期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 176, 期 2, 页码 157-167出版社
WILEY
DOI: 10.1111/bjh.14411
关键词
acute lymphoblastic leukaemia; central nervous system
类别
资金
- Israel Science Foundation
- German Israel Foundation
Central nervous system acute lymphoblastic leukaemia (CNS-ALL) is a major clinical problem. CNS-directed 'prophylactic' chemo-or radio - therapy is associated with significant early and long-term toxicity. Moreover, greater than a third of the relapses occur in the CNS. To design specific, more effective and less toxic therapy and for personalized precise adjustment of prophylactic therapy there is a need for better understanding of the biology of this disease. Specifically, the precise neurotropic mechanisms of ALL are currently unclear, as is the pathogenesis of CNS relapse. Here we review and contrast the recent findings with earlier studies of pathogenesis of CNS leukaemia. We also describe the challenges in research of this devastating complication of ALL.
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