Article
Pharmacology & Pharmacy
Rami Ahmed, Marique Aucamp, Naushaad Ebrahim, Halima Samsodien
Summary: The study successfully developed PEGylated G4 PAMAM dendrimers as a suitable drug carrier for rifampicin, with negligible cytotoxicity, high loading potential, and prolonged-release behavior. PEGylated dendrimers exhibited a slower release rate compared to the native/unmodified formulation and free drug, with significantly improved toxicity after PEGylation, and negligible toxicity detected for formulations with 100% functionalization.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Marija Petrovic, Alexandre Porcello, Stoyan Tankov, Oliwia Majchrzak, Martin Kiening, Annick Clara Laingoniaina, Tayeb Jbilou, Paul R. Walker, Gerrit Borchard, Olivier Jordan
Summary: Anti-tumor responses can be achieved through cancer immunotherapy, which stimulates the immune system. However, the presence of immune-suppressive tumor-associated macrophages (TAMs) in many solid tumors is associated with poor survival and low responsiveness to immunotherapy. Researchers have developed nanocarriers based on dendrimers to deliver 2 ' 3 ' Cyclic GMP-AMP (cGAMP) and convert TAMs into anti-tumoral macrophages. The best formulation was selected based on its low toxicity, biocompatibility, targeted delivery, and ability to promote M1 macrophage polarization.
Article
Biophysics
Bhavya Surekha, Naga Sreenu Kommana, Sunil Kumar Dubey, A. V. Pavan Kumar, Rahul Shukla, Prashant Kesharwani
Summary: PAMAM dendrimers are novel polymeric structures with defined nano-size and multiple active functional groups, ideal for cancer therapy. Their modifiable surface functionalities and high drug encapsulation rate make them widely used in drug delivery and gene therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Pharmacology & Pharmacy
Saghir Akhtar, Fawzi Babiker, Usman A. Akhtar, Ibrahim F. Benter
Summary: This study investigated the influence of physiochemical properties of dendrimer nanoparticles on cardiac function. The results showed that PAMAM dendrimers can impair heart recovery from ischemia-reperfusion injury in a dose, generation, and surface charge dependent manner. It was also found that the cardiotoxicity induced by PAMAM dendrimers can be mitigated by the activation of Ang-(1-7)/MAS receptor axis.
Article
Multidisciplinary Sciences
Cai He, Jingyun Yang, Weiqi Hong, Zimin Chen, Dandan Peng, Hong Lei, Aqu Alu, Xuemei He, Zhenfei Bi, Xiaohua Jiang, Guowen Jia, Yun Yang, Yanan Zhou, Wenhai Yu, Cong Tang, Qing Huang, Mengli Yang, Bai Li, Jingmei Li, Junbin Wang, Haiying Que, Li Chen, Wenyan Ren, Dandan Wan, Jiong Li, Wei Wang, Guobo Shen, Zhiwei Zhao, Li Yang, Jinliang Yang, Zhenling Wang, Zhaoming Su, Yuquan Wei, Xiaobo Cen, Yoshimasa Tanaka, Xiangrong Song, Shuaiyao Lu, Xiaozhong Peng, Guangwen Lu, Xiawei Wei
Summary: The researchers have developed a vaccine candidate called RBD-HR/trimer, which induces both humoral and cellular immune responses and provides effective protection against Omicron and Delta variants in various animal models. This vaccine candidate has great potential for being the next generation vaccine for preventing SARS-CoV-2.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Shanshan Chen, Junjie Deng, Li-Ming Zhang
Summary: PAMAM-Cs-DCA nanoparticles exhibit good gene transfection efficiency and low cytotoxicity, successfully encapsulating the anticancer drug DOX and forming complexes with pDNA, while the co-delivery of DOX enhances transgene expression synergistically.
