Article
Pharmacology & Pharmacy
Giovanni Amato, Maria Aurora Grimaudo, Carmen Alvarez-Lorenzo, Angel Concheiro, Claudia Carbone, Angela Bonaccorso, Giovanni Puglisi, Teresa Musumeci
Summary: The aim of this study was to design a new nanogel platform suitable for wound treatment, with two different formulations selected after the first formulation screening.
Article
Nanoscience & Nanotechnology
Fazli Wahid, Xiang-Jun Zhao, Xue-Qing Zhao, Xiao-Fang Ma, Na Xue, Xiao-Zhi Liu, Feng-Ping Wang, Shi-Ru Jia, Cheng Zhong
Summary: The study showed that BC membranes functionalized with epsilon-polylysine (epsilon-PL) and mussel-inspired polydopamine (PDA) exhibited strong antibacterial properties, potential for promoting infected wound healing, and enhanced thickness and smoothness of newborn skin.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Xiao Lin, Isabel Y. Moreno, Lawrence Nguyen, Tarsis F. Gesteira, Vivien J. Coulson-Thomas
Summary: Reactive oxygen species (ROS) can cause fragmentation of hyaluronan (HA), altering its physiological activity. The chemical structures and physiological properties of oxidized HA products (oxHA) vary depending on the oxidizing agent.
Article
Food Science & Technology
Huibao Xiao, Jun Liao, Yongshi Chen, Xiuping Tong, Xiangyun Sun, Jiqiang Yan, Jie Pang
Summary: Coating preservation using a composite coating made of konjac glucomannan (KGM) as the film-forming matrix and epsilon-polylysine hydrochloride (epsilon-PL) and ferulic acid (FA) as the preservative has a remarkable effect on the preservation of aquatic products. The composite coating significantly improves the surface color and texture of sea bass and delays deterioration, inhibiting the formation of odor compounds and improving freshness.
Article
Materials Science, Multidisciplinary
Lun Yuan, Ya Gao, Zhilang Xu, Guixin Chen, Liming Ge, Changdao Mu, Ye Tian, Defu Li
Summary: In this study, gelatin-based scaffolds with a preferred microstructure and antibacterial activity were fabricated using the emulsion template method. The scaffolds possessed a porous and interconnected microstructure with suitable pore sizes for skin regeneration, as well as good mechanical properties and swelling capacity. They showed potential application as antibacterial wound dressings.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Materials Science, Textiles
Xiaofei Gao, Guohua Jiang, Liming Ruan, Yanfang Sun, Khaydar E. Yunusov, Yanting Jing, Uladzislau E. Aharodnikau, Sergey O. Solomevich
Summary: Electrospun nanofibers with adjustable properties and drug delivery capabilities have been developed as a potential wound healing material. The electrospun polycaprolactone and porcine acellular dermal matrix composite scaffolds showed enhanced thermal stability and cell adhesion. In vivo experiments demonstrated their ability to promote wound healing through enhanced expression of vascular factor and reduced inflammation.
FIBERS AND POLYMERS
(2023)
Article
Biotechnology & Applied Microbiology
Chengjian Mou, Xinyuan Wang, Jiahui Teng, Zhigang Xie, Min Zheng
Summary: This study discovered anionic carbon dots with antimicrobial activity and applied them in disease therapy and tissue engineering. By constructing a self-healing hydrogel through conjugation with e-polylysine, these carbon dots can significantly accelerate wound healing and possess broad spectrum antibacterial activity.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emiliano Bedini, Elisabetta Cassese, Antonella D'Agostino, Marcella Cammarota, Maria Assunta Frezza, Maria Lepore, Marianna Portaccio, Chiara Schiraldi, Annalisa La Gatta
Summary: A new solid-state reaction method for self-esterifying hyaluronan has been developed, leading to products that gradually release hyaluronan for more effective tissue repair. This method is more efficient and avoids side reactions compared to traditional methods, and allows for the tuning of the released biopolymer's molecular weight.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Xiaoliang Qi, Wenhao Pan, Xianqin Tong, Teng Gao, Yajing Xiang, Shengye You, Ruiting Mao, Jun Chi, Rongdang Hu, Wenzhen Zhang, Hui Deng, Jianliang Shen
Summary: A new hydrogel dressing with robust and stable photothermal performance was constructed by introducing e-Polylysine (e-PL) into agarose/PDA matrix, efficiently locking PDA. The hybrid agarose/PDA/e-PL hydrogel (ADPH) achieved stable photothermal functionality and desirable physicochemical properties, showing satisfactory microbicidal efficacy in vivo for treating bacterial-infected skin wounds.
