Article
Pharmacology & Pharmacy
Fatemeh Hassaninejad Farahani, Fatemeh Moraffah, Nasrin Samadi, Mohammad Sharifzadeh, Hamidreza Motasadizadeh, Alireza Vatanara
Summary: Lactiplantibacillus plantarum cells were encapsulated in a mixture of cationic and anionic polymers and freeze-dried, resulting in a stable composition. The effects of polymer concentrations and prebiotics on probiotic viability and swelling behavior were examined using a D-optimal design. The optimized formulation showed a viability percentage of over 82% and should be stored refrigerated. In vivo testing demonstrated improved wound healing indicators and the ability to modify wound inflammatory responses, making it comparable to silver sulfadiazine ointment.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Aparna Yerra, D. M. Mamatha
Summary: Silk fibroin-based antibiotic films have been proven effective in combating bacterial pathogens, promoting cell viability and adhesion. These films maintain their antimicrobial properties, reducing the risk of infection at wound sites and accelerating the healing process of burn wounds.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Chemistry, Physical
Na Li, Wan Liu, Xiaoyan Zheng, Qing Wang, Lixin Shen, Junfeng Hui, Daidi Fan
Summary: Burns are a common medical problem worldwide, with wound infection as a major complication. To tackle this issue, a new strategy has been proposed to develop a pH-responsive antimicrobial P-ZIF by loading PHMB into ZIF-8 nanoparticles. These nanoparticles can release PHMB in the weak acid environment of an infected wound. Furthermore, P-ZIF nanoparticles were incorporated into a hydrogel dressing made of SA and H-A, which exhibited antibacterial and wound healing properties with dual pH responsiveness. The P-ZIF nanoparticles and corresponding hydrogel dressing are highly significant in antimicrobial, drug delivery, and wound repair applications.
Article
Polymer Science
Aparna Yerra, Mary Mamatha Dadala
Summary: The developed silk fibroin-based extracellular electrospun nanofibrous matrix showed positive effects on wound healing, antimicrobial sensitivity activity, and promotion of cell proliferation without losing the chemical properties of antibiotics.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Ying Huang, Lei Mu, Xin Zhao, Yong Han, Baolin Guo
Summary: Researchers have developed a self-healing hydrogel with good electrical conductivity and antioxidant activity for burn wound repair. The hydrogel can release antibiotics on demand and shows excellent antibacterial properties, in vivo antibacterial activity, and wound inflammation control compared to conventional dressings. This smart release hydrogel is highly advantageous for bacterial-infected burn wound healing.
Article
Immunology
Bolin Wang, Jianle Chen, Chuwei Zhang, Qingrong Zhang, Zhihan Zhu, Ling Qiu, Jun Yan, Zihan Li, Xinghua Zhu, Yi Zhang, Yun Jiang
Summary: This study demonstrates the potential of a novel delivery system, the platelet membrane-coated nanoparticle complex, in effectively delivering bFGF and VEGFA genes to deep burn wounds and promoting wound healing.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jiaojiao Zhu, Tiao Wen, Shuangquan Qu, Qingnian Li, Biwu Liu, Wenhu Zhou
Summary: This study developed a multifunctional silver nanoclusters-based hydrogel dressing for the treatment of infected wounds. The dressing has the capability to simultaneously fight infection and promote wound healing, showing excellent therapeutic efficacy in a mouse model of infected wounds.
Article
Polymer Science
Touseef Nawaz, Muhammad Iqbal, Barkat Ali Khan, Asif Nawaz, Talib Hussain, Khaled M. Hosny, Walaa A. Abualsunun, Waleed Y. Rizg
Summary: Nanoparticles loaded with acriflavine were successfully prepared and optimized using a Box-Behnken design. The optimized nanoparticles exhibited good stability and drug encapsulation efficiency, showing potential for the treatment of burn wounds.
