Metastatic disease from uveal melanoma: treatment options and future prospects

A phase III random assignment trial comparing percutaneous hepatic perfusion with melphalan (PHP-mel) to standard of care for patients with hepatic metastases from metastatic ocular or cutaneous melanoma.

(2017) J. F. Pingpank et al.   JOURNAL OF CLINICAL ONCOLOGY

Study design and rationale for a randomised, placebo-controlled, double-blind study to assess the efficacy of selumetinib (AZD6244; ARRY-142886) in combination with dacarbazine in patients with metastatic uveal melanoma (SUMIT)

(2015) Richard D. Carvajal et al.   BMC CANCER

Abstract 4262: PRAME as a biomarker for a new molecular subclass of uveal melanoma

(2015) Matthew G. Field et al.   CANCER RESEARCH

Nivolumab versus chemotherapy in patients with advanced melanoma who progressed after anti-CTLA-4 treatment (CheckMate 037): a randomised, controlled, open-label, phase 3 trial

(2015) Jeffrey S Weber et al.   LANCET ONCOLOGY

The Mayo Clinic experience with the use of kinase inhibitors, ipilimumab, bevacizumab, and local therapies in the treatment of metastatic uveal melanoma

(2015) Justin C. Moser et al.   MELANOMA RESEARCH

A phase 2 study of tremelimumab in patients with advanced uveal melanoma

(2015) Anthony M. Joshua et al.   MELANOMA RESEARCH

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Management of Posterior Uveal Melanoma: Past, Present, and Future

(2015) Jerry A. Shields et al.   OPHTHALMOLOGY

Phase II DeCOG-Study of Ipilimumab in Pretreated and Treatment-Naïve Patients with Metastatic Uveal Melanoma

(2015) Lisa Zimmer et al.   PLoS One

Hepatic intra-arterial versus intravenous fotemustine in patients with liver metastases from uveal melanoma (EORTC 18021): a multicentric randomized trial

(2014) S. Leyvraz et al.   ANNALS OF ONCOLOGY

Dabrafenib Therapy for Advanced Melanoma

(2014) Van Anh Trinh et al.   ANNALS OF PHARMACOTHERAPY

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Effect of Selumetinib vs Chemotherapy on Progression-Free Survival in Uveal Melanoma

(2014) Richard D. Carvajal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial

(2014) Caroline Robert et al.   LANCET

Clinical application of adoptive T cell therapy in solid tumors

(2014) Zong-You Chen   MEDICAL SCIENCE MONITOR

Single Nucleotide Polymorphism Array Analysis of Uveal Melanomas Reveals That Amplification of CNKSR3 Is Correlated With Improved Patient Survival

(2013) Sarah L. Lake et al.   AMERICAN JOURNAL OF PATHOLOGY

Efficacy and safety of ipilimumab in patients with pre-treated, uveal melanoma

(2013) M. Maio et al.   ANNALS OF ONCOLOGY

Isolated Hepatic Perfusion for Ocular Melanoma Metastasis: Registry Data Suggests a Survival Benefit

(2013) R. Olofsson et al.   ANNALS OF SURGICAL ONCOLOGY

Genome-wide profiling is a clinically relevant and affordable prognostic test in posterior uveal melanoma

(2013) Nathalie Cassoux et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Metastatic melanoma to the liver: A contemporary and comprehensive review of surgical, systemic, and regional therapeutic options

(2013) Sanjiv S. Agarwala et al.   CANCER

Clinical activity of ipilimumab for metastatic uveal melanoma

(2013) Jason J. Luke et al.   CANCER

KRASMutation: Should We Test for It, and Does It Matter?

(2013) Patrick J. Roberts et al.   JOURNAL OF CLINICAL ONCOLOGY

Treatment of metastatic uveal melanoma with intravenous fotemustine

(2013) Francesco Spagnolo et al.   MELANOMA RESEARCH

Inhibition of Mutant GNAQ Signaling in Uveal Melanoma Induces AMPK-Dependent Autophagic Cell Death

(2013) G. Ambrosini et al.   MOLECULAR CANCER THERAPEUTICS

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3

(2013) Marcel Martin et al.   NATURE GENETICS

Recurrent mutations at codon 625 of the splicing factor SF3B1 in uveal melanoma

(2013) J William Harbour et al.   NATURE GENETICS

Combined PKC and MEK inhibition in uveal melanoma with GNAQ and GNA11 mutations

(2013) X Chen et al.   ONCOGENE

SF3B1 Mutations Are Associated with Alternative Splicing in Uveal Melanoma

(2013) S. J. Furney et al.   Cancer Discovery

Association of Ocular and Oculodermal Melanocytosis With the Rate of Uveal Melanoma Metastasis

