期刊
BRITISH JOURNAL OF NUTRITION
卷 115, 期 9, 页码 1643-1660出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114516000696
关键词
25-Hydroxyvitamin D; P450 hydroxylases; Vitamin D supplementation
资金
- Dana-Farber Cancer Institute
- US National Institutes of Health [R01 CA151993, R35 CA197735, U01 CA138962, K07 CA148894]
- National Institutes of Health [U01 CA138962]
In many cells throughout the body, vitamin D is converted into its active form calcitriol and binds to the vitamin D receptor (VDR), which functions as a transcription factor to regulate various biological processes including cellular differentiation and immune response. Vitamin D-metabolising enzymes (including CYP24A1 and CYP27B1) and VDR play major roles in exerting and regulating the effects of vitamin D. Preclinical and epidemiological studies have provided evidence for anti-cancer effects of vitamin D (particularly against colorectal cancer), although clinical trials have yet to prove its benefit. In addition, molecular pathological epidemiology research can provide insights into the interaction of vitamin D with tumour molecular and immunity status. Other future research directions include genome-wide research on VDR transcriptional targets, gene-environment interaction analyses and clinical trials on vitamin D efficacy in colorectal cancer patients. In this study, we review the literature on vitamin D and colorectal cancer from both mechanistic and population studies and discuss the links and controversies within and between the two parts of evidence.
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