Article
Endocrinology & Metabolism
Linyi Song, Jin Yu, Danying Zhang, Xi Li, Lu Chen, Zailong Cai, Chaoqin Yu
Summary: Excess androgen could damage the mitochondrial ultrastructure and function of ovarian granulosa cells in PCOS model rats by down-regulating the expression of NDUFB8 and ATP5j.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Engineering, Chemical
Seong-Beom Cho
Summary: This study analyzed muscle samples from PCOS patients to identify androgen-responsive genes (ARGs) and found that a broad range of cellular processes is affected by androgen administration. These findings provide valuable information for the identification of ARGs.
Review
Cell Biology
Yi-Ru Tsai, Yen-Nung Liao, Hong-Yo Kang
Summary: Polycystic ovary syndrome (PCOS) is a common gynecological and endocrine disorder that affects the reproductive health of women. This article provides an overview of the latest cellular approaches used to study the pathophysiology of PCOS through in vitro cell models. It discusses abnormalities in folliculogenesis and explores potential treatments and underlying mechanisms, aiming to enhance our understanding of PCOS at a cellular level.
Article
Medicine, General & Internal
Yun S. Kim, Ji H. Lee
Summary: Granulosa cell tumors (GCTs) are rare malignant ovarian tumors that should be differentiated from other benign ovarian tumors. This case highlights the importance of considering GCTs in female patients with PCOS and amenorrhea.
Article
Immunology
Qi Xie, Wenli Hong, Yuan Li, Shuyi Ling, Ziqiong Zhou, Yuqing Dai, Wenbo Wu, Ruoxin Weng, Zhisheng Zhong, Jun Tan, Yuehui Zheng
Summary: Polycystic Ovary Syndrome (PCOS) is a common reproductive endocrine disorder that can cause infertility. This study investigated the impact of inflammation and oxidative stress on granulosa cells (GCs) in PCOS patients and found that chitosan oligosaccharide (COS) can improve GC function by reducing inflammation and oxidative stress.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Yanli Yang, Wenshuai Xu, Ruo-Lan Xiang, Xinlun Tian, Kai-Feng Xu
Summary: Autoimmune pulmonary alveolar proteinosis (APAP) is a rare lung disease. Long noncoding RNAs (lncRNAs) play a role in the pathogenesis of APAP. Differentially expressed lncRNAs and mRNAs were identified in APAP patient samples, providing insights for future functional research.
Article
Endocrinology & Metabolism
Qi Jiang, Ye Pan, Ping Li, Yanjun Zheng, Yuehong Bian, Wenqi Wang, Guihua Wu, Tian Song, Yuhua Shi
Summary: This study revealed higher expression of ANGPTL4 in ovarian granulosa cells of PCOS patients. Its association with glucose and lipid metabolism suggests that ANGPTL4 may play an important role in the metabolism and pathogenesis of PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Sihui Li, Shizhen Shen, Wanzhong Ge, Yixuan Cen, Songfa Zhang, Xiaodong Cheng, Xinyu Wang, Xing Xie, Weiguo Lu
Summary: This study found that the long non-coding RNA SLC25A21-AS1 is downregulated in ovarian cancer tissues compared to normal ovarian tissues. Upregulation of SLC25A21-AS1 significantly inhibits the proliferation and metastasis of EOC cells, while downregulation has the opposite effect. SLC25A21-AS1 functions by promoting the degradation of PTBP3 protein stability, thereby suppressing EOC cell proliferation and metastasis. This research reveals the impact of SLC25A21-AS1 on EOC development and suggests it as a prognostic target to improve patient survival by promoting PTBP3 degradation.
