期刊
JOURNAL OF CONTROLLED RELEASE
卷 318, 期 -, 页码 25-37出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2019.12.007
关键词
Intrauterine adhesion; Hormones; Cell therapy; Tissue membrane; Therapeutic delivery
资金
- National Natural Science Foundation of China [81803443, 81903551]
- Natural Science Foundation of Zhejiang Province [LQ19H300001]
- Wenzhou Science and Technology Bureau [Y20180180, Y20180208, Y20190177, ZY2019007]
- Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Intrauterine adhesions (IUAs) are bands of fibrous tissue that form in the endometrial cavity and associated with the increased risk of abnormal menstruation, recurrent pregnancy loss, secondary infertility, and pregnancy complications. Physical barriers, including intrauterine device and hydrogel, were clinical available to prevent the post-operational IUAs. But physically separation of the injured endometrium relies on the own limited healing power and often ends with recurrence. In recent years, the mechanisms driving IUAs treatment has validated the application of hormones, and further stem cell therapy has also led to the development of novel therapeutic agents with promising efficacy in pre-clinical and initial clinical studies. Still, it is challenging to delivery the therpaeutic factors to the injured uterus. Herein, in this review, we discuss the traditional intervention methods for the prevention of IUAs, as well as novel therapeutics and delivery strategies that will most likely change the treatment paradigms for better clinical outcomes. The combination strategy that using physical barriers as the delivery carriers for therapeutics might provide new alternatives for the prevention of IUAs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据