Article
Neurosciences
Catarina Bernardes, Marisa Lima, Diana Duro, Anuschka Silva-Spinola, Joao Duraes, Miguel Tabuas-Pereira, Ines Baldeiras, Sandra Freitas, Isabel Santana
Summary: This study confirms the role of cerebrospinal fluid Alzheimer's disease biomarkers in predicting conversion from mild cognitive impairment to dementia and suggests the utility of Montreal Cognitive Assessment in predicting conversion in highly educated subjects, supporting its use in the evaluation of MCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Aida Kamalian, Sara G. Ho, Megha Patel, Alexandria Lewis, Arnold Bakker, Marilyn Albert, Richard J. O'Brien, Abhay Moghekar, Michael W. Lutz
Summary: This study measured 3072 proteins in the CSF samples of AD-biomarker positive MCI patients and controls, and found an upregulation of neuroinflammatory pathways, particularly chemotactic and granulocyte recruitment pathways, in the CSF of early AD patients.
Article
Geriatrics & Gerontology
Woori Moon, Ji Won Han, Jong Bin Bae, Seung Wan Suh, Tae Hui Kim, Kyung Phil Kwak, Bong Jo Kim, Shin Gyeom Kim, Jeong Lan Kim, Seok Woo Moon, Joon Hyuk Park, Seung-Ho Ryu, Jong Chul Youn, Dong Young Lee, Dong Woo Lee, Seok Bum Lee, Jung Jae Lee, Jin Hyeong Jhoo, Ki Woong Kim
Summary: This study investigated the disease burden of various dementias and mild cognitive impairment in a representative South Korean population, predicting a significant increase in disability-adjusted life-years and years lived with disability due to these conditions by 2065.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Biotechnology & Applied Microbiology
Amanda Cano, Ester Esteban-de-Antonio, Mireia Bernuz, Raquel Puerta, Pablo Garcia-Gonzalez, Itziar de Rojas, Claudia Olive, Alba Perez-Cordon, Laura Montrreal, Raul Nunez-Llaves, Oscar Sotolongo-Grau, Emilio Alarcon-Martin, Sergi Valero, Montserrat Alegret, Elvira Martin, Pamela V. Martino-Adami, Miren Ettcheto, Antonio Camins, Assumpta Vivas, Marta Gomez-Chiari, Miguel angel Tejero, Adelina Orellana, Lluis Tarraga, Marta Marquie, Alfredo Ramirez, Merce Marti, Maria Isabel Pividori, Merce Boada, Agustin Ruiz
Summary: Alzheimer's disease (AD) is commonly preceded by a prodromal phase characterized by high levels of A beta and p-tau-mediated neuronal injury and mild cognitive impairment (MCI). Differential diagnosis of MCI causes in these prodromal stages is a challenge for clinicians. Blood biomarkers, particularly plasma extracellular vesicles (pEVs), are emerging as potential tools for early AD detection.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Immunology
Rong Yin, Linpeng Yang, Ying Hao, Zhiqi Yang, Tao Lu, Wanjun Jin, Meiling Dan, Liang Peng, Yingjie Zhang, Yaxuan Wei, Rong Li, Huiping Ma, Yuanyuan Shi, Pengcheng Fan
Summary: This study analyzed the clinical and proteomic data of patients with Japanese encephalitis (JE) and identified two subtypes of JE with significantly different prognoses. The JE2 subtype was associated with a higher risk of cognitive impairment. The findings also provided potential target proteins for the treatment of cognitive impairments caused by JE.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Aurore Delvenne, Johan Gobom, Betty Tijms, Isabelle Bos, Lianne M. Reus, Valerija Dobricic, Mara Ten Kate, Frans Verhey, Inez Ramakers, Philip Scheltens, Charlotte E. Teunissen, Rik Vandenberghe, Jolien Schaeverbeke, Silvy Gabel, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Magda Tsolaki, Yvonne Freund-Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J. B. Vos
Summary: The pathophysiology of MCI-SNAP is distinct from that of MCI-AD, highlighting the need for different treatment approaches.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Akram A. Hosseini, Thomas Brown, Luca Mannino, Bruno Gran, Kehinde Junaid, Elizabeta B. Mukaetova-Ladinska
