α-Tubulin detyrosination impairs mitotic error correction by suppressing MCAK centromeric activity

Coherent-hybrid STED: high contrast sub-diffraction imaging using a bi-vortex depletion beam

(2019) António Pereira et al.   OPTICS EXPRESS

Molecular basis of vasohibins-mediated detyrosination and its impact on spindle function and mitosis

(2019) Shanhui Liao et al.   CELL RESEARCH

Defective tubulin detyrosination causes structural brain abnormalities with cognitive deficiency in humans and mice

(2019) Alistair T Pagnamenta et al.   HUMAN MOLECULAR GENETICS

Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure

(2018) Christina Yingxian Chen et al.   NATURE MEDICINE

The Multifaceted Role of Chromosomal Instability in Cancer and Its Microenvironment

(2018) Samuel F. Bakhoum et al.   CELL

The Tubulin Detyrosination Cycle: Function and Enzymes

(2018) Joppe Nieuwenhuis et al.   TRENDS IN CELL BIOLOGY

Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation

(2017) Chrystelle Aillaud et al.   SCIENCE

Vasohibins: new transglutaminase-like cysteine proteases possessing a non-canonical Cys-His-Ser catalytic triad

(2016) Luis Sanchez-Pulido et al.   BIOINFORMATICS

Detyrosinated microtubules buckle and bear load in contracting cardiomyocytes

(2016) P. Robison et al.   SCIENCE

Adaptive Resistance to an Inhibitor of Chromosomal Instability in Human Cancer Cells

(2016) Bernardo Orr et al.   Cell Reports

Microtubule detyrosination guides chromosomes during mitosis

(2015) M. Barisic et al.   SCIENCE

Detyrosinated microtubules modulate mechanotransduction in heart and skeletal muscle

(2015) Jaclyn P. Kerr et al.   Nature Communications

Regulation of microtubule motors by tubulin isotypes and post-translational modifications

(2014) Minhajuddin Sirajuddin et al.   NATURE CELL BIOLOGY

Structural basis of tubulin tyrosination by tubulin tyrosine ligase

(2013) Andrea E. Prota et al.   JOURNAL OF CELL BIOLOGY

Cyclin A regulates kinetochore microtubules to promote faithful chromosome segregation

(2013) Lilian Kabeche et al.   NATURE

MCAK activity at microtubule tips regulates spindle microtubule length to promote robust kinetochore attachment

(2012) Sarah B. Domnitz et al.   JOURNAL OF CELL BIOLOGY

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Exotic mitotic mechanisms

(2012) H. Drechsler et al.   Open Biology

Mitotic Centromere-associated Kinesin (MCAK) Mediates Paclitaxel Resistance

(2011) Anutosh Ganguly et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Timing of centrosome separation is important for accurate chromosome segregation

(2011) William T. Silkworth et al.   MOLECULAR BIOLOGY OF THE CELL

Overexpression of Mitotic Centromere-Associated Kinesin Stimulates Microtubule Detachment and Confers Resistance to Paclitaxel

(2011) A. Ganguly et al.   MOLECULAR CANCER THERAPEUTICS

Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin

(2011) Agnieszka Szyk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle

(2010) A. A. Guerrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Motor-dependent microtubule disassembly driven by tubulin tyrosination

(2009) Leticia Peris et al.   JOURNAL OF CELL BIOLOGY

MCAK and Paclitaxel Have Differential Effects on Spindle Microtubule Organization and Dynamics

(2009) Rania S. Rizk et al.   MOLECULAR BIOLOGY OF THE CELL

Sensing Chromosome Bi-Orientation by Spatial Separation of Aurora B Kinase from Kinetochore Substrates

(2009) D. Liu et al.   SCIENCE

Genome stability is ensured by temporal control of kinetochore–microtubule dynamics

(2008) Samuel F. Bakhoum et al.   NATURE CELL BIOLOGY