Review
Oncology
Soudeh Ghafouri-Fard, Amin Aghabalazade, Hamed Shoorei, Jamal Majidpoor, Mohammad Taheri, Majid Mokhtari
Summary: Apoptosis is a coordinated cellular process that occurs in several physiological situations, and dysregulation of apoptosis has been documented in numerous pathological situations, particularly cancer. Non-coding RNAs regulate apoptosis via different mechanisms, and in lung cancer, these RNAs interact with important cancer-related pathways to influence cell fate. Over-expression of apoptosis-blocking non-coding RNAs has been associated with poor prognosis in patients, while apoptosis-promoting ones have the opposite effect.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Yan Xu, Yu Sun, Xiaobin Song, Jian Ren
Summary: Cervical cancer (CC) is a common cancer among women worldwide, with high rates of morbidity and mortality. ncRNAs, such as miRNAs and lncRNAs, have been found to play important roles in CC progression by targeting and modulating the expression of proteins involved in signaling pathways. Understanding these interactions can guide CC treatment by assisting with diagnosis, drug administration, and prognosis prediction.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemical Research Methods
Bashdar Mahmud Hussen, Safeen Jasim Saleem, Snur Rasool Abdullah, Sayran Mohamadtahr, Hazha Jamal Hidayat, Mohammed Fatih Rasul, Mohammad Taheri, Arda Kiani
Summary: Lung cancer is the leading cause of cancer-related deaths globally, and the TGF-beta family of growth factors and miRNA play critical roles in its development. Recent research suggests that TGF-beta signaling directly affects the synthesis of miRNA, ultimately influencing the fate of cancer cells. Understanding the key functions of miRNA in lung cancer progression and its impact on the TGF-beta signaling pathway can help identify potential therapeutic targets for improving lung cancer treatment.
MOLECULAR AND CELLULAR PROBES
(2023)
Review
Endocrinology & Metabolism
Cecilia Catellani, Gloria Ravegnini, Chiara Sartori, Sabrina Angelini, Maria E. Street
Summary: Growth hormone and the insulin-like growth factor system play crucial roles in cell proliferation, differentiation, apoptosis, and angiogenesis, while miRNAs and lncRNAs regulate gene expression and have been linked to diseases such as cancer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Atefe Abak, Shiva Tavakkoli Avval, Shayan Rahmani, Hamed Shoorei, Mohammad Taheri, Mohammad Samadian
Summary: Non-coding RNAs, particularly microRNAs and long non-coding RNAs, play crucial roles in osteogenesis by regulating signaling pathways and functioning as molecular sponges for miRNAs. These transcripts have significant impacts on bone development and related disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biology
Nicole Natarelli, Aleena Boby, Shaliz Aflatooni, Jasmine Thuy Tran, Michael Joseph Diaz, Kamil Taneja, Mahtab Forouzandeh
Summary: Non-coding RNAs (ncRNAs), including lncRNAs and miRNAs, play significant regulatory roles in skin cancer pathogenesis, impacting key signaling pathways and gene expression. Dysregulation of miRNAs affects cell cycle regulation, cellular differentiation, and immunological responses in skin cancer. In addition, ncRNAs have potential as diagnostic biomarkers and prognostic indicators, and unraveling their regulatory networks offers groundbreaking opportunities for targeted therapies in dermatologic care.
Article
Biochemistry & Molecular Biology
Guanglei Zhong, Qian Zhao, Zhiliao Chen, Tingting Yao
Summary: This study found that the TGF-ss pathway promotes cervical cancer metastasis through upregulation of CDR1as, which facilitates the stabilization of SLUG mRNA by regulating IGF2BP1. Additionally, CDR1as activates TGF-ss signaling factors known to promote EMT. These findings highlight the significance of the TGF-ss pathway in cervical cancer metastasis.
Review
Oncology
Maria Teresa Di Martino, Caterina Riillo, Francesca Scionti, Katia Grillone, Nicoletta Polera, Daniele Caracciolo, Mariamena Arbitrio, Pierosandro Tagliaferri, Pierfrancesco Tassone
Summary: Cancer onset and progression are influenced by immune system dysregulation, with noncoding RNAs playing a role in cancer cell immune escape and modulation of the tumor microenvironment. While immunotherapy holds promise for cancer treatment, efforts are needed to achieve cure for immune-refractory tumors.