CARBOHYDRATE POLYMERS
(2021)
Article
Veterinary Sciences
Elizabeth A. A. Larsen, Amy C. C. Lack, Erica Wassack
Summary: This case report describes the use of poloxamer 407 gel for the treatment of a sublingual abscess. The gel may have a positive effect on wound healing by reducing contamination, protecting exposed bone, and prolonging the release of penicillin G potassium.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Qianmin Ou, Shaohan Zhang, Chuanqiang Fu, Le Yu, Peikun Xin, Zhipeng Gu, Zeyuan Cao, Jun Wu, Yan Wang
Summary: The hydrogel wound dressings developed by incorporating PUE or FA via PDA nanoparticles show improved enzyme activity, reduced ROS and malondialdehyde levels, promoting wound healing and tissue regeneration.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Qiang Zhou, Victor H. Guaiquil, Matthea Wong, Alejandro Escobar, Evguenia Ivakhnitskaia, Ghasem Yazdanpanah, Hongwu Jing, Michael Sun, Joy Sarkar, Yuncin Luo, Mark Rosenblatt
Summary: The acellular porcine corneal stroma (APCS) hydrogel demonstrated optimal light transmittance and gelation properties, retaining critical corneal ECM components. It showed higher porosity, faster nutrition diffusion, improved proliferation of corneal cells, and enhanced viability and infiltration. The APCS-gel also improved corneal epithelial stemness and wound healing in vitro and in vivo, making it a promising option for clinical applications.
ACTA BIOMATERIALIA
(2021)
Article
Biochemistry & Molecular Biology
Jolana Kubickova, Tomas Medek, Jarmila Husby, Jana Matonohova, Hana Vagnerova, Lucie Marholdova, Vladimir Velebny, Josef Chmelar
Summary: This study aimed to develop biocompatible and biodegradable hyaluronan textiles for wound healing applications. The microscale fiber structure of the textiles can be adjusted by selected process parameters, affecting their mechanical properties and hydration. Cell viability testing confirmed the non-cytotoxicity and biocompatibility of the textiles. The high moisture absorption and convenient handling make hyaluronan textiles a promising material for wound healing.
Review
Pharmacology & Pharmacy
Vishal Jhanji, Isabelle Billig, Gary Hin-Fai Yam
Summary: Corneal opacification is the fourth most common cause of blindness globally. The standard treatment for serious corneal scarring is corneal transplantation, but there are limitations such as long-term graft survival and the lifelong use of immunosuppressants. Research is focused on finding new technologies to modulate wound healing and prevent corneal opacification.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Polymer Science
Lin Teng, Zheng-Wei Shao, Yu-Shi He, Jia-Yu Lu, De-Rong Zou, Chuan-Liang Feng, Chang-Ming Dong
Summary: In this study, we designed and prepared a hydrogel based on commercial ε-polylysine (EPL) with glucose and catechol functionalization. The hydrogel showed good biocompatibility and had excellent hemostatic and wound healing properties.
CHINESE JOURNAL OF POLYMER SCIENCE
(2022)
Article
Instruments & Instrumentation
Ana F. F. Pereira-da-Mota, Maria Vivero-Lopez, Piyush Garg, Chau-Minh Phan, Angel Concheiro, Lyndon Jones, Carmen Alvarez-Lorenzo
Summary: This study aimed to evaluate the release profiles of two drug-loaded contact lenses (CLs) in a 3D in vitro eye blink model and compare them with in vivo profiles. The results showed that the release of both drugs was more sustained and lower in the 3D eye model compared to in vitro release in vials. The findings suggest that the current 3D printed eye blink model could be a useful tool to measure the release of ophthalmic drugs from medicated CLs, but further optimization is needed.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Carmen Alvarez-Lorenzo, Maria Vivero-Lopez, Angel Concheiro
Summary: This study demonstrates the spontaneous formation of anisotropic gold nanoparticles (AuNPs) inside preformed contact lenses (CLs) without the need for additional reductant agents. The formation of AuNPs was achieved through a precise tuning of the monomeric composition, saline concentration, and the use of steam heat sterilization. The potential applications of incorporating AuNPs in CLs in the ocular field for prophylaxis, therapy, and diagnosis are highlighted. The developed CLs also exhibit photoresponsiveness and efficient filtering of highly penetrant light.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Carmela Tommasino, Giulia Auriemma, Carla Sardo, Carmen Alvarez-Lorenzo, Emilia Garofalo, Silvana Morello, Giovanni Falcone, Rita P. Aquino
Summary: In this study, a PCL/INU-PLA hybrid biomaterial was prepared, which showed improved surface properties, swelling ability, and in vitro biodegradation rate compared to PCL alone. The 3D printed scaffolds exhibited dimensional and structural parameters close to the digital model and showed favorable results in biocompatibility and osteogenic activity tests.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Kathleen Abigail Montoya-Villegas, Mirian Angelene Gonzalez-Ayon, Carmen Alvarez-Lorenzo, Angel Licea-Claverie, Emilio Bucio, Alejandro Ramirez-Jimenez
Summary: Thermo-responsive, hydrophilic, hemo- and biocompatible poly(DEGMA-co-OEGMA) was grafted onto silicone rubber using the gamma-radiation pre-irradiation method. The size of the grafted chains was controlled using a RAFT agent. The grafted materials showed enhanced hydrophilicity and excellent hemo- and cytocompatibility, indicating potential applications in the biomedical field.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Review
Nanoscience & Nanotechnology
Helena Rouco, Patricia Garcia-Garcia, Erik Briffault, Patricia Diaz-Rodriguez
Summary: Osteoclasts play a crucial role in the bone resorption process during bone remodeling. Osteoporosis, characterized by decreased bone mass density and altered bone microarchitecture, poses challenges in its treatment due to low patients' adherence to available therapies. Hence, the development of new and safe treatments, such as synthetic and natural nanoparticles, to modulate osteoclasts activity is necessary. Synthetic nanoparticles can carry antiresorptive drugs or regulate osteoclasts gene expression, while natural nanoparticles, known as extracellular vesicles, have been studied for their role in bone homeostasis. By controlling osteoclast activity using nanoparticles, the management of osteoporosis can be improved.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Axel Kattar, Ana Quelle-Regaldie, Laura Sanchez, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: The aim of this study was to develop cationic niosomes for the ocular delivery of epalrestat, a drug used in the treatment of diabetic eye damage. The niosomes were characterized and found to have a size of 80 nm, a charge ranging from -23 to +40 mV, and a spherical shape. The encapsulation efficiency of the niosomes was 99.76% and they showed a sustained release of the drug over 20 days. The niosomes were non-irritating, non-toxic, and showed higher permeation in the sclera compared to the unencapsulated drug.