Article
Biotechnology & Applied Microbiology
Huiyu Han, Lianheng Chen, Shu Liang, Jiawei Lu, Yashi Wu, Xiongjun Wang, Fei Xu, Lanlan Ge, Lingyun Xiao
Summary: A new drug carrier nanoparticle, SKN/BNP, was developed in this study. It showed sustained-release behavior and improved drug efficiency in exudate-rich burn wounds. It also demonstrated effectiveness against drug-resistant and biofilm-forming MRSA.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Environmental Sciences
Fuyong Wang, Yuhong Zheng, Jing Ning
Summary: In this study, a green strategy using table olive was employed to prepare copper oxide nanoparticles (CuO NPs), and their properties and applications were evaluated. The synthesized CuO NPs demonstrated remarkable catalytic activity and low cytotoxicity, making them suitable for organic pollutants reduction and wound care. Therefore, CuO NPs have potential applications in various fields including environmental remediation and medical treatment.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xushan Chen, Huimin Zhang, Xin Yang, Wuhong Zhang, Ming Jiang, Ting Wen, Jie Wang, Rui Guo, Hanjiao Liu
Summary: Infection is a major cause of death from burns, and traditional dressings are ineffective at inhibiting bacterial growth; a new hydrogel design shows excellent antibacterial activity and fast wound healing, promising to be a significant advancement in wound dressings.
Article
Engineering, Biomedical
Que Bai, Caiyun Zheng, Na Sun, Wenting Chen, Qian Gao, Jinxi Liu, Fangfang Hu, Tong Zhou, Yanni Zhang, Tingli Lu
Summary: This study presents an oxygen-releasing hydrogel that promotes cell survival, migration, and tube formation under hypoxic conditions, and facilitates tissue repair by reducing inflammation, increasing angiogenesis, and collagen deposition.
ACTA BIOMATERIALIA
(2022)
Article
Dermatology
Ying Lu, Jian Li
Summary: We conducted a meta-analysis to evaluate the impact of prolonged postoperative antibiotics (PA) on wound healing in orthognathic surgery (OS). A total of 1021 related studies were assessed, including 1057 OS subjects. Short-term PA led to significantly higher wound infection compared to long-term PA in OS, with an odds ratio (OR) of 4.27 (95% CI, 2.97-6.14, P < 0.001) and low heterogeneity (I-2 = 27%). However, caution is needed due to the small sample sizes in many selected studies.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Infectious Diseases
Ali Pormohammad, Nadia K. Monych, Sougata Ghosh, Diana L. Turner, Raymond J. Turner
Summary: Wounds continue to be a serious medical concern, with infectious microbes in biofilm form delaying the healing process. Developing novel wound dressing drug formulations and materials with combined antibacterial, antibiofilm, and wound healing properties are necessary. Nanomaterials show promising applicability for various wound types with their unique properties.
Article
Chemistry, Multidisciplinary
Minting Liu, Ying Chen, Qiang Zhu, Junjun Tao, Changming Tang, Huajun Ruan, Yunlong Wu, Xian Jun Loh
Summary: This study discovered that supercritical CO2 extracted pearl peptide hydrogels have the potential to promote wound healing. These hydrogels can increase skin fibroblast viability, enhance antioxidant stress resistance, promote tissue remodeling and angiogenesis, and significantly accelerate wound healing.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Applied
Alessio Alesci, Angelo Fumia, Anthea Miller, Concetta Calabro, Antonello Santini, Nicola Cicero, Patrizia Lo Cascio
Summary: This study found that spirulina has an immunostimulant effect on zebrafish liver macrophages, increasing their numbers and inducing aggregation. These findings are not only significant for studying complementary feed for fish immune cells but also contribute to a better understanding of the immune mechanisms in vertebrates.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Chemistry, Applied
Vita Di Stefano, Nicola Cicero, Maria Grazia Melilli, Enrico Ganguzza, Massimo Lucarini, Alessandra Durazzo
Summary: Quality control is crucial for protein supplements aimed at a large consumer base like sportspeople. A study analyzed 16 sports supplements from various European countries and found discrepancies in amino acid quantities compared to the label. Some samples exceeded the maximum tolerance regulated by the European Commission, while others had amino acid concentrations exceeding the analytical tolerance percentage. However, essential and branched amino acid supplements were found to conform to the declared quantities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Nutrition & Dietetics
Luciana Melo de Farias, Lays Arnaud Rosal Lopes Rodrigues, Layanne Cristina de Carvalho Lavor, Alessandro de Lima, Suzana Maria Rebelo Sampaio da Paz, Janyerson Dannys Pereira da Silva, Karoline de Macedo Goncalves Frota, Massimo Lucarini, Alessandra Durazzo, Daniel Dias Rufino Arcanjo, Maria do Carmo de Carvalho e Martins
Summary: This study aimed to evaluate the relationship between polyphenol intake and atherogenic lipid profile in adults and elders in Teresina, Brazil. The study included 501 participants and found that the mean intake of total polyphenols was 1006.53 mg/day. Individuals with high serum cholesterol and triglyceride levels had significantly higher polyphenol intake. Those with dyslipidemia also had higher polyphenol intake. The study provides valuable data on polyphenol intake and its relationship with lipid profile in this population.