Review
Cell Biology
Soudeh Ghafouri-Fard, Mohammadreza Hajiesmaeili, Hamed Shoorei, Zahra Bahroudi, Mohammad Taheri, Guive Sharifi
Summary: Stem cells and cancer stem cells possess the abilities of self-renewal and differentiation, with molecular pathways like Wnt, Notch, and Hedgehog influencing their functions. miRNAs and lncRNAs have been found to regulate the functions of CSCs, particularly in breast cancer and hepatocellular carcinoma.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Mark C. Glassy, Atefe Abak, Bashdar Mahmud Hussen, Vahid Niazi, Mohammad Taheri
Summary: The Notch pathway plays a crucial role in cell proliferation, differentiation, development, and tissue homeostasis, and is also involved in regulating stem cell properties and cancer cell metastasis. Various long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) interact with the Notch signaling cascade, playing important functional roles in both cancer and non-neoplastic conditions.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Cell Biology
Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Sai Kiang Lim, Carl-Henrik Heldin, Aristidis Moustakas
Summary: This review summarizes the impact of extracellular vesicles (EVs) on the transforming growth factor beta (TGF-beta) signaling pathway in cancer. The cargo of EVs, including various molecules associated with TGF-beta pathway, can influence tumorigenesis, metastatic spread, immune evasion, and response to treatment. Additionally, TGF-beta-related molecules in circulating EVs show potential as useful biomarkers for prognosis, diagnosis, and treatment response in cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Genetics & Heredity
Tejveer Singh, Mahesh Kaushik, Lokesh Chandra Mishra, Chesta Behl, Vijay Singh, Hardeep Singh Tuli
Summary: Breast cancer is a heterogeneous disease with a high degree of diversity between and within tumors. Various factors influence its prevalence, and early diagnosis and optimal management are crucial for reducing mortality. Nanotechnology, specifically the use of nanomaterial properties for drug delivery mechanisms, is showing promise in breast cancer treatment. Exosomes, a type of nanovesicles, are emerging as novel tools for diagnosing and treating breast cancer.
FRONTIERS IN GENETICS
(2023)
Review
Immunology
Juan-Juan Han, Xue-Qiang Wang, Xin-An Zhang
Summary: This review comprehensively summarizes the regulatory mechanisms of lncRNA/circRNA-miRNA-mRNA network in rheumatoid arthritis (RA) and discusses the potential roles of non-coding RNAs as biomarkers and therapeutic targets for the diagnosis and treatment of RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiasheng Cao, Huijiang Shao, Jiahao Hu, Renan Jin, Anyun Feng, Bin Zhang, Shijie Li, Tianen Chen, Sarun Jeungpanich, Win Topatana, Yitong Tian, Ziyi Lu, Xiujun Cai, Mingyu Chen
Summary: MiR-642a-3p and miR-145-5p were identified as invasion-metastasis associated miRNAs through bioinformatics and experimental validation, and the up-regulation of miR-642a-3p and down-regulation of miR-145-5p may serve as novel treatment options for GBC in the future.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Pathology
Mohammad Taheri, Hamed Shoorei, Farhad Tondro Anamag, Soudeh Ghafouri-Fard, Marcel E. Dinger
Summary: Cisplatin is widely used in chemotherapy for various cancers, but chemoresistance can impede its effectiveness. Recent research has highlighted the role of lncRNAs and miRNAs in the development of resistance to cisplatin, affecting overall survival of cancer patients.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Qi-Yuan Huang, Xing-Ning Lai, Xian-Ling Qian, Lin-Chen Lv, Jun Li, Jing Duan, Xing-Hua Xiao, Li-Xia Xiong
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Oncology
Qi-Yuan Huang, Guo-Feng Liu, Xian-Ling Qian, Li-Bo Tang, Qing-Yun Huang, Li-Xia Xiong
Review
Oncology
Yu-Bo Shi, Jun Li, Xing-Ning Lai, Rui Jiang, Rui-Chen Zhao, Li-Xia Xiong
Review
Biology
Li-Bo Tang, Shu-Xin Ma, Zhuo-Hui Chen, Qi-Yuan Huang, Long-Yuan Wu, Yi Wang, Rui-Chen Zhao, Li-Xia Xiong
Summary: This review comprehensively summarizes the roles, mechanisms, and clinical implications of exosomal microRNAs in breast cancer metastasis, laying a foundation for future personalized drug research.
Article
Medicine, Research & Experimental
Shu-Xin Ma, Li-Bo Tang, Zhi-Hang Chen, Min-Li Wei, Zi-Juan Tang, Yue-Hui Zheng, Guo Zong, Jia Li
Summary: Shikonin (SHK) suppresses the development of ovarian follicles and female germline stem cells (FGSCs), potentially through apoptosis induction and oxidative stress involvement.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