Review
Chemistry, Medicinal
Angela Bonaccorso, Anna Privitera, Margherita Grasso, Sonya Salamone, Claudia Carbone, Rosario Pignatello, Teresa Musumeci, Filippo Caraci, Giuseppe Caruso
Summary: Carnosine, an endogenous dipeptide, has been investigated for its pharmacodynamic profile in various disease models and clinical settings due to its anti-aggregant, antioxidant, and anti-inflammatory activities, as well as its ability to modulate energy metabolism in immune cells. However, the rapid hydrolysis of carnosine by carnosinases, especially at the plasma level, limits its therapeutic use. Therefore, the development of new strategies, such as chemical modification and drug delivery systems, is crucial to increase carnosine bioavailability and site-specific transport to different tissues.
Review
Engineering, Biomedical
Mariana Zarur, Alejandro Seijo-Rabina, Alvaro Goyanes, Angel Concheiro, Carmen Alvarez-Lorenzo
Summary: This review focuses on the recent advances in pH-responsive polymer-based scaffolds that have been demonstrated in vivo to be suitable for wound and bone healing. pH plays a critical role in the tissue regeneration process, and small changes can significantly impact the healing process. Various strategies, including changes in ionization of natural polymers, ionizable monomers and clays, reversible cross-linkers, coatings, and production of CO2 gas, have been tested to prepare pH-responsive scaffolds. These techniques have shown promise in achieving biocompatible and environment-friendly scaffolds that can be translated to clinical applications.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Physical
Angela Arnosa-Prieto, Patricia Diaz-Rodriguez, Manuel A. Gonzalez-Gomez, Pelayo Garcia-Acevedo, Lisandra de Castro-Alves, Yolanda Pineiro, Jose Rivas
Summary: Macrophages can exhibit different phenotypes depending on the microenvironment and the characteristics of magnetic iron oxide nanoparticles (MNPs). This study demonstrates that the concentration and morphology of MNPs can influence the polarization of macrophages. The findings have implications for therapeutics targeting tissue regeneration and tumor progression.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
Review
Biochemistry & Molecular Biology
Federica Ragucci, Francesca Sireci, Francesco Cavallieri, Jessica Rossi, Giuseppe Biagini, Giovanni Tosi, Chiara Lucchi, Rodolfo Molina-Pena, Natalia Helen Ferreira, Mariana Zarur, Alba Ferreiros, William Bourgeois, Francois Berger, Miguel Abal, Audrey Rousseau, Frank Boury, Carmen Alvarez-Lorenzo, Emmanuel Garcion, Anna Pisanello, Giacomo Pavesi, Corrado Iaccarino, Luca Ghirotto, Maria Chiara Bassi, Franco Valzania
Summary: Nanotechnology shows promise in cancer treatment, particularly in the field of neuro-oncology. It is important to explore clinicians' intentions and perspectives on using this new technology in clinical practice.
Article
Engineering, Biomedical
Carmen Alvarez-Lorenzo, Mariana Zarur, Alejandro Seijo-Rabina, Barbara Blanco-Fernandez, Isabel Rodriguez-Moldes, Angel Concheiro
Summary: The imbalance between life expectancy and quality of life is increasing due to the raising prevalence of chronic diseases. Scaffolds that can mimic natural physical stimuli and deliver dynamic physical stimuli, such as electrical signals, have shown potential for more efficient tissue regeneration.
MATERIALS TODAY BIO
(2023)
Review
Chemistry, Multidisciplinary
Paola Carou-Senra, Lucia Rodriguez-Pombo, Atheer Awad, Abdul W. Basit, Carmen Alvarez-Lorenzo, Alvaro Goyanes
Summary: Inkjet printing (IJP) enables precise material deposition for personalized medicine and drug delivery. This review explores the formulation and components of pharma-inks, various substrate materials, and potential improvements through hardware, software, and artificial intelligence integration. Further exploration and optimization are needed to fully harness the healthcare capabilities of IJP.
ADVANCED MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