BIOMARKER RESEARCH
(2023)
Article
Medicine, Research & Experimental
Xiaohong Chen, Hongliang Tang, Yingye Liang, Pingting Wu, Liuhong Xie, Yao Ding, Peng Yang, Bingcai Long, Jing Lin
Summary: Acupuncture can improve ovulation dysfunction and abnormal follicular development in patients with polycystic ovary syndrome by down-regulating LncMEG3 expression, inhibiting the PI3K/AKT/mTOR pathway, reducing granulosa cell autophagy, and ultimately normalizing their proliferation, suggesting its clinical potential as a safe treatment for PCOS ovulatory dysfunction.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Reza Salehi, Meshach Asare-Werehene, Brandon A. Wyse, Atefeh Abedini, Bo Pan, Alex Gutsol, Sahar Jahangiri, Peter Szaraz, Kevin D. Burns, Barbara Vanderhyden, Julang Li, Dylan Burger, Clifford L. Librach, Benjamin K. Tsang
Summary: Polycystic ovarian syndrome (PCOS) is associated with increased levels of androgen and arrested follicle growth. Previous studies have shown that androgen-induced release of miR-379-5p from follicle granulosa cells promotes cell proliferation through PDK1 upregulation. Androgen also affects macrophage polarization and increases the inflammatory M1 phenotype in rat follicles. However, the role of small extracellular vesicles (exosomes) in mediating the effects of miRNAs on receiving cells is not well understood. This study aimed to investigate the regulatory role of exosomal miR-379 from granulosa cells on macrophage polarization and ovarian inflammation, and its impact on granulosa cell proliferation in a stage-specific manner.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Buze Chen, Xiaoyuan Lu, Qingmei Zhou, Qing Chen, Siyan Zhu, Guilin Li, Hui Liu
Summary: It was found that the long non-coding RNA PAXIP1-AS1 promoted various functions in ovarian cancer cells, while its relationship with clinical characteristics, prognosis, and immune infiltration in OC patients and its regulatory network were unclear. Through various tests and analyses, it was discovered that low PAXIP1-AS1 expression was associated with poor survival and immune infiltration in OC patients. The study suggested that PAXIP1-AS1 could potentially serve as a biomarker for prognosis and response to immunotherapy in OC.
Article
Biochemistry & Molecular Biology
Ricardo Noriega-Rivera, Mariela Rivera-Serrano, Robert J. Rabelo-Fernandez, Josue Perez-Santiago, Fatima Valiyeva, Pablo E. Vivas-Mejia
Summary: In this study, it was found that the long noncoding RNA CASC10 is upregulated in cisplatin-resistant ovarian cancer cells and patients. Knockdown of CASC10 reduces cell proliferation and invasion, and increases sensitivity to cisplatin treatment. Moreover, liposomal CASC10-siRNA can inhibit tumor growth and metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Yi-bo He, Lu-wei Fang, Dan Hu, Shi-liang Chen, Si-yu Shen, Kai-li Chen, Jie Mu, Jun-yu Li, Hongpan Zhang, Liu Yong-lin, Li Zhang
Summary: In this study, necroptosis-associated lncRNAs were identified as reliable prognostic predictors in ovarian cancer. The risk model established can predict patient prognosis and provide treatment strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yong Wu, Qinhao Guo, Xingzhu Ju, Zhixiang Hu, Lingfang Xia, Yu Deng, Ping Zhao, Meng Zhang, Yang Shao, Shenglin Huang, Xianghuo He, Hao Wen, Xiaohua Wu
Summary: This study identified an oncogenic lincRNA, LINC00662, in ovarian cancer, which is associated with malignant features and serves as a prognostic indicator. LINC00662 promotes OC cell proliferation and metastasis through interaction with GRP78 and activation of the p38 MAPK signaling pathway.
Article
Endocrinology & Metabolism
Xiao-lin Jiang, He Tai, Xuan-si Xiao, Shi-yu Zhang, Shi-chao Cui, Shu-bo Qi, Dan-dan Hu, Li-na Zhang, Jin-song Kuang, Xian-sheng Meng, Shun-min Li
Summary: This study found that CFDT can alleviate pathological damage and apoptosis in PCOS rat model. In addition, CFDT can improve ovarian function, reduce inflammatory response, inhibit apoptosis of granular cells, and inhibit the operation of ASK1/JNK pathway in PCOS rats.
FRONTIERS IN ENDOCRINOLOGY
(2022)