Concept of Pharmacologic Target‐Mediated Drug Disposition in Large‐Molecule and Small‐Molecule Compounds

A Mechanism-Based Population Pharmacokinetics Model of Erythropoietin in Premature Infants and Healthy Adults Following Multiple Intravenous Doses

(2019) Ronilda D'Cunha et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Safety, Pharmacokinetics, and Pharmacodynamics of ASP3662, a Novel 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor, in Healthy Young and Elderly Subjects

(2019) Susan Bellaire et al.   CTS-Clinical and Translational Science

Target-mediated disposition population pharmacokinetics model of erythropoietin in premature neonates following multiple intravenous and subcutaneous dosing regimens

(2019) Ronilda D'Cunha et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Drug-Target Residence Time Affects in Vivo Target Occupancy through Multiple Pathways

(2019) Kin Sing Stephen Lee et al.   ACS Central Science

Importance of target-mediated drug disposition for small molecules

(2018) Dennis A. Smith et al.   DRUG DISCOVERY TODAY

Impact of target interactions on small-molecule drug disposition: an overlooked area

(2018) Robert A. B. van Waterschoot et al.   NATURE REVIEWS DRUG DISCOVERY

General Pharmacokinetic Features of Small-Molecule Compounds Exhibiting Target-Mediated Drug Disposition (TMDD): A Simulation-Based Study

(2018) Thanh Bach et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Small-Molecule Compounds Exhibiting Target-Mediated Drug Disposition (TMDD): A Minireview

(2016) Guohua An   JOURNAL OF CLINICAL PHARMACOLOGY

Small-molecule compounds exhibiting target-mediated drug disposition - A case example of ABT-384

(2015) Guohua An et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Population pharmacokinetics of the 11β-hydroxysteroid dehydrogenase type 1 inhibitor ABT-384 in healthy volunteers following single and multiple dose regimens

(2014) Guohua An et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Dynamics of target-mediated drug disposition: characteristic profiles and parameter identification

(2012) Lambertus A. Peletier et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Mechanism-based population pharmacokinetic modelling in diabetes: vildagliptin as a tight binding inhibitor and substrate of dipeptidyl peptidase IV

(2011) Cornelia B. Landersdorfer et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Pharmacokinetic Analysis of Continuous Erythropoietin Receptor Activator Disposition in Adult Sheep Using a Target-Mediated, Physiologic Recirculation Model and a Tracer Interaction Methodology

(2011) M. H. El-Komy et al.   DRUG METABOLISM AND DISPOSITION

Population Pharmacokinetic and Pharmacodynamic Model-Based Comparability Assessment of a Recombinant Human Epoetin Alfa and the Biosimilar HX575

(2011) Xiaoyu Yan et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Population PK and IgE Pharmacodynamic Analysis of a Fully Human Monoclonal Antibody Against IL4 Receptor

(2011) Tarundeep Kakkar et al.   PHARMACEUTICAL RESEARCH

Population Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Nathanael L. Dirks et al.   CLINICAL PHARMACOKINETICS

Impact of Target-Mediated Drug Disposition on Linagliptin Pharmacokinetics and DPP-4 Inhibition in Type 2 Diabetic Patients

(2010) Silke Retlich et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Binding to dipeptidyl peptidase-4 determines the disposition of linagliptin (BI 1356) - investigations in DPP-4 deficient and wildtype rats

(2009) Silke Retlich et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Selection between Michaelis–Menten and target-mediated drug disposition pharmacokinetic models

(2009) Xiaoyu Yan et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Concentration-dependent plasma protein binding of the novel dipeptidyl peptidase 4 inhibitor BI 1356 due to saturable binding to its target in plasma of mice, rats and humans

(2009) Holger Fuchs et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Approximations of the target-mediated drug disposition model and identifiability of model parameters

(2008) Leonid Gibiansky et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS