Article
Biochemistry & Molecular Biology
Ammara Saleem, Huma Khalid, Muhammad Furqan Akhtar, Alam Zeb
Summary: This study evaluated the antioxidant, anti-inflammatory, and anti-arthritic activities of Coronopus didymus. The extracts showed significant free radical scavenging activity and inhibited protein denaturation, as well as reducing inflammation and edema in arthritic rats. The extracts also had positive effects on blood parameters and oxidative stress biomarkers. These activities may be attributed to the presence of quercetin, ferulic acid, dihydromyricetin, apigenin, vitexin, and kaempferol in the extracts.
Article
Biotechnology & Applied Microbiology
Sajeev Kumar Babasahib, Roaddy Well Born, Nulgumnalli Manjunathaiah Raghavendra
Summary: In this study, the authors developed NAP and SULF ethosomes in hydrogel carrier, which showed stable and effective anti-inflammatory effects in vivo. The NAP-SULF ethosomes-hydrogel demonstrated sustained drug release and significant inhibition of inflammation, potentially serving as a novel approach for the treatment of RA.
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Na Wang, Xiaoyun Min, Ning Ma, Zhuoran Zhu, Bo Cao, Yuan Wang, Qing Yong, Jingjin Huang, Ke Li
Summary: In this study, it was found that Triptolide (TP), a compound extracted from Tripterygium wilfordii Hook F, has suppressive effects on human natural killer (NK) cell activity and effector functions. TP treatment downregulates the expression of NK-activating receptors and inhibits IFN-gamma secretion in a dose-dependent manner. Furthermore, TP treatment activates inhibitory signaling and inhibits MAPK signaling in NK cells. These findings provide new insights into the role of TP in NK cell functional suppression and the mechanisms of TP therapeutic treatment in autoimmune disease.
Article
Chemistry, Multidisciplinary
Feng Gao, Ziqi Dai, Tong Zhang, Yuhao Gu, Desheng Cai, Mingjun Lu, Zijie Zhang, Qi Zeng, Bingxian Shang, Bing Xu, Haimin Lei
Summary: In this study, a series of novel sinomenine derivatives were designed and synthesized. Compound 17 exhibited excellent anti-inflammatory and analgesic activities, indicating its potential as a drug.
Article
Immunology
Jian-ting Wen, Jian Liu, Lei Wan, Ling Xin, Jin-chen Guo, Yan-qiu Sun, Xin Wang, Jie Wang
Summary: This study demonstrated that Triptolide (TPL) has therapeutic effects on rheumatoid arthritis (RA) by repressing cell growth and inflammatory response of RA fibroblast-like synoviocytes (RAFLSs). The ceRNA axis of hsa-circ-0003353 (circ0003353), miR-31-5p, and CDK1 is identified as a potential biomarker for RA patients who respond to TPL treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Yury Maritza Zapata Lopera, Enrique Jimenez-Ferrer, Maribel Herrera-Ruiz, Alejandro Zamilpa, Manases Gonzalez-Cortazar, Gabriela Rosas-Salgado, Mayra Alejandra Santillan-Urquiza, Gabriela Trejo-Tapia, Antonio Ruperto Jimenez-Aparicio
Summary: The extract, fractions, and compounds of Bouvardia ternifolia root were evaluated for their antiarthritic activity. Two new compounds with anti-inflammatory activity and NF-kappa B inhibitory activity were isolated and identified. Changes in joint cytokine levels indicated that B. ternifolia modulated the inflammatory response at the joint and kidney levels.
