Article
Chemistry, Medicinal
Yushan Huang, Hongmei Hu, Rui Yan, Liwen Lin, Mingxia Song, Xiaodong Yao
Summary: A series of novel compounds containing an aminoguanidine moiety were designed, synthesized, and evaluated for their antimicrobial and anticancer activities. Compound 5k showed potent antimicrobial activity against Bacillus subtilis CMCC 63501 and multidrug-resistant Staphylococcus aureus ATCC 43300, as well as significant cytotoxicity against A549 cells, indicating its potential as a promising antimicrobial and anticancer drug.
ARCHIV DER PHARMAZIE
(2021)
Article
Pharmacology & Pharmacy
Bandar A. Babgi, Jalal Alsayari, Hana M. Alenezi, Magda H. Abdellatif, Naser E. Eltayeb, Abdul-Hamid M. Emwas, Mariusz Jaremko, Mostafa A. Hussien
Summary: A set of five gold complexes were synthesized and characterized, with Schiff base complexes showing superior protein binding affinities and anticancer activities. Small structural modifications significantly altered the physiochemical and anticancer properties of the complexes, highlighting the potential for developing new gold(I)-based anticancer drugs.
Article
Biochemistry & Molecular Biology
Thamer Alorini, Ahmed N. Al-Hakimi, Ismail Daoud, Fahad Alminderej, Abuzar E. A. E. Albadri, Lotfi Aroua
Summary: A new ligand was synthesized and complexes with different metals were formed. The compounds were characterized by various methods, and the results showed that the ligand has bidentate behavior and forms coordination bonds with metals. The antibacterial, antifungal, and cytotoxic activities of the ligand and its complexes were evaluated, and the Fe(III) complex showed the best activity against microbial strains, while the Cu(II) complex displayed the preeminent activity against cancer cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Chemistry, Medicinal
Renata Paprocka, Malgorzata Wiese-Szadkowska, Tomasz Kosmalski, Daria Frisch, Magdalena Ratajczak, Bozena Modzelewska-Banachiewicz, Renata Studzinska
Summary: Amidrazones are widely used in chemical synthesis, industry and agriculture. This review summarizes the important findings on the biological activities of amidrazones from 2010 to 2022, including different categories of active compounds and their mechanisms. The review focuses on new compounds with potential as drugs and repurposing of old drugs with new therapeutic targets, highlighting the potential and significance of amidrazone derivatives in drug development.
Article
Biochemistry & Molecular Biology
Sami A. Al-Harbi
Summary: Three carboxamide-based ligands and their iron(III) complexes were synthesized and characterized. The iron(III) complexes exhibited a 1:1 stoichiometric ratio and distorted octahedral geometry. Electrochemical measurements showed the complexes' SOD-like activity with IC50 values of 16.45, 15.24, and 9.70 μM. The iron(III) complexes demonstrated potent anticancer activity with increased safety on normal cells compared to cisplatin. Molecular docking calculations confirmed the experimental findings of the antibacterial and anticancer activities of the complexes and ligands.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Pharmacology & Pharmacy
Ines Marmol, Javier Quero, Paula Azcarate, Elena Atrian-Blasco, Carla Ramos, Joana Santos, Maria Concepcion Gimeno, Maria Jesus Rodriguez-Yoldi, Elena Cerrada
Summary: This paper describes the synthesis of new N-heterocyclic carbene (NHC) gold(I) derivatives and their screening for antimicrobial and anticancer activities. The compounds showed greater activity against bacteria than against colon cancer cells. The mechanism of action of one of the compounds, 1b, was evaluated and it was found to inhibit dihydrofolate reductase (DHFR) activity in E. coli cells and cause structural changes in the bacteria.
Article
Biochemistry & Molecular Biology
Vartika Mishra, Sarika Tomar, Priyanka Yadav, Shraddha Vishwakarma, Mohan Prasad Singh
Summary: Oyster mushrooms are widely used in diets due to their unique aroma, delicious taste, and nutritive value. This study found that oyster mushrooms contain various important elements and bioactive compounds, and exhibit significant antioxidant, antibacterial, and anticancer properties.
