期刊
JOURNAL OF ENVIRONMENTAL SCIENCES
卷 88, 期 -, 页码 187-199出版社
SCIENCE PRESS
DOI: 10.1016/j.jes.2019.08.016
关键词
Short-chain perfluorinated compounds; Human mesenchymal stem cells (hMSCs); Adipogenesis/osteogenesis; Developmental toxicity; PFBS/PFBA/PFHxS/PFHxA
资金
- National Natural Science Foundation of China [21876197, 21577166, 21707160]
- Chinese Academy of Sciences [XDB14040301, 29[2015]30, QYZDJ-SSW-DQC017]
- K. C. Wong Education Foundation
Per- and polyfluorinated alkyl substances (PFASs) are commonly used in industrial processes and daily life products. Because they are persistent, they accumulate in the environment, wildlife and humans. Although many studies have focused on two of the most representative PFASs, PFOS and PFOA, the potential toxicity of short-chain PFASs has not yet been given sufficient attention. We used a battery of assays to evaluate the toxicity of several four-carbon and six-carbon perfluorinated sulfonates and carboxyl acids (PFBS, PFHxS, PFBA and PFHxA), with a human mesenchymal stem cell (hMSC) system. Our results demonstrate significant cyto- and potential developmental toxicity for all the compounds analyzed, with shared but also distinct mechanisms of toxicity. Moreover, the effects of PFBS and PFHxS were stronger than those of PFBA and PFHxA, but occurred at higher doses compared to PFOS or PFOA. (C) 2019 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.
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