期刊
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
卷 860, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jelechem.2020.113869
关键词
MXene; Three-dimensional sodium titanate; Poly(3,4-ethylenedioxythiophene); Immunosensor; Prostate specific antigen; Electrochemical detection
资金
- National Natural Science Foundation of China [51762020, 21665010, 51862014, 31741103]
- Natural Science Foundation of Jiangxi Province [20171ACB20026, 20181BAB206015]
- Jiangxi Provincial Department of Education [GJJ170662]
- Academic and Technical Leader Plan of Jiangxi Provincial Main Disciplines [20182BCB22014]
- Open Project of Engineering Center of Jiangxi University for Fine Chemicals [ICFGJ18018]
- Collaborative Innovation Center of Jiangxi Typical Trees Cultivation and Utilization
- National College Students Innovation and Entrepreneurship Training Program [201810410013]
- One Hundred Person Yuan Hang Project (2015)
- Jiangxi Provincial Key Laboratory of Drug Design and Evaluation [20171BCD40015]
- Open fund of Chemistry Department of Qingdao University of Science and Technology [QVSTHX201938]
- Jiangxi Science and Technology Normal University [YC2019-X15]
- One Hundred Person Yuan Hang Project (2017)
Two-dimensional (2D) MXenes have emerged as an attractive platform to construct electrochemical biosensors because of their excellent electronic properties. However, the self-restacking and agglomeration of MXenes lead to unsatisfactory performance. To overcome these drawbacks, herein, the treatment of Ti3C2 MXene through a simultaneous oxidation and alkalization progress was proposed for the synthesis of 3D sodium titanate nanoribbons (M-NTO). Furthermore, conductive poly(3,4-ethyl-enedioxythiophene) (PEDOT) was anchored on 3D M-NTO to enhance its conductivity. The resulting M-NTO-PEDOT composite possessed high specific surface area, fast electron transfer ability, as well as excellent biocompatibility. Subsequently, Au nanoparticles (AuNPs) were electrodeposited on the surface of M-NTO-PEDOT for prostate specific antigen (PSA) antibodies immobilization. Thus, a facile electrochemical label-free immunosensor for sensitive detection of PSA was fabricated on a basis of AuNPs/M-NTO-PEDOT composite. Benefitting from the synergistic effects of M-NTO, PEDOT and AuNPs, the fabricated M-NTO-PEDOT based immunosensor exhibited good analytical performance with a low limit of detection (LOD) of 0.03 pg L-1 (S/N = 3). Additionally, high stability, good selectivity and recovery were achieved in the process of PSA detection in human serum samples.
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