Summary: This study conducted diagnostic lumbar puncture in patients with early onset Alzheimer's or related dementias and evaluated the measurements of amyloid-beta 42 (A beta(42)), total tau, and Thr181-phosphorylated tau (p-tau) in the cerebrospinal fluid (CSF). The results showed that low levels of CSF A beta(42) appear to be more sensitive than total and p-tau measures in differentiating AD MCI from other forms of dementia.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Neurosciences
Kate J. Russin, K. Sreekumaran Nair, Thomas J. Montine, Laura D. Baker, Suzanne Craft
Summary: This study aimed to investigate the impact of diets with different nutrient compositions on cerebrospinal fluid amino acid levels, finding that a high saturated fat/glycemic index diet can lead to changes in amino acid levels in individuals with mild cognitive impairment. The response to diet intervention varies according to cognitive status.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Endocrinology & Metabolism
Lene Palhaugen, Carole H. Sudre, Sandra Tecelao, Arne Nakling, Ina S. Almdahl, Lisa F. Kalheim, M. Jorge Cardoso, Stein H. Johnsen, Arvid Rongve, Dag Aarsland, Atle Bjornerud, Per Selnes, Tormod Fladby
Summary: Posterior WMH loads were increased in cases with subjective cognitive decline and mild cognitive impairment, while frontal WMHs were associated with vascular risk. This suggests that regional WMH load may serve as an early-stage marker of etiology.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Deepika Dinesh, Qing Shao, Madhuri Palnati, Sarah McDannold, Quanwu Zhang, Amir Abbas Tahami Monfared, Guneet K. Jasuja, Heather Davila, Weiming Xia, Lauren R. Moo, Donald R. Miller, Natalia Palacios
Summary: Based on electronic health records data, a study found that US veterans have a unique dementia risk profile that may be changing over time. From 2000 to 2019, the incidence and prevalence of Alzheimer's disease (AD) and related dementias (ADRD) decreased, while ADRD prevalence increased primarily due to an increase in dementia not otherwise specified. The prevalence and incidence of mild cognitive impairment (MCI) sharply increased, especially after 2010. The highest prevalence and incidence of AD, ADRD, and MCI were observed in the oldest veterans, female veterans, and African American and Hispanic veterans.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, Research & Experimental
Aonan Zhao, Yang Jiao, Guanyu Ye, Wenyan Kang, Lan Tan, Yuanyuan Li, Yulei Deng, Jun Liu
Summary: This study found that sTREM2 may serve as a potential predictive biomarker of the conversion from MCI to AD. Low levels of CSF sTREM2 and Aβ1-42 were associated with an increased risk of MCI-to-AD conversion, while elevated CSF sTREM2 levels were associated with a decreased risk. In the NRHAD cohort, individuals in the MCI group with high plasma sTREM2 levels were more likely to progress to AD, and those with low Aβ1-42 and high plasma sTREM2 levels had a faster cognitive decline. CSF sTREM2 levels were highly correlated with plasma sTREM2 levels in the CABLE database.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Geriatrics & Gerontology
Andrea M. Weinstein, Swathi Gujral, Meryl A. Butters, Christopher R. Bowie, Corinne E. Fischer, Alastair J. Flint, Nathan Herrmann, James L. Kennedy, Linda Mah, Shima Ovaysikia, Bruce G. Pollock, Tarek K. Rajji, Benoit H. Mulsant
Summary: This study compared diagnostic rates and clinical predictors between NIA-AA criteria and DSM-5 criteria, finding that discrepancies were more likely in individuals with a history of MDD or carrying at least one ApoE4 allele. Detailed neuropsychological testing and NIA-AA criteria identified a greater prevalence of cognitive impairment compared to DSM-5 criteria and the Montreal Cognitive Assessment.
