Article
Hematology
Evangelia Vlachodimitropoulou, Tsz Kin Lo, Clarissa Bambao, Greg Denomme, Gareth R. Seaward, Rory Windrim, Francine Tessier, Edmond Kelly, Tim Van Mieghem, Greg Ryan
Summary: Maternal intravenous immunoglobulin (IVIG) administration for severe red blood cell (RBC) alloimmunization can improve fetal outcomes and reduce the severity of hemolytic disease.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Evangelia Vlachodimitropoulou, Maciej Garbowski, Shelley Anne Solomon, Nimrah Abbasi, Gareth Seaward, Rory Windrim, Johannes Keunen, Edmond Kelly, Tim Van Mieghem, Nadine Shehata, Greg Ryan
Summary: Red blood cell alloimmunisation with anti-D and anti-K are the main causes of fetal hemolytic disease requiring intrauterine red cell transfusion. Studies have shown that certain hematological parameters can predict adverse fetal or neonatal outcomes, including preterm birth, intrauterine fetal demise, neonatal death, and need for neonatal transfusion. Identifying these predictors can help guide pregnancy management and improve outcomes for these pregnancies.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
Josine A. Oud, Dorothea Evers, Masja de Haas, Karen M. K. de Vooght, Daan van de Kerkhof, Nel Som, Nathalie C. V. Pequeriaux, Francisca Hudig, Arjan Albersen, Johanna G. van der Bom, Jaap Jan Zwaginga
Summary: The study found that under cEK matching, females had significantly lower cEK alloimmunisation incidences compared to males after receiving 10 units of transfusion, although overall alloimmunisation incidences were similar. However, despite the cEK-matching guidelines, a percentage of RBC units remained mismatched for c, E or K antigens.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Hematology
Eunike C. Mcgowan, Helen O'Brien, Mia E. Sarri, Genghis H. Lopez, James J. Daly, Robert L. Flower, Glenn J. Gardener, Catherine A. Hyland
Summary: This study reports on the feasibility of non-invasive prenatal testing using massively parallel sequencing (MPS) for predicting fetal blood type in alloimmunised women. MPS was able to cover multiple blood types in a single test by targeting multiple nucleotide variants and single nucleotide polymorphisms. Although caution is needed for the Rh system, this method has the potential to provide personalized services for alloimmunised women.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Hematology
Paul Kambale-Kombi, Roland Marini Djang'eing'a, Jean-Pierre Alworong'a Opara, Jean-Marc Minon, Edith Sepulchre, Vincent Bours, Aline Floch, France Pirenne, Charles Kayembe Tshilumba, Salomon Batina-Agasa
Summary: This study found that RBC alloimmunisation is a common complication in SCD patients in the DRC. In the resource-limited setting of this country, blood transfusion with minimal ABO, D, C and E antigen matching in addition to the use of compatibility tests could significantly reduce the incidence of this complication.
TRANSFUSION MEDICINE
(2023)
Review
Hematology
Patricia Davenport, Martha Sola-Visner
Summary: Recent studies have shown that RBC transfusions in neonates can increase pro-inflammatory cytokines, with sex-specific responses. Platelet transfusions in preterm neonates are associated with increased mortality and morbidity, potentially due to immune/inflammatory effects of transfused platelets.
CURRENT OPINION IN HEMATOLOGY
(2022)
Article
Medicine, General & Internal
Sondos Zayed, Timothy K. Nguyen, Cindy Lin, Gabriel Boldt, Sushil Beriwal, Carien L. Creutzberg, Mitchell Kamrava, Lucas C. Mendez, Vikram Velker, Corinne Doll, Amandeep Taggar, Eric Leung, David P. D'Souza
Summary: This study aimed to develop consensus statements to guide PRBC transfusion practices in patients with cervical cancer receiving curative-intent RT with EBRT and brachytherapy, using an international Delphi consensus method. Through the consensus, a hemoglobin transfusion target of 9 g/dL or more and less than 12 g/dL was endorsed for patients who receive a PRBC transfusion.