Article
Microbiology
Madhumanti Barman, Sonam Kamble, Sonti Roy, Vasundhra Bhandari, Siva Singothu, Debabrata Dandasena, Akash Suresh, Paresh Sharma
Summary: The social behavior of intense competition among animals and plants has long been considered a driving force in evolution, leading to the creation of superior genes and offspring. This competitive spirit is crucial in promoting biological evolution, biodiversity, and ecological balance.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Applied
Safaa S. Hassan, Nashwa M. H. Rizk, Manal A. Khidr, Samar A. Aly
Summary: A new series of metal complexes were synthesized and their structural characterization was carried out using various techniques. The biological screening results showed that the Ru(III) complex exhibited the strongest antibacterial activity, while the Ag(I) complex showed the highest efficiency in terms of antitumor activity.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Xiaodong Yao, Hongmei Hu, Shiben Wang, Wenhao Zhao, Mingxia Song, Qiugui Zhou
Summary: A series of aminoguanidine derivatives containing an acylhydrazone moiety were designed to find new antibacterial agents with wide spectra and high activities. Some compounds showed great antimicrobial activities against Gram-positive bacteria, including multidrug-resistant strains, while one compound exhibited promising potential against Staphylococcus aureus.
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2021)
Article
Chemistry, Inorganic & Nuclear
Balasubramanian Karpagam, Murugesan Sankarganesh, Lokesh Ravi, Mookkandi Palsamy Kesavan, Gujuluva Gangatharan Vinoth Kumar, Gurusamy Rajagopal, Jegathalaprathaban Rajesh
Summary: A new thiosemicarbazone ligand was synthesized and a corresponding Ni(II) complex was prepared, showing better antibacterial and anticancer activities than the ligand. Molecular docking analysis indicated that the Ni(II) complex had better interacting abilities with Human Serum Albumin and DNA.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Sara Janowska, Dmytro Khylyuk, Anna Bielawska, Anna Szymanowska, Agnieszka Gornowicz, Krzysztof Bielawski, Jaroslaw Noworol, Slawomir Mandziuk, Monika Wujec
Summary: We designed and synthesized 1,3,4-thiadiazole derivatives with different substituents at the C2 and C5 positions. The cytotoxic activity of these compounds was evaluated in MCF-7 and MDA-MB-231 breast cancer cells and normal fibroblast cells. The most potent anti-proliferative compound was found to be 2-(2-trifluorometylophenylamino)-5-(3-methoxyphenyl)-1,3,4-thiadiazole, which exhibited IC50 values of 49.6 μM and 53.4 μM against MCF-7 and MDA-MB-231 breast cancer cells, respectively. Importantly, the new compounds showed weaker cytotoxic activity towards normal cells compared to breast cancer cells. In silico studies suggested a potential multitarget mode of action for these compounds, with involvement of Caspase 3, Caspase 8, and BAX proteins.
Article
Biochemistry & Molecular Biology
Roman Tumskiy, Boris Khlebtsov, Anastasiia Tumskaia, Stella Evstigneeva, Evgeniya Antoshkina, Andrey Zakharevich, Nikolai G. Khlebtsov
Summary: This paper reports a simple synthesis of water-soluble glutathione-capped silver nanoclusters (GSH-Ag NCs), which showed enhanced antibacterial activity. The synthesized GSH-Ag NCs were found to be a pure composition without any impurities. The antibacterial activity of the chelated silver in the nanoclusters was significantly higher compared to free silver ions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Tao Chen, Yun Huang, Junxian Hong, Xikang Wei, Fang Zeng, Jialin Li, Geting Ye, Jie Yuan, Yuhua Long
Summary: The latest research suggests that anti-tumor agents with COX-2 inhibitory activity may enhance their efficacy. A series of sclerotiorin derivatives were synthesized and screened for their cytotoxic and COX-2 inhibitory activity. Some compounds showed good cytotoxicity and moderate to good COX-2 inhibition, with potential as anti-tumor agents.
Article
Chemistry, Multidisciplinary
Leena V. Hublikar, Sharanabasava V. Ganachari, Veerabhadragouda B. Patil
Summary: Averrhoa bilimbi leaf extract was used as a reducing agent to synthesize silver nanoparticles (AgNPs), which showed stability and controlled release. The synthesized nanoparticles were characterized as spherical and monodispersed using UV-visible, FT-IR spectroscopies, XRD, and SEM analyses. These bio-synthesized AB-AgNPs demonstrated effective cytotoxicity against lung cancer (A549 cell line) and breast cancer (MCF7 cell line), with optimized conditions. The IC50 values for A549 and MCF7 cells were found to be 49.52 g mL(-1) and 78.40 g mL(-1), respectively. Thus, the green synthesis of AB-AgNPs holds promise as a potential anticancer agent.
