Article
Clinical Neurology
Albert Puig-Pijoan, Joan Jimenez-Balado, Aida Fernandez-Lebrero, Greta Garcia-Escobar, Irene Navalpotro-Gomez, Jose Contador, Rosa-Maria Manero-Borras, Victor Puente-Periz, Antoni Suarez, Francisco J. Munoz, Oriol Grau-Rivera, Marc Suarez-Calvet, Rafael de la Torre, Jaume Roquer, Angel Ois
Summary: This study explored the association between blood-brain-barrier permeability (BBBp) and cognitive decline progression. The results suggested that increased BBBp may contribute to clinical worsening in individuals with cognitive decline, indicating potential targeted therapies.
ALZHEIMERS & DEMENTIA
(2023)
Review
Peripheral Vascular Disease
Nur Fazidah Asmuje, Sumaiyah Mat, Phyo Kyaw Myint, Maw Pin Tan
Summary: This scoping review identified and summarized articles that evaluated the relationship between blood pressure variability (BPV) and cognitive function. The review found conflicting findings on the relationship between BPV and cognition, as well as variations in the methods and devices used to measure BPV. There is a need for standardization in BPV assessments to streamline research in this area and determine if BPV could be a potential modifiable risk factor for cognitive decline.
CURRENT HYPERTENSION REPORTS
(2022)
Article
Peripheral Vascular Disease
Chao Jiang, Sitong Li, Yufeng Wang, Yiwei Lai, Yu Bai, Manlin Zhao, Liu He, Yu Kong, Xueyuan Guo, Songnan Li, Nian Liu, Chenxi Jiang, Ribo Tang, Caihua Sang, Deyong Long, Xin Du, Jianzeng Dong, Craig S. Anderson, Changsheng Ma
Summary: This study investigated the potential benefits or harms of intensive systolic blood pressure control on cognitive function and cerebral blood flow in individuals with low diastolic blood pressure. The results showed that participants in the intensive group had a lower incidence rate of probable dementia or mild cognitive impairment compared to those in the standard group, regardless of baseline diastolic blood pressure quartiles. This suggests that intensive blood pressure control does not have a detrimental effect on cognitive outcomes and cerebral perfusion in patients with low baseline diastolic blood pressure.
Article
Peripheral Vascular Disease
Justine E. Moonen, Behnam Sabayan, Sigurdur Sigurdsson, Mark A. van Buchem, Vilmundur Gudnason, Osorio Meirelles, Lenore J. Launer
Summary: Late-life diastolic blood pressure was negatively associated with cerebral blood flow, while late-life systolic blood pressure and pulse pressure were positively associated. Higher cerebral blood flow was related to better cognitive performance and lower risk of mild cognitive impairment or dementia.
Article
Cardiac & Cardiovascular Systems
Michael E. Ernst, Joanne Ryan, Enayet K. Chowdhury, Karen L. Margolis, Lawrence J. Beilin, Christopher M. Reid, Mark R. Nelson, Robyn L. Woods, Raj C. Shah, Suzanne G. Orchard, Rory Wolfe, Elsdon Storey, Andrew M. Tonkin, Amy Brodtmann, John J. McNeil, Anne M. Murray
Summary: This study found that high blood pressure variability in older adults, especially in men, is associated with increased risks of dementia and cognitive decline.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Clinical Neurology
Audrey Low, Maria A. Prats-Sedano, James D. Stefaniak, Elizabeth Frances McKiernan, Stephen F. Carter, Maria-Eleni Douvani, Elijah Mak, Li Su, Olivia Stupart, Graciela Muniz, Karen Ritchie, Craig W. Ritchie, Hugh S. Markus, John Tiernan O'Brien
Summary: Markers of cerebrovascular disease are common in midlife adults, but their clinical relevance in predicting future dementia remains unclear. This study found that the Cardiovascular Risk Factors, Ageing and Dementia (CAIDE) risk score is associated with markers of cerebral small vessel disease (SVD) and predicts the progression of SVD in midlife adults. The study also highlighted the potential of the CAIDE score as a prognostic and predictive marker for managing modifiable risk factors in cerebrovascular disease.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Peripheral Vascular Disease
Kazuomi Kario
Summary: Home blood pressure monitoring (HBPM) is a reliable and cost-effective alternative to ambulatory blood pressure monitoring (ABPM) for hypertension diagnosis and management. It has become more widely recognized and recommended by guidelines in recent years. HBPM provides valuable data for predicting cardiovascular events and optimizing blood pressure control in hypertensive patients.
