gichua, John Kamau Muchuku, Elizabeth Kamande, Guang-Wan Hu
Summary: This article reviews the traditional uses, pharmacological properties, and phytoconstituents of Balanophora species, revealing that they contain diverse chemical compounds with interesting biological activities. However, research on many species in this genus is still lacking.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Luqi Cai, Yu Chen, Huizhong Xue, Yimeng Yang, Yuqi Wang, Junhe Xu, Chunyan Zhu, Long He, Yonghua Xiao
Summary: Salvia miltiorrhiza Bunge (SM) has been proven to have potential therapeutic effects for diabetic nephropathy (DN) through its multi-component, multi-target, and multi-pathway pharmacological effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Chao Wang, Rui-Jia Fu, Ding-Qiao Xu, Qian Zuo, Ji-Ping Liu, Yu-Ping Tang
Summary: This study aimed to explore the hepatoprotective effects of Shicao on CCl4-induced acute liver injury. A rat model of acute liver injury was established and liver function indices were assessed. Untargeted metabolomics was conducted to identify differential metabolites. Network pharmacology was used to construct a network of metabolite-reaction-enzyme-gene constituents, and key components and hub genes were screened. Shicao showed hepatoprotective effects against acute liver injury in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)