Article
Medicine, General & Internal
Dimitris A. Tsitsikas, Saket Badle, Rhys Hall, John Meenan, Oloruntoyin Bello-Sanyaolu, Funmilayo Orebayo, Jibril Abukar, Mohamed Elmi, Afsana Mulla, Shalini Dave, Natasha Lewis, Manisha Sharma, Basabi Chatterjee, Roger J. Amos
Summary: Automated red cell exchange is an effective treatment for sickle cell disease, reducing symptom severity and frequency, and benefiting patients in managing pain crises.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Hematology
Denis F. Noubouossie, Nigel S. Key
Summary: This review examines the characteristics of extracellular vesicles in stored PRBC units and their generation in relation to storage conditions. It also discusses the interactions of extracellular vesicles with coagulation pathways and their potential impact on inflammatory pathways. However, it remains unclear whether these interactions have clinical implications in recipients of PRBC units.
CURRENT OPINION IN HEMATOLOGY
(2023)
Review
Hematology
Eric A. Gehrie, Bipin N. Savani, Garrett S. Booth
Summary: Advancements in laboratory testing, pathogen reduction, and donor qualification have significantly reduced the risk of infection from blood transfusions. However, the prevention and recognition of hemolytic reactions, particularly due to donor-recipient incompatibility, have seen little recent progress. The article discusses the role of compatibility testing and transfusion practices in acute hemolysis, emphasizing clinical scenarios with increased risk and outlining initial clinical management for severe hemolytic reactions.
Article
Immunology
Rebekka Mispelbaum, Sandra Tessa Hattenhauer, Peter Brossart, Annkristin Heine
Summary: This study demonstrates that administration of red blood cell transfusion during immunotherapy, but not before, negatively affects response rates. The findings suggest a need for restrictive transfusion management in patients undergoing immunotherapy to optimize response rates.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Piotr F. Czempik, Dawid Gierczak, Dawid Wilczek, Lukasz J. Krzych
Summary: The study analyzed the impact of red blood cell transfusion (RBCT) on blood lactate and the factors that may increase its concentration. It found that RBCT did not normalize mildly elevated lactate and common causes of elevated lactate had no impact on its concentration. Therefore, lactate may have a limited role as a physiologic RBCT trigger in non-bleeding severely anemic critically ill patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dania Fischer, Fabian Thies, Omar Awad, Camilla Brat, Patrick Meybohm, Patrick C. Baer, Markus M. Mueller, Anja Urbschat, Thorsten J. Maier, Kai Zacharowski, Jessica Roos
Summary: The relationship between allogeneic blood transfusions and increased rates of cancer recurrence, metastasis and death in colorectal cancer patients is still not fully understood. This study focused on the in vitro effects of microparticles derived from red blood cell units on colon carcinoma cells and found that these microparticles did not significantly affect cell characteristics or signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Timothy J. McMahon, Cole C. Darrow, Brooke A. Hoehn, Hongmei Zhu
Summary: Metabolic homeostasis in animals relies on the evolved mechanisms of how red blood cell hemoglobin senses oxygen needs and responds accordingly. The dynamic control of ATP production and antioxidant systems within the RBC helps adapt to physiological and pathophysiological stresses. Impairments in the ability of RBCs to adapt to the metabolic environment can occur in various diseases and conditions, but emerging therapies may offer clinical interventions to optimize or correct RBC function via metabolite delivery mechanisms.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Olivier Peyrony, Danae Gamelon, Romain Brune, Anthony Chauvin, Daniel Aiham Ghazali, Youri Yordanov, Aude Arsicaud, Pauline Gilleron, Sonja Curac, Marie-Caroline Richard, Anne-Laure Feral-Pierssens, Barbara Villoing, Sebastien Beaune, Helene Goulet, Jean-Paul Fontaine, Anne Francois, France Pirenne
Summary: RBC transfusions in the emergency department involved patients with a variety of medical conditions, most of whom had chronic anemia, primarily due to vitamin or iron deficiency or malignancy. The majority of transfusion motives were not documented in the medical charts.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Hematology
Loes L. Cornelissen, Aukje L. Kreuger, Camila Caram-Deelder, Menno Huisman, Rutger A. Middelburg, Jean Louis H. Kerkhoffs, Peter A. von Dem Borne, Erik A. M. Beckers, Karen M. K. de Vooght, Jurgen Kuball, Johanna G. van der Bom, Jaap Jan Zwaginga
Summary: This study aimed to investigate whether cardiovascular risk factors can predict intracranial hemorrhage in patients with acute leukemia. The case-control study found that pre-existing hypertension and ischemic heart disease were associated with an increased risk of intracranial hemorrhage.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
Rik P. B. Tonino, Martin R. Schipperus, Jaap Jan Zwaginga
Summary: The survey revealed a wide variation in RBC transfusion strategies for chronically transfusion-dependent patients in the Netherlands, including differences in the number of units transfused and transfusion thresholds. Patient-specific clinical factors and softer parameters play a significant role in influencing the transfusion strategy.
