期刊
JOURNAL OF DIGESTIVE DISEASES
卷 21, 期 3, 页码 147-159出版社
WILEY
DOI: 10.1111/1751-2980.12849
关键词
ecosystem; fecal microbiota transplantation; gut microbiota; interaction; spatial distribution; ulcerative colitis
资金
- Beijing Natural Science Foundation [7192072] Funding Source: Medline
- Youth Program of National Natural Science Foundation of China [81300294] Funding Source: Medline
- Project of Digestive Medical Coordinated Development Center of Beijing Hospitals Authority [XXT11] Funding Source: Medline
- Incubation Program Project of Beijing Municipal Administration of Hospitals of China [PX2018011] Funding Source: Medline
Gut microbiota constitute the largest reservoir of the human microbiome and are an abundant and stable ecosystem-based on its diversity, complexity, redundancy, and host interactions This ecosystem is indispensable for human development and health. The integrity of the intestinal mucosal barrier depends on its interactions with gut microbiota. The commensal bacterial community is implicated in the pathogenesis of inflammatory bowel disease (IBD), including ulcerative colitis (UC). The dysbiosis of microbes is characterized by reduced biodiversity, abnormal composition of gut microbiota, altered spatial distribution, as well as interactions among microbiota, between different strains of microbiota, and with the host. The defects in microecology, with the related metabolic pathways and molecular mechanisms, play a critical role in the innate immunity of the intestinal mucosa in UC. Fecal microbiota transplantation (FMT) has been used to treat many diseases related to gut microbiota, with the most promising outcome reported in antibiotic-associated diarrhea, followed by IBD. This review evaluated the results of various reports of FMT in UC. The efficacy of FMT remains highly controversial, and needs to be regularized by integrated management, standardization of procedures, and individualization of treatment.
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