AMERICAN JOURNAL OF HYPERTENSION
(2021)
Article
Health Policy & Services
Jason M. Lazar, Alexandra Posner, Kamal Akbar, Gulzhan Tologonova, Thomas Monaghan, Christopher Murray, Jeffrey Weiss, Karel Everaert, Tine DeBacker, Elizabeth Helzner, Rose Calixte, Rasheda Browne, Sarah Goldman, Louis Salciccioli
Summary: Nocturia is often associated with various non-urological conditions. Home blood pressure monitoring has shown that higher systolic blood pressure is related to increased nocturia frequency. However, there is no significant correlation between nocturia frequency and diastolic blood pressure, blood pressure variability, or arterial stiffness.
JOURNAL OF COMMUNITY HEALTH
(2023)
Article
Peripheral Vascular Disease
Nadia Boubouchairopoulou, Angeliki Ntineri, Anastasios Kollias, Antonios Destounis, George S. Stergiou
Summary: This study compared blood pressure variability (BPV) among different measurement methods and found that out-of-office BPV was higher than office BPV, with ambulatory BP monitoring giving the highest values. There was weak association among BPV indices assessed using different methods, but stronger agreement between out-of-office BPV indices in identifying individuals with high BPV. Older age was independently associated with increased office BPV, while older age, female sex, smoking, and overweight/obesity were determinants of increased out-of-office BPV. The study suggests that choosing the BPV index may be less important compared to the method of measurement, and office and out-of-office BP measurements can complement each other in assessing BPV.
HYPERTENSION RESEARCH
(2021)
Article
Clinical Neurology
Yuan Ma, Junhong Zhou, Maryam Kavousi, Lewis A. Lipsitz, Francesco Mattace-Raso, Berend E. Westerhof, Frank J. Wolters, Julia W. Wu, Brad Manor, M. Kamran Ikram, Jaap Goudsmit, Albert Hofman, M. Arfan Ikram
Summary: The study suggests that lower complexity and higher variability of beat-to-beat SBP are potential novel risk factors or biomarkers for dementia.
ALZHEIMERS & DEMENTIA
(2021)
Article
Cardiac & Cardiovascular Systems
Hang Guo, Yi Tan, Zhizheng Yao, Zilu Zhang, Jiafu Yan, Xiaofeng Meng
Summary: High blood pressure variability and hypertension are risk factors for mild cognitive impairment and probable dementia. This study found that higher systolic blood pressure variability and pulse pressure variability were associated with an increased risk of probable dementia in the intensive group, while higher systolic blood pressure variability was associated with an increased risk of mild cognitive impairment in the intensive group. These findings emphasize the importance of monitoring blood pressure variability in intensive blood pressure treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Peripheral Vascular Disease
Eline H. Groenland, Jean-Paul A. C. Vendeville, Remy H. H. Bemelmans, Houshang Monajemi, Michiel L. Bots, Frank L. J. Visseren, Wilko Spiering
Summary: This study evaluated the agreement between app-assisted home blood pressure monitoring and 24-hour ambulatory blood pressure monitoring, and found significant disagreement between the two methods. App-assisted home blood pressure monitoring had high sensitivity in diagnosing sustained and masked hypertension, and can be used as a complement to 24-hour ambulatory blood pressure monitoring.
Article
Peripheral Vascular Disease
Pingping Jia, Helen W. Y. Lee, Joyce Y. C. Chan, Karen K. L. Yiu, Kelvin K. F. Tsoi
Summary: The study reveals that blood pressure variability is an independent predictor for cognitive impairment and dementia, with a linear relationship between long-term blood pressure variability and the risk of cognitive decline.
Article
Cardiac & Cardiovascular Systems
Fosca Quarti-Trevano, Raffaella Dell ' Oro, Jennifer Vanoli, Michele Bombelli, Rita Facchetti, Giuseppe Mancia, Guido Grassi
Summary: This study found that there is no significant association between chronic coffee consumption and blood pressure changes, particularly when assessed through 24-hour ambulatory and home blood pressure monitoring. However, consuming coffee during the day can cause a slight increase in blood pressure, which disappears at night.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Clinical Neurology
Esmee Verburgt, Esther Janssen, Mina Jacob, Mengfei Cai, Annemieke Ter Telgte, Kim Wiegertjes, Roy P. C. Kessels, David G. Norris, Jose Marques, Marco Duering, Anil M. Tuladhar, Frank-Erik De Leeuw
Summary: Small hyperintense lesions on diffusion-weighted imaging (DWI) in patients with sporadic small vessel disease (SVD) are found to be associated with the radiological progression of SVD and cognitive decline.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Ralf W. J. Weijs, Daria A. Shkredova, Anna C. M. Brekelmans, Dick H. J. Thijssen, Jurgen A. H. R. Claassen
Summary: This study systematically reviewed and meta-analyzed longitudinal studies to examine the relationship between global cerebral blood flow (CBF) changes and cognitive decline in subjects with Alzheimer's disease. Although cross-sectional studies found lower CBF in patients with cognitive decline, longitudinal studies did not support this association. However, the small sample sizes of these studies may have limited their power to detect small effect sizes, and larger studies are needed to further investigate this issue.