Review
Immunology
Aleksandra Zielinska, Piotr Eder, Jacek Karczewski, Marlena Szalata, Szymon Hryhorowicz, Karolina Wielgus, Milena Szalata, Agnieszka Dobrowolska, Atanas G. Atanasov, Ryszard Slomski, Eliana B. Souto
Summary: This study discusses the use of monoclonal antibodies for targeted drug delivery in the treatment of COVID-19. It proposes the use of solid lipid nanoparticles (SLN) loaded with tocilizumab (TCZ) and cannabidiol (CBD) for oral administration. TCZ attenuates cytokine storm in SARS-CoV-2 infected patients, while CBD has anti-inflammatory properties and can modulate gene expression. The use of SLN for oral administration of TCZ-tailored CBD-loaded SLN shows potential in managing SARS-CoV-2 and related infections. Rating: 7/10
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ian M. R. Blanco, Raquel de Melo Barbosa, Julita M. P. Borges, Silvio A. B. Vieira de Melo, Ramon dos Santos El-Bacha, Cesar Viseras, Patricia Severino, Elena Sanchez-Lopez, Eliana B. B. Souto, Elaine Cabral-Albuquerque
Summary: Traditional medicine uses resin oils from plants for medicinal purposes, and this study focuses on understanding their pharmacological properties. Liposomes containing resin oils or extracts from Copaifera sabulicola leaves were prepared and characterized. The liposomes showed cytotoxic effects against cancer cells and have potential applications in chemotherapy.
Article
Biochemistry & Molecular Biology
Andrea V. Machado, Luana R. O. Menezes, Adilson A. M. Santana, Maria N. Marques, Adriana K. de Lima, Amanda Cano, Patricia Severino, Eliana B. Souto, Juliana C. Cardoso
Summary: This work describes a new hair dyeing method using geniposide to react with the amino group in hair keratin. The study evaluated the effects of reaction conditions on color change, hair morphology, and mechanical properties. The results showed that geniposide treatment can significantly change hair color and affect its mechanical properties and morphology.