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Clinical Neurology
Anna Dittrich, Nicholas J. J. Ashton, Henrik Zetterberg, Kaj Blennow, Anna Zettergren, Joel Simren, Tobias Skillback, Sara Shams, Alejandra Machado, Eric Westman, Michael Scholl, Ingmar Skoog, Silke Kern
Summary: This study investigates the relationship between chronic kidney disease (CKD) and neurodegenerative diseases. It shows that CKD patients have higher levels of plasma neurofilament light (P-NfL) compared to individuals with normal kidney function. Therefore, P-NfL may serve as a potential biomarker linking CKD to neurodegenerative diseases.
Article
Neurosciences
Karolina Minta, Gunnar Brinkmalm, Erik Portelius, Per Johansson, Johan Svensson, Petronella Kettunen, Anders Wallin, Henrik Zetterberg, Kaj Blennow, Ulf Andreasson
Summary: The study identified that the concentrations of brevican and neurocan peptides were significantly decreased in the cerebrospinal fluid of VaD patients, suggesting their potential as diagnostic biomarkers for VaD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Liu Shi, Laura M. Winchester, Sarah Westwood, Alison L. Baird, Sneha N. Anand, Noel J. Buckley, Abdul Hye, Nicholas J. Ashton, Isabelle Bos, Stephanie J. B. Vos, Mara ten Kate, Philip Scheltens, Charlotte E. Teunissen, Rik Vandenberghe, Silvy Gabel, Karen Meersmans, Sebastiaan Engelborghs, Ellen E. De Roeck, Kristel Sleegers, Giovanni B. Frisoni, Olivier Blin, Jill C. Richardson, Regis Bordet, Jose L. Molinuevo, Lorena Rami, Anders Wallin, Petronella Kettunen, Magda Tsolaki, Frans Verhey, Alberto Lleo, Isabel Sala, Julius Popp, Gwendoline Peyratout, Pablo Martinez-Lage, Mikel Tainta, Peter Johannsen, Yvonne Freund-Levi, Lutz Froeich, Valerija Dobricic, Cristina Legido-Quigley, Frederik Barkhof, Ulf Andreasson, Kaj Blennow, Henrik Zetterberg, Johannes Streffer, Christina M. Lill, Lars Bertram, Pieter Jelle Visser, Hartmuth C. Kolb, Vaibhav A. Narayan, Simon Lovestone, Alejo J. Nevado-Holgado
Summary: The study found that blood proteins can predict the presence of AD pathology as measured in the ATN framework as well as clinical diagnosis.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Johan Svensson, Maria Blomqvist, Petronella Kettunen, Carl Eckerstrom, Marcus Henricsson, Michael Jonsson, Maria Bjerke, Jan-Eric Mansson, Anders Wallin
Summary: This study investigated the diagnostic utility of CSF ST levels in subcortical small vessel type of dementia (SSVD). The results showed a correlation between CSF ST levels and WMH volume, but there was no significant difference in CSF ST levels between dementia groups and controls, suggesting that CSF total ST level may not be an ideal biomarker of demyelination in SSVD. Further research is needed to explore the mechanisms underlying the correlation between CSF ST levels and CSF/serum albumin ratio.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Developmental Biology
Marica Andersson, Petronella Kettunen
Summary: The welfare of zebrafish is influenced by various environmental factors, including food access, water quality, and holding density. Despite the widespread use of zebrafish in research, the impact of holding density on its welfare remains poorly understood. Future recommendations on holding density may vary depending on the specific welfare aspects being considered, indicating a need for further research on the interactive effects of density on welfare indicators.
Article
Multidisciplinary Sciences
Hanri Afghahi, Salmir Nasic, Bjoern Peters, Helena Rydell, Henrik Hadimeri, Johan Svensson
Summary: The study investigates the association between HbA1c variability and the risk of all-cause mortality in diabetic patients with PD. The results suggest that higher HbA1c variability is associated with increased risk of death in diabetic patients with PD.