(2013) Carol L. Shields et al.   JAMA Ophthalmology

Prognostic significance of chromosome 3 alterations determined by microsatellite analysis in uveal melanoma: a long-term follow-up study

(2012) S Thomas et al.   BRITISH JOURNAL OF CANCER

MRI in the detection of hepatic metastases from high-risk uveal melanoma: a prospective study in 188 patients

(2012) Ernie Marshall et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Radioembolization as Locoregional Therapy of Hepatic Metastases in Uveal Melanoma Patients

(2012) A. Klingenstein et al.   CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY

Identification of Unique MEK-Dependent Genes in GNAQ Mutant Uveal Melanoma Involved in Cell Growth, Tumor Cell Invasion, and MEK Resistance

(2012) G. Ambrosini et al.   CLINICAL CANCER RESEARCH

Progress in the management of patients with uveal melanoma. The 2012 Ashton Lecture

(2012) B Damato   EYE

Activity of the oral MEK inhibitor trametinib in patients with advanced melanoma: a phase 1 dose-escalation trial

(2012) Gerald S Falchook et al.   LANCET ONCOLOGY

Safety, pharmacokinetic, pharmacodynamic, and efficacy data for the oral MEK inhibitor trametinib: a phase 1 dose-escalation trial

(2012) Jeffrey R Infante et al.   LANCET ONCOLOGY

Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF- B Pathways

(2012) X. Wu et al.   MOLECULAR CANCER THERAPEUTICS

Detection and Time to Treatment of Uveal Melanoma in the United Kingdom: An Evaluation of 2384 Patients

(2012) Erika M. Damato et al.   OPHTHALMOLOGY

Collaborative Ocular Oncology Group Report Number 1: Prospective Validation of a Multi-Gene Prognostic Assay in Uveal Melanoma

(2012) Michael D. Onken et al.   OPHTHALMOLOGY

The genetics of uveal melanoma: an emerging framework for targeted therapy

(2012) J. William Harbour   Pigment Cell & Melanoma Research

Histone Deacetylase Inhibitors Induce Growth Arrest and Differentiation in Uveal Melanoma

(2011) S. Landreville et al.   CLINICAL CANCER RESEARCH

Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers

(2011) M. H. Abdel-Rahman et al.   JOURNAL OF MEDICAL GENETICS

Cabozantinib (XL184), a Novel MET and VEGFR2 Inhibitor, Simultaneously Suppresses Metastasis, Angiogenesis, and Tumor Growth

(2011) F. M. Yakes et al.   MOLECULAR CANCER THERAPEUTICS

Uveal Melanoma: Trends in Incidence, Treatment, and Survival

(2011) Arun D. Singh et al.   OPHTHALMOLOGY

A Melanoma Molecular Disease Model

(2011) Smruti J. Vidwans et al.   PLoS One

Pharmacokinetics and pharmacodynamics of AZD6244 (ARRY-142886) in tumor-bearing nude mice

(2010) Cathrine L. Denton et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Genotypic Profiling of 452 Choroidal Melanomas with Multiplex Ligation-Dependent Probe Amplification

(2010) B. Damato et al.   CLINICAL CANCER RESEARCH

The First-in-Human Study of the Hydrogen Sulfate (Hyd-Sulfate) Capsule of the MEK1/2 Inhibitor AZD6244 (ARRY-142886): A Phase I Open-Label Multicenter Trial in Patients with Advanced Cancer

(2010) U. Banerji et al.   CLINICAL CANCER RESEARCH

Mutations inGNA11in Uveal Melanoma

(2010) Catherine D. Van Raamsdonk et al.   NEW ENGLAND JOURNAL OF MEDICINE

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

Locoregional Management of Hepatic Metastasis From Primary Uveal Melanoma

(2010) Takami Sato   SEMINARS IN ONCOLOGY

Effectiveness of Treatments for Metastatic Uveal Melanoma

(2009) James J. Augsburger et al.   AMERICAN JOURNAL OF OPHTHALMOLOGY

Liver Resection for Metastatic Melanoma with Postoperative Tumor-Infiltrating Lymphocyte Therapy

(2009) R. Taylor Ripley et al.   ANNALS OF SURGICAL ONCOLOGY

Metastasis of Uveal Melanoma Millimeter-by-Millimeter in 8033 Consecutive Eyes

(2009) Carol L. Shields   ARCHIVES OF OPHTHALMOLOGY

Targeted therapy for uveal melanoma

(2008) Pierre L. Triozzi et al.   CANCER TREATMENT REVIEWS

Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

(2008) Catherine D. Van Raamsdonk et al.   NATURE

Hepatic Arterial Chemoembolization for Management of Metastatic Melanoma

(2007) Karun V. Sharma et al.   AMERICAN JOURNAL OF ROENTGENOLOGY