CHEMISTRY & BIODIVERSITY
(2023)
Review
Pharmacology & Pharmacy
Camilla A. S. Valenca, Ana A. T. Barbosa, Silvio S. Dolabella, Patricia Severino, Carla Matos, Karolline Krambeck, Eliana B. Souto, Sona Jain
Summary: The global problem of antibiotic resistance is a serious threat to the treatment of infectious diseases. New antimicrobials and improved delivery systems are needed. Bacterial secondary metabolites have potential as antimicrobial agents, but few molecules make it to the clinical phase.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Food Science & Technology
Beatriz N. Guedes, Faezeh Fathi, Amelia M. Silva, Antonello Santini, M. Beatriz P. P. Oliveira, Eliana B. Souto
Summary: Prickly pear, also known as Opuntia ficus-indica (OFI), is a beneficial plant with dietary fibers, vitamins and various bioactive compounds. This article reviews its nutritional composition, biological activities, and extraction techniques commonly used for different parts of the plant.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2023)
Article
Instruments & Instrumentation
Marismar F. do Nascimento, Clauberto R. de Oliveira, Juliana C. Cardoso, Natalia C. T. Bordignon, Rogerio Gondak, Patricia Severino, Eliana B. Souto, Ricardo L. C. de Albuquerque Jr
Summary: This study aimed to develop and analyze the healing properties of GelMA containing AEPG, gallic acid, or ellagic acid. The results showed that GPG and GGA significantly accelerated wound closure, improved collagenization, increased histological grading, and hastened myofibroblast differentiation.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Instruments & Instrumentation
Venancio A. Amaral, Juliana Ferreira de Souza, Thais F. R. Alves, Jose M. de Oliveira Junior, Patricia Severino, Norberto Aranha, Eliana B. Souto, Marco V. Chaud
Summary: The aim of this work was to develop a dense lamellar scaffold for tracheal tissue regeneration using phenolic compounds from Psidium guajava Linn. Fourier transform infrared spectroscopy and differential scanning calorimetry confirmed chemical interactions between the polymers and cross-linking of phenolic compounds. Morphological analyses showed scaffolds with porosity and a porous surface structure. The addition of phenolic compounds modulated the morphological and mechanical properties of the scaffolds.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Multidisciplinary Sciences
Isabella S. A. Peres, Kiara A. O. Conceicao, Larissa A. F. Silva, Nadia G. Khouri, Cristiana M. P. Yoshida, Viktor O. C. Concha, Massimo Lucarini, Alessandra Durazzo, Antonello Santini, Eliana B. Souto, Patricia Severino
Summary: This article discusses the nutraceutical and pharmaceutical applications of Dragon's Blood, focusing on its antioxidant properties. Through literature research analysis, the current status and future development directions of this topic are explored. The study reveals that Dragon's Blood extracts possess various activities such as anti-inflammatory, wound healing, antidiarrheal, anticancer, antirheumatic, antiseptic, and antioxidant effects, which provide novel perspectives for its use in the food and pharmaceutical industries.
RENDICONTI LINCEI-SCIENZE FISICHE E NATURALI
(2023)
Article
Pharmacology & Pharmacy
Smita Khairnar, Elena Sanchez-Lopez, Eliana B. Souto, Kamalinder K. Singh
Summary: Microspheres-enriched ocular gels were developed as a controlled release system for moxifloxacin hydrochloride. The ocular gel containing microspheres showed improved drug release, penetration, and therapeutic efficacy, with reduced administration frequency, which may improve patient compliance to ocular treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Agriculture, Dairy & Animal Science
Andy Wai Kan Yeung, Natalia Ksepka, Maima Matin, Dongdong Wang, Eliana B. Souto, Jivko Stoyanov, Javier Echeverria, Devesh Tewari, Jaroslaw Olav Horbanczuk, Massimo Lucarini, Alessandra Durazzo, Joanna Marchewka, Vasil Pirgozliev, Ren-You Gan, Nikolay T. Tzvetkov, Kamil Wysocki, Farhan Bin Matin, Olena Litvinova, Anupam Bishayee, Hari Prasad Devkota, Amr El-Demerdash, Mladen Brncic, Antonello Santini, Olaf. K. Horbanczuk, Michel-Edwar Mickael, Michal Lawinski, Niranjan Das, Bodrun Naher Siddiquea, Dalibor Hrg, Atanas G. Atanasov
Summary: This study provides a quantitative literature analysis on the influence of diet on non-alcoholic fatty liver disease (NAFLD). The analysis reveals that China and the United States are significant contributors to this field, and key dietary compounds such as resveratrol and polyphenols are frequently mentioned and cited, showing potential benefits for NAFLD in both human and animal studies.
ANIMAL SCIENCE PAPERS AND REPORTS
(2023)
Review
Green & Sustainable Science & Technology
Simone Kelly Rodrigues Lima, Alessandra Durazzo, Massimo Lucarini, Joao Jose Alves de Oliveira, Robson Alves da Silva, Daniel Dias Rufino Arcanjo
Summary: This study reviewed the literature to understand the current situation and challenges of converting fruit residues into value-added co-products. The findings showed that the drying process is important in obtaining flours with enhanced characteristics from fruit co-products. While there are technological difficulties, these strategies contribute to managing losses in the agri-food chains and improving food and nutrition security.
