4.7 Article

Dietary Supplementation of n-3 LCPUFAs Prevents Salmonellosis in a Murine Model

期刊

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
卷 68, 期 1, 页码 128-137

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.jafc.9b05899

关键词

n-3 LCPUFAs; prevention; Salmonella; mechanism

资金

  1. National Natural Science Foundation of China [31470161, 31530056, 31801543, JUFSTR20180102]
  2. collaborative innovation center of food safety and quality control in Jiangsu Province

向作者/读者索取更多资源

Salmonellosis is a world-wide epidemic, and n-3 long chain polyunsaturated fatty acids (LCPUFAs) possess various health benefits. This study is aimed to investigate the preventive effects of n-3 LCPUFAs against Salmonella infection. By pretreatment with n-3 LCPUFAs, but not n-6 LCPUFAs, the survival rate of the infected mice was increased. Further studies showed that n-3 LCPUFAs significantly increased the fecal contents of short-chain fatty acids (SCFAs). The cytokine expression in the liver and production in serum were both modulated by n-3 LCPUFAs into an anti-inflammatory profile against infection. Moreover, the changes in gut microbiota by n-3 LCPUFAs favored the host against pathogens, closely related to the modified SCFA production and immune responses. In conclusion, n-3 LCPUFAs prevented Salmonella infection through multiple mechanisms, especially by the interaction with gut microbiota and host immunology. Our results suggested great perspectives for n-3 LCPUFAs and their related products to control the prevalence of Salmonella, a most predominant food-borne pathogen.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

Article Biochemistry & Molecular Biology

Multiple mechanisms applied by Lactobacillus pentosus AT6 to mute the lethal effects of Salmonella in a mouse model

Junsheng Liu, Zhennan Gu, Wenwei Lu, Diangeng Hu, Xi Zhao, Hongxuan Huang, Hao Zhang, Jianxin Zhao, Wei Chen

FOOD & FUNCTION (2018)

Article Biochemistry & Molecular Biology

Strain-specific properties of Lactobacillus plantarum for prevention of Salmonella infection

Junsheng Liu, Diangeng Hu, Yingqi Chen, Hongxuan Huang, Hao Zhang, Jianxin Zhao, Zhennan Gu, Wei Chen

FOOD & FUNCTION (2018)

Article Microbiology

Lactobacillus plantarum ZS2058 and Lactobacillus rhamnosus GG Use Different Mechanisms to Prevent Salmonella Infection in vivo

Junsheng Liu, Zhennan Gu, Fanfen Song, Hao Zhang, Jianxin Zhao, Wei Chen

FRONTIERS IN MICROBIOLOGY (2019)

Article Food Science & Technology

Preventive effects of Lactobacillus plantarum ST-III against Salmonella infection

Junsheng Liu, Zhennan Gu, Hao Zhang, Jianxin Zhao, Wei Chen

LWT-FOOD SCIENCE AND TECHNOLOGY (2019)

Article Nutrition & Dietetics

Synergistic Effect of Eugenol and ProbioticLactobacillus PlantarumZs2058 againstSalmonellaInfection in C57bl/6 Mice

Fanfen Song, Junsheng Liu, Wenyu Zhao, Hongxuan Huang, Diangeng Hu, Haiqin Chen, Hao Zhang, Wei Chen, Zhennan Gu

NUTRIENTS (2020)

Article Food Science & Technology

The gut microbiota alteration and the key bacteria in Astragalus polysaccharides (APS)-improved osteoporosis

Junsheng Liu, Jun Liu, Liu Liu, Guangwen Zhang, Aimei Zhou, Xichun Peng

FOOD RESEARCH INTERNATIONAL (2020)

Article Food Science & Technology

Chemical, microbial, and metabolic analysis of Taisui cultured in honey solution

Yunjing Chen, Shuxiu Zheng, Guangwen Zhang, Jianming Luo, Junsheng Liu, Xichun Peng

Summary: This study investigated the macronutrients, trace elements, microbial community, and extracellular metabolites of artificially cultured Taisui, discovering that most of the metabolites are beneficial to human health. While acTS may not be a good source of macronutrients and trace elements, and the safety of some microorganisms remains unknown, it does provide probiotics and beneficial metabolites for human consumption. Further research is needed to ensure the safety of each microorganism before developing acTS into food products.

FOOD SCIENCE & NUTRITION (2021)

Article Food Science & Technology

Dietary supplementation with low-dose xylooligosaccharide promotes the anti-Salmonella activity of probiotic Lactiplantibacillus plantarum ZS2058 in a murine model

Junsheng Liu, Xiangfei Li, Fanfen Song, Shumao Cui, Wenwei Lu, Jianxin Zhao, Hao Zhang, Zhennan Gu, Wei Chen

Summary: The study found that low dose xylooligosaccharide (XOS) can promote the anti-Salmonella activity of probiotic Lactiplantibacillus plantarum ZS2058 by increasing survival rate and changing gut microbiota to protect the host.

FOOD RESEARCH INTERNATIONAL (2022)

Article Biochemistry & Molecular Biology

Poria cocos polysaccharides attenuate chronic nonbacterial prostatitis by targeting the gut microbiota: Comparative study of Poria cocos polysaccharides and finasteride in treating chronic prostatitis

Junsheng Liu, Liu Liu, Guangwen Zhang, Xichun Peng

Summary: Both Poria cocos polysaccharides (PPs) and finasteride have therapeutic effects on chronic nonbacterial prostatitis (CNP) rats, but they work through different mechanisms, with PPs alleviating CNP symptoms by modulating the gut microbiota.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2021)

Article Biochemistry & Molecular Biology

Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice

Youying Tu, Hyunuk Kang, Eunhye Kim, Jiangfan Yang, Puming He, Yuanyuan Wu, Bo Li, Xiaobo Liu, Junsheng Liu

Summary: The study found that Tieguanyin tea extracts could alter fecal metabolites in AD mice, with Tgy-C being the most effective. Metabolomics analysis showed Tgy-C's reduction effect on fecal metabolites in AD mice, which may involve pathways like protein digestion and absorption, and amino acid biosynthesis.

METABOLITES (2022)

Article Biochemistry & Molecular Biology

Reprogrammed intestinal functions in Astragalus polysaccharide-alleviated osteoporosis: combined analysis of transcriptomics and DNA methylomics demonstrates the significance of the gut-bone axis in treating osteoporosis

Junsheng Liu, Jun Liu, Liu Liu, Guangwen Zhang, Xichun Peng

Summary: Researchers found that dexamethasone-induced osteoporosis and APS-ameliorated osteoporosis altered the gene expression profile of the intestine, resulting in intestinal dysfunction. APS was able to restore intestinal functions by affecting 53 differentially expressed genes, contributing to the improvement of osteoporosis. This study supports the concept of a gut-bone axis and suggests new therapeutic opportunities for osteoporosis treatment through this axis.

FOOD & FUNCTION (2021)

暂无数据