Review
Immunology
Ri Zhang, Yujia Wei, Tingmei Wang, Xiaoqi Nie, Zeqi Shi, Yunhua Deng, Dong Li
Summary: Exosomes, small vesicles coated with phospholipids, are released by cells and contain miRNA that plays a significant role in the pathogenesis of autoimmune skin diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Desislava (Daisy) Ilchovska, Dr Michelle Barrow
Summary: NF-kB and RANKL play important roles in RA, with potential side effects from long-term non-specific suppression of the NF-kB pathway. Vitamin D supplementation may help to lower RANKL levels, serving as a potential nutrition intervention for RA management.
AUTOIMMUNITY REVIEWS
(2021)
Review
Biochemistry & Molecular Biology
Angel Yun-Kuan Thye, Yi-Rou Bah, Jodi Woan-Fei Law, Loh Teng-Hern Tan, Ya-Wen He, Sunny-Hei Wong, Sivakumar Thurairajasingam, Kok-Gan Chan, Learn-Han Lee, Vengadesh Letchumanan
Summary: Evidence suggests that the gut microbiome plays a role in modulating the development of diseases beyond the gastrointestinal tract, including skin disorders. The gut-skin axis refers to the bidirectional relationship between the gut microbiome and skin health, regulated through mechanisms such as inflammatory mediators and the immune system. Microbiota dysregulation has been observed in various inflammatory skin conditions, such as atopic dermatitis, rosacea, and psoriasis. Understanding the involvement of the gut microbiome in regulating skin health could lead to the development of novel therapies for these skin disorders, particularly psoriasis.
Review
Chemistry, Multidisciplinary
Juan L. Paris, Alejandro Baeza
Summary: Nano- and microparticles have attracted attention for delivering therapeutic molecules, particularly in their interaction with the immune system. Selective targeting towards specific cell types and controlled co-delivery of active molecules using these particles can lead to the development of various therapeutic strategies for different pathological scenarios.
Article
Immunology
Nourhan S. Soliman, Mohamed A. Kandeil, Marwa M. Khalaf
Summary: This study investigates the potential pharmacological effect of LQ scorpion venom in CFA-induced arthritis, demonstrating its therapeutic effect through various mechanisms. The results indicate that LQ venom has the potential to be used in the treatment of rheumatoid arthritis by reducing inflammation and improving pathological changes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Grant Sprow, Mohsen Afarideh, Joshua Dan, Rui Feng, Emily Keyes, Madison Grinnell, Josef Concha, Victoria P. Werth
Summary: The study found that fully vaccinated dermatomyositis patients were more likely to report exacerbation of autoimmune signs and symptoms after vaccination compared to fully vaccinated lupus erythematosus patients. However, given the risks of COVID-19, clinicians should still promote vaccination in most patients with autoimmune skin disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Roberta Lotti, Claudio Giacinto Atene, Emma Dorotea Zanfi, Matteo Bertesi, Carlo Pincelli, Tommaso Zanocco-Marani
Summary: Researchers have developed new active models to mimic the main forms of Pemphigus, including PV and mucocutaneous Pemphigus. Immunized animals and animals that received splenocytes from the immunized donors produced high concentrations of circulating antibodies against specific antigens, but the effectiveness of treatment with corticosteroids was limited.
Article
Pharmacology & Pharmacy
Sreeja C. Nair, Kollencheri Puthenveettil Vinayan, Sabitha Mangalathillam
Summary: The study demonstrates that nanosized phenytoin sodium loaded NLCs of < 50 nm can achieve direct and rapid nose to brain drug transport through the olfactory epithelium, offering promising potential for treating acute epileptic seizures.
Article
Pharmacology & Pharmacy
Rabab Kamel, Mona M. Abou Samra, Sherif M. Afifi, Asmaa F. Galal
Summary: This study developed a novel nanometric delivery system for the oral administration of morin hydrate using beta-sitosterol as a replacement for cholesterol. The system showed high drug release efficiency and significant antitumor efficacy, making it a promising option for the treatment of leukemia.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Artur Swierczek, Krzysztof Pociecha, Hanna Plutecka, Marietta Slusarczyk, Grazyna Chlon-Rzepa, Elzbieta Wyska
Summary: In this study, the potential treatment effect of a new theophylline derivative, compound 34, as a phosphodiesterase (PDE)4 and PDE7 inhibitor for autoimmune diseases was evaluated. The results showed that compound 34 displayed high efficacy in animal models of multiple sclerosis, rheumatoid arthritis, and autoimmune hepatitis. Inhibition of PDE types in immune cells may serve as an alternative treatment strategy for autoimmune diseases.
Article
Medicine, General & Internal
Maria Efenesia Baffa, Alberto Corra, Roberto Maglie, Elena Biancamaria Mariotti, Francesca Montefusco, Carlo Pipito, Stefano Senatore, Lavinia Quintarelli, Marzia Caproni, Emiliano Antiga
Summary: This study evaluated a case series of patients with mucous membrane pemphigoid (MMP) treated with RTX. The results showed that adding RTX to conventional therapies can safely and effectively achieve rapid disease control in the majority of refractory MMP patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Nanoscience & Nanotechnology
Jie Zhang, Jinghu Jiao, Meng Niu, Xiaotong Gao, Guisen Zhang, Honghua Yu, Xiaohong Yang, Lei Liu
Summary: The complex drug delivery barrier in the eye can be overcome by utilizing nanotechnology and various nano-carriers to enhance drug bioavailability, retention time, and permeability in the eye. These approaches hold great potential for treating ocular diseases effectively.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Plant Sciences
Nourhan S. Soliman, Mohamed A. Kandeil, Marwa M. Khalaf
Summary: This study demonstrates the potential pharmacological effects of cerastes venom in treating rheumatoid arthritis. By evaluating various tissue and serum parameters, it was found that cerastes venom has significant anti-inflammatory and immunomodulatory effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Wanwu Dai, Pan Jin, Xingyan Li, Jinmin Zhao, Ying Lan, Hongmian Li, Li Zheng
Summary: Researchers designed a new carrier-free self-assembly nanomedicine Curcumin (Cur)/icariin (ICA) nanoparticles with adjustable particle size. These nanoparticles showed low cytotoxicity, high cellular uptake, sustained drug release, and the ability to inhibit inflammatory cytokine secretion and reduce cartilage degeneration. Both in vitro and in vivo experiments demonstrated that the nanoparticles had superior synergism effects in anti-inflammatory and cartilage protection compared to using Cur or ICA alone, and their retention could be monitored by autofluorescence.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Immunology
Johanna Huttelmaier, Sandrine Benoit, Matthias Goebeler
Summary: Bullous pemphigoid is a common autoimmune blistering disease, especially in elderly people. Understanding the association between bullous pemphigoid and other diseases may improve patient care. This review provides a systematic overview on comorbidity in bullous pemphigoid patients.
FRONTIERS IN IMMUNOLOGY
(2023)