Article
Engineering, Biomedical
Yang Liu, Jianqiu Jin, Hao Xu, Chao Wang, Yanping Yang, Yongjian Zhao, Haihui Han, Tong Hou, Guoliang Yang, Li Zhang, Yongjun Wang, Weian Zhang, Qianqian Liang
Summary: This study presents a novel strategy for delivering Triptolide (TP) at ultralow doses using pH-responsive micelles for the effective treatment of rheumatoid arthritis (RA). The engineered nanomedicine showed promising therapeutic effects with reduced toxicity, suggesting its potential as a safe and effective therapy for RA and other autoimmune diseases.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Kaja Kasarello, Iwona Koehling, Anna Kosowska, Katarzyna Pucia, Anna Lukasik, Agnieszka Cudnoch-Jedrzejewska, Leszek Paczek, Urszula Zielenkiewicz, Piotr Zielenkiewicz
Summary: Cross-kingdom gene expression regulation by xenomiRs, particularly from plants, has been found to have potential scientific significance. In this study, miR172a derived from Brassica oleracea was shown to decrease the levels of FAN protein in human and mouse cells. Furthermore, treatment with miR172a was found to mitigate inflammation in a mouse model of rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xuesong Liu, Ruru Guo, Shicheng Huo, Huan Chen, Qingxiang Song, Gan Jiang, Ye Yu, Jialin Huang, Shaowei Xie, Xiaoling Gao, Liangjing Lu
Summary: This study evaluated the potential of HIF-1 alpha siRNA-loaded CaP-rHDL nanoparticles in the treatment of RA. The nanoparticles showed significant anti-inflammatory effects and reduced joint damage and osteoclastogenesis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Rudaba Saleem, Mujeeb-ur Rehman, Saadat Hussain, Aqsa Arif, Hira Noor Malik, Farwa Naqvi, Almas Jabeen
Summary: In this study, lipidic prodrugs of celecoxib were successfully synthesized and formulated into nanoparticles. These nanoparticles exhibited small size, stability, high encapsulation efficiency, and maintained the anti-inflammatory activity both in vitro and in vivo. Therefore, these nanoscale prodrugs have significant potential for inflammation therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Minseon Kim, Yongae Kim
Summary: Cytokine imbalance leads to inflammation, which is difficult to treat without side effects. Therefore, we aimed to develop a peptide drug with minimal side effects. Previous research identified three peptides with anti-inflammatory activity based on a truncated IK (tIK) protein. This study optimized the process of expressing, isolating, and purifying the peptides using bacterial strains and analyzed their secondary structure using circular dichroism and nuclear magnetic resonance spectroscopy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Wen-jun Pei, Ye-zhen Wu, Yu-shuai Wang, Qi Ding, Xu-liang Guo, Fang-li Ren, Xiu Wang
Summary: This study developed lipid cubic crystal nanoparticles gels of triptolide (TP-LCNPS-GEL) for transdermal delivery in the treatment of rheumatoid arthritis (RA). The results showed that TP-LCNPS-GEL significantly improved the percutaneous permeability and bioavailability of triptolide, while reducing its toxicity, indicating its potential clinical value.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rebecca Sohn, Marius Junker, Andrea Meurer, Frank Zaucke, Rainer H. Straub, Zsuzsa Jenei-Lanzl
Summary: The study showed that synoviocytes of OA and RA patients have the ability to synthesize adenosine/inosine, with adenosine predominantly responsible for the anti-inflammatory effects. Inhibiting CD73 increased IL-6 and decreased IL-10, while inhibiting ADA reduced IL-6 and induced IL-10. A(2A)- and A(2B)AR play a crucial role in mediating anti-inflammatory or pro-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Hong Ki Min, Se Hee Kim, Hae-Rim Kim, Sang-Heon Lee
Summary: Targeting specific pathologic pro-inflammatory cytokines or related molecules with biologic disease-modifying anti-rheumatic drugs (bDMARDs), such as monoclonal antibodies, has shown excellent therapeutic effects in various forms of inflammatory arthritis. These bDMARDs can target different pro-inflammatory cytokines, including tumor necrosis factor-alpha, interleukin (IL)-17A, IL-6, and IL-23/12, and control the inflammatory response by targeting specific cell-surface molecules. The therapeutic efficacy and adverse events of bDMARDs vary among different types of inflammatory arthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Shujing Ren, Heng Liu, Xitong Wang, Jiquan Bi, Shengfeng Lu, Chenqi Zhu, Huizhu Li, Wenliang Kong, Rui Chen, Zhipeng Chen
Summary: The study developed a novel acupoint nanocomposite hydrogel for targeted delivery of anti-inflammatory drugs, which enhanced analgesic effects and reduced systemic toxicity, showing potential therapeutic effects for rheumatoid arthritis.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)