ALZHEIMERS & DEMENTIA
(2023)
Article
Public, Environmental & Occupational Health
Suzanne M. Cosh, Ronette Pinto, Linley Denson, Phillip J. Tully
Summary: Over 20% of cardiovascular disease patients with comorbid mental health disorders are at a higher risk of recurring major adverse cardiac events and mortality. Patients with depression or anxiety disorders are twice as likely to be non-adherent to secondary prevention. This study aims to explore the perceptions, understandings, and experiences of adherence to secondary prevention among cardiac patients with diagnosed depression and/or anxiety disorder. Result highlight unique barriers and limited patient understandings of adherence, which may impact engagement with secondary prevention.
PSYCHOLOGY HEALTH & MEDICINE
(2023)
Review
Endocrinology & Metabolism
Ronney B. Panerai, Patrice Brassard, Joel S. Burma, Pedro Castro, Jurgen A. H. R. Claassen, Johannes J. van Lieshout, Jia Liu, Samuel Je Lucas, Jatinder S. Minhas, Georgios D. Mitsis, Ricardo C. Nogueira, Shigehiko Ogoh, Stephen J. Payne, Caroline A. Rickards, Andrew D. Robertson, Gabriel D. Rodrigues, Jonathan D. Smirl, David M. Simpson
Summary: This study improved the evaluation method of cerebral autoregulation (CA) by introducing guidelines for data acquisition, analysis, and reporting, and proposed new recommendations to reflect recent advances in the field. The implementation of these recommendations is crucial for improving the reliability and reproducibility of studies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Neurosciences
Gemma Sole-Guardia, Emma Custers, Arthur de Lange, Elyne Clijncke, Bram Geenen, Jose Gutierrez, Benno Kusters, Jurgen A. H. R. Claassen, Frank-Erik De Leeuw, Maximilian Wiesmann, Amanda J. Kiliaan
Summary: Cerebral small vessel disease (SVD), including white matter hyperintensities (WMH), is the major vascular cause of dementia. Chronic hypertension and neuroinflammation are recognized as important risk factors for SVD and the conversion of normal-appearing white matter (NAWM) to WMH. This study investigated the impact of hypertension on perivascular- and neuroinflammation in WMH and NAWM using high field brain magnetic resonance imaging (MRI) and (immuno-)histopathological staining. The findings suggest that neurovascular inflammation plays a critical role in the etiology of WMH, and future therapeutic strategies targeting hypertension and neuroinflammation may ameliorate WMH progression.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Article
Psychiatry
Mina A. Jacob, Mengfei Cai, Vera van de Donk, Mayra Bergkamp, Jose Marques, David G. Norris, Roy P. C. Kessels, Jurgen A. H. R. Claassen, Marco Duering, Anil M. Tuladhar, Frank-Erik de Leeuw
Summary: The study investigated the relationship between baseline severity and progression of cerebral small vessel disease (SVD) on MRI markers and incident dementia over a 14-year follow-up period. The results showed that both baseline SVD severity and SVD progression were independently associated with an increased risk of all-cause dementia. Slowing SVD progression may delay the onset of dementia.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Review
Cardiac & Cardiovascular Systems
Juan Mundisugih, Kyle B. Franke, Phillip J. Tully, Dian A. Munawar, Saurabh Kumar, Rajiv Mahajan
Summary: Atrial fibrillation (AF) is associated with different subtypes of heart failure (HF), with intermediate prevalence in HF with mildly reduced Ejection Fraction (HFmrEF) compared to HF with preserved Ejection Fraction (HFpEF) and HF with reduced Ejection Fraction (HFrEF). The coexistence of AF and HF predicts increased all-cause mortality across all HF categories.
HEART LUNG AND CIRCULATION
(2023)
Editorial Material
Endocrinology & Metabolism
Rachel A. M. Heutz, Ralf W. J. Weijs, Rianne A. A. de Heus, Jurgen A. H. R. Claassen
Summary: We discussed the current evidence of antihypertensive treatment in people with dementia, exploring both the potential benefits and harms. Our conclusion is that there is insufficient evidence to support the claim of an increased risk of cerebral hypoperfusion with antihypertensive treatment in dementia, and there is growing evidence contradicting this claim.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Psychology
Inge Scheper, Inti A. Brazil, Jurgen A. H. R. Claassen, Dirk Bertens, Sofie Geurts, Roy P. C. Kessels
Summary: Alzheimer's disease leads to a decline in memory and learning ability. This study investigated the impact of positive and negative feedback on memory performance and behavior adjustment in early-stage AD patients. Results showed that errorless learning had a beneficial effect on memory performance, but this effect was not significantly different between AD patients and healthy controls. No group differences were found in the probabilistic learning task. Errors during learning may interfere with storage or retrieval of object locations for AD patients.
