Review
Medicine, General & Internal
Nia Paddison Rees, Walaa Shaheen, Christopher Quince, Chris Tselepis, Richard D. Horniblow, Naveen Sharma, Andrew D. Beggs, Tariq H. Iqbal, Mohammed Nabil Quraishi
Summary: This systematic review aims to identify clinical, microbial, and metabolomic biomarkers in donors and recipients that predict the response to FMT in UC. The results suggest that distinct changes in gut microbiota profiles, along with specific baseline characteristics and microbial and metabolomic alterations, may predispose patients towards a successful therapeutic outcome.
Article
Gastroenterology & Hepatology
Craig Haifer, Laurence Don Wai Luu, Sudarshan Paramsothy, Thomas J. Borody, Rupert W. Leong, Nadeem O. Kaakoush
Summary: This study characterized the differences in gut microbiota between two FMT donors and found that donor microbiota stability and species evenness were associated with therapeutic efficacy in UC. These findings have important implications for improving FMT donor selection.
Article
Gastroenterology & Hepatology
Ruiqiao He, Pan Li, Jinfeng Wang, Bota Cui, Faming Zhang, Fangqing Zhao
Summary: Fecal microbiota transplantation is a promising treatment for microbiota dysbiosis associated diseases. This study investigated the effect of different types of donor-derived microbiota on FMT efficacy. The research found two dominant types of microbiota in CDI and IBD patients, and observed the interaction between recipient and donor-derived microbiota during FMT.
Article
Biotechnology & Applied Microbiology
Haiming Fang, Lian Fu, Xuejun Li, Chunxia Lu, Yuan Su, Kangwei Xiong, Lijiu Zhang
Summary: The study demonstrates that monotherapy with a single fresh FMT is an effective and safe strategy for inducing long-term remission in patients with active UC, providing a potential alternative to drug therapy for recurrent or primary UC.
MICROBIAL CELL FACTORIES
(2021)
Article
Nutrition & Dietetics
Wei Li, Le Zhang, Qingbiao Xu, Wenbo Yang, Jianan Zhao, Ying Ren, Zhendong Yu, Libao Ma
Summary: This study found that taxifolin can ameliorate DSS-induced colitis by altering gut microbiota to increase the production of SCFAs, thereby reducing intestinal inflammation and mucosal damage.
Article
Multidisciplinary Sciences
Laura A. Bolte, Marjolein A. Y. Klaassen, Valerie Collij, Arnau Vich Vila, Jingyuan Fu, Taco A. van der Meulen, Jacco J. de Haan, Gerbrig J. Versteegen, Aafje Dotinga, Alexandra Zhernakova, Cisca Wijmenga, Rinse K. Weersma, Floris Imhann
Summary: Research found that the majority of Dutch patients are willing to participate in faecal sample collection for gut microbiome research, mainly driven by altruistic motives. Storing samples in the home freezer and unclear sampling procedures were identified as the main barriers to participation. Providing clear instructions and explaining the purpose of sampling can increase participant willingness.
Article
Agriculture, Multidisciplinary
Tao Wang, Caihong Shi, Shuxuan Wang, Yu Zhang, Shuang Wang, Mohamedelfaieh Ismael, Jing Zhang, Xin Wang, Xin Lu
Summary: This study used fecal microbiota transplantation (FMT) to verify the potential of Companilactobacillus crustorum MN047 (CCMN) in regulating gut microbiota and alleviating inflammation in ulcerative colitis (UC).
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Medicine, General & Internal
Dianbo Yao, Wanlin Dai, Ming Dong, Chaoliu Dai, Shuodong Wu
Summary: The MUC2 mucus barrier plays a crucial role in ulcerative colitis (UC). Interventions such as dietary adjustment, repair of the mucus barrier, microbiota transplantation, and targeted elimination of pathogenic bacteria can reduce the occurrence and recurrence of UC, maintaining a long-term remission period.
Article
Medicine, General & Internal
Xiaochen Zhang, Dai Ishikawa, Kei Nomura, Naoyuki Fukuda, Mayuko Haraikawa, Keiichi Haga, Tomoyoshi Shibuya, Toshihiro Mita, Akihito Nagahara
Summary: Fecal microbiota transplantation is considered a promising treatment for dysbiosis-related diseases. The authors report their experience with donor screening and provide references to improve future donor screening criteria.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Chunlan Huang, Zehua Huang, Ling Ding, Yang Fu, Junjie Fan, Qixiang Mei, Lihong Lou, Jingjing Wang, Nuoming Yin, Yingying Lu, Sanwei Guo, Yue Zeng
Summary: This study compared the efficacy and safety of fecal microbiota transplantation (FMT) with glucocorticoids as induction therapy in ulcerative colitis (UC). The results showed that FMT was as effective as glucocorticoids in inducing remission in active mild to moderate UC, with fewer adverse events. Changes in certain cytokines in the serum might be related to the efficacy of FMT therapy in UC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Ajit Sood, Arshdeep Singh, Ramit Mahajan, Vandana Midha, Kirandeep Kaur, Dharmatma Singh, Namita Bansal, Khushdeep Dharni
Summary: This study analyzed 140 patients with active UC treated with FMT, showing that younger age, disease extent E2, and endoscopic Mayo score 2 significantly predict the achievement of clinical remission in active UC with FMT. The prediction model developed in this study can aid in selecting individuals for FMT, but further validation in larger cohorts is necessary.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Microbiology
Fangyuan Zhu, Yifan Ke, Yiting Luo, Jiaqian Wu, Pei Wu, Fangxiao Ma, Yingchao Liu
Summary: Ulcerative colitis (UC) is a chronic inflammatory bowel disease, and fecal microbiota transplantation (FMT) has been shown to improve UC symptoms. Results of the study indicate that frozen FMT has a better therapeutic effect in treating UC in rat models compared to fresh FMT.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Xiaoxia Liu, Yunhui Zhang, Wanhua Li, Bowei Zhang, Jia Yin, Sijing Liuqi, Jin Wang, Bo Peng, Shuo Wang
Summary: Gut dysbiosis and bile acid metabolism disturbance are involved in the pathogenesis of ulcerative colitis. This study aimed to investigate the effect of fucoidan on BA metabolism and gut microbiota in dextran sulfate sodium-induced colitis mice. Our results showed that fucoidan effectively suppressed colonic inflammation and repaired the gut barrier. In addition, fucoidan increased the relative abundance of certain bacteria families and short-chain fatty acids, while modulating bile acid metabolism. These findings suggest that fucoidan may be a potential functional food for colitis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Infectious Diseases
Zhi Wang, Li Yang, Shan Sun
Summary: This study evaluated the effect of intestinal microbiota transplantation (IMT) on intestinal flora and inflammatory factor levels in patients with ulcerative colitis. The results showed that IMT can improve treatment efficiency, balance intestinal microbiota, relieve symptoms, promote the restoration of intestinal mucosal barrier function, and does not increase adverse effects.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Oncology
Dengshun Lei, Hong Xu, Renqun Peng, Mei Yang, Xinghui Li, Wei Zuo, Juhua Gou, Shuangjiang Yu, Min Huang, Hao Liu
Summary: The study demonstrates that FMT has significant clinical efficacy in the treatment of ulcerative colitis, which may be achieved through improvement of immune function, alleviation of inflammatory response, and promotion of gastrointestinal motility recovery.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