Article
Hematology
Sufia N. Amini, Leendert Porcelijn, Annemieke Sobels, Marina Kartachova, Masja de Haas, Jaap Jan Zwaginga, Martin R. Schipperus
Summary: This study investigated the association between anti-GP antibodies and platelet sequestration patterns and clearance rate in ITP patients. The results showed that anti-GPV antibodies are associated with a splenic sequestration pattern, and in patients where antibodies were present, the clearance rate was higher in patients with a splenic sequestration.
Article
Multidisciplinary Sciences
Saeed Katiraei, Janna A. van Diepen, Luciana P. Tavares, Lisa R. Hoving, Amanda Pronk, Ineke Verschueren, Patrick C. N. Rensen, Jaap Jan Zwaginga, Sarantos Kostidis, Martin Giera, Mauro Teixera, Ko Willems van Dijk, Mihai G. Netea, Jimmy F. P. Berbee, Vanessa van Harmelen
Summary: Bone marrow transplantation can induce changes in the gut microbiota, leading to increased cytokine responsiveness of splenocytes. These changes seem to persist and can be transferred to other individuals via co-housing and transplantation of cecum content.
SCIENTIFIC REPORTS
(2022)
Review
Immunology
Chelsea Gootjes, Jaap Jan Zwaginga, Bart O. Roep, Tatjana Nikolic
Summary: Type 1 diabetes is an autoimmune disease caused by the interaction of genetic and environmental factors. In addition to HLA gene composition, over 60 non-HLA gene regions also contribute to the susceptibility of the disease. Combining these risk genes into a score significantly improves the prediction of disease progression. Many minor-risk SNPs associated with immune genes have been identified, but their impact on gene and protein expression and their functional changes at a cellular level require further investigation.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Hematology
Josine A. Oud, Dorothea Evers, Masja de Haas, Karen M. K. de Vooght, Daan van de Kerkhof, Nel Som, Nathalie C. V. Pequeriaux, Francisca Hudig, Johanna G. van Der Bom, Jaap Jan Zwaginga
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Editorial Material
Hematology
Sufia N. Amini, Vivianne S. Nelson, Leendert Porcelijn, Tanja Netelenbos, Jaap Jan Zwaginga, Masja de Haas, Martin R. Schipperus, Rick Kapur
Summary: ITP is an autoimmune bleeding disorder characterized by platelet clearance in the spleen and liver. Thrombopoietin (TPO) levels remain low in ITP. The role of GPIb antibodies in relation to platelet hepatic sequestration and TPO levels in ITP remains unclear. This study found a positive association between GPIb antibodies and TPO levels as well as platelet hepatic sequestration in patients with severe thrombocytopenic ITP.
Article
Hematology
Astrid G. S. van Halteren, Jessica S. Suwandi, Sander Tuit, Jelske Borst, Sandra Laban, Roula Tsonaka, Ada Struijk, Anna-Sophia Wiekmeijer, Melissa van Pel, Bart O. Roep, Jaap Jan Zwaginga, Arjan C. Lankester, Koen Schepers, Maarten J. D. van Tol, Willem E. Fibbe
Summary: Acute graft-versus-host disease (aGVHD) is a potentially fatal complication of stem cell transplantation. This study used mass cytometry to analyze the immune cells in children with severe aGVHD and compared the results with control groups. The onset of aGVHD was associated with the appearance of specific myeloid and lymphoid cells in the blood and affected organs such as the skin and gastrointestinal tract. The findings highlight the importance of immune cell profiling for evaluating clinical response and managing severe aGVHD.