JOURNAL OF NEUROPSYCHOLOGY
(2023)
Article
Geriatrics & Gerontology
Ralf W. J. Weijs, Madelijn H. Oudegeest-Sander, Janneke I. A. Vloet, Maria T. E. Hopman, Jurgen A. H. R. Claassen, Dick H. J. Thijssen
Summary: Research suggests that changes in cerebrovascular health, specifically reductions in cerebral blood flow and increases in cerebrovascular resistance, are associated with early subjective cognitive decline. However, a decade of aging does not lead to deterioration in cerebral blood flow or autoregulation.
Article
Cardiac & Cardiovascular Systems
Ralf W. J. Weijs, Selma C. Tromp, Robin H. Heijmen, Antje A. Seeber, Nicole J. C. W. van Belle-van Haaren, Jurgen A. H. R. Claassen, Dick H. J. Thijssen
Summary: This study aimed to investigate the relationship between perioperative changes in cerebral blood flow and postoperative neurological deficits in patients undergoing aortic arch surgery with antegrade selective cerebral perfusion. The study found that lower blood velocity during ASCP was significantly related to postoperative neurological deficits.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Correction
Geriatrics & Gerontology
Marjolein Klop, Rianne A. A. de Heus, Andrea B. Maier, Anne van Alphen, Marianne J. Floor-Westerdijk, Mathijs Bronkhorst, Rene J. F. Melis, Carel G. M. Meskers, Jurgen A. H. R. Claassen, Richard J. A. van Wezel
Article
Geriatrics & Gerontology
Liping Wang, Anouschka C. C. Pronk, Eveline P. P. van Poelgeest, Robert Briggs, Jurgen A. H. R. Claassen, Sofie Jansen, Marjolein Klop, Frederik J. J. de Lange, Carel C. G. M. Meskers, Vincent J. J. Odekerken, Stephen J. J. Payne, Marijke C. C. Trappenburg, Roland D. D. Thijs, Jeroen F. F. Uleman, Alfons G. G. Hoekstra, Nathalie van der Velde
Summary: Orthostatic hypotension (OH) is a common cardiovascular risk factor for falls. This study used group model building (GMB) to develop a causal loop diagram (CLD) to understand the pathophysiological mechanisms contributing to OH-related falls. The CLD identified decreased cerebral blood flow, low blood pressure, impaired baroreflex activity, and physical inactivity as key factors involved in OH-related falls.
Article
Geriatrics & Gerontology
Marjolein Klop, Rianne A. A. de Heus, Andrea B. Maier, Anne van Alphen, Marianne J. Floor-Westerdijk, Mathijs Bronkhorst, Rene J. F. Melis, Carel G. M. Meskers, Jurgen A. H. R. Claassen, Richard J. A. van Wezel
Summary: Orthostatic hypotension (OH) is common in older adults and has various negative effects. Current diagnosis relies on single-time point cuff measurements, while continuous blood pressure (BP) devices are not suitable for daily monitoring. Near-infrared spectroscopy (NIRS) has potential diagnostic value in continuously measuring cerebral oxygenation, but further validation is needed. This study aimed to compare NIRS-measured cerebral oxygenation with continuous BP and transcranial Doppler-measured cerebral blood velocity (CBv) during postural changes. The results showed that BP and O(2)Hb had good curve-based correlations in the initial 30 seconds after standing up, with significant associations between early and 1-minute BP recovery and O(2)Hb. Associations between CBv and O(2)Hb were poor, but stronger for long-channel than short-channel measurements. The findings suggest that NIRS-measured O(2)Hb in the first 30 seconds after postural change is well associated with BP, and long-channel NIRS specifically reflects cerebral blood flow during postural transitions, providing insights into OH consequences.
Article
Neurosciences
Stacha F. I. Reumers, Dennis J. L. G. Schutter, Roderick P. P. W. M. Maas, Frank-Erik de Leeuw, Roy P. C. Kessels, Bart P. C. van de Warrenburg
Summary: Cognitive and affective symptoms are common among patients with degenerative cerebellar disorders and have a significant impact on daily life functioning. There are discrepancies between patients and informants about the extent of executive problems. This research highlights the importance of increasing awareness of cognitive symptoms and their impact in patients with cerebellar ataxia.