CARBOHYDRATE POLYMERS
(2021)
Article
Materials Science, Multidisciplinary
Andre Luiz Teixeira, Isis Oliveira Szlachetka, Aparecido Ribeiro Souza, Jason Jerry Atoche Medrano, Jose Antonio Huamani Coaquira, Denilson Rabelo, Tais Augusto Pitta Garcia Cotta, Paulo Cesar Morais, Sebastiao William da Silva
Summary: This study presents the fabrication and characterization of a new magnetic nanocarrier by associating magnetite nanoparticles (NPs) with poly(amidoamine) (PAMAM) dendrimers loaded with dirhodium(II) acetate complex (DiRh(II)). The magnetite NPs were coated with ATPS (3-aminopropyltriethoxysilane). The interaction between PAMAM dendrimer and DiRh(II) and its effects on magnetic properties were investigated.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Review
Polymer Science
Mahak Fatima, Afsana Sheikh, Nazeer Hasan, Amirhossein Sahebkar, Yassine Riadi, Prashant Kesharwani
Summary: Nano carriers, such as PAMAM dendrimers, play a crucial role in overcoming the challenges of cancer chemotherapy by reducing cytotoxicity, non-specificity, and drug resistance. These nano-sized molecules encapsulate drugs and target tumor cells specifically, while minimizing impact on normal cells. The PAMAM dendrimer structure allows for high solubility of hydrophobic chemotherapeutic drugs, and its periphery can be modified for tumor specificity. Folic acid conjugated dendrimers are widely studied for targeting cancer cells that overexpress folate receptors.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Rishi Sharma, Joshua E. Porterfield, Hyoung-Tae An, Ambar Scarlet Jimenez, Seulki Lee, Sujatha Kannan, Anjali Sharma, Rangaramanujam M. Kannan
Summary: The GAL-24 glycodendrimer is designed for targeted drug delivery to hepatocytes by exploiting the asialoglycoprotein receptor 1 (ASGP-R). It demonstrates significant accumulation in the liver shortly after systemic administration and maintains hepatocyte-targeting capabilities in mouse and rat models, showing promise for improved drug delivery in treating various liver disorders.
Review
Cell & Tissue Engineering
Hendrik Setia Budi, Firdaus Nuri Ahmad, Harun Achmad, Mohammad Javed Ansari, Maria Vladimirovna Mikhailova, Wanich Suksatan, Supat Chupradit, Navid Shomali, Faroogh Marofi
Summary: Due to the overexpression or amplification of human epidermal growth factor receptor 2 (HER2) with poor prognosis in various human tumors, recent studies have focused on HER2-targeted therapies. Immunotherapy using HER2-specific chimeric antigen receptor (CAR) expressing immune cells has shown great anti-tumor potential and attracted increasing attention.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Immunology
Zhiling Yan, Huanxin Zhang, Jiang Cao, Cheng Zhang, Hui Liu, Hongming Huang, Hai Cheng, Jianlin Qiao, Ying Wang, Yan Wang, Lei Gao, Ming Shi, Wei Sang, Feng Zhu, Depeng Li, Haiying Sun, Qingyun Wu, Yuekun Qi, Hujun Li, Xiangmin Wang, Zhenyu Li, Hong Liu, Junnian Zheng, Wenbin Qian, Xi Zhang, Kailin Xu
Summary: Clinical trials have shown that CAR T cell therapies are changing the treatment of relapsed or refractory hematological tumors, with CRS being a common adverse event. Understanding the characteristics and risk factors of CRS is crucial for effective management. Different B-cell hematological tumors have varying characteristics and risk factors for CRS during CAR-T cell therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Anna Niu, Jintao Zou, Xuan Hu, Zhang Zhang, Lingyu Su, Jing Wang, Xing Lu, Wei Zhang, Wei Chen, Xiaopeng Zhang
Summary: Chimeric antigen receptor (CAR)-T cell therapy is an innovative treatment for CD19-expressing lymphomas, and CAR-T cells can be manufactured through different approaches. Manufacturing CAR-T cells using the PiggyBac transposon results in higher CAR expression and more cytotoxic T cell subsets, while Lentivirus manufacturing leads to a more pronounced memory phenotype. RNA-sequencing analysis reveals substantial disparities between the two CAR-T cell groups. Overall, these findings provide important insights into the phenotypic alterations induced by different manufacturing methods and their clinical implications.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Rensong Sun, Linlin Fang, Xia Lv, Jiani Fang, Yuting Wang, Dapeng Chen, Liang Wang, Jun Chen, Yan Qi, Zeyao Tang, Jianbin Zhang, Yan Tian
Summary: The study developed novel liver-targeting chitosan nanoparticles to selectively overcome HCC via ASGPR, demonstrating strong anti-cancer efficacy and good biocompatibility. These galactosylated chitosan nanoparticles have great potential for clinical applications in treating hepatocellular carcinoma.
Article
Materials Science, Multidisciplinary
Alex Yang-Hao Yu, Ru-Huei Fu, Shan-hui Hsu, Chen-Feng Chiu, Wei-Hsiang Fang, Chun-An Yeh, Cheng-Ming Tang, Hsien-Hsu Hsieh, Huey-Shan Hung
Summary: Utilizing collagen gold nanoparticles as a carrier for EGFR siRNA shows promising results in treating lung cancer, leading to significant tumor suppression effects and improved survival rates.
MATERIALS TODAY ADVANCES
(2021)
Correction
Biochemistry & Molecular Biology
Jeong-Yub Kim, Hee-Jin Kim, Chan-Woong Jung, Byung-Il Choi, Dae-Hee Lee, Myung-Jin Park
Summary: A correction to this paper has been published.