Letter
Medicine, General & Internal
Henrik Ryberg, Per Johansson, Anders Wallin, Johan F. Emilsson, Elias Eriksson, Johan Svensson, Claes Ohlsson
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Muhammad M. Ali, Yun Ju Sung, Fengxian Wang, Maria Fernandez, John M. Morris, Anne Fagan, Kaj Blennow, Henrik Zetterberg, Amanda Heslegrave, Per Johansson, Johan Svensson, Bengt Nellgard, Alberto Lleo, Daniel Alcolea, Jordi Clarimon, Lorena Rami, Jose Luis Molinuevo, Marc Suarez-Calvet, Estrella R. Morenas-Rodriguez, Gernot J. Kleinberger, Christian Haass, Michael Ewers, Johannes Levin, Martin Farlow, Richard Perrin, Carlos Cruchaga
Summary: Two genetic variants in the KL gene are associated with Alzheimer's disease risk and may lower the incidence of neurodegeneration and cognitive decline.
Article
Endocrinology & Metabolism
Patrick Quinlan, Alexandra Horvath, Carl Eckerstrom, Anders Wallin, Johan Svensson
Summary: This study found that higher thyroid hormone levels were associated with lower brain volume and increased risk of Alzheimer's disease (AD) in elderly individuals. However, the relationship between serum thyroid hormones and hippocampal atrophy rates has not been previously investigated. The results showed that FT3/FT4 ratio was related to baseline hippocampal volume in all study groups, but only in AD patients, higher levels of thyroid hormones were associated with greater annual loss of hippocampal volume.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Neurosciences
Susanna Larsson, Petronella Kettunen, Helena Caren
Summary: Brain tumours are a leading cause of death in children with solid tumours, and high-grade gliomas are particularly devastating. This study presents a clinically relevant in vivo model for paediatric glioma using zebrafish larvae and primary glioma stem cell cultures. The model allows for the monitoring of tumour invasion and evaluation of drug treatments. This research has the potential to improve understanding of cellular behaviour and personalized treatments for paediatric high-grade gliomas.
Article
Biology
Marica Andersson, Jonathan A. C. Roques, Geoffrey Mukisa Aliti, Karin Ademar, Henrik Sundh, Kristina Sundell, Mia Ericson, Petronella Kettunen
Summary: The housing density of zebrafish affects their welfare, with a density of 1 fish/L leading to higher stress levels and aggressive behavior. However, densities between 4 and 16 fish/L do not compromise the welfare of zebrafish.
Article
Endocrinology & Metabolism
Johan Svensson, Klara Sjogren, Lina Lawenius, Antti Koskela, Juha Tuukkanen, Karin H. Nilsson, Sofia Moverare-Skrtic, Claes Ohlsson
Summary: Insulin-like growth factor-I (IGF-I) levels and cortical bone dimensions play important roles in determining fracture risk in elderly people. Inactivation of liver-derived circulating IGF-I reduces periosteal bone expansion in young and older mice. This study investigates the effect of inducible inactivation of IGF-I specifically in bone on the bone phenotype in adult/old mice, finding that it results in reduced radial growth of cortical bone, suggesting the importance of locally derived IGF-I in regulating the cortical bone phenotype in older mice.
Article
Clinical Neurology
Petronella Kettunen, Maria Bjerke, Carl Eckerstrom, Michael Jonsson, Henrik Zetterberg, Kaj Blennow, Johan Svensson, Anders Wallin
Summary: We found that SSVD patients have a different biomarker profile, with lower levels of sAPP-β compared to AD patients and controls. We also observed signs of blood-brain barrier dysfunction in SSVD. These findings support the concept that SSVD is a distinct form of vascular cognitive disorder (VCD).
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2022)
Article
Clinical Neurology
C. Eckerstrom, J. Svensson, P. Kettunen, M. Jonsson, M. Eckerstrom
Summary: The study evaluated the usefulness of the 2018 NIA-AA research framework in a longitudinal memory clinic study, finding that the ATN system is supportive in detecting early AD or mixed dementia, with the majority of patients converting to AD and mixed dementia belonging to A positive ATN groups.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2021)
Article
Clinical Neurology
Petronella Kettunen, Maria Bjerke, Carl Eckerstrom, Michael Jonsson, Henrik Zetterberg, Kaj Blennow, Johan Svensson, Anders Wallin
Summary: SSVD patients exhibit distinct biomarker profiles from AD and mixed AD/SSVD, with lower sAPP-β levels and blood-brain barrier dysfunction suggesting possible diagnostic tools for SSVD.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2022)