NANOSCALE ADVANCES
(2023)
Letter
Rheumatology
Martin Sebastian Winkler, Peter Korsten, Claudia Binder, Bjoern Tampe
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Environmental Sciences
Paula Yumi Takeda, Jackeline Tatiane Gotardo, Simone Damasceno Gomes
Summary: This study evaluated the performance of anaerobic co-digestion of landfill leachate and crude glycerol, and found that the association of these substrates led to high organic matter removal efficiency and specific biogas production. Optimization through Central Composite Rotational Design and the modified Gompertz model improved the digestion conditions and significantly increased specific biogas production.
ENVIRONMENTAL TECHNOLOGY
(2022)
Article
Oncology
Yi Liao, Senmao Li, Hao Chen, Chunyu Chen, Jintuan Huang, Feng Lin, Jianping Wang, Zuli Yang
Summary: A risk prediction system combining FIT and risk factors was developed to improve the sensitivity of colonoscopy screening. The system effectively stratified participants into high risk and low risk groups, with better predictive ability for colorectal neoplasia compared to using FIT alone.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Luca Giraldi, Jovana Stojanovic, Dario Arzani, Roberto Persiani, Jinfu Hu, Kenneth C. Johnson, Zuo-Feng Zhang, Monica Ferraroni, Domenico Palli, Guo-Pei Yu, Carlo La Vecchia, Claudio Pelucchi, Nuno Lunet, Ana Ferro, Reza Malekzadeh, Joshua Muscat, David Zaridze, Dmitry Maximovich, Nuria Aragones, Vicente Martin, Jesus Vioque, Eva M. Navarrete-Munoz, Mohammadreza Pakseresht, Eva Negri, Matteo Rota, Farhad Pourfarzi, Lina Mu, Robert C. Kurtz, Areti Lagiou, Pagona Lagiou, Roberta Pastorino, Stefania Boccia
Summary: This study aimed to examine the association between height and risk of gastric cancer. Through a large pooled analysis of case-control studies, the study found no significant association between adult height and gastric cancer.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Oncology
Maria A. Karalexi, Marina Servitzoglou, Vassilios Papadakis, Denis Kachanov, Maja Cesen Mazic, Margaret Baka, Maria Moschovi, Maria Kourti, Sofia Polychronopoulou, Eftichia Stiakaki, Emmanuel Hatzipantelis, Helen Dana, Kalliopi Stefanaki, Astero Malama, Marios S. Themistocleous, Katerina Strantzia, Tatyana Shamanskaya, Panagiota Bouka, Paraskevi Panagopoulou, Maria Kantzanou, Evangelia Ntzani, Nick Dessypris, Eleni Th. Petridou
Summary: The prognosis of children with neuroblastoma varies depending on the stage and biology of the tumor, and early-stage neuroblastoma has a better prognosis. Treatment with anti-GD2 antibody can improve the prognosis of high-risk patients.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2023)
Article
Emergency Medicine
Asami Okada, Yohei Okada, Hiromichi Narumiya, Wataru Ishii, Tetsuhisa Kitamura, Ryoji Iiduka
Summary: This study found an association between hypothermia and hyperthermia at hospital arrival and increased in-hospital mortality in adult trauma patients.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Shubhangi Kandwal, Darren Fayne
Summary: The COVID-19 pandemic has had a negative impact on global human life, causing economic crises and health emergencies. In this study, computational drug design technologies were used to repurpose existing drugs as inhibitors of SARS-CoV-2 viral proteins. The results may help accelerate drug development against COVID-19 and have significant implications.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Public, Environmental & Occupational Health
Li-Chien Chien, Christian K. Bey, Kristi L. Koenig
Summary: The authors discuss how Taiwan achieved control of COVID-19 without economic shutdown by implementing established public health principles and non-pharmaceutical interventions. Taiwan's success in creating quasi population immunity and preventing local transmission serves as a model for optimal public health management of COVID-19 and future emerging infectious diseases.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Review
Clinical Neurology
Christoph Eckhard Heyde, Ulrich Josef Albert Spiegl, Anna Voelker, Nicolas von der Hoeh, Jeanette Henkelmann
Summary: The prevalence of nonspecific pyogenic spondylodiskitis has increased, causing high morbidity and mortality. The diagnosis is often delayed due to nonspecific clinical manifestations at the early stage. CT can assess the bony condition, while MRI is still the gold standard for diagnosis.
