期刊
JOURNAL OF CONTROLLED RELEASE
卷 317, 期 -, 页码 78-95出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2019.11.021
关键词
Drug delivery; Nerve guidance conduits; Biomaterials; Peripheral nerve injury; Neural tissue engineering
资金
- National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health [R01EB020640]
- Connecticut Regenerative Medicine Research Fund [15-RMBUCHC-08]
- National Science Foundation (NSF) Graduate Research Fellowship [DGE-1747453]
Peripheral nerve injuries can be extremely debilitating, resulting in sensory and motor loss-of-function. Endogenous repair is limited to non-severe injuries in which transection of nerves necessitates surgical intervention. Traditional treatment approaches include the use of biological grafts and alternative engineering approaches have made progress. The current article serves as a comprehensive, in-depth perspective on peripheral nerve regeneration, particularly nerve guidance conduits and drug delivery strategies. A detailed background of peripheral nerve injury and repair pathology, and an in-depth look into augmented nerve regeneration, nerve guidance conduits, and drug delivery strategies provide a state-of-the-art perspective on the field.
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