期刊
JOURNAL OF CLINICAL ONCOLOGY
卷 38, 期 6, 页码 576-+出版社
AMER SOC CLINICAL ONCOLOGY
DOI: 10.1200/JCO.19.01674
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资金
- Medical Research Council [MR/S000828/1] Funding Source: Medline
- NCATS NIH HHS [UL1 TR001863] Funding Source: Medline
- NCI NIH HHS [P30 CA016672, P30 CA008748, K12 CA133250, K12 CA090625] Funding Source: Medline
- NIDDK NIH HHS [K08 DK114563] Funding Source: Medline
PURPOSE The risk of immune checkpoint inhibitor therapy?related GI adverse events in patients with cancer and inflammatory bowel disease (IBD) has not been well described. We characterized GI adverse events in patients with underlying IBD who received immune checkpoint inhibitors. PATIENTS AND METHODS We performed a multicenter, retrospective study of patients with documented IBD who received immune checkpoint inhibitor therapy between January 2010 and February 2019. Backward selection and multivariate logistic regression were conducted to assess risk of GI adverse events. RESULTS Of the 102 included patients, 17 received therapy targeting cytotoxic T-lymphocyte antigen-4, and 85 received monotherapy targeting programmed cell death 1 or its ligand. Half of the patients had Crohn?s disease, and half had ulcerative colitis. The median time from last active IBD episode to immunotherapy initiation was 5 years (interquartile range, 3-12 years). Forty-three patients were not receiving treatment of IBD. GI adverse events occurred in 42 patients (41%) after a median of 62 days (interquartile range, 33-123 days), a rate higher than that among similar patients without underlying IBD who were treated at centers participating in the study (11%; P < .001). GI events among patients with IBD included grade 3 or 4 diarrhea in 21 patients (21%). Four patients experienced colonic perforation, 2 of whom required surgery. No GI adverse event?related deaths were recorded. Anti?cytotoxic T-lymphocyte antigen-4 therapy was associated with increased risk of GI adverse events on univariable but not multivariable analysis (odds ratio, 3.19; 95% CI, 1.8 to 9.48; P = .037; and odds ratio, 4.72; 95% CI, 0.95 to 23.53; P = .058, respectively). CONCLUSION Preexisting IBD increases the risk of severe GI adverse events in patients treated with immune checkpoint inhibitors.
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