Article
Infectious Diseases
Arvind Gharbharan, Carlijn Jordans, Lisa Zwaginga, Grigorios Papageorgiou, Nan van Geloven, Peter van Wijngaarden, Jan den Hollander, Faiz Karim, Elena van Leeuwen-Segarceanu, Robert Soetekouw, Jolanda Lammers, Douwe Postma, Linda Kampschreur, Geert Groeneveld, Francis Swaneveld, C. Ellen van der Schoot, Hannelore Gotz, Bart Haagmans, Marion Koopmans, Susanne Bogers, Corine Geurtsvankessel, Jaap Jan Zwaginga, Casper Rokx, Bart Rijnders
Summary: This study aimed to determine the effectiveness of convalescent plasma therapy in high-risk outpatients with COVID-19. The results showed that convalescent plasma therapy did not improve the disease severity score.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Medicine, Research & Experimental
Tim W. H. Rijnhout, Femke Noorman, Robert A. van der Horst, Edward C. T. H. Tan, Victor V. A. Viersen, Oscar J. F. van Waes, Leo M. G. van de Watering, B. L. S. Borger van der Burg, Jaap J. Zwaginga, Michael H. J. Verhofstad, Rigo Hoencamp
Summary: The Netherlands Armed Forces have been successfully using deep-frozen thrombocyte concentrate (DTC) for the treatment of bleeding trauma patients since 2001. However, there is a lack of evidence for the effectiveness and safety of DTCs. The MAFOD trial aims to compare the haemostatic effect of DTCs versus room temperature-stored platelets (RSP) in surgical bleeding treatment. If proven non-inferior, frozen platelets may be used in civilian settings to improve logistics and availability for bleeding trauma patients.
Article
Immunology
Tatjana Nikolic, Jessica S. S. Suwandi, Joris Wesselius, Sandra Laban, Antoinette M. M. Joosten, Petra Sonneveld, Dick Mul, Henk-Jan Aanstoot, John S. S. Kaddis, Jaap Jan Zwaginga, Bart O. O. Roep
Summary: This study demonstrates the safety and efficacy of the tolerogenic dendritic cells (tolDC) vaccine for type 1 diabetes patients. The vaccine not only reduces autoimmune responses but also increases the number of regulatory T cells and memory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Adam C. Levine, Yuriko Fukuta, Moises A. Huaman, Jiangda Ou, Barry R. Meisenberg, Bela Patel, James H. Paxton, Daniel F. Hanley, Bart J. A. Rijnders, Arvind Gharbharan, Casper Rokx, Jaap Jan Zwaginga, Andrea Alemany, Oriol Mitja, Dan Ouchi, Pere Millat-Martinez, Valerie Durkalski-Mauldin, Frederick K. Korley, Larry J. Dumont, Clifton W. Callaway, Romina Libster, Gonzalo Perez Marc, Diego Wappner, Ignacio Esteban, Fernando Polack, David J. Sullivan
Summary: COVID-19 convalescent plasma treatment can reduce the risk of hospitalization, especially when administered within 5 days of symptom onset and with higher antibody titers.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Physiology
R. P. B. Tonino, L. M. Zwaginga, M. R. Schipperus, J. J. Zwaginga
Summary: Abnormal hemoglobin concentration significantly affects a person's quality of life and physiology. Current tools for evaluating hemoglobin-related outcomes are lacking, leading to uncertainty in optimal hemoglobin levels and treatment targets. Reviews show that increasing hemoglobin improves patient-reported and physical outcomes, particularly at lower hemoglobin levels. However, there is a lack of high-quality evidence in this area.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Laura F. Ouboter, Marieke C. Barnhoorn, Hein W. Verspaget, Leonie Plug, Emma S. Pool, Karoly Szuhai, Lukas J. A. C. Hawinkels, Melissa van Pel, Jaap Jan Zwaginga, Dave Roelen, Frits Koning, M. Fernanda Pascutti, Andrea E. van der Meulen-de Jong
Summary: A phase IIa clinical study evaluated the impact of local mesenchymal stromal cell (MSC) therapy on ulcerative proctitis (UP), and found it to be safe, feasible, and showed encouraging signs of clinical efficacy and modulation of local immune responses.
Article
Cardiac & Cardiovascular Systems
Judith Van Paassen, Alice De Graaf-Dijkstra, Anja H. Brunsveld-Reinders, Evert De Jonge, Robert J. M. Klautz, Roula Tsonaka, Jaap Jan Zwaginga, M. Sesmu Arbous
Summary: Acute lung injury after cardiac surgery is associated with an unfavorable outcome. Prior to surgery, cardiac surgery patients who developed lung injury showed higher platelet activatability and indications for higher neutrophil turnover. Further research is needed to determine the relationship between these factors and the development of lung injury after cardiac surgery.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)