JOURNAL OF NEUROLOGICAL SURGERY PART A-CENTRAL EUROPEAN NEUROSURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Yanan Sun, Yiming Jia, Mingxia Song, Yan Liu, Le Xin, Xiangwei Chen, Hongfei Fu, Yequn Wang, Yunyang Wang
Summary: RF thawing is more efficient than air thawing and has positive effects on the color, texture, and quality of meat. Compared with air thawing, RF thawing results in less thawing loss, lower TVB-N content, and lower TVC. It also reduces myofibrillar protein content and causes less damage to the microstructure.
FOOD AND BIOPRODUCTS PROCESSING
(2023)
Article
Engineering, Chemical
Mingxia Song, Bofeng Zhang, Ziwei Zhai, Sibao Liu, Li Wang, Guozhu Liu
Summary: Atomically dispersed metal catalysts can maximize metal utilization and provide unique chemical properties. Self-pillared nanosheet-supported metal catalysts, such as PtZn/SP-S-1, exhibit high stability and specific activity, with no obvious deactivation after 90 hours at high temperature. They have potential to guide high-temperature catalysis.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Wennan Zhao, Mingxia Song, Yi Hua, Yangnv Zhu, Wenli Liu, Qishan Xia, Xianqing Deng, Yushan Huang
Summary: This study designed, synthesized, and investigated a series of new triazole-quinolinone compounds as CNS active agents. These compounds significantly reduced immobility time in the forced swim test in mice and showed superior antidepressant activity compared to fluoxetine. Compound 3g demonstrated antidepressant activity through an activity reversal test and almost all compounds showed antiseizure activity in the maximal electroshock seizure model. Further experiments confirmed that compound 3g affected GABA concentration in mice brain and had good interaction with the amino acid residue of the GABA(A) receptor. These findings provide a new skeleton for developing drugs for the treatment of epilepsy and depression comorbidities.
Article
Biochemistry & Molecular Biology
Yi Hua, Mingxia Song, Qiaoyue Guo, Yiqin Luo, Xianqing Deng, Yushan Huang
Summary: This study synthesized a series of 6-aminoalkoxy-3,4-dihydroquinolin-2(1H)-ones to screen their H3R antagonistic activities and antiseizure effects. The majority of the compounds displayed potent H3R antagonistic activity, with compounds 2a, 2c, 2h, and 4a showing submicromolar activity. Three compounds (2h, 4a, and 4b) were found to have antiseizure activity in the maximal electroshock seizure model. However, none of the compounds were able to resist seizures induced by pentylenetetrazole (PTZ). Compound 4a's antiseizure role was believed to be achieved through antagonizing the H3R receptor. Molecular docking studies predicted that compounds 2h, 4a, and PIT had similar binding patterns with H3R.
Article
Chemistry, Physical
Qiuwen Liu, Yuhua Zhang, Yawei Wu, Mingxia Song, Caijin Huang
Summary: This paper explores the direct use of coal as a catalyst for the selective oxidative dehydrogenation of propane. It shows high selectivity and productivity, with carbonyl groups identified as the active sites. This work expands the application of abundant and low-price coal in catalysis, with potential for practical scale use.
Article
Ergonomics
Elpidio Maria Garzillo, Maria Grazia Lourdes Monaco, Antonio Spacone, Enrica Inglese, Monica Lamberti, Domenico Pompei
Summary: This study evaluates the response capacity of some Italian companies to the emergency regarding the health and safety of workers. The study found that Italian companies have shown a good response to the regulatory restrictions resulting from the SARS-CoV-2 emergency, especially large enterprises and the banking sector.
INTERNATIONAL JOURNAL OF OCCUPATIONAL SAFETY AND ERGONOMICS
(2022)
