期刊
JOURNAL OF BASIC MICROBIOLOGY
卷 60, 期 3, 页码 207-215出版社
WILEY
DOI: 10.1002/jobm.201900537
关键词
AiiA-AgNPs; biofilm; cytotoxicity; Helicobacter pylori; quorum sensing
类别
资金
- start-up project funding Sri Balaji Vidyapeeth University
The treatment of Helicobacter pylori usually fails due to their ability to form biofilms and resistance to antibiotics. This might potentially lead to gastric carcinoma and mucosa-associated lymphoid tissue lymphoma. In the present study, we elucidate the potential role of N-acylhomoserine lactonase stabilized silver nanoparticles (AiiA-AgNPs) in treating biofilms produced by H. pylori. AiiA-AgNPs inhibited quorum sensing (QS) by degradation of QS molecules, thereby reducing biofilm formation, urease production, and altering cell surface hydrophobicity of H. pylori. AiiA-AgNPs showed no cytotoxic effects on RAW 264.7 macrophages at the effective concentration (1-5 mu M) of antibiofilm activity. In addition, AiiA-AgNP in high concentration (80-100 mu M) exhibited cytotoxicity against HCT-15 carcinoma cells, depicting its therapeutic role in treating cancer.
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